oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciencesoncotomsk-103Research ArticleОБЗОРЫREVIEWSТаргетная терапия в лечении HER2-позитивного рака молочной железыTarget therapy in treatment of HER2-positive breast cancerБелохвостоваА. С.BelokhvostovaA. S.anna.belokchvostova@gmail.comСмирноваИ. А.SmirnovaI. A.ЕнилееваА. А.EnileevaA. A.ФГБУ «Медицинский радиологический научный центр» Минздравсоцразвития, г. ОбнинскРоссияMedical Radiological Research Center of the Russian Ministry of Health and Social DevelopmentRussian Federation201316022016028488Copyright © Белохвостова А.С., Смирнова И.А., Енилеева А.А., 20162016Белохвостова А.С., Смирнова И.А., Енилеева А.А.Belokhvostova A.S., Smirnova I.A., Enileeva A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/103

Рак молочной железы (РМЖ) занимает первое место в структуре онкологической заболеваемости женского населения во всем мире. Особое место занимают опухоли с избыточной экспрессией HER2-фактора, который определяется у 25–30 % больных.Интерес к таким пациентам обусловлен агрессивным течением болезни, ранним метастазированием, резистентностью к химио- и гормонотерапии. Основным таргетным препаратом, зарегистрированным в РФ для лечения HER2-позитивного РМЖ, являетсяТрастузумаб (герцептин®). В представленном обзоре содержатся данные исследований по применению препарата герцептин в различных схемах химиотерапии. Продолжается изучение комбинирования Трастузумаба с цитостатиками, другими таргетными препаратами при различных стадиях опухолевого процесса.

The breast cancer (BC) wins first place in structure of oncological incidence of the female population around the world. The special place is occupied by tumors with a superfluous expression of HER2 of a factor which is defined at 25–30 % of patients. Interest to suchpatients is defined by an aggressive course of disease, an early metastasis, resistance to chemo-and hormonotherapy. The main targeted drugs registered in the Russian Federation for treatment of HER2-positive BC is Trastuzumab (herceptin®). The presented review contains data of researches on application of a preparation of herceptin in various schemes of chemotherapy. Studying of a combination of trastuzumab with cytostatics, other targeted drugs proceeds at various stages of tumoral process.

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The authors declare that there are no conflicts of interest present.