oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2019-18-5-97-107oncotomsk-1195Research ArticleОБЗОРЫREVIEWSРАСПРОСТРАНЕННЫЙ РАК ГОРТАНИ: ОБЗОР ЛИТЕРАТУРЫADVANCED LARYNGEAL CANCER (LITERATURE REVIEW)https://orcid.org/0000-0002-6895-0497РаджабоваЗ. А-Г.RadzhabovaZ. A-G.

Раджабова Замира Ахмед-Гаджиевна, кандидат медицинских наук, заведующая хирургическим отделением опухолей головы и шеи

 г. Санкт-Петербург, 197758, пос. Песочный, ул. Ленинградская, 68

SPIN-код: 5137-6393

Researcher ID (WOS): X-6941-2018

Zamira A-G. Radzhabova, MD, PhD, Head of the Department of Head and Neck Tumor Surgery

68, St. Leningradskaya, 197758-St. Petersburg

Researcher ID (WOS): X-6941-2018

radzam@mail.ruhttps://orcid.org/0000-0002-2586-1240КотовМ. А.KotovM. A.

Котов Максим Андреевич, врач-онколог

 г. Санкт-Петербург, 197758, пос. Песочный, ул. Ленинградская, 68

SPIN-код: 5761-6697

Researcher ID (WOS): X-5062-2018

Maxim A. Kotov, MD, Oncologist

68, St. Leningradskaya, 197758-St. Petersburg

Researcher ID (WOS): X-5062-2018

https://orcid.org/0000-0001-7304-8214ЭбертМ. А.EbertM. A.

Эберт Мария Альбертовна, клинический ординатор

 г. Санкт-Петербург, 197758, пос. Песочный, ул. Ленинградская, 68

SPIN-код: 7830-1339

Researcher ID (WOS): X-5390-2018

Maria A. Ebert, MD, Resident

68, St. Leningradskaya, 197758-St. Petersburg

Researcher ID (WOS): X-5390-2018

https://orcid.org/0000-0001-7490-4019МитрофановА. С.MitrophanovA. S.

Митрофанов Александр Сергеевич, клинический ординатор

 г. Санкт-Петербург, 197758, пос. Песочный, ул. Ленинградская, 68

SPIN-код: 9891-4050

Researcher ID (WOS): X-5078-2018

Aleksandr S. Mitrofanov, MD, Resident

68, St. Leningradskaya, 197758-St. Petersburg

Researcher ID (WOS): X-5078-2018

https://orcid.org/0000-0001-7679-129XРаджабоваМ. А.RadzhabovaM. A.

Раджабова Мадина Абдурахмановна

г. Санкт-Петербург, 194044, ул. Академика Лебедева, 6

SPIN-код: 5004-8995

Researcher ID (WOS): X-9163-2018

 

Madina A. Radzhabova

6, Academician Lebedev Street, 194044-St. Petersburg

Researcher ID (WOS): X-91632018

https://orcid.org/0000-0003-3837-2515ЛевченкоЕ. В.LevchenkoE. V.

Левченко Евгений Владимирович, доктор медицинских наук, профессор, заведующий хирургическим отделением торакальной онкологии

 г. Санкт-Петербург, 197758, пос. Песочный, ул. Ленинградская, 68

SPIN-код: 2743-8968

Researcher ID (WOS): X-8697-2018

Evgeny V. Levchenko, MD, DSc, Professor, Head of Thoracic Oncology Department

68, St. Leningradskaya, 197758-St. Petersburg

Researcher ID (WOS): X-8697-2018

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава РоссииРоссияN. N. Petrov National Medical Research Oncology CenterRussian FederationФГБВОУВО «Военно-медицинская академия им. С.М. Кирова»РоссияKirov Military Medical AcademyRussian Federation20190111201918597107Copyright © Раджабова З.А., Котов М.А., Эберт М.А., Митрофанов А.С., Раджабова М.А., Левченко Е.В., 20192019Раджабова З.А., Котов М.А., Эберт М.А., Митрофанов А.С., Раджабова М.А., Левченко Е.В.Radzhabova Z.A., Kotov M.A., Ebert M.A., Mitrophanov A.S., Radzhabova M.A., Levchenko E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/1195Актуальность

Актуальность. Плоскоклеточная карцинома гортани остается самым распространенным злокачественным новообразованием области головы и шеи во многих западных странах. По данным мировой литературы, ежегодно в мире регистрируется 238 000 случаев рака гортани и 106 000 летальных исходов от этого заболевания. Гортань играет ключевую роль для таких важных функций организма, как дыхание, голосообразование, защита дыхательных путей и глотание. Таким образом, цель лечения рака гортани – обеспечить максимально возможный контроль над прогрессированием онкологического заболевания с одновременной оптимизацией функциональных результатов.

Целью исследования является обзор хирургических и нехирургических вариантов лечения поздних стадий рака гортани, а также доказательств, подтверждающих эффективность каждого из них, включая онкологические результаты (общая выживаемость, безрецидивная выживаемость, локальный контроль над болезнью, функциональные результаты и связанное с ним качество жизни).

Материал и методы

Материал и методы. Поиск литературы осуществлялся в поисковых системах Medline, Cochrane Library, Elibrary, включались исследования с 1987 по 2016 г.

Выводы

Выводы. Парадигма лечения последних стадий рака гортани перешла от оперативного вмешательства (тотальной ларингэктомии) в качестве золотого стандарта лечения к нехирургическому органосохраняющему лечению с использованием лучевой терапии или химиолучевой терапии. Однако возникли опасения относительно функциональных результатов после химиолучевой терапии, а также возможного снижения общей выживаемости у пациентов с раком гортани.

Background

Background. Squamous carcinoma of the larynx is still the most common head and neck cancer in many Western countries. The larynx plays a key role for many essential functions, including breathing, voice production, airway protection, and swallowing. According to the world literature, 23,800 new cases of laryngeal cancer and 106,000 deaths from this disease are registered annually in the world. Laryngeal cancer treatment is aimed at achieving tumor control while optimizing functional outcomes.

Objective

Objective: to review available data on surgical and non-surgical treatment options for locally advanced laryngeal cancer, as well as the evidence supporting each of these, including oncological outcomes (overall survival, disease-free survival, local control of the disease, functional outcomes and quality of life).

Material and Methods

Material and Methods. A systematic literature search was conducted in the electronic databases Medline, Cochrane Library, and Elibrary in the interval time between 1987 and 2016.

Conclusions

Conclusions. In recent decades, the treatment paradigm for advanced laryngeal cancer has shifted from surgery (total laryngectomy) as the gold standard of treatment to nonsurgical organ-preserving treatment using radiation therapy or chemoradiation therapy. However, concerns have arisen regarding functional outcomes after chemoradiation therapy, as well as a possible reduction in overall survival in laryngeal cancer patients, risk factors, laryngectomy.

рак гортанихирургическое лечениехимиолучевая терапияфакторы рискаларингоэктомияlaryngeal cancersurgical treatmentchemoradiotherapyrisk factorslaryngectomyReferencesTalamini R., Bosetti C., La Vecchia C., Dal Maso L., Levi F., Bidoli E., Negri E., Pasche C., Vaccarella S., Barzan L., Franceschi S. Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study. Cancer Causes Control. 2002 Dec; 13(10): 957–64.Talamini R., Bosetti C., La Vecchia C., Dal Maso L., Levi F., Bidoli E., Negri E., Pasche C., Vaccarella S., Barzan L., Franceschi S. Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study. Cancer Causes Control. 2002 Dec; 13(10): 957–64.Anantharaman D., Marron M., Lagiou P., Samoli E., Ahrens W., Pohlabeln H., Slamova A., Schejbalova M., Merletti F., Richiardi L., Kjaerheim K., Castellsague X., Agudo A., Talamini R., Barzan L., Macfarlane T.V., Tickle M., Simonato L., Canova C., Conway D.I., McKinney P.A., Thomson P., Znaor A., Healy C.M., McCartan B.E., Hashibe M., Brennan P., Macfarlane G.J. Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer. Oral Oncol. 2011 Aug; 47(8): 725–31. doi: 10.1016/j.oraloncology.2011.05.004.Anantharaman D., Marron M., Lagiou P., Samoli E., Ahrens W., Pohlabeln H., Slamova A., Schejbalova M., Merletti F., Richiardi L., Kjaerheim K., Castellsague X., Agudo A., Talamini R., Barzan L., Macfarlane T.V., Tickle M., Simonato L., Canova C., Conway D.I., McKinney P.A., Thomson P., Znaor A., Healy C.M., McCartan B.E., Hashibe M., Brennan P., Macfarlane G.J. Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer. Oral Oncol. 2011 Aug; 47(8): 725–31. doi: 10.1016/j.oraloncology.2011.05.004.Cheremisina O.V., Choinzonov E.L., Pankova O.V., Menshikov K. Yu. Chronic hypeplastic laryngitis as a criterion for defining groups at high risk of laryngeal cancer. Russian otorinolaryngology. 2013; 2 (63): 84–89. (in Russian).Cheremisina O.V., Choinzonov E.L., Pankova O.V., Menshikov K. Yu. Chronic hypeplastic laryngitis as a criterion for defining groups at high risk of laryngeal cancer. Russian otorinolaryngology. 2013; 2 (63): 84–89. (in Russian).Wang X., Lin S., Yu I., Qiu H., Lan Y., Yano E. Causespecific mortality in a Chinese chrysotile textile worker cohort. Cancer Sci. 2013 Feb; 104(2): 245–9. doi: 10.1111/cas.12060.Wang X., Lin S., Yu I., Qiu H., Lan Y., Yano E. Causespecific mortality in a Chinese chrysotile textile worker cohort. Cancer Sci. 2013 Feb; 104(2): 245–9. doi: 10.1111/cas.12060.Offermans N.S., Vermeulen R., Burdorf A., Goldbohm R.A., Kauppinen T., Kromhout H., van den Brandt P.A. Occupational asbestos exposure and risk of pleural mesothelioma, lung cancer, and laryngeal cancer in the Prospective Netherlands Cohort Study. J Occup Environ Med. 2014 Jan; 56(1): 6–19. doi: 10.1097/JOM.0000000000000060.Offermans N.S., Vermeulen R., Burdorf A., Goldbohm R.A., Kauppinen T., Kromhout H., van den Brandt P.A. Occupational asbestos exposure and risk of pleural mesothelioma, lung cancer, and laryngeal cancer in the Prospective Netherlands Cohort Study. J Occup Environ Med. 2014 Jan; 56(1): 6–19. doi: 10.1097/JOM.0000000000000060.Paget-Bailly S., Cyr D., Luce D. Occupational exposures and cancer of the larynx-systematic review and meta-analysis. J Occup Environ Med. 2012 Jan; 54(1): 71–84. doi: 10.1097/JOM.0b013e31823c1343.Paget-Bailly S., Cyr D., Luce D. Occupational exposures and cancer of the larynx-systematic review and meta-analysis. J Occup Environ Med. 2012 Jan; 54(1): 71–84. doi: 10.1097/JOM.0b013e31823c1343.Garavello W., Turati F., Bosetti C., Talamini R., Levi F., Lucenteforte E., Chiesa F., Franceschi S., La Vecchia C., Negri E. Family history of cancer and the risk of laryngeal cancer: a case-control study from Italy and Switzerland. Int J Cancer. 2012 Feb 1; 130(3): 665–70. doi: 10.1002/ijc.26055.Garavello W., Turati F., Bosetti C., Talamini R., Levi F., Lucenteforte E., Chiesa F., Franceschi S., La Vecchia C., Negri E. Family history of cancer and the risk of laryngeal cancer: a case-control study from Italy and Switzerland. Int J Cancer. 2012 Feb 1; 130(3): 665–70. doi: 10.1002/ijc.26055.Bidoli E., Bosetti C., La Vecchia C., Levi F., Parpinel M., Talamini R., Negri E., Maso L.D., Franceschi S. Micronutrients and laryngeal cancer risk in Italy and Switzerland: a case-control study. Cancer Causes Control. 2003 Jun; 14(5): 477–84.Bidoli E., Bosetti C., La Vecchia C., Levi F., Parpinel M., Talamini R., Negri E., Maso L.D., Franceschi S. Micronutrients and laryngeal cancer risk in Italy and Switzerland: a case-control study. Cancer Causes Control. 2003 Jun; 14(5): 477–84.Gallus S., Talamini R., Giacosa A., Montella M., Ramazzotti V., Franceschi S., Negri E., La Vecchia C. Does an apple a day keep the oncologist away? Ann Oncol. 2005; 16: 1841–4. doi.org/10.1093/annonc/mdi361.Gallus S., Talamini R., Giacosa A., Montella M., Ramazzotti V., Franceschi S., Negri E., La Vecchia C. Does an apple a day keep the oncologist away? Ann Oncol. 2005; 16: 1841–4. doi.org/10.1093/annonc/mdi361.Aune D., De Stefani E., Ronco A., Boffetta P., Deneo-Pellegrini H., Acosta G., Mendilaharsu M. Legume intake and the risk of cancer: a multisite case-control study in Uruguay. Cancer Causes Control. 2009; 20: 1605–15. doi: 10.1007/s10552-009-9406-z.Aune D., De Stefani E., Ronco A., Boffetta P., Deneo-Pellegrini H., Acosta G., Mendilaharsu M. Legume intake and the risk of cancer: a multisite case-control study in Uruguay. Cancer Causes Control. 2009; 20: 1605–15. doi: 10.1007/s10552-009-9406-z.van Dijk B.A., Karim-Kos H.E., Coebergh J.W., Marres H.A., de Vries E. Progress against laryngeal cancer in The Netherlands between 1989 and 2010. Int J Cancer. 2013; 134: 674–81. doi.org/10.1002/ijc.28388.van Dijk B.A., Karim-Kos H.E., Coebergh J.W., Marres H.A., de Vries E. Progress against laryngeal cancer in The Netherlands between 1989 and 2010. Int J Cancer. 2013; 134: 674–81. doi.org/10.1002/ijc.28388.Edge S.B., Byrd D.R., Compton C.C., Fritz A.G., Greene F.L., Trotti A. Larynx AJCC Cancer Staging Manual. 7th ed. New York: Springer; 2010: 57–62.Edge S.B., Byrd D.R., Compton C.C., Fritz A.G., Greene F.L., Trotti A. Larynx AJCC Cancer Staging Manual. 7th ed. New York: Springer; 2010: 57–62.McCoul E.D., Har-El G. Meta-analysis of impaired vocal cord mobility as a prognostic factor in T2 glottic carcinoma. Arch Otolaryngol Head Neck Surg. 2009 May; 135(5): 479–86. doi: 10.1001/archoto.2009.47.McCoul E.D., Har-El G. Meta-analysis of impaired vocal cord mobility as a prognostic factor in T2 glottic carcinoma. Arch Otolaryngol Head Neck Surg. 2009 May; 135(5): 479–86. doi: 10.1001/archoto.2009.47.Department of Veterans Affairs Laryngeal Cancer Study Group, Wolf G.T., Fisher S.G., Hong W.K., Hillman R., Spaulding M., Laramore G.E., Endicott J.W., McClatchey K., Henderson W.G. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med. 1991; 324: 1685–90. doi: 0.1056/NEJM199106133242402.Department of Veterans Affairs Laryngeal Cancer Study Group, Wolf G.T., Fisher S.G., Hong W.K., Hillman R., Spaulding M., Laramore G.E., Endicott J.W., McClatchey K., Henderson W.G. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med. 1991; 324: 1685–90. doi: 0.1056/NEJM199106133242402.Sheahan P., Ganly I., Rhys-Evans P.H., Patel S.G. Tumors of the Larynx. Principles and Practice of Head and Neck Surgery and Oncology. London: Informa; 2009. 658.Sheahan P., Ganly I., Rhys-Evans P.H., Patel S.G. Tumors of the Larynx. Principles and Practice of Head and Neck Surgery and Oncology. London: Informa; 2009. 658.Forastiere A.A., Goepfert H., Maor M., Pajak T.F., Weber R., Morrison W., Glisson B., Trotti A., Ridge J.A., Chao C., Peters G., Lee D.J., Leaf A., Ensley J., Cooper J. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003; 349: 2091–8. doi: 10.1056/NEJMoa031317.Forastiere A.A., Goepfert H., Maor M., Pajak T.F., Weber R., Morrison W., Glisson B., Trotti A., Ridge J.A., Chao C., Peters G., Lee D.J., Leaf A., Ensley J., Cooper J. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003; 349: 2091–8. doi: 10.1056/NEJMoa031317.Ambrosch P. The role of laser microsurgery in the treatment of laryngeal cancer. Curr Opin Otolaryngol Head Neck Surg. 2007; 15: 82–8. doi: 10.1097/MOO.0b013e3280147336.Ambrosch P. The role of laser microsurgery in the treatment of laryngeal cancer. Curr Opin Otolaryngol Head Neck Surg. 2007; 15: 82–8. doi: 10.1097/MOO.0b013e3280147336.Cheremisina O.V., Vusik M.V., Soldatov A.N., Reiner I.B. Endoscopic laser technologies in clinical oncology. Siberian Journal of Oncology. 2007; 4: 5–11. (in Russian).Cheremisina O.V., Vusik M.V., Soldatov A.N., Reiner I.B. Endoscopic laser technologies in clinical oncology. Siberian Journal of Oncology. 2007; 4: 5–11. (in Russian).Sperry S.M., Rassekh C.H., Laccourreye O., Weinstein G.S. Supracricoid partial laryngectomy for primary and recurrent laryngeal cancer. JAMA Otolaryngol Head Neck Surg. 2013; 139: 1226–35. doi. org/10.1001/jamaoto.2013.4990.Sperry S.M., Rassekh C.H., Laccourreye O., Weinstein G.S. Supracricoid partial laryngectomy for primary and recurrent laryngeal cancer. JAMA Otolaryngol Head Neck Surg. 2013; 139: 1226–35. doi. org/10.1001/jamaoto.2013.4990.Page C., Mortuaire G., Mouawad F., Ganry O., Darras J., Pasquesoone X., Chevalier D. Supracricoid laryngectomy with cricohyoidoepiglottopexy (CHEP) in the management of laryngeal carcinoma: oncologic results. A 35-year experience. Eur Arch Otorhinolaryngol. 2013 May; 270(6): 1927–32. doi: 10.1007/s00405-012-2300-4.Page C., Mortuaire G., Mouawad F., Ganry O., Darras J., Pasquesoone X., Chevalier D. Supracricoid laryngectomy with cricohyoidoepiglottopexy (CHEP) in the management of laryngeal carcinoma: oncologic results. A 35-year experience. Eur Arch Otorhinolaryngol. 2013 May; 270(6): 1927–32. doi: 10.1007/s00405-012-2300-4.Clayburgh D.R., Graville D.J., Palmer A.D., Schindler J.S. Factors associated with Supracricoid laryngectomy functional outcomes. Head Neck. 2013; 35: 1397–403. doi.org/10.1002/hed.23144.Clayburgh D.R., Graville D.J., Palmer A.D., Schindler J.S. Factors associated with Supracricoid laryngectomy functional outcomes. Head Neck. 2013; 35: 1397–403. doi.org/10.1002/hed.23144.Pinar E., Imre A., Calli C., Oncel S., Katilmis H. Supracricoid partial laryngectomy: analyses of oncologic and functional outcomes. Otolaryngol Head Neck Surg. 2012 Dec; 147(6): 1093–8. doi: 10.1177/0194599812457334.Pinar E., Imre A., Calli C., Oncel S., Katilmis H. Supracricoid partial laryngectomy: analyses of oncologic and functional outcomes. Otolaryngol Head Neck Surg. 2012 Dec; 147(6): 1093–8. doi: 10.1177/0194599812457334.Park J.O., Joo Y.H., Cho K.J., Kim N.G., Kim M.S. Functional and oncologic results of extended supracricoid partial laryngectomy. Arch Otolaryngol Head Neck Surg. 2011 Nov; 137(11): 1124–9. doi: 10.1001/archoto.2011.182.Park J.O., Joo Y.H., Cho K.J., Kim N.G., Kim M.S. Functional and oncologic results of extended supracricoid partial laryngectomy. Arch Otolaryngol Head Neck Surg. 2011 Nov; 137(11): 1124–9. doi: 10.1001/archoto.2011.182.Benito J., Holsinger F.C., Perez-Martin A., Garcia D., Weinstein G.S., Laccourreye O. Aspiration after supra-cricoid partial laryngectomy: incidence, risk factors, management, and outcomes. Head Neck. 2011 May; 33(5): 679–85. doi: 10.1002/hed.21521.Benito J., Holsinger F.C., Perez-Martin A., Garcia D., Weinstein G.S., Laccourreye O. Aspiration after supra-cricoid partial laryngectomy: incidence, risk factors, management, and outcomes. Head Neck. 2011 May; 33(5): 679–85. doi: 10.1002/hed.21521.Raffia M., Hassoun M.S., Abdel Fattah Ale F., Barden H. Experience with supracricoid laryngectomy variants. Head Neck. 2011 Aug; 33(8): 1177–83. doi: 10.1002/hed.21593.Raffia M., Hassoun M.S., Abdel Fattah Ale F., Barden H. Experience with supracricoid laryngectomy variants. Head Neck. 2011 Aug; 33(8): 1177–83. doi: 10.1002/hed.21593.Laccourreye O., Hans S., Borzog-Grayeli A., Maulard-Durdux C., Brasnu D., Housset M. Complications of postoperative radiation therapy after partial laryngectomy in supraglottic cancer: a long-term evaluation. Otolaryngol Head Neck Surg. 2000; 122: 752–7. doi: 10.1067/mhn.2000.98756.Laccourreye O., Hans S., Borzog-Grayeli A., Maulard-Durdux C., Brasnu D., Housset M. Complications of postoperative radiation therapy after partial laryngectomy in supraglottic cancer: a long-term evaluation. Otolaryngol Head Neck Surg. 2000; 122: 752–7. doi: 10.1067/mhn.2000.98756.Spriano G., Antognoni P., Sanguineti G., Sormani M., Richetti A., Ameli F., Piantanida R., Luraghi R., Magli A., Corvo R., Tordiglione M., Vitale V. Laryngeal long-term morbidity after supraglottic laryngectomy and postoperative radiation therapy. Am J Otolaryngol. 2000; 21: 14–21. doi: 10.1016/S0196-0709(00)80119-2.Spriano G., Antognoni P., Sanguineti G., Sormani M., Richetti A., Ameli F., Piantanida R., Luraghi R., Magli A., Corvo R., Tordiglione M., Vitale V. Laryngeal long-term morbidity after supraglottic laryngectomy and postoperative radiation therapy. Am J Otolaryngol. 2000; 21: 14–21. doi: 10.1016/S0196-0709(00)80119-2.Caicedo-Granados E., Beswick D.M., Christopoulos A., Cunningham D.E., Razfar A., Ohr J.P., Heron D.E., Ferris R.L. Oncologic and functional outcomes of partial laryngeal surgery for intermediate-stage laryngeal cancer. Otolaryngol Head Neck Surg. 2013 Feb; 148(2): 235–42. doi: 10.1177/0194599812466367.Caicedo-Granados E., Beswick D.M., Christopoulos A., Cunningham D.E., Razfar A., Ohr J.P., Heron D.E., Ferris R.L. Oncologic and functional outcomes of partial laryngeal surgery for intermediate-stage laryngeal cancer. Otolaryngol Head Neck Surg. 2013 Feb; 148(2): 235–42. doi: 10.1177/0194599812466367.Canis M., Martin A., Ihler F., Wolff H.A., Kron M., Matthias C., Steiner W. Transoral laser microsurgery in treatment of pT2 and pT3 glottic laryngeal squamous cell carcinoma results of 391 patients. Head Neck. 2014 Jun; 36(6): 859–66. doi: 10.1002/hed.23389.Canis M., Martin A., Ihler F., Wolff H.A., Kron M., Matthias C., Steiner W. Transoral laser microsurgery in treatment of pT2 and pT3 glottic laryngeal squamous cell carcinoma results of 391 patients. Head Neck. 2014 Jun; 36(6): 859–66. doi: 10.1002/hed.23389.Suárez C., Rodrigo J.P., Silver C.E., Hartl D.M., Takes R.P., Rinaldo A., Strojan P., Ferlito A. Laser surgery for early to moderately advanced glottic, supraglottic, and hypopharyngeal cancers. Head Neck. 2012; 34: 1028–35. doi: 10.1002/hed.21766.Suárez C., Rodrigo J.P., Silver C.E., Hartl D.M., Takes R.P., Rinaldo A., Strojan P., Ferlito A. Laser surgery for early to moderately advanced glottic, supraglottic, and hypopharyngeal cancers. Head Neck. 2012; 34: 1028–35. doi: 10.1002/hed.21766.Hinni M.L., Salassa J.R., Grant D.G., Pearson B.W., Hayden R.E., Martin A., Christiansen H., Haughey B.H., Nussenbaum B., Steiner W. Transoral laser microsurgery for advanced laryngeal cancer. Arch Otolaryngol Head Neck Surg. 2007; 133: 1198–204. doi: 10.1001/archotol.133.12.1198.Hinni M.L., Salassa J.R., Grant D.G., Pearson B.W., Hayden R.E., Martin A., Christiansen H., Haughey B.H., Nussenbaum B., Steiner W. Transoral laser microsurgery for advanced laryngeal cancer. Arch Otolaryngol Head Neck Surg. 2007; 133: 1198–204. doi: 10.1001/archotol.133.12.1198.Mantsopoulos K., Psychogios G., Bohr C., Zenk J., Kapsreiter M., Waldfahrer F., Iro H. Primary surgical treatment of T3 glottic carcinoma: long-term results and decision-making aspects. Laryngoscope. 2012 Dec; 122(12): 2723–7. doi: 10.1002/lary.23580.Mantsopoulos K., Psychogios G., Bohr C., Zenk J., Kapsreiter M., Waldfahrer F., Iro H. Primary surgical treatment of T3 glottic carcinoma: long-term results and decision-making aspects. Laryngoscope. 2012 Dec; 122(12): 2723–7. doi: 10.1002/lary.23580.Richard J.M., Sancho-Garnier H., Pessey J.J., Luboinski B., Lefebvre J.L., Dehesdin D., Stromboni-Luboinski M., Hill C. Randomized trial of induction chemotherapy in larynx carcinoma. Oral Oncol 1998; 34: 224–8. doi: 10.1016/S1368-8375(97)00090-0.Richard J.M., Sancho-Garnier H., Pessey J.J., Luboinski B., Lefebvre J.L., Dehesdin D., Stromboni-Luboinski M., Hill C. Randomized trial of induction chemotherapy in larynx carcinoma. Oral Oncol 1998; 34: 224–8. doi: 10.1016/S1368-8375(97)00090-0.Forastiere A.A., Zhang Q., Weber R.S., Maor M.H., Goepfert H., Pajak T.F., Morrison W., Glisson B., Trotti A., Ridge J.A., Thorstad W., Wagner H., Ensley J.F., Cooper J.S. Long-term results of RTOG 91-11: a comparison of three non-surgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol. 2013 Mar 1; 31(7): 845–52. doi: 10.1200/JCO.2012.43.6097.Forastiere A.A., Zhang Q., Weber R.S., Maor M.H., Goepfert H., Pajak T.F., Morrison W., Glisson B., Trotti A., Ridge J.A., Thorstad W., Wagner H., Ensley J.F., Cooper J.S. Long-term results of RTOG 91-11: a comparison of three non-surgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol. 2013 Mar 1; 31(7): 845–52. doi: 10.1200/JCO.2012.43.6097.Machtay M., Moughan J., Trotti A., Garden A.S., Weber R.S., Cooper J.S., Forastiere A., Ang K.K. Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol. 2008 Jul 20; 26(21): 3582–9. doi: 10.1200/JCO.2007.14.8841.Machtay M., Moughan J., Trotti A., Garden A.S., Weber R.S., Cooper J.S., Forastiere A., Ang K.K. Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol. 2008 Jul 20; 26(21): 3582–9. doi: 10.1200/JCO.2007.14.8841.Ghadjar P., Simcock M., Zimmermann F., Betz M., Bodis S., Bernier J., Studer G., Aebersold D.M.; Swiss Group for Clinical Cancer Research (SAKK). Predictors of severe late radiotherapy-related toxicity after hyperfractionated radiotherapy with or without concomitant cisplatin in locally advanced head and neck cancer. Secondary retrospective analysis of a randomized phase III trial (SAKK 10/94). Radiother Oncol. 2012; 104: 213–18. doi: 10.1016/j.radonc.2012.05.004.Ghadjar P., Simcock M., Zimmermann F., Betz M., Bodis S., Bernier J., Studer G., Aebersold D.M.; Swiss Group for Clinical Cancer Research (SAKK). Predictors of severe late radiotherapy-related toxicity after hyperfractionated radiotherapy with or without concomitant cisplatin in locally advanced head and neck cancer. Secondary retrospective analysis of a randomized phase III trial (SAKK 10/94). Radiother Oncol. 2012; 104: 213–18. doi: 10.1016/j.radonc.2012.05.004.Wang J.J., Goldsmith T.A., Holman A.S., Cianchetti M., Chan A.W. Pharyngoesophageal stricture after treatment for head and neck cancer. Head Neck. 2012; 34: 967–73. doi: 10.1002/hed.21842.Wang J.J., Goldsmith T.A., Holman A.S., Cianchetti M., Chan A.W. Pharyngoesophageal stricture after treatment for head and neck cancer. Head Neck. 2012; 34: 967–73. doi: 10.1002/hed.21842.Citrin D., Mansueti J., Likhacheva A., Sciuto L., Albert P.S., Rudy S.F., Cooley-Zgela T., Cotrim A., Solomon B., Colevas A.D., Russo A., Morris J.C., Herscher L., Smith S., Van Waes C. Long-term outcomes and toxicity of concurrent paclitaxel and radiotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2009; 74: 1040–6. doi: 10.1016/j.ijrobp.2008.09.053.Citrin D., Mansueti J., Likhacheva A., Sciuto L., Albert P.S., Rudy S.F., Cooley-Zgela T., Cotrim A., Solomon B., Colevas A.D., Russo A., Morris J.C., Herscher L., Smith S., Van Waes C. Long-term outcomes and toxicity of concurrent paclitaxel and radiotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2009; 74: 1040–6. doi: 10.1016/j.ijrobp.2008.09.053.Pointreau Y., Garaud P., Chapet S., Sire C., Tuchais C., Tortochaux J., Faivre S., Guerrif S., Alfonsi M., Calais G. Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation. J Natl Cancer Inst. 2009 Apr 1; 101(7): 498–506. doi: 10.1093/jnci/djp007.Pointreau Y., Garaud P., Chapet S., Sire C., Tuchais C., Tortochaux J., Faivre S., Guerrif S., Alfonsi M., Calais G. Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation. J Natl Cancer Inst. 2009 Apr 1; 101(7): 498–506. doi: 10.1093/jnci/djp007.Posner M.R., Hershock D.M., Blajman C.R., Mickiewicz E., Winquist E., Gorbounova V., Tjulandin S., Shin D.M., Cullen K., Ervin T.J., Murphy B.A., Raez L.E., Cohen R.B., Spaulding M., Tishler R.B., Roth B., Viroglio Rdel C., Venkatesan V., Romanov I., Agarwala S., Harter K.W., Dugan M., Cmelak A., Markoe A.M., Read P.W., Steinbrenner L., Colevas A.D., Norris CM Jr., Haddad R.I.; TAX 324 Study Group. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med. 2007; 357: 1705–15. doi: 10.1056/NEJMoa070956.Posner M.R., Hershock D.M., Blajman C.R., Mickiewicz E., Winquist E., Gorbounova V., Tjulandin S., Shin D.M., Cullen K., Ervin T.J., Murphy B.A., Raez L.E., Cohen R.B., Spaulding M., Tishler R.B., Roth B., Viroglio Rdel C., Venkatesan V., Romanov I., Agarwala S., Harter K.W., Dugan M., Cmelak A., Markoe A.M., Read P.W., Steinbrenner L., Colevas A.D., Norris CM Jr., Haddad R.I.; TAX 324 Study Group. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med. 2007; 357: 1705–15. doi: 10.1056/NEJMoa070956.Urba S., Wolf G., Eisbruch A., Worden F., Lee J., Bradford C., Teknos T., Chepeha D., Prince M., Hogikyan N., Taylor J. Single-cycle induction chemotherapy selects patients with advanced laryngeal cancer for combined chemoradiation: a new treatment paradigm. J Clin Oncol. 2006; 24: 593–8. doi: 10.1200/JCO.2005.01.2047.Urba S., Wolf G., Eisbruch A., Worden F., Lee J., Bradford C., Teknos T., Chepeha D., Prince M., Hogikyan N., Taylor J. Single-cycle induction chemotherapy selects patients with advanced laryngeal cancer for combined chemoradiation: a new treatment paradigm. J Clin Oncol. 2006; 24: 593–8. doi: 10.1200/JCO.2005.01.2047.Worden F.P., Moyer J., Lee J.S., Taylor J.M., Urba S.G., Eisbruch A., Teknos T.N., Chepeha D.B., Prince M.E., Hogikyan N., Lassig A.A., Emerick K., Mukherji S., Hadjiski L., Tsien C.I., Miller T.H., Wallace N.E., Mason H.L., Bradford C.R., Wolf G.T. Chemoselection as a strategy for organ preservation in patients with T4 laryngeal squamous cell carcinoma with cartilage invasion. Laryngoscope. 2009 Aug; 119(8): 15107. doi: 10.1002/lary.20294.Worden F.P., Moyer J., Lee J.S., Taylor J.M., Urba S.G., Eisbruch A., Teknos T.N., Chepeha D.B., Prince M.E., Hogikyan N., Lassig A.A., Emerick K., Mukherji S., Hadjiski L., Tsien C.I., Miller T.H., Wallace N.E., Mason H.L., Bradford C.R., Wolf G.T. Chemoselection as a strategy for organ preservation in patients with T4 laryngeal squamous cell carcinoma with cartilage invasion. Laryngoscope. 2009 Aug; 119(8): 15107. doi: 10.1002/lary.20294.Ganly I., Patel S.G., Matsuo J., Singh B., Kraus D.H., Boyle J., Wong R.J., Lee N., Pfister D.G., Shaha A.R., Shah J.P. Predictors of outcome for advanced-stage supraglottic laryngeal cancer. Head Neck. 2009 Nov; 31(11): 1489–95. doi: 10.1002/hed.21113.Ganly I., Patel S.G., Matsuo J., Singh B., Kraus D.H., Boyle J., Wong R.J., Lee N., Pfister D.G., Shaha A.R., Shah J.P. Predictors of outcome for advanced-stage supraglottic laryngeal cancer. Head Neck. 2009 Nov; 31(11): 1489–95. doi: 10.1002/hed.21113.Nguyen-Tan P.F., Le Q.T., Quivey J.M., Singer M., Terris D.J., Goffinet D.R., Fu K.K. Treatment results and prognostic factors of advanced T34 laryngeal carcinomas: the University of California, San Francisco (UCSF) and Stanford University Hospital (SUH) experience. Int J Radiat Oncol Biol Phys. 2001; 50: 1172–80. doi: 10.1016/S03603016(01)01538-3.Nguyen-Tan P.F., Le Q.T., Quivey J.M., Singer M., Terris D.J., Goffinet D.R., Fu K.K. Treatment results and prognostic factors of advanced T34 laryngeal carcinomas: the University of California, San Francisco (UCSF) and Stanford University Hospital (SUH) experience. Int J Radiat Oncol Biol Phys. 2001; 50: 1172–80. doi: 10.1016/S03603016(01)01538-3.Basheeth N., O’Leary G., Sheahan P. Pharyngocutaneous fistula after salvage laryngectomy: impact of interval between radiotherapy and surgery, and performance of bilateral neck dissection. Head Neck. 2014 Apr; 36(4): 580–4. doi: 10.1002/hed.23337Basheeth N., O’Leary G., Sheahan P. Pharyngocutaneous fistula after salvage laryngectomy: impact of interval between radiotherapy and surgery, and performance of bilateral neck dissection. Head Neck. 2014 Apr; 36(4): 580–4. doi: 10.1002/hed.23337Chen A.Y., Halpern M. Factors predictive of survival in advanced laryngeal cancer. Arch Otolaryngol Head Neck Surg. 2007 Dec; 133(12): 1270–6.Chen A.Y., Halpern M. Factors predictive of survival in advanced laryngeal cancer. Arch Otolaryngol Head Neck Surg. 2007 Dec; 133(12): 1270–6.Mendenhall W.M., Parsons J.T., Mancuso A.A., Pameijer F.J., Stringer S.P., Cassisi N.J. Definitive radiotherapy for T3 squamous cell carcinoma of the glottic larynx. J Clin Oncol. 1997; 15: 2394–402. doi: 10.1200/JCO.1997.15.6.2394.Mendenhall W.M., Parsons J.T., Mancuso A.A., Pameijer F.J., Stringer S.P., Cassisi N.J. Definitive radiotherapy for T3 squamous cell carcinoma of the glottic larynx. J Clin Oncol. 1997; 15: 2394–402. doi: 10.1200/JCO.1997.15.6.2394.Spaulding C.A., Gillenwater A., Constable W.C., Hahn S.S., Kersh C.R. Prognostic value of vocal cord fixation with respect to treatment in cancers of the supraglottis and pyriform sinus. Laryngoscope. 1987; 97: 1450–3. doi: 10.1288/00005537-198712000-00013.Spaulding C.A., Gillenwater A., Constable W.C., Hahn S.S., Kersh C.R. Prognostic value of vocal cord fixation with respect to treatment in cancers of the supraglottis and pyriform sinus. Laryngoscope. 1987; 97: 1450–3. doi: 10.1288/00005537-198712000-00013.Singer S., Wollbrück D., Dietz A., Schock J., Pabst F., Vogel H.J., Oeken J., Sandner A., Koscielny S., Hormes K., Breitenstein K., Richter H., Deckelmann A., Cook S., Fuchs M., Meuret S. Speech rehabilitation during the first year after total laryngectomy. Head Neck. 2013 Nov; 35(11): 1583–90. doi: 10.1002/hed.23183.Singer S., Wollbrück D., Dietz A., Schock J., Pabst F., Vogel H.J., Oeken J., Sandner A., Koscielny S., Hormes K., Breitenstein K., Richter H., Deckelmann A., Cook S., Fuchs M., Meuret S. Speech rehabilitation during the first year after total laryngectomy. Head Neck. 2013 Nov; 35(11): 1583–90. doi: 10.1002/hed.23183.Chone C.T., Gripp F.M., Spina A.L., Crespo A.N. Primary versus secondary tracheoesophageal puncture for speech rehabilitation in total laryngectomy: long-term results with indwelling voice prosthesis. Otolaryngol Head Neck Surg. 2005 Jul; 133(1): 89–93.Chone C.T., Gripp F.M., Spina A.L., Crespo A.N. Primary versus secondary tracheoesophageal puncture for speech rehabilitation in total laryngectomy: long-term results with indwelling voice prosthesis. Otolaryngol Head Neck Surg. 2005 Jul; 133(1): 89–93.Bozec A., Poissonnet G., Chamorey E., Demard F., Santini J., Peyrade F., Ortholan C., Benezery K., Thariat J., Sudaka A., Anselme K., Adrey B., Giacchero P., Dassonville O. Results of vocal rehabilitation using tracheoesophageal voice prosthesis after total laryngectomy and their predictive factors. Eur Arch Otorhinolaryngol. 2010 May; 267(5): 751–8. doi: 10.1007/s00405-009-1138-x.Bozec A., Poissonnet G., Chamorey E., Demard F., Santini J., Peyrade F., Ortholan C., Benezery K., Thariat J., Sudaka A., Anselme K., Adrey B., Giacchero P., Dassonville O. Results of vocal rehabilitation using tracheoesophageal voice prosthesis after total laryngectomy and their predictive factors. Eur Arch Otorhinolaryngol. 2010 May; 267(5): 751–8. doi: 10.1007/s00405-009-1138-x.Cocuzza S., Bonfiglio M., Grillo C., Maiolino L., Malaguarnera M., Martines F., Serra A. Post laryngectomy speech rehabilitation outcome in elderly patients. Eur Arch Otorhinolaryngol. 2013 May; 270(6): 1879–84. doi: 10.1007/s00405-013-2430-3.Cocuzza S., Bonfiglio M., Grillo C., Maiolino L., Malaguarnera M., Martines F., Serra A. Post laryngectomy speech rehabilitation outcome in elderly patients. Eur Arch Otorhinolaryngol. 2013 May; 270(6): 1879–84. doi: 10.1007/s00405-013-2430-3.Lassaletta L., Garcia-Pallares M., Morera E., Bernaldez R., Gavilan J. T3 glottic cancer: oncologic results and prognostic factors. Otolaryngol Head Neck Surg. 2001; 124: 556–60. doi: 10.1067/mhn.2001.115498.Lassaletta L., Garcia-Pallares M., Morera E., Bernaldez R., Gavilan J. T3 glottic cancer: oncologic results and prognostic factors. Otolaryngol Head Neck Surg. 2001; 124: 556–60. doi: 10.1067/mhn.2001.115498.Nikolaou A., Markou K., Petridis D., Vlachtsis K., Nalbantian M., Daniilidis L. Factors influencing tumour relapse after total laryngectomy. B-ENT. 2005; 1: 1–10.Nikolaou A., Markou K., Petridis D., Vlachtsis K., Nalbantian M., Daniilidis L. Factors influencing tumour relapse after total laryngectomy. B-ENT. 2005; 1: 1–10.Kowalski L.P., Batista M.B., Santos C.R., Scopel A., Salvajolli J.V., Torloni H. Prognostic factors in T3, N0-1 glottic and transglottic carcinoma. A multifactorial study of 221 cases treated by surgery or radiotherapy. Arch Otolaryngol Head Neck Surg. 1996; 122: 77–82. doi: 10.1001/archotol.1996.01890130069011.Kowalski L.P., Batista M.B., Santos C.R., Scopel A., Salvajolli J.V., Torloni H. Prognostic factors in T3, N0-1 glottic and transglottic carcinoma. A multifactorial study of 221 cases treated by surgery or radiotherapy. Arch Otolaryngol Head Neck Surg. 1996; 122: 77–82. doi: 10.1001/archotol.1996.01890130069011.Basheeth N., Khan H., O’Leary G., Sheahan P. Oncologic outcomes of total laryngectomy: impact of margins and preoperative tracheostomy. Head Neck. 2015 Jun; 37(6): 862–9. doi: 10.1002/hed.23681.Basheeth N., Khan H., O’Leary G., Sheahan P. Oncologic outcomes of total laryngectomy: impact of margins and preoperative tracheostomy. Head Neck. 2015 Jun; 37(6): 862–9. doi: 10.1002/hed.23681.Hutcheson K.A., Lewin J.S., Sturgis E.M., Risser J. Multivariable analysis of risk factors for enlargement of the tracheoesophageal puncture after total laryngectomy. Head Neck. 2012 Apr; 34(4): 557–67. doi: 10.1002/hed.21777.Hutcheson K.A., Lewin J.S., Sturgis E.M., Risser J. Multivariable analysis of risk factors for enlargement of the tracheoesophageal puncture after total laryngectomy. Head Neck. 2012 Apr; 34(4): 557–67. doi: 10.1002/hed.21777.Patel U.A., Moore B.A., Wax M., Rosenthal E., Sweeny L., Militsakh O.N., Califano J.A., Lin A.C., Hasney C.P., Butcher R.B., Flohr J., Arnaoutakis D., Huddle M., Richmon J.D. Impact of pharyngeal closure technique on fistula after salvage laryngectomy. JAMA Otolaryngol Head Neck Surg. 2013 Nov; 139(11): 1156–62. doi: 10.1001/jamaoto.2013.2761.Patel U.A., Moore B.A., Wax M., Rosenthal E., Sweeny L., Militsakh O.N., Califano J.A., Lin A.C., Hasney C.P., Butcher R.B., Flohr J., Arnaoutakis D., Huddle M., Richmon J.D. Impact of pharyngeal closure technique on fistula after salvage laryngectomy. JAMA Otolaryngol Head Neck Surg. 2013 Nov; 139(11): 1156–62. doi: 10.1001/jamaoto.2013.2761.Oosthuizen J.C., Leonard D.S., Kinsella J.B. The role of pectoralis major myofascial flap in salvage laryngectomy: a single surgeon experience. Acta Otolaryngol. 2012 Sep; 132(9): 1002–5. doi: 10.3109/00016489.2012.672768.Oosthuizen J.C., Leonard D.S., Kinsella J.B. The role of pectoralis major myofascial flap in salvage laryngectomy: a single surgeon experience. Acta Otolaryngol. 2012 Sep; 132(9): 1002–5. doi: 10.3109/00016489.2012.672768.Righini C., Lequeux T., Cuisnier O., Morel N., Reyt E. The pectoralis myofascial flap in pharyngolaryngeal surgery after radiotherapy. Eur Arch Otorhinolaryngol. 2005; 262: 357–61. doi: 10.1007/s00405004-0827-8.Righini C., Lequeux T., Cuisnier O., Morel N., Reyt E. The pectoralis myofascial flap in pharyngolaryngeal surgery after radiotherapy. Eur Arch Otorhinolaryngol. 2005; 262: 357–61. doi: 10.1007/s00405004-0827-8.Gil Z., Gupta A., Kummer B., Cordeiro P.G., Kraus D.H., Shah J.P., Patel S.G. The role of pectoralis major muscle flap in salvage total laryngectomy. Arch Otolaryngol Head Neck Surg. 2009; 135: 1019–23. doi: 10.1001/archoto.2009.126.Gil Z., Gupta A., Kummer B., Cordeiro P.G., Kraus D.H., Shah J.P., Patel S.G. The role of pectoralis major muscle flap in salvage total laryngectomy. Arch Otolaryngol Head Neck Surg. 2009; 135: 1019–23. doi: 10.1001/archoto.2009.126.Scola B., Fernandez-Vega M., Martinez T., Fernandez-Vega S., Ramirez C. Management of cancer of the supraglottis. Otolaryngol Head Neck Surg. 2001; 124: 195–8. doi: 10.1067/mhn.2001.112202.Scola B., Fernandez-Vega M., Martinez T., Fernandez-Vega S., Ramirez C. Management of cancer of the supraglottis. Otolaryngol Head Neck Surg. 2001; 124: 195–8. doi: 10.1067/mhn.2001.112202.Hicks W.L.Jr., Kollmorgen D.R., Kuriakose M.A., Orner J., Bakamjian V.Y., Winston J., Loree T.R. Patterns of nodal metastasis and surgical management of the neck in supraglottic laryngeal carcinoma. Otolaryngol Head Neck Surg. 1999; 121: 57–61. doi: 10.1016/S01945998(99)70125-7.Hicks W.L.Jr., Kollmorgen D.R., Kuriakose M.A., Orner J., Bakamjian V.Y., Winston J., Loree T.R. Patterns of nodal metastasis and surgical management of the neck in supraglottic laryngeal carcinoma. Otolaryngol Head Neck Surg. 1999; 121: 57–61. doi: 10.1016/S01945998(99)70125-7.Ferlito A., Silver C.E., Rinaldo A. Selective neck dissection (IIA, III): a rational replacement for complete functional neck dissection in patients with N0 supraglottic and glottic squamous carcinoma. Laryngoscope. 2008; 118: 676–9. doi: 10.1097/MLG.0b013e31815f6f25.Ferlito A., Silver C.E., Rinaldo A. Selective neck dissection (IIA, III): a rational replacement for complete functional neck dissection in patients with N0 supraglottic and glottic squamous carcinoma. Laryngoscope. 2008; 118: 676–9. doi: 10.1097/MLG.0b013e31815f6f25.Candela F.C., Shah J., Jaques D.P., Shah J.P. Patterns of cervical node metastases from squamous carcinoma of the larynx. Arch Otolaryngol Head Neck Surg. 1990; 116: 432–5. doi: 10.1001/archotol.1990.01870040054013.Candela F.C., Shah J., Jaques D.P., Shah J.P. Patterns of cervical node metastases from squamous carcinoma of the larynx. Arch Otolaryngol Head Neck Surg. 1990; 116: 432–5. doi: 10.1001/archotol.1990.01870040054013.Khafif A., Fliss D.M., Gil Z., Medina J.E. Routine inclusion of level IV in neck dissection for squamous cell carcinoma of the larynx: is it justified? Head Neck. 2004; 26: 309–12. doi.org/10.1002/hed.10390.Khafif A., Fliss D.M., Gil Z., Medina J.E. Routine inclusion of level IV in neck dissection for squamous cell carcinoma of the larynx: is it justified? Head Neck. 2004; 26: 309–12. doi.org/10.1002/hed.10390.Ozturkcan S., Katilmis H., Ozdemir I., Tuna B., Guvenc I.A., Dundar R. Occult contralateral nodal metastases in supraglottic laryngeal cancer crossing the midline. Eur Arch Otorhinolaryngol. 2009 Jan; 266(1): 117–20. doi: 10.1007/s00405-008-0721-x.Ozturkcan S., Katilmis H., Ozdemir I., Tuna B., Guvenc I.A., Dundar R. Occult contralateral nodal metastases in supraglottic laryngeal cancer crossing the midline. Eur Arch Otorhinolaryngol. 2009 Jan; 266(1): 117–20. doi: 10.1007/s00405-008-0721-x.Davis R.K., Kriskovich M.D., Galloway E.B., Buntin C.S., Jepsen M.C. Endoscopic supraglottic laryngectomy with postoperative irradiation. Ann Otol Rhinol Laryngol. 2004; 113: 132–8. doi: 10.1177/000348940411300210.Davis R.K., Kriskovich M.D., Galloway E.B., Buntin C.S., Jepsen M.C. Endoscopic supraglottic laryngectomy with postoperative irradiation. Ann Otol Rhinol Laryngol. 2004; 113: 132–8. doi: 10.1177/000348940411300210.Alpert T.E., Morbidini-Gaffney S., Chung C.T., Bogart J.A., Hahn S.S., Hsu J., Kellman R.M. Radiotherapy for the clinically negative neck in supraglottic laryngeal cancer. Cancer J. 2004; 10: 335–8. doi: 10.1097/00130404-200411000-00001.Alpert T.E., Morbidini-Gaffney S., Chung C.T., Bogart J.A., Hahn S.S., Hsu J., Kellman R.M. Radiotherapy for the clinically negative neck in supraglottic laryngeal cancer. Cancer J. 2004; 10: 335–8. doi: 10.1097/00130404-200411000-00001.de Bree R., Leemans C.R., Silver C.E., Robbins K.T., Rodrigo J.P., Rinaldo A., Takes R.P., Shaha A.R., Medina J.E., Suárez C., Ferlito A. Paratracheal lymph node dissection in cancer of the larynx, hypopharynx, and cervical esophagus: the need for guidelines. Head Neck. 2011; 33: 912–16. doi: 10.1002/hed.21472.de Bree R., Leemans C.R., Silver C.E., Robbins K.T., Rodrigo J.P., Rinaldo A., Takes R.P., Shaha A.R., Medina J.E., Suárez C., Ferlito A. Paratracheal lymph node dissection in cancer of the larynx, hypopharynx, and cervical esophagus: the need for guidelines. Head Neck. 2011; 33: 912–16. doi: 10.1002/hed.21472.Chan A.W., Ancukiewicz M., Carballo N., Montgomery W., Wang C.C. The role of postradiotherapy neck dissection in supraglottic carcinoma. Int J Radiat Oncol Biol Phys. 2001; 50: 367–75. doi: 10.1016/S03603016(01)01468-7.Chan A.W., Ancukiewicz M., Carballo N., Montgomery W., Wang C.C. The role of postradiotherapy neck dissection in supraglottic carcinoma. Int J Radiat Oncol Biol Phys. 2001; 50: 367–75. doi: 10.1016/S03603016(01)01468-7.Forest V.I., Nguyen-Tan P.F., Tabet J.C., Olivier M.J., Larochelle D., Fortin B., Gélinas M., Soulières D., Charpentier D., Guertin L. Role of neck dissection following concurrent chemoradiation for advanced head and neck carcinoma. Head Neck. 2006; 28: 1099–105. doi: 10.1002/hed.20479.Forest V.I., Nguyen-Tan P.F., Tabet J.C., Olivier M.J., Larochelle D., Fortin B., Gélinas M., Soulières D., Charpentier D., Guertin L. Role of neck dissection following concurrent chemoradiation for advanced head and neck carcinoma. Head Neck. 2006; 28: 1099–105. doi: 10.1002/hed.20479.Corry J., Peters L., Fisher R., Macann A., Jackson M., McClure B., Rischin D. N2-N3 neck nodal control without planned neck dissection for clinical/radiologic complete responders-results of Trans Tasman Radiation Oncology Group Study 98.02. Head Neck. 2008 Jun; 30(6): 737–42. doi: 10.1002/hed.20769.Corry J., Peters L., Fisher R., Macann A., Jackson M., McClure B., Rischin D. N2-N3 neck nodal control without planned neck dissection for clinical/radiologic complete responders-results of Trans Tasman Radiation Oncology Group Study 98.02. Head Neck. 2008 Jun; 30(6): 737–42. doi: 10.1002/hed.20769.Hamoir M., Ferlito A., Schmitz S., Hanin F.X., Thariat J., Weynand B., Machiels J.P., Grégoire V., Robbins K.T., Silver C.E., Strojan P., Rinaldo A., Corry J., Takes R.P. The role of neck dissection in the setting of chemoradiation therapy for head and neck squamous cell carcinoma with advanced neck disease. Oral Oncol. 2012; 48: 20310. doi: 10.1016/j.oraloncology.2011.10.015.Hamoir M., Ferlito A., Schmitz S., Hanin F.X., Thariat J., Weynand B., Machiels J.P., Grégoire V., Robbins K.T., Silver C.E., Strojan P., Rinaldo A., Corry J., Takes R.P. The role of neck dissection in the setting of chemoradiation therapy for head and neck squamous cell carcinoma with advanced neck disease. Oral Oncol. 2012; 48: 20310. doi: 10.1016/j.oraloncology.2011.10.015.Liu X.K., Li Q., Zhang Q., Su Y., Shi Y.X., Li H., Zeng Z.Y., Guo Z.M. Planned neck dissection before combined chemoradiation in organ preservation protocol for N2–N3 of supraglottic or hypopharyngeal carcinoma. ORL J Otorhinolaryngol Relat Spec. 2012; 74(2): 64–9. doi: 10.1159/000333111.Liu X.K., Li Q., Zhang Q., Su Y., Shi Y.X., Li H., Zeng Z.Y., Guo Z.M. Planned neck dissection before combined chemoradiation in organ preservation protocol for N2–N3 of supraglottic or hypopharyngeal carcinoma. ORL J Otorhinolaryngol Relat Spec. 2012; 74(2): 64–9. doi: 10.1159/000333111.Amit M., Hilly O., Leider-Trejo L., Popovtzer A., Gutfeld O., Shvero J., Fliss D.M., Cohen J.T., Bachar G., Gil Z. The role of elective neck dissection in patients undergoing salvage laryngectomy. Head Neck. 2013 Oct; 35(10): 1392–6. doi: 10.1002/hed.23145.Amit M., Hilly O., Leider-Trejo L., Popovtzer A., Gutfeld O., Shvero J., Fliss D.M., Cohen J.T., Bachar G., Gil Z. The role of elective neck dissection in patients undergoing salvage laryngectomy. Head Neck. 2013 Oct; 35(10): 1392–6. doi: 10.1002/hed.23145.Wax M.K., Touma B.J. Management of the N0 neck during salvage laryngectomy. Laryngoscope. 1999; 109: 4–7. doi: 10.1097/00005537199901000-00002.Wax M.K., Touma B.J. Management of the N0 neck during salvage laryngectomy. Laryngoscope. 1999; 109: 4–7. doi: 10.1097/00005537199901000-00002.Basheeth N., O’Leary G., Sheahan P. Elective neck dissection for no neck during salvage total laryngectomy: findings, complications, and oncological outcome. JAMA Otolaryngol Head Neck Surg. 2013 Aug 1; 139(8): 790–6. doi: 10.1001/jamaoto.2013.3995.Basheeth N., O’Leary G., Sheahan P. Elective neck dissection for no neck during salvage total laryngectomy: findings, complications, and oncological outcome. JAMA Otolaryngol Head Neck Surg. 2013 Aug 1; 139(8): 790–6. doi: 10.1001/jamaoto.2013.3995.Farrag T.Y., Lin F.R., Cummings C.W., Koch W.M., Flint P.W., Califano J.A., Broussard J., Bajaj G., Tufano R.P. Neck management in patients undergoing postradiotherapy salvage laryngeal surgery for recurrent/ persistent laryngeal cancer. Laryngoscope. 2006; 116: 1864–6. doi: 10.1097/01.mlg.0000234917.08822.cd.Farrag T.Y., Lin F.R., Cummings C.W., Koch W.M., Flint P.W., Califano J.A., Broussard J., Bajaj G., Tufano R.P. Neck management in patients undergoing postradiotherapy salvage laryngeal surgery for recurrent/ persistent laryngeal cancer. Laryngoscope. 2006; 116: 1864–6. doi: 10.1097/01.mlg.0000234917.08822.cd.Bohannon I.A., Desmond R.A., Clemons L., Magnuson J.S., Carroll W.R., Rosenthal E.L. Management of the N0 neck in recurrent laryngeal squamous cell carcinoma. Laryngoscope. 2010; 120: 58–61. doi: 10.1002/lary.20675.Bohannon I.A., Desmond R.A., Clemons L., Magnuson J.S., Carroll W.R., Rosenthal E.L. Management of the N0 neck in recurrent laryngeal squamous cell carcinoma. Laryngoscope. 2010; 120: 58–61. doi: 10.1002/lary.20675.Dagan R., Morris C.G., Kirwan J.M., Werning J.W., Vaysberg M., Amdur R.J., Mendenhall W.M. Elective neck dissection during salvage surgery for locally recurrent head and neck squamous cell carcinoma after radiotherapy with elective nodal irradiation. Laryngoscope. 2010; 120: 945–52. doi: 10.1002/lary.20854.Dagan R., Morris C.G., Kirwan J.M., Werning J.W., Vaysberg M., Amdur R.J., Mendenhall W.M. Elective neck dissection during salvage surgery for locally recurrent head and neck squamous cell carcinoma after radiotherapy with elective nodal irradiation. Laryngoscope. 2010; 120: 945–52. doi: 10.1002/lary.20854.Yao M., Roebuck J.C., Holsinger F.C., Myers J.N. Elective neck dissection during salvage laryngectomy. Am J Otolaryngol. 2005; 26: 388–92. doi: 10.1016/j.amjoto.2005.05.002.Yao M., Roebuck J.C., Holsinger F.C., Myers J.N. Elective neck dissection during salvage laryngectomy. Am J Otolaryngol. 2005; 26: 388–92. doi: 10.1016/j.amjoto.2005.05.002.Раджабова З.А., Левченко Е.В., Дунаевский И.В., Горохов Л.В., Котов М.А., Хандогин Н.В., Ракитина Д.А., Нажмудинов Р.А., Гиршович М.М., Тюряева Е.И., Ткаченко Е.В., Пономарева О.И. Анализ результатов комбинированного лечения пациентов с верифицированным раком шейного отдела пищевода и гортаноглотки с применением хирургического лечения с одномоментной пластикой дефекта. Опухоли головы и шеи. 2016; 6(3): 61–63. doi: 10.17650/2222-1468-2016-6-3-61-63.Radzhabova Z.A., Levchenko E.V., Dunaevsky I.V., Gorohov L.V., Kotov M.A., Handogin N.V., Rakitina D.A., Nazhmudinov R.A., Girshovich M.M., Tjurjaeva E.I., Tkachenko E.V., Ponomareva O.I. Analysis results of combined treatment of patients with verified cancer of the cervical esophagus and hypopharynx with the application of surgical treatment with one-stage defect’s plastic. Head and neck tumors. 2016; 6(3): 61–63. (in Russian). doi: 10.17650/2222-1468-2016-6-3-61-63.

The authors declare that there are no conflicts of interest present.