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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21294/1814-4861-2019-18-6-39-49</article-id><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-1242</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛАБОРАТОРНЫЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LABORATORY AND EXPERIMENTAL STUDIES</subject></subj-group></article-categories><title-group><article-title>ИНТЕГРАЛЬНЫЙ АНАЛИЗ ГЕНОМНЫХ И ТРАНСКРИПТОМНЫХ ИЗМЕНЕНИЙ ПРИ СВЕТЛОКЛЕТОЧНОЙ ПОЧЕЧНО-КЛЕТОЧНОЙ КАРЦИНОМЕ В РОССИЙСКОЙ ПОПУЛЯЦИИ</article-title><trans-title-group xml:lang="en"><trans-title>INTEGRAL ANALYSIS OF GENOMIC AND TRANSCRIPTOMIC CHANGES IN CLEAR CELL RENAL CELL CARCINOMA IN THE RUSSIAN POPULATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3761-6776</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солодских</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Solodskikh</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>младший научный сотрудник кафедры генетики, цитологии и биоинженерии</p><p>SPIN-код: 5833-6368Россия, г. Воронеж, 394000, Университетская площадь, 1 </p></bio><bio xml:lang="en"><p>Junior Researcher</p><p>1, Universitetskaya square, 394000, Voronezh, Russia </p></bio><email xlink:type="simple">s.solodskih@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4721-3447</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Паневина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Panevina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>лаборант</p><p>SPIN-код: 2356-2166  Россия, г. Воронеж, 394000, Университетская площадь, 1 </p></bio><bio xml:lang="en"><p>laboratory assistant</p><p>1, Universitetskaya square, 394000, Voronezh, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новикова</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikova</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>student</p><p>1, Universitetskaya square, 394000, Voronezh, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5820-1804</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дворецкая</surname><given-names>Ю. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Dvoretskaya</surname><given-names>J. D.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2076-3868</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Грязнова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gryaznova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1334-4828</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Старков</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Starkov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>PhD, профессор</p><p>AuthorID (РИНЦ): 81262США, г. Нью-Йорк, 1300, Йорк Авеню, 10065 </p></bio><bio xml:lang="en"><p>PhD, Professor</p><p>1, Universitetskaya square, 394000, Voronezh, Russia </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маслов</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Maslov</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат биологических наук, старший научный сотрудник, профессор </p><p>SPIN-код: 9137-3622. AuthorID (РИНЦ): 746138 Россия, г. Воронеж, 394000, Университетская площадь, 1</p><p>США, г. Бронкс, 1300, Моррис Парк Авеню, 10461</p></bio><bio xml:lang="en"><p>PhD, Senior Researcher, Professor</p><p>1, Universitetskaya square, 394000, Voronezh, Russia </p><p>1300, Morris Park avenue, 10461, Bronx, USA </p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Михайлов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mikhailov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Россия, 394000, г. Воронеж, ул. Вайцеховского, 4 </p></bio><bio xml:lang="en"><p>1, Universitetskaya square, 394000, Voronezh, Russia</p><p> </p><p>4, Vaitsekhovskogo street, 394000, Voronezh, Russia </p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0183-4149</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хинопулос</surname><given-names>К.</given-names></name><name name-style="western" xml:lang="en"><surname>Khinolupos</surname><given-names>K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>PhD, профессор </p><p> Author ID (Scopus): 6602951392Венгрия, г. Будапешт, 1085, ул. Ульти, 26</p><p> </p></bio><bio xml:lang="en"><p>PhD, Professor</p><p>26, ulti street, 1085, Budapest, Hungary </p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1294-8686</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попов</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Popov</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор биологических наук, заведующий кафедрой генетики, цитологии и биоинженерии; ректор</p><p>SPIN-код: 7257-5052. AuthorID (РИНЦ): 88213Россия, г. Воронеж, 394000, Университетская площадь, 1</p><p>Россия, г. Воронеж, 394000, просп. Революции, 19 </p></bio><bio xml:lang="en"><p>DSc, Head of the Department of Genetics, Cytology and Bioengineering</p><p>1, Universitetskaya square, 394000, Voronezh, Russia </p><p>19, Prospect Revolution, 394000, Voronezh, Russia </p></bio><xref ref-type="aff" rid="aff-6"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Воронежский государственный университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Voronezh State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Колледж Уэилл Медикал Корнеллского университета</institution><country>Соединённые Штаты Америки</country></aff><aff xml:lang="en"><institution>Cornell University Weill Medical College</institution><country>United States</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Воронежский государственный университет»,&#13;
Медицинский колледж им. Альберта Эйнштейна</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Voronezh State University,&#13;
College of Medicine Albert Einstein</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБОУ ВО «Воронежский государственный университет»,&#13;
БУЗ ВО «Воронежский областной клинический онкологический диспансер»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Voronezh State University,&#13;
Voronezh Regional Clinical Oncology Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Университет Земмельвайса</institution><country>Венгрия</country></aff><aff xml:lang="en"><institution>Semmelweis University</institution><country>Hungary</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>ФГБОУ ВО «Воронежский государственный университет»,&#13;
ФГБОУ ВО «Воронежский государственный университет инженерных технологий»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Voronezh State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>04</day><month>01</month><year>2020</year></pub-date><volume>18</volume><issue>6</issue><fpage>39</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Солодских С.А., Паневина А.В., Новикова А.Г., Дворецкая Ю.Д., Грязнова М.В., Старков А.А., Маслов А.Ю., Михайлов А.А., Хинопулос К., Попов В.Н., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Солодских С.А., Паневина А.В., Новикова А.Г., Дворецкая Ю.Д., Грязнова М.В., Старков А.А., Маслов А.Ю., Михайлов А.А., Хинопулос К., Попов В.Н.</copyright-holder><copyright-holder xml:lang="en">Solodskikh S.A., Panevina A.V., Novikova A.G., Dvoretskaya J.D., Gryaznova M.V., Starkov A.A., Maslov A.Y., Mikhailov A.A., Khinolupos K., Popov V.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/1242">https://www.siboncoj.ru/jour/article/view/1242</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>рак</kwd><kwd>микроматрицы</kwd><kwd>мутации</kwd><kwd>геном</kwd><kwd>транскриптом</kwd><kwd>почечно-клеточная карцинома</kwd><kwd>рак почки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cancer</kwd><kwd>microarrays</kwd><kwd>mutations</kwd><kwd>genome</kwd><kwd>transcript</kwd><kwd>renal cell carcinoma</kwd><kwd>kidney cancer</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена при поддержке гранта Министерства науки и высшего образования Российской Федерации 14.586.21.0062 (уникальный идентификатор договора RFMEFI58618X0062) (В.Н. Попов).</funding-statement><funding-statement xml:lang="en">This study was financially supported by the grant of the Ministry of Science and Higher Education of the Russian Federation 14.586.21.0062 (unique contract identifier RFMEFI58618X0062) (V.N. Popov).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6): 394–424. doi:10.3322/caac.21492.</mixed-citation><mixed-citation xml:lang="en">Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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