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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21294/1814-4861-2019-18-6-82-89</article-id><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-1247</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛАБОРАТОРНЫЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LABORATORY AND EXPERIMENTAL STUDIES</subject></subj-group></article-categories><title-group><article-title>РОЛЬ СИРТУИНА 1 В РЕГУЛЯЦИИ КЛЕТОК МЕЛАНОМЫ</article-title><trans-title-group xml:lang="en"><trans-title>ROLE OF SIRTUIN 1 IN REGULATION OF MELANOMA CELL PROLIFERATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0754-9955</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дубовцева</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Dubovtseva</surname><given-names>I. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры патологической физиологии им. проф. В.В. Иванова</p><p>Researcher ID (WOS): S-9831-2018</p><p>Россия, г. Красноярск, 660022, ул. Партизана Железняка, 1 </p></bio><bio xml:lang="en"><p>Postgraduate student of the Department of Pathophysiology</p><p>Researcher ID (WOS): S-9831-2018</p><p>1, P. Zheleznyaka street, 660022, Krasnoyarsk, Russia </p></bio><email xlink:type="simple">dubovtseva14@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7660-700X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аксененко</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Aksenenko</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, доцент кафедры патологической физиологии</p><p>SPIN-код: 6958-9122. Researcher ID (WOS): V-1055-2017. Author ID (Scopus): 55330015100Россия, г. Красноярск, 660022, ул. Партизана Железняка, 1 </p></bio><bio xml:lang="en"><p>MD, PhD, Associate Professor of the Department of Pathophysiology</p><p>Researcher ID (WOS): V-1055-2017. Author ID (Scopus): 55330015100</p><p>1, P. Zheleznyaka street, 660022, Krasnoyarsk, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8142-4283</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рукша</surname><given-names>Т. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Ruksha</surname><given-names>T. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующая кафедрой патологической физиологии</p><p>SPIN-код: 5412-2148. Researcher ID (WOS): A-4801-2014. Author ID (Scopus): 23009925600 Россия, г. Красноярск, 660022, ул. Партизана Железняка, 1 </p></bio><bio xml:lang="en"><p>MD, DSc, Professor, Head of the Department of Pathophysiology</p><p>Researcher ID (WOS): A-4801-2014. Author ID (Scopus): 23009925600</p><p>1, P. Zheleznyaka street, 660022, Krasnoyarsk, Russia </p></bio><email xlink:type="simple">tatyana_ruksha@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.F. Voino-Yasenetsky Krasnoyarsk State Medical&#13;
University of the Ministry of Health Care of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, the Ministry of Health Care of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>05</day><month>01</month><year>2020</year></pub-date><volume>18</volume><issue>6</issue><fpage>82</fpage><lpage>89</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дубовцева И.Ю., Аксененко М.Б., Рукша Т.Г., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Дубовцева И.Ю., Аксененко М.Б., Рукша Т.Г.</copyright-holder><copyright-holder xml:lang="en">Dubovtseva I.Y., Aksenenko M.V., Ruksha T.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/1247">https://www.siboncoj.ru/jour/article/view/1247</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>меланома</kwd><kwd>siRNA</kwd><kwd>miR-204-5р</kwd><kwd>микроРНК</kwd><kwd>сиртуин 1</kwd><kwd>гены-мишени</kwd><kwd>апоптоз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>melanoma</kwd><kwd>siRNA</kwd><kwd>miR-204-5p</kwd><kwd>miRNA</kwd><kwd>sirtuin 1</kwd><kwd>target genes</kwd><kwd>apoptosis</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при поддержке Российского научного фонда (проект № 14-15-00074П).</funding-statement><funding-statement xml:lang="en">The study was supported by a grant from the Russian Science Foundation (project №14-15-00074).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Молочков В.А., Демидова Л.В. 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