oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciencesoncotomsk-125Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯКЛИНИКО-ИММУНОЛОГИЧЕСКАЯ ОЦЕНКА ЭФФЕКТИВНОСТИ НЕОАДЪЮВАНТНОЙ ФОТОДИНАМИЧЕСКОЙ ТЕРАПИИ В ХИРУРГИЧЕСКОМ ЛЕЧЕНИИ ПЕРВИЧНОЙ МЕЛАНОМЫ КОЖИCLINICAL-IMMUNOLOGICAL ASSESSMENT OF EFFICACY OF NEOADJUVANT PHOTODYNAMIC THERAPY IN SURGICAL MANAGEMENT OF PRIMARY MELANOMAГафтонГ. И.GaftonG. I.

Гафтон Георгий Иванович - доктор медицинских наук, зав. хирургическим отделением общей онкологии

mark.gelfond@gmail.comАнисимовВ. В.AnisimovV. V.

Анисимов Валентин Вадимович - доктор медицинских наук, ведущий научный сотрудник

Anisimov Valentin Vadimovich - MD, DSc., Principal Investigator

mark.gelfond@gmail.comГельфондМ. Л.GelfondM. L.

Гельфонд Марк Львович - старший научный сотрудник, отделение торакальной онкологии.E-mail: mark.gelfond@gmail.com. SPIN-код: 7120-8633

mark.gelfond@gmail.comСемилетоваЮ. В.SemiletovaYu. V.mark.gelfond@gmail.comБалдуеваИ. А.BalduevaI. A.

Балдуева Ирина Александровна - доктор медицинских наук, отдел терапевтической онкологии. SPIN-код: 7512-8789

mark.gelfond@gmail.comНехаеваТ. Л.NekhaevaТ. L.

Нехаева Татьяна Леонидовна - отдел иммуноонкологии.

SPIN-код: 5366-8969

mark.gelfond@gmail.comНовикА. В.NovikA. V.

Новик Алексей Викторович – кандидат медицинских наук, старший научный сотрудник отдела онкоиммунологии НИИ онкологии имени Н.Н. Петрова, врач-онколог отделения химиотерапии и инновационных технологий, доцент кафедры онкологии с курсом лучевой диагностики и лучевой терапии.E-mail: anovik@ list.ru. ResearcherID H-7700-2014, ORCID 0000-0002-2430-7409, SPIN 4549-7885

anovik@list.ruМяснянкинМ. Ю.MyasnyankinМ. Yu.

Мяснянкин Михаил Юрьевич

mark.gelfond@gmail.comНаучно-исследовательский институт онкологии имени Н.Н. Петрова, Санкт-ПетербургРоссияN.N. Petrov Research Institute of Oncology, St. Petersburg, PesochnyRussian Federation201517022016123138Copyright © Гафтон Г.И., Анисимов В.В., Гельфонд М.Л., Семилетова Ю.В., Балдуева И.А., Нехаева Т.Л., Новик А.В., Мяснянкин М.Ю., 20162016Гафтон Г.И., Анисимов В.В., Гельфонд М.Л., Семилетова Ю.В., Балдуева И.А., Нехаева Т.Л., Новик А.В., Мяснянкин М.Ю.Gafton G.I., Anisimov V.V., Gelfond M.L., Semiletova Y.V., Baldueva I.A., Nekhaeva Т.L., Novik A.V., Myasnyankin М.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/125

В экспериментально-клиническом исследовании проведена оценка эффективности неоадъювантной ФДТ с фотодитазином и радахлорином при лечении 42 больных первичной меланомой кожи I–III стадий. В контрольной группе хирургическое лечение по поводу МК получили 42 пациента. При анализе отдаленных результатов (2,5-летняя общая и безрецидивная выживаемость) установлено, что эти показатели в группе больных, получавших неоадъювантную ФДТ, значимо выше, чем в контрольной группе. Выявлено, что неоадъювантная ФДТ, проведенная за 2 дня до хирургического вмешательства, способствует активации Ти В-клеточного звена иммунной системы. В экспериментальной части работы выявлено, что увеличение времени лазерного облучения культуры клеток меланомы сопровождается достоверным повышением доли поздних форм апоптоза.

Efficacy of neoadjuvant photodynamic therapy (PDT) with photoditazine and radachlorine was assessed in 42 patients with stage I–III primary melanoma. The control group consisted of 42 patients with melanoma who underwent surgery alone. The 2.5-year overall and recurrence-free survival rates were significantly higher in patients who received neoadjuvant PDT than in the control group patients.  Neoadjuvant PDT performed 2 days before surgery was found to promote the activation of T-and B-cell immunity.   In the experimental study it was shown that the increase in time of laser irradiation of melanoma cell culture accompanied by a significant increase in the proportion of late apoptotic cells.

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The authors declare that there are no conflicts of interest present.