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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21294/1814-4861-2019-18-6-105-113</article-id><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-1250</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>СОВРЕМЕННЫЕ СХЕМЫ ЛУЧЕВОЙ ТЕРАПИИ И БИОМАРКЕРЫ РАДИОРЕЗИСТЕНТНОСТИ ОПУХОЛЕВЫХ КЛЕТОК ПРЯМОЙ КИШКИ</article-title><trans-title-group xml:lang="en"><trans-title>MODERN RADIOTHERAPY REGIMENS AND BIOMARKERS OF RADIORESISTANT RECTAL TUMOR CELLS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8829-3861</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильченко</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilchenko</surname><given-names>N. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>младший научный сотрудник лаборатории молекулярной онкологии</p><p>SPIN-код: 5411-1182. Author ID (Scopus): 57196449311Россия, г. Ростов-на-Дону, 344037, ул. 14-я линия, 63 </p></bio><bio xml:lang="en"><p>Junior Researcher, Laboratory of Molecular Oncology</p><p>Author ID (Scopus): 57196449311</p><p>63, 14 Line street, Rostov-on-Don, 344037, Russia </p></bio><email xlink:type="simple">wnikita37@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8942-3733</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кутилин</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kutilin</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат биологических наук, старший научный сотрудник лаборатории молекулярной онкологии</p><p>SPIN-код 8382-4460 Author ID (Scopus): 55328886800 Россия, г. Ростов-на-Дону, 344037, ул. 14-я линия, 63 </p></bio><bio xml:lang="en"><p>PhD, Senior Researcher Laboratory of Molecular Oncology</p><p>Author ID (Scopus): 55328886800</p><p>63, 14 Line street, Rostov-on-Don, 344037, Russia </p></bio><email xlink:type="simple">k.denees@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тимошкина</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Timoshkina</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>63, 14 Line street, Rostov-on-Don, 344037, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5221-3644</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Потемкин</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Potyomkin</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>младший научный сотрудник лаборатории молекулярной онкологии</p><p>SPIN-код: 2789-0569Россия, г. Ростов-на-Дону, 344037, ул. 14-я линия, 63 </p></bio><bio xml:lang="en"><p>63, 14 Line street, Rostov-on-Don, 344037, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полуэктов</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Poluektov</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>63, 14 Line street, Rostov-on-Don, 344037, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гусарева</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gusareva</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>63, 14 Line street, Rostov-on-Don, 344037, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кошелева</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosheleva</surname><given-names>N. G.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>63, 14 Line street, Rostov-on-Don, 344037, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солдатова</surname><given-names>К. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Soldatova</surname><given-names>K. I.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>63, 14 Line street, Rostov-on-Don, 344037, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8373-6165</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максимов</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksimov</surname><given-names>A. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заместитель генерального директора по науке</p><p>SPIN-код: 7322-5589Россия, г. Ростов-на-Дону, 344037, ул. 14-я линия, 63 </p></bio><bio xml:lang="en"><p>63, 14 Line street, Rostov-on-Don, 344037, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3061-6108</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кит</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kit</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, член-корреспондент РАН, генеральный директор</p><p>SPIN-код: 1728-0329Россия, г. Ростов-на-Дону, 344037, ул. 14-я линия, 63 </p></bio><bio xml:lang="en"><p>63, 14 Line street, Rostov-on-Don, 344037, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8511-7280</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сидоренко</surname><given-names>Ю. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sidorenko</surname><given-names>Yu. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, академик РАН, заведующий отделом опухолей репродуктивной системы, </p><p>SPIN-код: 8341-5407. Author ID (Scopus): 6603967956</p><p>Россия, г. Ростов-на-Дону, 344037, ул. 14-я линия, 63 </p></bio><bio xml:lang="en"><p>MD, Head of the Department of Tumors of the Reproductive System, Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences </p><p>Author ID (Scopus): 6603967956</p><p>63, 14 Line street, Rostov-on-Don, 344037, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov Research Institute of Oncology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>05</day><month>01</month><year>2020</year></pub-date><volume>18</volume><issue>6</issue><fpage>105</fpage><lpage>113</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Васильченко Н.Г., Кутилин Д.С., Тимошкина Н.Н., Потемкин Д.С., Полуэктов С.И., Гусарева М.А., Кошелева Н.Г., Солдатова К.И., Максимов А.Ю., Кит О.И., Сидоренко Ю.С., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Васильченко Н.Г., Кутилин Д.С., Тимошкина Н.Н., Потемкин Д.С., Полуэктов С.И., Гусарева М.А., Кошелева Н.Г., Солдатова К.И., Максимов А.Ю., Кит О.И., Сидоренко Ю.С.</copyright-holder><copyright-holder xml:lang="en">Vasilchenko N.G., Kutilin D.S., Timoshkina N.N., Potyomkin D.S., Poluektov S.I., Gusareva M.A., Kosheleva N.G., Soldatova K.I., Maksimov A.Y., Kit O.I., Sidorenko Y.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/1250">https://www.siboncoj.ru/jour/article/view/1250</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>рак прямой кишки</kwd><kwd>биомаркеры</kwd><kwd>лучевая терапия</kwd><kwd>радиорезистентность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rectal cancer</kwd><kwd>biomarkers</kwd><kwd>radiation therapy</kwd><kwd>radioresistance</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено в рамках гос. задания «Поиск предикторов радиорезистентности рака прямой кишки и разработка персонифицированных неоадъювантных терапевтических подходов».</funding-statement><funding-statement xml:lang="en">Research as part of a state assignment «Search for predictors of radioresistance of colorectal cancer and development of personalized neoadjuvant therapeutic approaches».</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. 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