oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciencesoncotomsk-130Research ArticleЛАБОРАТОРНЫЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯLABORATORY AND EXPERIMENTAL STUDIESЗависимость уровня белка-транслокатора TSPO и цитохрома Р450SCC от гистотипа опухоли у больных почечно-клеточным ракомTHE DEPENDENCE OF TRANSLOCATOR PROTEIN TSPO LEVEL AND CYTOCHROME P450SCC FROM HISTOTYPE OF TUMOR IN PATIENTS WITH RENAL CELL CARCINOMAЗуковР. А.ZukovR. A.zukov_rus@mail.ruРукшаТ. Г.RukshaT. G.ДыхноЮ. А.DykhnoYu. A.СеменовЭ. В.SemenovE. V.БояковаН. В.BoyakovaN. V.Красноярский государственный медицинский университет им. проф. В.Ф. Войно-ЯсенецкогоРоссияV.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation201318022016034751Copyright © Зуков Р.А., Рукша Т.Г., Дыхно Ю.А., Семенов Э.В., Боякова Н.В., 20162016Зуков Р.А., Рукша Т.Г., Дыхно Ю.А., Семенов Э.В., Боякова Н.В.Zukov R.A., Ruksha T.G., Dykhno Y.A., Semenov E.V., Boyakova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/130

Описаны особенности экспрессии белка-транслокатора (TSPO) и цитохрома P450scc (CYP 450scc) у больных почечно-клеточным раком (ПКР). Установлена зависимость уровня экспрессии TSPO от стадии и гистологического варианта рака почки. Изменение уровня экспрессии CYP 450scc в клетках опухоли свидетельствует об изменении выраженности стероидогенеза при различных гисто- типах ПКР. Полученные данные важны для понимания патогенеза рака почки, а также могут иметь прогностическое значение.

The features of expression of translocator protein (TSPO) and cytochrome P450scc (CYP 450scc) in patients with renal cell carcinoma (RCC) were described in the article. The dependence of level expression of TSPO from stage and histological subtypes of renal cell carcinoma were established. The changing of expression level of CYP 450scc in tumor cells indicates a change of severity of steroidogenesis in different histological subtypes of RCC. These findings were important for interpretation the pathogenesis of RCC and also they could have prognostic value

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The authors declare that there are no conflicts of interest present.