oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2020-19-4-132-137oncotomsk-1539Research ArticleОБЗОРЫREVIEWSКЛИНИЧЕСКАЯ ЭФФЕКТИВНОСТЬ ТАРГЕТНОЙ ТЕРАПИИ В ОТНОШЕНИИ МЕТАСТАТИЧЕСКОГО РАКА ЛЁГКОГО С РАЗЛИЧНЫМИ ТИПАМИ ТРАНСЛОКАЦИЙ ГЕНА ALKCLINICAL EFFICACY OF TARGETED THERAPY TOWARDS METASTATIC LUNG CANCER CARRYING DISTINCT TYPES OF ALK REARRANGEMENTShttps://orcid.org/0000-0002-0179-3191МитюшкинаН. В.MitiushkinaN. V.

Митюшкина Наталья Владимировна, кандидат биологических наук, научный сотрудник научной лаборатории молекулярной онкологии  Researcher ID (WOS): N-4855-2016. Author ID (Scopus): 8639200300.

197758, г. Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

Natalia V. Mitiushkina, PhD, Research Fellow, Laboratory of Molecular Oncology. Researcher ID (WOS): N-4855-2016. Author ID (Scopus): 8639200300.

68, Leningradskaya Street, Pesochny, 197758-Saint-Petersburg

https://orcid.org/0000-0001-6074-9775СтепановИ. А.StepanovI. A.

Степанов Илья Александрович, лаборант-исследователь научной лаборатории молекулярной онкологии

197758, г. Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68;194100, г. Санкт-Петербург, ул. Литовская, 2

Ilya A. Stepanov, Laboratory Assistant, Laboratory of Molecular Oncology

68, Leningradskaya Street, Pesochny, 197758-Saint-Petersburg;2, Litovskaya Street, 194100-Saint-Petersburg

https://orcid.org/0000-0001-8564-9199ЮрловД. О.YurlovD. O.

Юрлов Дмитрий Олегович, клинический ординатор отделения химиотерапии и инновационных технологий

197758, г. Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

Dmitriy O. Yurlov, MD, Chemotherapy and Innovative Technologies Department

68, Leningradskaya Street, Pesochny, 197758-Saint-Petersburg

ФилипповаЕ. А.FilippovaE. A.

Филиппова Елена Александровна, кандидат медицинских наук, врач-онколог

197022, г. Санкт-Петербург, ул. Льва Толстого, 6–8

Elena A. Filippova, MD, PhD, Oncologist

6-8, Lva Tolstogo Street, 197022-Saint-Petersburg

ОдинцоваС. В.OdintsovaS. V.

Одинцова Светлана Валентиновна, кандидат медицинских наук, врач-онколог

197022, г. Санкт-Петербург, ул. Льва Толстого, 6–8

Svetlana V. Odintsova, MD, PhD, Oncologist

6-8, Lva Tolstogo Street, 197022-Saint-Petersburg

ЛожкинаА. М.LozhkinaA. M.

Ложкина Александра Михайловна, кандидат медицинских наук, врач-онколог

197022, г. Санкт-Петербург, ул. Льва Толстого, 6–8

Alexandra M. Lozhkina, MD, PhD, Oncologist

6-8, Lva Tolstogo Street, 197022-Saint-Petersburg

ОрловС. В.OrlovS. V.

Орлов Сергей Владимирович, доктор медицинских наук, профессор, член-корреспондент РАН, директор

197022, г. Санкт-Петербург, ул. Льва Толстого, 6–8;354376, г. Сочи, Адлерский район, с. Весёлое, ул. Мира, 177

Sergei V. Orlov, MD, PhD, Corresponding member of the Russian Academy of Sciences, Director

6-8, Lva Tolstogo Street, 197022-Saint-Petersburg;177, Mira Street, Adlersky District, Veseloe, 354376-Sochi

https://orcid.org/0000-0001-5454-5186ИевлеваА. Г.IyevlevaA. G.

Иевлева Аглая Геннадьевна, кандидат медицинских наук, старший научный сотрудник научной лаборатории молекулярной онкологии. Researcher ID (WOS): P-8305-2016. Author ID (Scopus): 6506417697.

197758, г. Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68;194100, г. Санкт-Петербург, ул. Литовская, 2

Aglaya G. Iyevleva, MD, PhD, Research Fellow, Laboratory of Molecular Oncology Researcher ID (WOS): P-8305-2016. Author ID (Scopus): 6506417697

68, Leningradskaya Street, Pesochny, 197758-Saint-Petersburg;2, Litovskaya Street, 194100-Saint-Petersburg

aglayai@inbox.ruФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава РоссииРоссияN.N. Petrov National Medical Research Center of OncologyRussian FederationФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава России; ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава РоссииРоссияN.N. Petrov National Medical Research Center of Oncology; Saint-Petersburg State Pediatric Medical UniversityRussian FederationФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» Минздрава РоссииРоссияI.P. Pavlov First Saint-Petersburg State Medical UniversityRussian FederationФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» Минздрава России; ФГБНУ «Научно-исследовательский институт медицинской приматологии»РоссияI.P. Pavlov First Saint-Petersburg State Medical University; Research Institute of Medical PrimatologyRussian Federation202001092020194132137Copyright © Митюшкина Н.В., Степанов И.А., Юрлов Д.О., Филиппова Е.А., Одинцова С.В., Ложкина А.М., Орлов С.В., Иевлева А.Г., 20202020Митюшкина Н.В., Степанов И.А., Юрлов Д.О., Филиппова Е.А., Одинцова С.В., Ложкина А.М., Орлов С.В., Иевлева А.Г.Mitiushkina N.V., Stepanov I.A., Yurlov D.O., Filippova E.A., Odintsova S.V., Lozhkina A.M., Orlov S.V., Iyevleva A.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/1539рак легкоготранслокации ALKкризотинибцеритинибалектинибlung cancerALK translocationcrizotinibceritinibalectinibРабота поддержана грантом Российского научного фонда № 19-15-00312.This work was supported by the grant of the Russian Science Foundation № 19-15-00312.ReferencesSoda M., Choi Y.L., Enomoto M., Takada S., Yamashita Y., Ishikawa S., Fujiwara S,. 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The authors declare that there are no conflicts of interest present.