oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2020-19-4-146-151oncotomsk-1543Research ArticleОБЗОРЫREVIEWSИНФЕКЦИОННЫЕ ОСЛОЖНЕНИЯ, ВЫЗВАННЫЕ НЕСПОРООБРАЗУЮЩИМИ АНАЭРОБНЫМИ МИКРООРГАНИЗМАМИ, У ОНКОЛОГИЧЕСКИХ БОЛЬНЫХ. АКТУАЛЬНОСТЬ ПРОБЛЕМЫINFECTIOUS COMPLICATIONS CAUSED BY NON-SPOREFORMING ANAEROBIC BACTERIA IN CANCER PATIENTS. RELEVANCE OF THE PROBLEMТерещенкоИ. В.TereshchenkoI. V.

Терещенко Инна Васильевна, научный сотрудник микробиологической лаборатории SPIN‑код: 3185‑9586. Author ID (РИНЦ): 929834. Author ID (Scopus): 57193277015.

115478, г. Москва, Каширское шоссе, 24.

Inna V. Tereshchenko, Researcher, Microbiologic Laboratory Author ID (Scopus): 57193277015.

24, Kashirskoye shosse, 115478-Moscow

in.ter68@inbox.ruhttps://orcid.org/0000-0003-4294-1995ГригорьевскаяЗ. В.GrigoryevskayaZ. V.

Григорьевская Злата Валерьевна, доктор медицинских наук, ведущий научный сотрудник микробиологической лаборатории SPIN-код: 4416-5191. Author ID (РИНЦ):710236. Author ID (Scopus): 57200538935. 

115478, г. Москва, Каширское шоссе, 24.

Zlata V. Grigoryevskaya, MD, DSc, Principal Investigator, Microbiologic Laboratory Author ID (Scopus): 57200538935.

24, Kashirskoye shosse, 115478-Moscow

https://orcid.org/0000-0003-3077-0447ПетуховаИ. Н.PetukhovaI. N.

Петухова Ирина Николаевна, доктор медицинских наук, ведущий научный сотрудник микробиологической лаборатории SPIN-код: 1265-2875. Author ID (РИНЦ): 710090. Author ID (Scopus): 6701329760. 

115478, г. Москва, Каширское шоссе, 24.

Irina N. Petukhova, MD, DSc, Principal Investigator, Microbiologic Laboratory Author ID (Scopus): 6701329760

24, Kashirskoye shosse, 115478-Moscow

https://orcid.org/0000-0003-1405-3536БагироваН. С.BagirovaN. S.

Багирова Наталия Сергеевна, доктор медицинских наук, старший научный сотрудник микробиологической лаборатории SPIN-код: 3189-8188. AuthorID (РИНЦ): 266234. Author ID (Scopus): 6603332319. 

115478, г. Москва, Каширское шоссе, 24.

Natalia S. Bagirova, MD, DSc, Senior Researcher, Microbiologic Laboratory Author ID (Scopus): 6603332319.

24, Kashirskoye shosse, 115478-Moscow

ВинниковаВ. Д.VinnikovaV. D.

Винникова Валерия Дмитриевна, студент лечебного факультета

127473, г. Москва, ул. Делегатская, 20/1

Valeria D. Vinnikova, Student

20/1, Delegatskaya Street, 127473-Moscow

ВершинскаяВ. А.VershinskayaV. A.

Вершинская Валентина Алексеевна, студент лечебного факультета

127473, г. Москва, ул. Делегатская, 20/1

Valentina A. Vershinskaya, Student

20/1, Delegatskaya Street, 127473-Moscow

ДмитриеваН. В.DmitrievaN. V.

Дмитриева Наталья Владимировна, доктор медицинских наук, профессор, заведующая микробиологической лабораторией SPIN-код: 4727-2018. AuthorID (РИНЦ): 243733. Author ID (Scopus): 56338598600.

115478, г. Москва, Каширское шоссе, 24.

Natalya V. Dmitrieva, DSc, Professor, Head of Microbiologic Laboratory Author ID (Scopus): 56338598600.

24, Kashirskoye shosse, 115478-Moscow

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииРоссияN.N. Blokhin National Medical Research Center of OncologyRussian FederationФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииРоссияA.I. Evdokimov Moscow State University of Medicine and DentistryRussian Federation202002092020194146151Copyright © Терещенко И.В., Григорьевская З.В., Петухова И.Н., Багирова Н.С., Винникова В.Д., Вершинская В.А., Дмитриева Н.В., 20202020Терещенко И.В., Григорьевская З.В., Петухова И.Н., Багирова Н.С., Винникова В.Д., Вершинская В.А., Дмитриева Н.В.Tereshchenko I.V., Grigoryevskaya Z.V., Petukhova I.N., Bagirova N.S., Vinnikova V.D., Vershinskaya V.A., Dmitrieva N.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/1543неспорообразующие анаэробные микроорганизмыонкологические больныеметронидазолклиндамицинзащищенные пенициллинырезистентностьантианаэробные препаратыnon-sporeforming anaerobic bacteriacancer patientsmetronidazoleclindamycinprotected penicillinsresistanceanti-anaerobic drugsReferencesЗубков М.Н. Современная таксономия и номенклатура облигатно-анаэробных бактерий, выделенных от человека. Клиническая микробиология и антимикробная химиотерапия. 2005; 7(4): 312–314.Zubkov M.N. Modern taxonomy and nomenclature of obligate-anaerobic bacteria isolated from humans. Clinical Microbiology and Antimicrobial Chemotherapy. Clinical Microbiology and Antimicrobial Chemotherapy 2005; 7(4): 312–314. (in Russian).Finegold S.M., George W.L. Anaerobic infections in humans. NewYork: Academic Press. 1989. 851 p.Finegold S.M., George W.L. Anaerobic infections in humans. NewYork: Academic Press. 1989. 851 p.Давыдов М.И., Дмитриева Н.В. Инфекции в онкологии. М., 2009. 472 с.Davydov M.I., Dmitrieva N.V. Infections in oncology. Moscow, 2009.472 p. (in Russian).Brooк I. Contemporary Diagnosis and Management of Anaerobic infections. Pennsylvania. Newtown: HHC. 2004. 268 p.Brooк I. Contemporary Diagnosis and Management of Anaerobic infections. Pennsylvania. Newtown: HHC. 2004. 268 p.Григорьевская З.В. Актуальность проблемы госпитальных инфекций в онкологической клинике. Вестник РОНЦ им. Н.Н. Блохина РАМН. 2013; 24(3–4): 46–49.Grigorievskaya Z.V. Urgency of the problem of hospital infections in cancer patients. Journal of N.N. Blokhin Russian Cancer Research Center RAMS. 2013; 24 (3–4): 46–49. (in Russian).Dewhirst F.E., Chen T., Izard J., Paster B.J., Tanner A.C., Yu W.H., Lakshmanan A., Wade W.G. The human oral microbiome. J Bacteriol. 2010 Oct; 192(19): 5002–17. doi: 10.1128/JB.00542-10.Dewhirst F.E., Chen T., Izard J., Paster B.J., Tanner A.C., Yu W.H., Lakshmanan A., Wade W.G. The human oral microbiome. J Bacteriol. 2010 Oct; 192(19): 5002–17. doi: 10.1128/JB.00542-10.Finegold S.M., Jousimies-Somer H. Recently described clinically important anaerobic bacteria: medical aspects. Clin Infect Dis. 1997 Sep; 25 Suppl 2: S88–93. doi: 10.1086/516237.Finegold S.M., Jousimies-Somer H. Recently described clinically important anaerobic bacteria: medical aspects. Clin Infect Dis. 1997 Sep; 25 Suppl 2: S88–93. doi: 10.1086/516237.Jousimies-Somer H., Summanen P., Citron D., Baron E., Wexler H., Finegold S. Anaerobic Bacteriology Manual. Belmont, California: Star Publishing Company. 2002. 287 p.Jousimies-Somer H., Summanen P., Citron D., Baron E., Wexler H., Finegold S. Anaerobic Bacteriology Manual. Belmont, California: Star Publishing Company. 2002. 287 p.Byung K., Geoffrey M. Bacterial Physiology and Metabolism. Cambridge: Cambridge University Press. 2008. 496–529 p.Byung K., Geoffrey M. Bacterial Physiology and Metabolism. Cambridge: Cambridge University Press. 2008. 496–529 p.Bowler P.G., Duerden B.I., Armstrong D.G. Wound microbiology and associated approaches to wound management. Clin Microbiol Rev. 2001 Apr; 14(2): 244–69. doi: 10.1128/CMR.14.2.244-269.2001.Bowler P.G., Duerden B.I., Armstrong D.G. Wound microbiology and associated approaches to wound management. Clin Microbiol Rev. 2001 Apr; 14(2): 244–69. doi: 10.1128/CMR.14.2.244-269.2001.Гельфонд В.М. Инфекционные осложнения у онкологических больных. Практическая онкология. 2009; 10(3): 141–146.Gelfond V.M. Infectious complications in cancer patients. Practical Oncology. 2009; 10(3): 141–146. (in Russian).Greene J. Infections in cancer Patients. New York: Marcel Dekker. 2004. 534 р.Greene J. Infections in cancer Patients. New York: Marcel Dekker. 2004. 534 р.Shilnikova I.I., Dmitrieva N.V. Evaluation of antibiotic susceptibility of Bacteroides, Prevotella and Fusobacterium species isolated from cancer patients of the N.N. Blokhin Cancer Research Center, Moscow, Russia. Anaerobe. 2014; 31: 1–4. doi: 10.1016/j.anaerobe.2014.08.003.Shilnikova I.I., Dmitrieva N.V. Evaluation of antibiotic susceptibility of Bacteroides, Prevotella and Fusobacterium species isolated from cancer patients of the N.N. Blokhin Cancer Research Center, Moscow, Russia. Anaerobe. 2014; 31: 1–4. doi: 10.1016/j.anaerobe.2014.08.003.Терещенко И.В., Григорьевская З.В., Петухова И.Н., Шильникова И.И., Григорьевский Е.Д., Терещенко О.В., Агинова В.В., Дмитриева Н.В. Место анаэробных микроорганизмов рода Veillonella в инфекционных осложнениях у онкологических больных. Сибирский онкологический журнал. 2018; 17(1): 11–18. doi: 10.21294/1814-4861-2018-17-1-11-18.Tereshchenko I.V., Grigorievskaya Z.V., Petukhova I.N., Shilnikova I.I., Grigorievsky Е.D., Tereshchenko О.V., Aginova V.V., Dmitrieva N.V. Role of gram-negative anaerobic cocci belonging to the genus Veillonella in infectious complications in cancer patients. Siberian Journal of Oncology. 2018; 17(1): 11–18. (in Russian). doi: 10.21294/1814-4861-2018-17-1-11-18.Shah H.N., Olsen I., Bernard K., Finegold S.M., Gharbia S., Gupta R.S. Approaches to the study of the systematics of anaerobic, gramnegative, non-sporeforming rods: current status and perspectives. Anaerobe. 2009 Oct; 15(5): 179–94. doi: 10.1016/j.anaerobe.2009.08.003.Shah H.N., Olsen I., Bernard K., Finegold S.M., Gharbia S., Gupta R.S. Approaches to the study of the systematics of anaerobic, gramnegative, non-sporeforming rods: current status and perspectives. Anaerobe. 2009 Oct; 15(5): 179–94. doi: 10.1016/j.anaerobe.2009.08.003.Barreau M., Pagnier I., La Scola B. Improving the identification of anaerobes in the clinical microbiology laboratory through MALDITOF mass spectrometry. Anaerobe. 2013; 22: 123–5. doi: 10.1016/j.anaerobe.2013.04.011.Barreau M., Pagnier I., La Scola B. Improving the identification of anaerobes in the clinical microbiology laboratory through MALDITOF mass spectrometry. Anaerobe. 2013; 22: 123–5. doi: 10.1016/j.anaerobe.2013.04.011.Fedorko D.P., Drake S.K., Stock F., Murray P.R. Identification of clinical isolates of anaerobic bacteria using matrix-assisted laser desorption ionization-time of flight mass spectrometry. Eur J Clin Microbiol Infect Dis. 2012 Sep; 31(9): 2257–62. doi: 10.1007/s10096-012-1563-4.Fedorko D.P., Drake S.K., Stock F., Murray P.R. Identification of clinical isolates of anaerobic bacteria using matrix-assisted laser desorption ionization-time of flight mass spectrometry. Eur J Clin Microbiol Infect Dis. 2012 Sep; 31(9): 2257–62. doi: 10.1007/s10096-012-1563-4.Fournier R., Wallet F., Grandbastien B., Dubreuil L., Courcol R., Neut C., Dessein R. Chemical extraction versus direct smear for MALDITOF mass spectrometry identification of anaerobic bacteria. Anaerobe. 2012 Jun; 18(3): 294–7. doi: 10.1016/j.anaerobe.2012.03.008.Fournier R., Wallet F., Grandbastien B., Dubreuil L., Courcol R., Neut C., Dessein R. Chemical extraction versus direct smear for MALDITOF mass spectrometry identification of anaerobic bacteria. Anaerobe. 2012 Jun; 18(3): 294–7. doi: 10.1016/j.anaerobe.2012.03.008.Kostrzewa M., Schubert S. MALDI-TOF mass spectrometry in microbiology. Bremen: Caister Academic Press. 2016. 170 p.Kostrzewa M., Schubert S. MALDI-TOF mass spectrometry in microbiology. Bremen: Caister Academic Press. 2016. 170 p.Дмитриева Н.В., Петухова И.Н. Антимикробная терапия внутрибольничных инфекций. М., 2014. 326 с.Dmitrieva N.V., Petuhova I.N. Antimicrobial therapy for nosocomial infections. Moscow, 2014. 326 p. (in Russian).Галкин Д.В., Кречикова О.И., Сухорукова М.В., Дехнич А.В. Современные возможности терапии анаэробных инфекций. Клиническая микробиология и антимикробная химиотерапия. 2006; 8(4): 298–313.Galkin D.V., Krechikova O.I., Suhorukova M.V., Dehnich A.V. Current state of anty-anaerobic therapy. Clinical Microbiology and Antimicrobial Chemotherapy. 2006; 8(4): 298–313. (in Russian).Brooк I. Antibiotic Resistance of Anaerobic Bacteria. Antimicrobial drug resistance. Humana press. 2009. 873–899 p.Brooк I. Antibiotic Resistance of Anaerobic Bacteria. Antimicrobial drug resistance. Humana press. 2009. 873–899 p.Dubreuil L., Odou M.F. Anaerobic bacteria and antibiotics: What kind of unexpected resistance could I find in my laboratory tomorrow? Anaerobe. 2010 Dec; 16(6): 555–9. doi: 10.1016/j.anaerobe.2010.10.002.Dubreuil L., Odou M.F. Anaerobic bacteria and antibiotics: What kind of unexpected resistance could I find in my laboratory tomorrow? Anaerobe. 2010 Dec; 16(6): 555–9. doi: 10.1016/j.anaerobe.2010.10.002.Alauzet C., Mory F., Teyssier C., Hallage H., Carlier J.P., Grollier G., Lozniewski A. Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. Antimicrob Agents Chemother. 2010 Jan; 54(1): 60–4. doi: 10.1128/AAC.01003-09.Alauzet C., Mory F., Teyssier C., Hallage H., Carlier J.P., Grollier G., Lozniewski A. Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae. Antimicrob Agents Chemother. 2010 Jan; 54(1): 60–4. doi: 10.1128/AAC.01003-09.Achermann Y., Goldstein E.J., Coenye T., Shirtliff M.E. PropionibacteriumAchermann Y., Goldstein E.J., Coenye T., Shirtliff M.E. Propionibacteriumacnes: from commensal to opportunistic biofilm-associated implant pathogen. Clin Microbiol Rev. 2014 Jul; 27(3): 419–40. doi: 10.1128/CMR.00092-13.acnes: from commensal to opportunistic biofilm-associated implant pathogen. Clin Microbiol Rev. 2014 Jul; 27(3): 419–40. doi: 10.1128/CMR.00092-13.Viswanath B.G., Lakshmi G.J., Nagamani K., Reddy N.V.N., Rao G.P., Srinivas S.S.S., Dashetwar A.M. Emergence of Antimicrobial Resistance among Anaerobic Bacteria. Am J Infect Dis Microbiol. 2017; 5(2): 87–93. doi: 10.12691/ajidm-5-2-3.Viswanath B.G., Lakshmi G.J., Nagamani K., Reddy N.V.N., Rao G.P., Srinivas S.S.S., Dashetwar A.M. Emergence of Antimicrobial Resistance among Anaerobic Bacteria. Am J Infect Dis Microbiol. 2017; 5(2): 87–93. doi: 10.12691/ajidm-5-2-3.Экспертные правила EUCAST [Интернет]. URL: http://www.antibiotic.ru/iacmac/ru/docs/eucast/eucast-expert-rules-intrinsicresistance-and-exceptional-phenotypes-3.1-rus.pdf (cited 20.04.2020).EUCAST Expert Rules [Internet]. URL: http://www.antibiotic.ru/iacmac/ru/docs/eucast/eucast-expert-rules-intrinsic-resistance-and-exceptionalphenotypes-3.1-rus.pdf (cited 20.04.2020). (in Russian).Hecht D.W. Prevalence of antibiotic resistance in anaerobic bacteria: worrisome developments. Clin Infect Dis. 2004 Jul 1; 39(1): 92–7. doi: 10.1086/421558.Hecht D.W. Prevalence of antibiotic resistance in anaerobic bacteria: worrisome developments. Clin Infect Dis. 2004 Jul 1; 39(1): 92–7. doi: 10.1086/421558.Kirchner M., Mafura M., Hunt T., Card R., Anjum M.F. Antibiotic resistance gene profiling of faecal and oral anaerobes collected during an antibiotic challenge trial. Anaerobe. 2013; 23: 20–2. doi: 10.1016/j.anaerobe.2013.07.011.Kirchner M., Mafura M., Hunt T., Card R., Anjum M.F. Antibiotic resistance gene profiling of faecal and oral anaerobes collected during an antibiotic challenge trial. Anaerobe. 2013; 23: 20–2. doi: 10.1016/j.anaerobe.2013.07.011.Treviño M., Areses P., Peñalver M.D., Cortizo S., Pardo F., del Molino M.L., García-Riestra C., Hernández M., Llovo J., Regueiro B.J. Susceptibility trends of Bacteroides fragilis group and characterisation of carbapenemase-producing strains by automated REP-PCR and MALDI TOF. Anaerobe. 2012 Feb; 18(1): 37–43. doi: 10.1016/j.anaerobe.2011.12.022.Treviño M., Areses P., Peñalver M.D., Cortizo S., Pardo F., del Molino M.L., García-Riestra C., Hernández M., Llovo J., Regueiro B.J. Susceptibility trends of Bacteroides fragilis group and characterisation of carbapenemase-producing strains by automated REP-PCR and MALDI TOF. Anaerobe. 2012 Feb; 18(1): 37–43. doi: 10.1016/j.anaerobe.2011.12.022.Aldridge K.E., Ashcraft D., O'Brien M., Sanders C.V. Bacteremia due to Bacteroides fragilis group: distribution of species, beta-lactamase production, and antimicrobial susceptibility patterns. Antimicrob Agents Chemother. 2003 Jan; 47(1): 148–53. doi: 10.1128/aac.47.1.148-153.2003.Aldridge K.E., Ashcraft D., O'Brien M., Sanders C.V. Bacteremia due to Bacteroides fragilis group: distribution of species, beta-lactamase production, and antimicrobial susceptibility patterns. Antimicrob Agents Chemother. 2003 Jan; 47(1): 148–53. doi: 10.1128/aac.47.1.148-153.2003.Könönen E., Wade W.G. Actinomyces and related organisms in human infections. Clin Microbiol Rev. 2015 Apr; 28(2): 419–42. doi: 10.1128/CMR.00100-14.Könönen E., Wade W.G. Actinomyces and related organisms in human infections. Clin Microbiol Rev. 2015 Apr; 28(2): 419–42. doi: 10.1128/CMR.00100-14.Marchand-Austin A., Rawte P., Toye B., Jamieson F.B., Farrell D.J., Patel S.N. Antimicrobial susceptibility of clinical isolates of anaerobic bacteria in Ontario, 2010-2011. Anaerobe. 2014; 28: 120–5. doi: 10.1016/j.anaerobe.2014.05.015.Marchand-Austin A., Rawte P., Toye B., Jamieson F.B., Farrell D.J., Patel S.N. Antimicrobial susceptibility of clinical isolates of anaerobic bacteria in Ontario, 2010-2011. Anaerobe. 2014; 28: 120–5. doi: 10.1016/j.anaerobe.2014.05.015.Григорьевская З.В., Петухова И.Н., Багирова Н.С., Шильникова И.И., Терещенко И.В., Григорьевский Е.Д., Дмитриева Н.В. Нозокомиальные инфекции у онкологических больных: проблема нарастающей резистентности грамотрицательных микроорганизмов. Сибирский онкологический журнал. 2017; 16(1): 91–97. doi: 10.21294/1814-4861-2017-16-1-91-97.Grigorievskaya Z.V., Petukhova I.N., Bagirova N.S., Shilnikova I.I., Tereshchenko I.V., Grigorievsky E.D., Dmitrieva N.V. Nasocomial infectoions in cancer patients: problem of gram-negative bacterial resistance. Siberian Journal of Oncology. 2017; 16(1): 91–97. (in Russian). doi: 10.21294/1814-4861-2017-16-1-91-97.Goldstein E., Citron D. Resistance Trends in Antimicrobial susceptibility of Anaerobic Bacteria, Part II. Clin Microbiol. Newsletter. 2011; 33(1): 1–8. doi: 10.1016/j.clinmicnews.2010.12.001.Goldstein E., Citron D. Resistance Trends in Antimicrobial susceptibility of Anaerobic Bacteria, Part II. Clin Microbiol. Newsletter. 2011; 33(1): 1–8. doi: 10.1016/j.clinmicnews.2010.12.001.

The authors declare that there are no conflicts of interest present.