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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21294/1814-4861-2021-20-1-24-33</article-id><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-1688</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>БЕЗОПАСНОСТЬ И ЭФФЕКТИВНОСТЬ ТОРАКОСКОПИЧЕСКОЙ ЛОБЭКТОМИИ У БОЛЬНЫХ НЕМЕЛКОКЛЕТОЧНЫМ РАКОМ ЛЕГКОГО I СТАДИИ</article-title><trans-title-group xml:lang="en"><trans-title>SAFETY AND EFFICACY OF THORACOSCOPIC LOBECTOMY IN PATIENTS WITH STAGE I NON-SMALL CELL LUNG CANCER</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1037-2364</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рябов</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryabov</surname><given-names>A. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, заместитель директора </p><p>SPIN-код: 9810-5315</p><p>Россия, 125284, г. Москва, 2-й Боткинский пр., 3 </p></bio><bio xml:lang="en"><p>3, 2nd Botkinsky pr., 125284, Moscow, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6871-6804</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пикин</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pikin</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, руководитель отделения торакальной хирургии</p><p>SPIN-код: 2381-5969Россия, 125284, г. Москва, 2-й Боткинский пр., 3 </p></bio><bio xml:lang="en"><p>3, 2nd Botkinsky pr., 125284, Moscow, Russia</p></bio><email xlink:type="simple">pikin_ov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0461-1146</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Багров</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bagrov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>3, 2nd Botkinsky pr., 125284, Moscow, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0536-7613</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колбанов</surname><given-names>К. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolbanov</surname><given-names>K. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, ведущий научный сотрудник отделения торакальной хирургии</p><p>SPIN-код: 6916-1830Россия, 125284, г. Москва, 2-й Боткинский пр., 3</p></bio><bio xml:lang="en"><p>3, 2nd Botkinsky pr., 125284, Moscow, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1420-4579</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глушко</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Glushko</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, ведущий научный сотрудник отделения торакальной хирургии</p><p>SPIN-код: 6540-2366Россия, 125284, г. Москва, 2-й Боткинский пр., 3 </p></bio><bio xml:lang="en"><p>3, 2nd Botkinsky pr., 125284, Moscow, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3091-014X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вурсол</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vursol</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, научный сотрудник отделения торакальной хирургии</p><p>SPIN-код: 6983-2598Россия, 125284, г. Москва, 2-й Боткинский пр., 3 </p></bio><bio xml:lang="en"><p>3, 2nd Botkinsky pr., 125284, Moscow, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1616-198X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Амиралиев</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Amiraliev</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, старший научный сотрудник отделения торакальной хирургии</p><p>SPIN-код: 6983-2598Россия, 125284, г. Москва, 2-й Боткинский пр., 3</p></bio><bio xml:lang="en"><p>3, 2nd Botkinsky pr., 125284, Moscow, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5629-340X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бармин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Barmin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, научный сотрудник отделения торакальной хирургии</p><p>SPIN-код: 2010-5336Россия, 125284, г. Москва, 2-й Боткинский пр., 3 </p></bio><bio xml:lang="en"><p>3, 2nd Botkinsky pr., 125284, Moscow, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4131-9179</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Александров</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Aleksandrov</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>младший научный сотрудник отделения торакальной хирургии</p><p>SPIN-код: 7170-8030Россия, 125284, г. Москва, 2-й Боткинский пр., 3 </p></bio><bio xml:lang="en"><p>3, 2nd Botkinsky pr., 125284, Moscow, Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский научно-исследовательский онкологический институт им. П.a. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow P.A. Hertzen Cancer Research Center – branch of National Medical Research Center of Radiology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>02</day><month>03</month><year>2021</year></pub-date><volume>20</volume><issue>1</issue><fpage>24</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Рябов А.Б., Пикин О.В., Багров В.А., Колбанов К.И., Глушко В.А., Вурсол Д.А., Амиралиев А.М., Бармин В.В., Александров О.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Рябов А.Б., Пикин О.В., Багров В.А., Колбанов К.И., Глушко В.А., Вурсол Д.А., Амиралиев А.М., Бармин В.В., Александров О.А.</copyright-holder><copyright-holder xml:lang="en">Ryabov A.B., Pikin O.V., Bagrov V.A., Kolbanov K.I., Glushko V.A., Vursol D.A., Amiraliev A.M., Barmin V.V., Aleksandrov O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/1688">https://www.siboncoj.ru/jour/article/view/1688</self-uri><abstract><p>Цель исследования – оценить непосредственные и отдаленные результаты торакоскопической лобэктомии у больных немелкоклеточным раком легкого (НМРЛ), оперированных в одном лечебном учреждении. </p><sec><title>Материл и методы</title><p>Материл и методы. Проведен анализ непосредственных и отдаленных результатов торакоскопической лобэктомии у 479 больных НМРЛ с клинической i  стадией заболевания, оперированных в торакальном отделении МНИОИ им. П.А.  Герцена с 2010 по 2019 г. </p></sec><sec><title>Результаты</title><p>Результаты. Конверсия в торакотомный доступ потребовалась у 62 (12,9 %) больных. Частота послеоперационных осложнений в группе торакоскопических операций составила 19,9 %, в группе конверсий – 25,8 %, летальность – 0,4 % и 1,6 % соответственно. Наиболее частое осложнение – длительная негерметичность легочной ткани – встретилось в 11,9 % и 8,0 % соответственно. У больных старше 70 лет частота осложнений после торакосокпической операции составила 35,6 %, а в группе конверсии – 41,2 %. Отмечено преимущество торакоскопической лобэктомии в  виде менее выраженного болевого сидрома и изменений показателей ОФВ1 в послеоперационном периоде. Общая и безрецидивная 5-летняя выживаемость в группе больных НМРЛ i стадии (pt1a-bN0m0; pt2aN0m0) после торакоскопической лобэктомии составила 92,2 % и 86,6 %, а у больных, перенесших конверсию, – 87,5 % и 81,2 % соответственно.</p></sec><sec><title>Заключение</title><p>Заключение. Торакоскопическая лобэктомия – относительно безопасная операция у больных НМРЛ i стадии. Для освоения техники выполнения торакоскопической лобэктомии необходимо пройти «кривую обучения». Отдаленные результаты торакоскопической лобэктомии не уступают таковым в открытой хирургии.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim: to analyze short-and long-term treatment outcomes of thoracoscopic lobectomy in patients with stageI NSCLC .</p></sec><sec><title>Material and Methods</title><p>Material and Methods. A total of 479 NSCLC patients with clinical stage I NSCLC were treated at the Department of Thoracic Surgery of Hertzen Research Cancer Center from 2010 to 2019.</p></sec><sec><title>Results</title><p>Results. Conversion to thoracotomy was required in 62 (12.9 %) of patients. Postoperative complications occurred in 19.9 % of patients in the thoracoscopic group and in 25.8 % of patients in the conversion group: the mortality rates were 0.4 % and 1.6 % respectively. The most common complication was prolonged air-leak (&gt;5 days), which was diagnosed in 11.9 % and 8.0 % of patients respectively. In patients aged &gt;70 years, the rate of complications was 35.8 % in the thoracoscopic group and 41.2 % in the conversion group. Thoracoscopic lobectomy had advantages over thoracotomy in terms of less postoperative pain syndrome and much less decrease in FEV1 during the first postoperative days and months. In patients with pT1-2aN0M0, stage I NSCLC , the overall and disease-free 5-year survival rates were respectively 92.2 % and 86.6 % after thoracoscopic lobectomy and 87.5 % и 81.2 % after conversion.</p></sec><sec><title>Conclusion</title><p>Conclusion. Thoracoscopic lobectomy is relatively safe procedure for patients with stage I NSCLC . To perform this type of surgery safely, the surgeon should pass the learning curve. Long-term outcomes were similar between patients undergoing thoracoscopic lobectomy and patients undergoing thoracotomy.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>рак легкого</kwd><kwd>торакоскопическая лобэктомия</kwd><kwd>конверсия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>lung cancer</kwd><kwd>thoracoscopic lobectomy</kwd><kwd>conversion</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Landreneau R.J., Mack M.J., Hazelrigg S.R., Dowling R.D., Acuff T.E., Magee M.J., Ferson P.F. Video-assisted thoracic surgery: basic technical concepts and intercostal approach strategies. Ann Thorac Surg. 1992 Oct; 54(4): 800–7. doi: 10.1016/0003-4975(92)91040-g.</mixed-citation><mixed-citation xml:lang="en">Landreneau R.J., Mack M.J., Hazelrigg S.R., Dowling R.D., Acuff T.E., Magee M.J., Ferson P.F. 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