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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21294/1814-4861-2021-20-2-5-12</article-id><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-1748</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURES</subject></subj-group></article-categories><title-group><article-title>РЕГЕНЕРАЦИЯ ТКАНЕЙ И ОНКОГЕНЕЗ – СХОДСТВО И РАЗЛИЧИЯ</article-title><trans-title-group xml:lang="en"><trans-title>TISSUE REGENERATION AND ONCOGENESIS-SIMILARITIES AND DIFFERENCES</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7492-747X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачук</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkachuk</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p> доктор биологических наук, академик РАН, директор Института регенеративной медицины, заведующий кафедрой биохимии и молекулярной медицины факультета фундаментальной медицины</p><p>SPIN-код: 5515-4266. Researcher ID (WOS): J-9357-2012. Author ID (Scopus): 24455385800 </p><p>Россия, 119192, г. Москва, Ломоносовский пр-т., 27/10</p></bio><bio xml:lang="en"><p> DSc, Member of the Russian Academy of Sciences, Director of Medical Research and Education Center; Head of Biochemistry and Molecular Medicine</p><p>Researcher ID (WOS): J-9357-2012. Author ID (Scopus): 24455385800 </p><p> 27/10, Lomonosovsky prospect, 119192, Moscow, Russia </p></bio><email xlink:type="simple">tkachuk@fbm.msu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт регенеративной медицины Медицинского научно-образовательного центра, МГУ имени М.В. Ломоносова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medical Research and Education Center, Institute for Regenerative Medicine,&#13;
Lomonosov Moscow State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>28</day><month>04</month><year>2021</year></pub-date><volume>20</volume><issue>2</issue><fpage>5</fpage><lpage>12</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ткачук В.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Ткачук В.А.</copyright-holder><copyright-holder xml:lang="en">Tkachuk V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/1748">https://www.siboncoj.ru/jour/article/view/1748</self-uri><abstract><p> Регенеративная медицина – это область медицины, которая ставит своей задачей выращивание утраченных или несформировавшихся органов и тканей человека. На данном этапе она научилась это делать с некоторыми полыми и морфологически простыми органами. Однако у нее есть великая перспектива, которая заключается в создании нового типа терапии, направленной на регенерацию и репарацию тканей и органов в теле человека. Успехи и перспективы развития этой науки держатся на колоссальном потенциале обновления клеток в нашем организме: оно может достигать около килограмма в день, десятки тонн за нашу жизнь. Совокупность данных последних лет свидетельствует о том, что опухоль представляет собой ткань, во многом повторяющую модель  роста и регенерации нормальной ткани. Так же, как и в нормальной ткани, для опухолей описаны стволовые клетки, способные инициировать опухоль и поддерживать её рост. Некоторые биологи рассматривают раковые опухоли как плату за многоклеточность, за обновление тканей [<xref ref-type="bibr" rid="cit1">1</xref>]. Разумеется, этим потенциалом нужно учиться управлять.Это очень непростая задача, так как не раскрыты многие фундаментальные механизмы образования и гибели клеток. Развитие регенеративной медицины как принципиально нового вида медицины позволит не только управлять  процессами обновления клеток, но и препятствовать их  онкологическому перерождению, а идентификация белков, микроРНК и других факторов, регулирующих образованиеи гибель клеток, определит потенциальные мишени как для стимуляции эндогенной регенерации, так и для сдерживания онкологических процессов в организме. </p></abstract><trans-abstract xml:lang="en"><p> Regenerative medicine represents the field of medicine that aims to grow lost or damaged human organs and tissues. The promise of regenerative medicine focuses on the development of therapy that can regenerate and restore tissues and organs in the human body. The regenerative medicine  has the potential of cell renewal in our body, reaching about a kilogram per day, tens of tons in our life. Recent data indicate that a tumor is a tissue that largely repeats the pattern of growth and regeneration of normal tissue. Similar to normal stem cells, tumor stem cells are capable of initiating tumor and its growth. Scientists consider that cancer is a payment for multicellularity [<xref ref-type="bibr" rid="cit1">1</xref>]. Undoubtedly, this potential must be learned to manage. This is a very difficult problem, since many fundamental mechanisms of cell formation and death have not been fully understood. The development of regenerative medicine as a fundamentally new type of medicine will make it  possible not only to control stem cell renewal, but also to prevent malignant transformation. The identification of proteins, micro-RNAs and other factors that regulate the formation and death of cells will identify potential targets  for both stimulating endogenous regeneration and controlling cancer. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>регенеративная медицина</kwd><kwd>онкогенез</kwd><kwd>перепрограммирование</kwd><kwd>трансдифференцировка</kwd><kwd>секретом стволовых клеток</kwd></kwd-group><kwd-group xml:lang="en"><kwd>regenerative medicine</kwd><kwd>oncogenesis</kwd><kwd>reprogramming</kwd><kwd>transdifferentiation</kwd><kwd>stem cells secretome</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена при финансовой поддержке Российского научного фонда (проект № 19-75- 30007).</funding-statement><funding-statement xml:lang="en">This research was supported by the Russian Science Foundation (Project No. 19-75-30007).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Pennisi E. 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