oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2021-20-2-110-117oncotomsk-1763Research ArticleОБЗОРЫREVIEWSВЗАИМОСВЯЗЬ МЕЖДУ ЗНАЧЕНИЯМИ ИЗМЕРЯЕМОГО КОЭФФИЦИЕНТА ДИФФУЗИИ И ИНДЕКСОМ ПРОЛИФЕРАТИВНОЙ АКТИВНОСТИ KI67 В ОПУХОЛЯХ ГОЛОВНОГО МОЗГА: СИСТЕМАТИЧЕСКИЙ ОБЗОРASSOCIATION BETWEEN APPARENT DIFFUSION COEFFICIENT AND KI67 IN BRAIN TUMORS: A SYSTEMATIC REVIEWhttps://orcid.org/0000-0001-9039-9147СтепановИ. А.StepanovI. A.

аспирант кафедры нейрохирургии и инновационной медицины

SPIN-код: 5485-5316

Россия, 664003, г. Иркутск, ул. Красного Восстания, 1 

 MD, Postgraduate, Department of Neurosurgery and Innovative Medicine 

 Russia, 664003, Irkutsk, Krasnogo Vosstaniya Street, 1 

edmoilers@mail.ruhttps://orcid.org/0000-0002-3085-2998ШамееваМ. А.ShameevaM. A.

 клинический ординатор кафедры нейрохирургии и инновационной медицины

 Россия, 664003, г. Иркутск, ул. Красного Восстания, 1 

 Clinical Resident, Department of Neurosurgery and Innovative Medicine 

 Russia, 664003, Irkutsk, Krasnogo Vosstaniya Street, 1 

https://orcid.org/0000-0001-9604-5614КручининД. Б.KruchininD. B.

 клинический ординатор кафедры нейрохирургии и инновационной медицины

 Россия, 664003, г. Иркутск, ул. Красного Восстания, 1 

 Clinical Resident, Department of Neurosurgery and Innovative Medicine 

 Russia, 664003, Irkutsk, Krasnogo Vosstaniya Street, 1 

ФГБОУ ВО «Иркутский государственный медицинский университет» Министерства здравоохранения РФРоссияIrkutsk State Medical UniversityRussian Federation202101052021202110117Copyright © Степанов И.А., Шамеева М.А., Кручинин Д.Б., 20212021Степанов И.А., Шамеева М.А., Кручинин Д.Б.Stepanov I.A., Shameeva M.A., Kruchinin D.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/1763 Введение

 Введение. Определенные гистологические варианты опухолей имеют корреляционную зависимость между значениями измеряемого коэффициента диффузии (ИКД), клеточной плотностью и индексом пролиферативной активности MIB-I (Ki67). Результаты исследований, изучающих взаимосвязь между значениями ИКД и индексом Ki67 в опухолях головного мозга, неоднозначны и противоречивы.

Цель исследования – выполнить систематический обзор клинических исследований, в которых изучалась взаимосвязь между значениями ИКД и индексом  пролиферативной активности Ki67 в опухолях головного  мозга.

Материал и методы

Материал и методы. Выполнен поиск клинических  исследований в базах данных pubmed, EMBASE, Cohrane Library и eLibrary, опубликованных в период с января 2000 г. по январь 2020 г., в которых изучали взаимосвязь между значениями ИКД и индексом пролиферативной активности Ki67 в опухолях головного мозга.

Результаты

Результаты. В систематический обзор включены 17  ретроспективных когортных нерандомизированных клинических исследований. Среднее значение коэффициента достоверной корреляционной зависимости  между ИКД и митотическим индексом Ki67 в группе  менингиом составило -0,493. Указанная зависимость чаще встречалась в группах типических (МI) и атипических(MII) менингиом головного мозга. Коэффициент статистически значимой корреляции между изучаемыми параметрами в группе глиом головного мозга в среднем  составил -0,443. Зависимость между значениями ИКД и индексом пролиферативной активности Ki67 отмечалась в группе глиом как низкой (GI–II), так и высокой (GIII–IV) злокачественности. У больных с аденомами гипофиза, первичными лимфомами и метастазами головного мозга взаимосвязь между изучаемыми параметрами достоверно не подтверждена.

Заключение

Заключение. Применение диффузионно-взвешенной магнитно-резонансной томографии с последующим подсчетом значений ИКД может быть рекомендовано к использованию в клинической практике для оценки пролиферативного потенциала церебральных менингиом и глиом. 

 Certain histological variants of tumors have a correlation between the values of the apparent diffusion coefficients (AdC), cell density and the proliferative activity index MIB-I (Ki67). The results of studies on the relationship between the values of the AdC and the Ki67 index in brain  tumors are ambiguous and largely contradictory.

The purpose of this study was to perform a systematic review based on the results of clinical studies that examined the relationship between AdC values  and the Ki67 proliferative activity index in brain tumors.

Material and Methods

Material and Methods. Clinical studies were searched in the databases pubmed, EMBASE, Cohrane Library and eLibrary published from January 2000 to January 2020,  which studied the relationship between AdC values and the Ki67 proliferative activity index in brain tumors.

Results

Results. A systematic review included 17 retrospective cohort nonrandomized clinical studies. The average value of the coefficient of reliable correlation between AdC and the mitotic index Ki67 in the group of meningiomas was -0.493. The indicated dependence was more often found in groups of typical (MI) and atypical (MII) brain meningiomas. The average coefficient of statistically significant correlation between the studied parameters in the group of brain gliomas was -0.443. The relationship between the AdC values and the Ki67 proliferative activity index was observed both in the glioma group of low (GI–II) and high (GIII–IV) grade of malignancy. In groups of patients with pituitary adenomas, primary lymphomas and brain metastases, the relationship between the studied parameters was not reliably confirmed.

Conclusion

Conclusion. The use of diffusion-weighted magnetic resonance imagingtechniques with subsequent calculation of AdC values can be recommended for use in the clinical practice of oncologists in order to assess the proliferative potential of brain meningiomas and gliomas. 

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The authors declare that there are no conflicts of interest present.