oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2021-20-3-124-133oncotomsk-1818Research ArticleОБЗОРЫREVIEWSМЕТОД ЭЛЕКТРОХИМИЧЕСКОГО ЛИЗИСА В ОНКОЛОГИЧЕСКОЙ ПРАКТИКЕ (ОБЗОР ЛИТЕРАТУРЫ)ELECTROCHEMICAL LYSIS IN ONCOLOGY: LITERATURE REVIEWhttps://orcid.org/0000-0001-8524-129XАникановаЕ. В.AnikanovaE. V.

 врач онколог-уролог, отделение онкологии (урологии)

SPIN-код: 6826-7877. AuthorID (РИНЦ): 856575. 

 Россия, 129128, г. Москва, ул. Будайская, 2 

 MD, Urology Department

 2, Budayskaya street, 129128, Moscow, Russia 

anikanova1801@gmail.comhttps://orcid.org/0000-0001-8708-2712ГенсГ. П.GuensG. P.

 доктор медицинских наук, профессор, заведующая кафедрой онкологии и лучевой терапии

SPIN-код: 3867-9491. AuthorID (РИНЦ): 731350. Author ID (Scopus): 55378413900 

 Россия, 127473, г. Москва, ул. Делегатская, 20/1 

 MD, DSc, Professor, Head of Oncology and Radiation Therapy Department

Author ID (Scopus): 55378413900 

 20/1, Delegatskaya street, 127473, Moscow, Russia 

https://orcid.org/0000-0003-4511-5998КолонтаревК. С.KolontarevK. B.

 доктор медицинских наук, профессор кафедры урологии,

SPIN-код 2352-1103. AutorID (РИНЦ): 711843. Author ID (Scopus): 24780767600

 Россия, 127473, г. Москва, ул. Делегатская, 20/1 

 MD, DSc, Professor of Urology Department

Author ID (Scopus): 24780767600 

 20/1, Delegatskaya street, 127473, Moscow, Russia 

https://orcid.org/0000-0002-9752-6804МусловС. А.MuslovS. A.

 доктор биологических наук, кандидат физико-математических наук, профессор кафедры нормальной физиологии и медицинской физики

SPIN-код: 7213-2852. AuthorID (РИНЦ): 185513

 Россия, 127473, г. Москва, ул. Делегатская, 20/1 

 PhD, DSc, Professor, Department of Normal Physiology and Medical Physics 

 20/1, Delegatskaya street, 127473, Moscow, Russia 

ЧУЗ ЦКБ № 2 «РЖД-Медицина»РоссияCentral Clinical Hospital «Russian Railways-Medicine»Russian FederationФГБОУ ВО «Московский медико-стоматологический государственный университет им. А.И. Евдокимова» Минздрава РоссииРоссияA.I. Yevdokimov Moscow State University of Medicine and DentistryRussian Federation202129062021203124133Copyright © Аниканова Е.В., Генс Г.П., Колонтарев К.С., Муслов С.А., 20212021Аниканова Е.В., Генс Г.П., Колонтарев К.С., Муслов С.А.Anikanova E.V., Guens G.P., Kolontarev K.B., Muslov S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/1818

В онкологической практике все более востребованными становятся методы малоинвазивного лечения, основанные на применении различных физических факторов, к которым, в том числе, относят электрохимический лизис, вызывающий разрушение опухолевых клеток в результате местного воздействия постоянным электрическим током низкого напряжения.

Цель исследования – представить результаты применения метода электрохимического лизиса в терапии различных новообразований, сведения о механизме противоопухолевого действия, способах доставки электрического тока к опухоли, параметрах воздействия и позиционирования электродов.

Материал и методы

Материал и методы. Поиск проводили в базах данных Medline, eMBase, Web of science, scopus, РинЦ, опубликованных до декабря 2019 г. В обзор включали работы, посвященные применению электрохимического лизиса in vitro, in vivo, а также клинические наблюдения и исследования, в которых метод был использован как в качестве самостоятельной терапии, так и в комбинации с другими методами лечения с момента появления первой публикации в 1984 г.

Результаты

Результаты. Представлены современные знания о механизмах повреждающего действия электрохимического лизиса, методологии планирования и распределения дозы электровоздействия и позиционирования электродов. В клинических исследованиях оценены осложнения и онкологические результаты. Анализ литературы показал, что метод электрохимического лизиса является безопасным, эффективным и относительно неинвазивным методом противоопухолевого лечения различных новообразований с обнадеживающими краткосрочными онкологическими и функциональными результататами.

Заключение

Заключение. Метод электрохимического лизиса является перспективным вариантом малоинвазивного лечения, который может быть использован при различных новообразованиях. Однако отсутствие проспективных клинических исследований с хорошей доказательной базой пока не позволяет включить его в рекомендации по лечению злокачественных опухолей и применять в широкой клинической практике.

Recently, minimally invasive treatment modalities based on the application of various physical factors have been widely used in anticancer therapy. Electrochemical lysis is a method in which tumor cells are destroyed by local exposure to a constant low voltage electric current.

Purpose

Purpose: to present the current results of using electrochemical lysis in the treatment of various tumors, to describe the mechanism of tumor destruction and methods of delivering electric current to the tumor, as well as to evaluate the electrical parameters and positioning of the electrodes.

Material and Methods

Material and Methods.aliterature search included the Medical literatureanalysis and Retrieval system Online (Medline), the excerpta Medica data Base (embase), Web of science, scopus, Russian citation index. All articles were published before december 2019. The review included studies on the investigation electrochemical lysis in vitro, in vivo, as well as clinical observations and clinical studies in which electrochemical lysis has been used as an independent treatment, or in combination with other methods of anticancer treatment since 1984.

Results

Results. This review provides information regarding the electrochemical mechanisms of tumor destruction, anti-tumoral effects of electrochemical therapy, methodology for planning and distributing the dose of electrical lysis and positioning of electrodes. We have evaluated complications and oncological results. Electrochemical lysis is a safe, simple, effective, and relatively non-invasive method of antitumor treatment.

Conclusion

Conclusion. The electrochemical lysis is a promising minimally invasive method which can be used for the treatment of tumors. However, long-term data are needed to validate this treatment before it can be included into clinical recommendation for the treatment of cancer patients.

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The authors declare that there are no conflicts of interest present.