Материал и методы

oncotomsk

Сибирский онкологический журнал

Siberian journal of oncology

1814-48612312-3168

Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences

10.21294/1814-4861-2021-20-3-134-143

oncotomsk-1821

Research Article

ОБЗОРЫ

REVIEWS

ОБЗОР ИССЛЕДОВАНИЙ ВЗАИМОСВЯЗИ ЦИРКАДИАННЫХ РИТМОВ И КАНЦЕРОГЕНЕЗА, ВЫПОЛНЕННЫХ НА ЭКСПЕРИМЕНТАЛЬНЫХ МОДЕЛЯХ

REVIEW OF RESEARCH ON THE RELATIONSHIP BETWEEN CIRCADIAN RHYTHMS AND CARCINOGENESIS USING ANIMAL MODELS

https://orcid.org/0000-0002-4732-5895

Киреева

Г. С.

Kireeva

G. S.

кандидат биологических наук, старший научный сотрудник научной лаборатории канцерогенеза и старения

Researcher ID (WOS): H-6963-2016. Author ID (Scopus): 56184283000

Россия, 197758, г. Санкт-Петербург, п. Песочный, ул. Ленинградская, 68

PhD, Senior Researcher, Laboratory of Carcinogenesis and Aging

Researcher ID (WOS): H-6963-2016. Author ID: (Scopus): 56184283000

68, Leningradskaya street, 197758, Pesochny, Saint-Petersburg, Russia

galinakireyeva@mail.ru

Губарева

Е. А.

Gubareva

E. A.

научный сотрудник лаборатории канцерогенеза и старения

Author ID (Scopus): 56909987000

Россия, 197758, г. Санкт-Петербург, п. Песочный, ул. Ленинградская, 68

Researcher, Laboratory of Carcinogenesis and Aging

AuthorID (Scopus): 56909987000

68, Leningradskaya street, 197758, Pesochny, Saint-Petersburg, Russia

Майдин

М. А.

Maydin

M. A.

научный сотрудник лаборатории канцерогенеза и старения,

Author ID (Scopus): 56184141100

Россия, 197758, г. Санкт-Петербург, п. Песочный, ул. Ленинградская, 68

Researcher, Laboratory of Carcinogenesis and Aging

AuthorID (Scopus): 56184141100

68, Leningradskaya street, 197758, Pesochny, Saint-Petersburg, Russia

Панченко

А. В.

Panchenko

A. V.

кандидат медицинских наук, заведующий научной лабораторией канцерогенеза и старения

Россия, 197758, г. Санкт-Петербург, п. Песочный, ул. Ленинградская, 68

MD, PhD, Head of Laboratory of Carcinogenesis and Aging

68, Leningradskaya street, 197758, Pesochny, Saint-Petersburg, Russia

Тындык

М. Л.

Tyndyk

M. L.

кандидат биологических наук, старший научный сотрудник научной лаборатории канцерогенеза и старения

Россия, 197758, г. Санкт-Петербург, п. Песочный, ул. Ленинградская, 68

PhD, Senior Researcher, Laboratory of Carcinogenesis and Aging

68, Leningradskaya street, 197758, Pesochny, Saint-Petersburg, Russia

Федорос

Е. И.

Fedoros

E. I.

кандидат сельскохозяйственных наук, старший научный сотрудник научной лаборатории канцерогенеза и старения

Россия, 197758, г. Санкт-Петербург, п. Песочный, ул. Ленинградская, 68

PhD, Senior Researcher, Laboratory of Carcinogenesis and Aging

68, Leningradskaya street, 197758, Pesochny, Saint-Petersburg, Russia

Круглов

С. С.

Kruglov

S. S.

научный сотрудник лаборатории канцерогенеза и старения

Россия, 197758, г. Санкт-Петербург, п. Песочный, ул. Ленинградская, 68

Researcher, Laboratory of Carcinogenesis and Aging

68, Leningradskaya street, 197758, Pesochny, Saint-Petersburg, Russia

Осетник

В. К.

Osetnik

V. K.

аспирант

Россия, 199034, г. Санкт-Петербург, Университетская набережная, 7–9

Postgraduate

7–9, University Enbarkment, 199034, Saint-Petersburg, Russia

Анисимов

В. Н.

Anisimov

V. N.

доктор медицинских наук, профессор, член-корреспондент РАН, заведующий научным отделом канцерогенеза и геронтологии

Россия, 197758, г. Санкт-Петербург, п. Песочный, ул. Ленинградская, 68

MD, PhD, Professor, Corresponding Member of the Russian Academy of Science, Head of the Department of Carcinogenesis and Gerontology

68, Leningradskaya street, 197758, Pesochny, Saint-Petersburg, Russia

ФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава РоссииРоссияN.N. Petrov National Medical Research Center of Oncology of the Russian Ministry of HealthRussian Federation

ФГБУ ВО «Санкт-Петербургский государственный университет»РоссияSaint-Petersburg University Russian Federation

2021

29062021

203134143

2021

Киреева Г.С., Губарева Е.А., Майдин М.А., Панченко А.В., Тындык М.Л., Федорос Е.И., Круглов С.С., Осетник В.К., Анисимов В.Н.

Kireeva G.S., Gubareva E.A., Maydin M.A., Panchenko A.V., Tyndyk M.L., Fedoros E.I., Kruglov S.S., Osetnik V.K., Anisimov V.N.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.siboncoj.ru/jour/article/view/1821

Цель исследования – провести обзор экспериментальных исследований in vivo, посвященных изучению взаимосвязи и роли различных молекулярно-генетических компонентов системы циркадианных ритмов в процессе инициации и развития злокачественных новообразований. интерес к исследованиям на животных моделях обусловлен тем, что, в отличие от клинических и эпидемиологических исследований по данному вопросу, на них возможно моделировать (в том числе на трансгенных моделях животных) различные изменения и нарушения в активности часовых генов и отслеживать результаты данных изменений.

Материал и методы

Материал и методы. В обзор включены данные исследований, выполненных за последние 10 лет на животных моделях, изучающих механизмы и эффекты нарушений в системе циркадианных ритмов в контексте формирования и развития опухолей. источниками данных для обзора послужили базы данных Medline, embase и scopus.

Результаты

Результаты. Анализ литературы показал, что вмешательство в работу «биологических часов» путем изменений цикла освещенности, нарушения экспрессии часовых генов и других манипуляций является фактором, предрасполагающим к развитию опухолей. В опухолях различных типов экспрессия часовых генов зачастую рассогласована, причем неясно, на каком этапе их формирования это происходит. Помимо этого, само развитие опухолей нарушает циркадианный гомеостаз организма. Можно выделить три ключевых аспекта проводимых исследований, направленных на изучение роли циркадианных ритмов в развитии опухоли: нарушение циркадианных ритмов как канцерогенный фактор, нарушения в системе часовых генов в опухоли, нарушения в системе часовых генов всего организма, спровоцированные развитием опухоли.

Заключение

Заключение. Результаты исследований на животных моделях демонстрируют, что взаимосвязь между нарушением циркадианных ритмов и опухолевым процессом носит комплексный характер с не до конца изученной причинно-следственной связью. Поэтому перспектива направленной фармакологической корректировки циркадианных ритмов в клинической практике у онкологических пациентов в настоящее время не выглядит ближайшей.

Purpose of the study

Purpose of the study: to review in vivo studies on the relationship and role of various molecular genetic components of the circadian rhythm system in the initiation and development of malignant neoplasms. in contrast to clinical and epidemiological studies, animal models, including transgenic animal models, can model various changes and disturbances in the activity of clock genes and track the results of these changes.

Material and Methods

Material and Methods. the review includes data from studies carried out over the past 10 years in animal models, studying the mechanisms and effects of disturbances in the system of circadian rhythms related to the formation and development of tumors. the data sources for the review were the Medline, embase and scopus databases.

Results

Results. analysis of the literature has shown that interference with the work of the «biological clock» by changing the light cycle, disrupting the expression of clock genes and other manipulations is a factor predisposing to the development of tumors. in tumors of various types, the expression of clock genes is often mismatched, and it is unclear at what stage of their formation this occurs. in addition, the development of tumors disrupts the circadian homeostasis of the body. there are three key areas of research aimed at studying the role of circadian rhythms in tumor development: disturbance of circadian rhythms as a carcinogenic factor, disturbances in the clock gene system in a tumor, disturbances in the clock gene system of the whole organism, provoked by tumor development.

Conclusion

Conclusion. the results of studies on animal models demonstrate that the relationship between the disturbance of circadian rhythms and the tumor process is complex since the causal relationship has not yet been studied. in this regard, the prospect of targeted pharmacological correction of circadian rhythms in clinical practice in cancer patients does not seem to be the nearest one.

циркадианные ритмычасовые геныэкспериментальные моделиканцерогенезBMal1ClOCKPeRCRY

circadian rhythmsclock genesexperimental modelscarcinogenesisBMal1ClOCKPeRCRY

Исследование выполнено за счет гранта Российского научного фонда (проект № 18-75-10017).

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The authors declare that there are no conflicts of interest present.