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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21294/1814-4861-2021-20-4-39-48</article-id><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-1860</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL STUDIES</subject></subj-group></article-categories><title-group><article-title>КОНТРАСТНАЯ КОМПЬЮТЕРНО-ТОМОГРАФИЧЕСКАЯ ХОЛАНГИОГРАФИЯ В ДИФФЕРЕНЦИАЛЬНОЙ ДИАГНОСТИКЕ ПРИЧИН БИЛИАРНОЙ ОБСТРУКЦИИ ЗЛОКАЧЕСТВЕННОГО И ДОБРОКАЧЕСТВЕННОГО ГЕНЕЗА</article-title><trans-title-group xml:lang="en"><trans-title>CONTRAST-ENHANCED COMPUTED TOMOGRAPHIC CHOLANGIOGRAPHY IN DIFFERENTIAL DIAGNOSIS OF THE MALIGNANT AND BENIGN CAUSES OF BILIARY OBSTRUCTION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5986-1030</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зарубин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zarubin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> аспирант кафедры лучевой диагностики и лучевой терапии</p><p> Россия, 634050, Томск, Московский тракт, 2 </p></bio><bio xml:lang="en"><p> Postgraduate student of Diagnostic and Therapeutic Radiology Department</p><p>2, Moskovsky Tract, 634050, Tomsk, Russia</p></bio><email xlink:type="simple">vladislav.zrb@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1316-5421</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куражов</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurazhov</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p> доктор медицинских наук, профессор кафедры лучевой диагностики и лучевой терапии</p><p> Россия, 634050, Томск, Московский тракт, 2 </p></bio><bio xml:lang="en"><p> MD, PhD, Professor of Diagnostic and Therapeutic Radiology Department </p><p>2, Moskovsky Tract, 634050, Tomsk, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6231-7650</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Завадовская</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Zavadovskaja</surname><given-names>V. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p> доктор медицинских наук, профессор, заведующая кафедрой лучевой диагностики и лучевой терапии</p><p> Россия, 634050, Томск, Московский тракт, 2 </p></bio><bio xml:lang="en"><p> MD, PhD, Professor of Diagnostic and Therapeutic Radiology Department </p><p>2, Moskovsky Tract, 634050, Tomsk, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Родионова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rodionova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> кандидат медицинских наук, врач-рентгенолог отделения томографических методов исследования </p><p> Россия, 634050, Томск, Московский тракт, 2 </p></bio><bio xml:lang="en"><p> MD, PhD, Radiologist, Computed Tomography Department </p><p>2, Moskovsky Tract, 634050, Tomsk, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тонких</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Tonkikh</surname><given-names>O. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p> кандидат медицинских наук, заведующая отделением томографических методов исследования </p><p> Россия, 634050, Томск, Московский тракт, 2 </p></bio><bio xml:lang="en"><p> MD, PhD, Head of Computed Tomography Department </p><p>2, Moskovsky Tract, 634050, Tomsk, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клиновицкий</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Klinovitskiy</surname><given-names>I. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p> кандидат медицинских наук, заведующий клиникой общей хирургии </p><p> Россия, 634050, Томск, Московский тракт, 2 </p></bio><bio xml:lang="en"><p> MD, PhD, Head of Department, General Surgery Department </p><p>2, Moskovsky Tract, 634050, Tomsk, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зоркальцев</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zorkaltsev</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p> доктор медицинских наук, доцент кафедры лучевой диагностики и лучевой терапии </p><p> Россия, 634050, Томск, Московский тракт, 2 </p></bio><bio xml:lang="en"><p> MD, PhD, Professor of Diagnostic and Therapeutic Radiology Department </p><p>2, Moskovsky Tract, 634050, Tomsk, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Харитонкин</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Haritonkin</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p> врач-хирург клиники общей хирургии </p><p> Россия, 634050, Томск, Московский тракт, 2 </p></bio><bio xml:lang="en"><p> MD, PhD, Surgeon, General Surgery Department </p><p>2, Moskovsky Tract, 634050, Tomsk, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>26</day><month>08</month><year>2021</year></pub-date><volume>20</volume><issue>4</issue><fpage>39</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зарубин В.В., Куражов А.П., Завадовская В.Д., Родионова О.В., Тонких О.С., Клиновицкий И.Ю., Зоркальцев М.А., Харитонкин В.И., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Зарубин В.В., Куражов А.П., Завадовская В.Д., Родионова О.В., Тонких О.С., Клиновицкий И.Ю., Зоркальцев М.А., Харитонкин В.И.</copyright-holder><copyright-holder xml:lang="en">Zarubin V.V., Kurazhov A.P., Zavadovskaja V.D., Rodionova O.V., Tonkikh O.S., Klinovitskiy I.Y., Zorkaltsev M.A., Haritonkin V.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/1860">https://www.siboncoj.ru/jour/article/view/1860</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Определение причины холестаза и лечение пациентов с синдромом механической желтухи остаются актуальной задачей из-за устойчивого роста заболеваний гепатопанкреатодуоденальной зоны и высокой частоты диагностических ошибок. В дифференциальной диагностике причин механической желтухи наибольшее значение имеют методы медицинской визуализации. В мировой литературе имеются немногочисленные сообщения об оценке диагностического потенциала мультиспиральной компьютерной томографии в условиях прямого контрастирования билиарного дерева с помощью эндоскопической ретроградной холангиопанкреатографии, чрескожно-чреспеченочной холангиографии либо через предустановленный паллиативный дренаж в желчных протоках. Не существует общепринятого лучевого алгоритма для определения причин билиарной обструкции, что приводит к многократному или последовательному неэффективному использованию различных методов медицинской визуализации, усложняя диагностический процесс.</p><p>Цель исследования – оценить диагностическую эффективность контрастной компьютерно-томографической холангиографии (МСКТ-ХГ) в дифференциальной диагностике злокачественных и доброкачественных причин обструкции желчных путей при синдроме механической желтухи.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование включены 55 пациентов с механической желтухой, находившихся на лечении в хирургическом стационаре с июля 2016 г. по июль 2019 г.</p></sec><sec><title>Результаты</title><p>Результаты. Установлено, что контрастная МСКТ-ХГ в диагностике уровня и причин билиарной обструкции как злокачественного, так и доброкачественного генеза обладает более высокой информативностью по сравнению с рентгеновской эндоскопической ретроградной холангиопанкреатографией. Диагностическая эффективность МСКТ-ХГ в выявлении злокачественных причин билиарной обструкции составила: чувствительность – 93,3 %, специфичность – 92,9 %, точность – 93,1 %, а доброкачественных – 92,9, 93,3 и 93,1 % соответственно.</p></sec><sec><title>Заключение</title><p>Заключение. Контрастная компьютерно-томографическая холангиография на основании высокой точности является перспективной диагностической методикой при обструкции желчных путей.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Determination of the cause of cholestasis and treatment of patients with obstructive jaundice syndrome remains challenging owing to the steady rise in diseases of the hepatopancreatoduodenal zone and the high frequency of diagnostic errors. In the differential diagnosis of the causes of obstructive jaundice, diagnostic imaging techniques are of the greatest importance. In the world literature, there are few reports on the assessment of the diagnostic potential of multispiral computed tomography under conditions of direct contrasting of the biliary tree using endoscopic retrograde cholangiopancreatography, percutaneous transhepatic cholangiography, or through pre-installed palliative drainage in the bile ducts. There is no generally accepted algorithm for determining the causes of biliary obstruction. It leads to ineffective use of various diagnostic imaging techniques, complicating the diagnostic process.</p><p>The purpose of the study was to evaluate the diagnostic efficacy of contrast-enhanced ct cholangiography (ct-cg) in the differential diagnosis of causes of malignant and benign biliary obstruction in cases with obstructive jaundice syndrome.</p></sec><sec><title>Material and methods</title><p>Material and methods. The study included 55 patients with obstructive jaundice, who were treated in a surgical hospital from july 2016 to july 2019.</p></sec><sec><title>Results</title><p>Results. It was found that contrast ct-cg in diagnosing the causes of biliary obstruction of both malignant and benign genesis is more informative than x-ray endoscopic retrograde cholangiopancreatography. The diagnostic efficacy of ct-cg in detecting causes of malignant biliary obstruction was: 93.3% sensitivity, 92.9% specificity, and 93.1% accuracy. The diagnostic efficacy of ct-cg in detecting causes of benign biliary obstruction was: 92.9%, 93.3% and 93.1%, respectively.</p></sec><sec><title>Conclusion</title><p>Conclusion. Based on the high accuracy, contrast-enhanced ct-cg is a promising imaging technique in cases with bile duct obstruction.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>механическая желтуха</kwd><kwd>холангиокарцинома</kwd><kwd>рак поджелудочной железы</kwd><kwd>холангиопанкреатография</kwd><kwd>компьютерная томография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>obstructive jaundice</kwd><kwd>cholangiocarcinoma</kwd><kwd>pancreatic cancer</kwd><kwd>cholangiopancreatography</kwd><kwd>computed tomography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Савельев В.С., Кириенко А.И., Абакумов М.М., Андрияшкин В.В., Астапов Д.А., Белов Ю.В., Гаврилов С.Г. 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