oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciencesoncotomsk-191Research ArticleОПЫТ РАБОТЫ ОНКОЛОГИЧЕСКИХ УЧРЕЖДЕНИЙONCOLOGY PRACTICEК проблеме радиационного канцерогенеза после лечения лимфомы ходжкина и острого лимфобластного лейкоза у детей и подростковTO THE PROBLEM OF RADIATION-INDUCED CARCINOGENESIS AFTER TREATMENT OF HODGKIN’S LYMPHOMA AND ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN AND ADOLESCENTSЩербенкоО. И.ScherbenkoO. I.

лаборатория детской рентгенорадиологии

Sherbenko@mail.ruПархоменкоР. А.ParkhomenkoR. A.

лаборатория детской рентгенорадиологии

Российский научный центр рентгенорадиологии Минздрава РФРоссияRussian Scientific Center of Roentgenoradiology, MoscowRussian Federation201320022016046265Copyright © Щербенко О.И., Пархоменко Р.А., 20162016Щербенко О.И., Пархоменко Р.А.Scherbenko O.I., Parkhomenko R.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/191

Проведен анализ 26 случаев вторых злокачественных опухолей у детей и подростков, получавших комплексное лечение по по- воду лимфомы Ходжкина и острого лимфобластного лейкоза. Во всех случаях опухоли развились в зоне бывшего радиационного воздействия или по краю ее. Интервал между первичным лечением и развитием второй опухоли составил от 3 до 29 лет, дозы лучевой терапии – от 12 до 45 Гр. Только у 5 больных лечение второй опухоли было успешным, остальные умерли от ее прогрес- сирования. Риск развития второй опухоли должен учитываться при планировании комплексного лечения больных гемобластозами и в случаях благоприятного прогноза (достижение полной ремиссии в результате индукционной химиотерапии, наличие других признаков благоприятного прогноза) целесообразно воздерживаться от проведения лучевой терапии как наиболее канцерогенного фактора в лечебном комплексе.

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The authors declare that there are no conflicts of interest present.