oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2021-20-5-138-148oncotomsk-1927Research ArticleОБЗОРЫREVIEWSКАРДИОВАСКУЛЯРНЫЕ ОСЛОЖНЕНИЯ ПРОТИВООПУХОЛЕВОЙ ТЕРАПИИ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ: ДИАГНОСТИКА, ПРОФИЛАКТИКА И ЛЕЧЕНИЕCARDIOVASCULAR COMPLICATIONS OF ANTITUMOR THERAPY FOR BREAST CANCER: DIAGNOSIS, PREVENTION AND TREATMENThttps://orcid.org/0000-0002-2459-7273ПотиевскаяВ. И.PotievskayaV. I.

доктор медицинских наук, главный научный сотрудник, заведующая кардиологическим отделением, 

125284, Москва, 2-й Боткинский проезд, 3

MD, DSc, Chief Researcher, Head of the Cardiology Department, 

3, 2-nd Botkinsky proezd, 125284, Moscow

https://orcid.org/0000-0002-6395-5790АхобековА. А.AkhobekovA. A.

кандидат медицинских наук, заведующий отделением кардиологии, 

143081, Лапино, 1-е Успенское шоссе, 111

MD, PhD, Head of the Department of Cardiology,

111, 1st Uspenskoe sh., 143081, Lapino

https://orcid.org/0000-0003-4879-2687БолотинаЛ. В.BolotinaL. V.

доктор медицинских наук, руководитель отделения химиотерапии, 

125284, Москва, 2-й Боткинский проезд, 3

MD, DSc, Head of the Department of Chemotherapy,

3, 2-nd Botkinsky proezd, 125284, Moscow

КоролеваЛ. А.KorolevaL. A.

кандидат медицинских наук, врач-онколог отделения химиотерапии,

125284, Москва, 2-й Боткинский проезд, 3

MD, PhD, Oncologist, Department of Chemotherapy, 

3, 2-nd Botkinsky proezd, 125284, Moscow

https://orcid.org/0000-0001-8784-8415КапринА. Д.KaprinA. D.

доктор медицинских наук, профессор, академик РАН, генеральный директор ФГБУ «НМИЦрадиологии» Минздрава России, 

125284, Москва, 2-й Боткинский проезд, 3

MD, DSc, Professor, Academician of the Russian Academy of Sciences, General Director,

3, 2-nd Botkinsky proezd, 125284, Moscow

Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Научный медицинский исследовательский центр радиологии» Минздрава РоссииРоссияP.A. Gertsen Moscow Research Cancer Institute – branch of the National Medical Research Radiology CenterRussian FederationКлинический госпиталь ЛапиноРоссияClinical Hospital LapinoRussian Federation202129102021205138148Copyright © Потиевская В.И., Ахобеков А.А., Болотина Л.В., Королева Л.А., Каприн А.Д., 20212021Потиевская В.И., Ахобеков А.А., Болотина Л.В., Королева Л.А., Каприн А.Д.Potievskaya V.I., Akhobekov A.A., Bolotina L.V., Koroleva L.A., Kaprin A.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/1927

Наряду со значительными успехами в лечении рака молочной железы, позволившими улучшить выживаемость, сердечно-сосудистые заболевания стали основной причиной инвалидизации и смертности, не связанной с рецидивом злокачественного новообразования. В общей популяции сердечно-сосудистые заболевания являются основной причиной смертности как у женщин, так и у мужчин. У пациенток с раком молочной железы частота сердечно-сосудистых заболеваний еще выше, чем в общей популяции. Высокая частота сердечно-сосудистых заболеваний у пациенток с раком молочной железы, вероятно, обусловлена наличием общих факторов риска, а также кардиотоксичностью противоопухолевой терапии. Рост развития сердечно-сосудистых заболеваний у выживших пациенток с раком молочной железы является серьезной проблемой. В данном обзоре литературы описаны частота встречаемости сердечно-сосудистых осложнений при разных схемах лечения рака молочной железы, факторы риска их развития, стратегии мониторинга функции сердечно-сосудистой системы во время и после противоопухолевой терапии, а также стратегии профилактики и лечения кардиотоксичности. 

Although significant advances have been made in breast cancer treatment resulting in improved survival, cardiovascular disease has become the main cause of disability and mortality not related to cancer recurrence. In the general population, cardiovascular disease is the leading cause of death in both women and men. In patients with breast cancer, the incidence of cardiovascular diseases is even higher than in the general population. The high incidence of cardiovascular disease in breast cancer patients is likely due to the presence of common risk factors as well as the patients with breast cancer, the incidence of cardiovascular diseases is even higher than in the general population. The high incidence of cardiovascular disease in breast cancer patients is likely due to the presence of common risk factors as well as cardiotoxicity of anticancer therapy. The rise in the development of cardiovascular disease in breast cancer survivors is a major concern. This literature review will describe the incidence of cardiovascular complications with different treatment regimens for breast cancer, risk factors for their development, strategies for monitoring cardiovascular function during and after anticancer therapy, and strategies for the prevention and treatment of cardiotoxicity. 

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The authors declare that there are no conflicts of interest present.