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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-194</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURES</subject></subj-group></article-categories><title-group><article-title>CОВРЕМЕННОЕ СОСТОЯНИЕ ТЕРАПИИ БЫСТРЫМИ НЕЙТРОНАМИ</article-title><trans-title-group xml:lang="en"><trans-title>FAST NEUTRON THERAPY: A STATUS REPORT</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Wagner</surname><given-names>F. M.</given-names></name><name name-style="western" xml:lang="en"><surname>Wagner</surname><given-names>F. M.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Research neutron source FRM II</p></bio><email xlink:type="simple">franz.wagner@frm2.tum.de</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Specht</surname><given-names>H.</given-names></name><name name-style="western" xml:lang="en"><surname>Specht</surname><given-names>H.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Research neutron source FRM II</p></bio><email xlink:type="simple">franz.wagner@frm2.tum.de</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Loeper-Kabasakal</surname><given-names>B.</given-names></name><name name-style="western" xml:lang="en"><surname>Loeper-Kabasakal</surname><given-names>B.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Research neutron source FRM II, Research neutron source FRM II</p></bio><email xlink:type="simple">franz.wagner@frm2.tum.de</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Breitkreutz</surname><given-names>H.</given-names></name><name name-style="western" xml:lang="en"><surname>Breitkreutz</surname><given-names>H.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">franz.wagner@frm2.tum.de</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Technische Universität München<country>Германия</country></aff><aff xml:lang="en">Technische Universität München<country>Germany</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>20</day><month>02</month><year>2016</year></pub-date><volume>0</volume><issue>6</issue><fpage>5</fpage><lpage>12</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Wagner F.M., Specht H., Loeper-Kabasakal B., Breitkreutz H., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Wagner F.M., Specht H., Loeper-Kabasakal B., Breitkreutz H.</copyright-holder><copyright-holder xml:lang="en">Wagner F.M., Specht H., Loeper-Kabasakal B., Breitkreutz H.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/194">https://www.siboncoj.ru/jour/article/view/194</self-uri><abstract><p>В первой части статьи представлен анализ возможностей клинического применения терапии быстрыми нейтронами (ТБН), технические и статистические данные, а также биологические свойства быстрых нейтронов по сравнению с другими методами лучевой терапии. Рассматривается ситуация с клиническим применением бор-нейтрон захватной терапии (БНЗТ). Вторая часть статьи посвящена опыту применения ТБН на исследовательских реакторах FRM I и FRM II Технического университета Мюнхена в Гархинге (Германия).</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>терапия быстрыми нейтронами</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Томский научно­-исследовательский институт онкологии</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Auberger T., Reuschel W. The Role of Fast Neutrons in the Treatment of Squamous Cell Carcinomas of Head and Neck: The European Experience // Recent Results in Cancer Research Vol. 150. Springer-Verlag Berlin, Heidelberg, 1998.</mixed-citation><mixed-citation xml:lang="en">Auberger T., Reuschel W. The Role of Fast Neutrons in the Treatment of Squamous Cell Carcinomas of Head and Neck: The European Experience // Recent Results in Cancer Research Vol. 150. Springer-Verlag Berlin, Heidelberg, 1998.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Auberger T., Reuschel W., Kneschaurek P., Wehrmann R., Wagner F.M., Lukas P., Molls M. Reactor Neutron Therapy of Locally Recurrent Breast Cancer // Progress in RadioOncology V / Ed. H.D. Kogelnik. Monduzzi Editore Bologna, 1995. P. 691–694.</mixed-citation><mixed-citation xml:lang="en">Auberger T., Reuschel W., Kneschaurek P., Wehrmann R., Wagner F.M., Lukas P., Molls M. Reactor Neutron Therapy of Locally Recurrent Breast Cancer // Progress in RadioOncology V / Ed. H.D. Kogelnik. Monduzzi Editore Bologna, 1995. P. 691–694.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Breitkreutz H., Wagner F.M., Röhrmoser A., Petry W. Spectral fluence rates of the fast reactor neutron beam MedApp at FRM II // Nucl. Instr. Methods. 2008. Vol. 593. P. 466–471.</mixed-citation><mixed-citation xml:lang="en">Breitkreutz H., Wagner F.M., Röhrmoser A., Petry W. Spectral fluence rates of the fast reactor neutron beam MedApp at FRM II // Nucl. Instr. Methods. 2008. Vol. 593. P. 466–471.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bremer M., Neuhofer C., Zimmermann F., Kneschaurek P., Reuschel W., Molls M. Palliative radiotherapy of malignant melanoma with reactor fission neutron therapy (RENT): a prospective study // Radiat. Oncol. Investig. 1999. Vol. 7 (2). P. 118–124.</mixed-citation><mixed-citation xml:lang="en">Bremer M., Neuhofer C., Zimmermann F., Kneschaurek P., Reuschel W., Molls M. Palliative radiotherapy of malignant melanoma with reactor fission neutron therapy (RENT): a prospective study // Radiat. Oncol. Investig. 1999. Vol. 7 (2). P. 118–124.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Jungwirth M., Breitkreutz H., Wagner F.M., Bücherl T. Determination of the photon spectrum in an intense fission neutron beam // J. of Instrumentation. 2012. Vol. 7. C. 03022. (8 pages). doi:10.1088/1748-0221/7/03/C03022.</mixed-citation><mixed-citation xml:lang="en">Jungwirth M., Breitkreutz H., Wagner F M., Bücherl T. Determination of the photon spectrum in an intense fission neutron beam // J. of Instrumentation. 2012. Vol. 7. C. 03022. (8 pages). doi:10.1088/1748-0221/7/03/C03022.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kampfer S., Wagner F.M., Loeper B., Kneschaurek P. Erste dosimetrische Ergebnisse an der neuen Neutronentherapieanlage am FRM II // Medizinische Physik. 2006. Vol. 37. P. 318–319.</mixed-citation><mixed-citation xml:lang="en">Kampfer S., Wagner F. M., Loeper B., Kneschaurek P. Erste dosimetrische Ergebnisse an der neuen Neutronentherapieanlage am FRM II // Medizinische Physik. 2006. Vol. 37. P. 318–319.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Koester L. Applicability of Reactor Fission Neutrons for Radiation Therapy of Cancer // Nuclear Science Applications. 1984. Vol. 2. P. 79–96.</mixed-citation><mixed-citation xml:lang="en">Koester L. Applicability of Reactor Fission Neutrons for Radiation Therapy of Cancer // Nuclear Science Applications. 1984. Vol. 2. P. 79–96.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kummermehr J., Schraube H., Ries G., Koester L., Höver K.-H., Blattmann H., Stas P., Burger G. Biological effectiveness of neutrons and pi-mesons in gut, bone, and transplantable tumours // Strahlenther. Onkol. 1989. Vol. 165 (4). P. 276–282.</mixed-citation><mixed-citation xml:lang="en">Kummermehr J., Schraube H., Ries G., Koester L., Höver K.-H., Blattmann H., Stas P., Burger G. Biological effectiveness of neutrons and pi-mesons in gut, bone, and transplantable tumours // Strahlenther. Onkol. 1989. Vol. 165 (4). P. 276–282.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Magaddino V., Wagner F.M., Kummermehr J. Preclinical Screening of the Biological Effectiveness of a Therapeutic Neutron Beam at the FRM II // Exp. Strahlenther. Klin. Strahlenbiol. 2007. Vol. 16. P. 129–131.</mixed-citation><mixed-citation xml:lang="en">Magaddino V., Wagner F.M., Kummermehr J. Preclinical Screening of the Biological Effectiveness of a Therapeutic Neutron Beam at the FRM II // Exp. Strahlenther. Klin. Strahlenbiol. 2007. Vol. 16. P. 129–131.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ries G., Breit A., Kummermehr J., Breiter N., Trott K.-R. The RENT Project: Radiobiological Results and Planned Clinical Application // Strahlentherapie. 1985. Vol. 161 (12). P. 791–793.</mixed-citation><mixed-citation xml:lang="en">Ries G., Breit A., Kummermehr J., Breiter N., Trott K.-R. The RENT Project: Radiobiological Results and Planned Clinical Application // Strahlentherapie. 1985. Vol. 161 (12). P. 791–793.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Schmid E., Wagner F.M., Romm H., Walsh L., Roos H. Doseresponse relationship of dicentric chromosomes in human lymphocytes obtained for the fission neutron therapy facility MEDAPP at the research reactor FRM II // Radiat. Environ Biophys 2009. Vol. 48 (1). P. 67–75. doi: 10.1007/s00411-008-0202-z.</mixed-citation><mixed-citation xml:lang="en">Schmid E., Wagner F.M., Romm H., Walsh L., Roos H. Doseresponse relationship of dicentric chromosomes in human lymphocytes obtained for the fission neutron therapy facility MEDAPP at the research reactor FRM II // Radiat. Environ Biophys 2009. Vol. 48 (1). P. 67–75. doi: 10.1007/s00411-008-0202-z.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Wagner F.M., Bücherl Th., Kampfer S., Kastenmüller A., Waschkowski W. Thermal Neutron Converter for Irradiations with Fission Neutrons // Nuclear Physics and Atomic Energy. 2007. Nr. 3 (21). P. 30–36.</mixed-citation><mixed-citation xml:lang="en">Wagner F.M., Bücherl Th., Kampfer S., Kastenmüller A., Waschkowski W. Thermal Neutron Converter for Irradiations with Fission Neutrons // Nuclear Physics and Atomic Energy. 2007. Nr. 3 (21). P. 30–36.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Wagner F.M., Kneschaurek P., Kampfer S., Kastenmüller A., Loeper-Kabasakal B., Waschkowski W., Breitkreutz H., Molls M., Petry W. The Munich Fission Neutron Therapy Facility MEDAPP at the Research Reactor FRM II // Strahlenther. Onkol. 2008. Vol. 184 (12). P. 643–646. doi: 10.1007/s00066-008-1878-3.</mixed-citation><mixed-citation xml:lang="en">Wagner F.M., Kneschaurek P., Kampfer S., Kastenmüller A., Loeper-Kabasakal B., Waschkowski W., Breitkreutz H., Molls M., Petry W. The Munich Fission Neutron Therapy Facility MEDAPP at the Research Reactor FRM II // Strahlenther. Onkol. 2008. Vol. 184 (12). P. 643–646. doi: 10.1007/s00066-008-1878-3.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Wagner F.M., Loeper-Kabasakal B., Breitkreutz H. Neutron medical treatment of tumours – a survey of facilities // J. of Instrumentation. 2012. Vol. 7. C. 03041 (14 pages). doi:10.1088/1748-0221/7/03/C03041.</mixed-citation><mixed-citation xml:lang="en">Wagner F.M., Loeper-Kabasakal B., Breitkreutz H. Neutron medical treatment of tumours – a survey of facilities // J. of Instrumentation. 2012. Vol. 7. C. 03041 (14 pages). doi:10.1088/1748-0221/7/03/C03041</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
