oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciencesoncotomsk-200Research ArticleЛАБОРАТОРНЫЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯLABORATORY AND EXPERIMENTAL STUDIESКЛИНИКО-МОРФОЛОГИЧЕСКОЕ ИССЛЕДОВАНИЕ МИЕЛОФИБРОЗА ПРИ ХРОНИЧЕСКОМ МИЕЛОЛЕЙКОЗЕCLINICAL AND PATHOMORPHOLOGICAL EXAMINATION OF MYELOFIBROSIS IN CHRONIC MYELOID LEUKEMIAДолгихТ. Ю.DolgikhT. Yu.

Долгих Татьяна Юрьевна, кандидат медицинских наук, старший научный сотрудник лаборатории молекулярно-клеточных и иммуноморфологических основ онкогематологии.

E-mail: pathol@inbox.ru. SPIN-код: 5896-2991 

Dolgikh Tatiana Yurievna, MD, PhD, senior researcher, Laboratory of Molecular-Cellular and Immunomorphological Basis of Hematologic Oncology.

E-mail: pathol@inbox. ru. SPIN-code: 5896-2991. 

pathol@inbox.ruКачесовИ. В.KachesovI. V.

Качесов Игорь Викторович, научный сотрудник лаборатории общей патологической анатомии.

 

Kachesov Igor Viktorovich, researcher, Laboratory of General Pathology. 

pathol@inbox.ruМарченкоА. А.MarchenkoA. A.

Марченко Андрей Анатольевич, научный сотрудник лаборатории молекулярно-клеточных и иммуноморфологических основ онкогематологии.

 

Marchenko Andrey Anatolievich, researcher, Laboratory of Molecular-Cellular and Immunomorphological Basis of Hematologic Oncology.

pathol@inbox.ruДомниковаН. П.DomnikovaN. P.

Домникова Наталья Петровна, доктор медицинских наук, профессор, заведующая лабораторией молекулярно-клеточных и иммуноморфологических основ онкогематологии.

E-mail: pathol@inbox.ru. SPIN-код: 7107-6405

Domnikova Natalia Petrovna, Head of Laboratory of Molecular-Cellular and Immunomorphological Basis of Hematologic Oncology.

E-mail: pathol@inbox.ru. SPIN-code: 7107-6405.

pathol@inbox.ruИнститут молекулярной патологии и патоморфологии, НовосибирскРоссияInstitute of Molecular Pathology and Pathomorphology, NovosibirskRussian Federation201520022016063945Copyright © Долгих Т.Ю., Качесов И.В., Марченко А.А., Домникова Н.П., 20162016Долгих Т.Ю., Качесов И.В., Марченко А.А., Домникова Н.П.Dolgikh T.Y., Kachesov I.V., Marchenko A.A., Domnikova N.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/200

Pathomorphology study of marrow fibrosis in patients with chronic myeloid leukemia was carried out using morphometric image analysis software. It was revealed that every second patient had myelofibrosis. The initial and expressed myelofibrosis occur at approximately the same frequency, and their combination is observed more often. Myelofibrosis is more common in the accelerated-phase and blast crisis that in the chronicphase. It was found a direct correlation between the relative area of fibrous tissue in initial and expression myelofibrosis and the number of megakaryocytes, the number of dwarf megakaryocytes in the bone marrow trephine biopsy. The relative area of fibrous tissue in initial and expression myelofibrosis directly correlates with the percentage of blasts in myelogram, the percentage of blasts in the bone marrow trephine biopsy and the percentage of blasts in the peripheral blood in the accelerated phase and blast crisis. The prevalence of both initial and expressed myelofibrosis regardless of the phase of chronic myeloid leukemia directly correlated with the duration of the disease. Expressed myelofibrosis associates with the chemotherapy regardless of the phase of chronic myeloid leukemia. Initial myelofibrosis with the chemotherapy is not connected. Gender and age of the patients are not associated with marrow fibros

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The authors declare that there are no conflicts of interest present.