<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-205</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>ДИССЕМИНИРОВАННЫЙ РАК ЯИЧНИКОВ: СОВРЕМЕННЫЙ ПОДХОД К ЛЕКАРСТВЕННОЙ ТЕРАПИИ (ОБЗОР ЛИТЕРАТУРЫ)</article-title><trans-title-group xml:lang="en"><trans-title>DISSEMINATED OVARIAN CANCER: MODERN APPROACH TO DRUG THERAPY (REVIEW OF PUBLISHED LITERATURE)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Молчанов</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Molchanov</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Молчанов Сергей Валериевич, кандидат медицинских наук, научный сотрудник отделения гинекологии с группой профилактики.</p><p>E-mail: SergeyMolchanov1980@gmail.com. SPIN-код 2719-3289.</p></bio><bio xml:lang="en"><p>Molchanov Sergey Valerievich, MD, PhD, Researcher, Department of Gynecology with the Group of Cancer Prevention.</p><p>E-mail: SergeyMolchanov1980@gmail.com. SPIN-code: 2719-3289.</p></bio><email xlink:type="simple">ergeyMolchanov1980@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коломиец</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolomiets</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коломиец Лариса Александровна, доктор медицинских наук, профессор, заслуженный деятель науки РФ, заведующая отделением гинекологии с группой профилактики.</p><p>E-mail: kolomietsla@oncology.tomsk.ru. SPIN-код: 6316-1146.</p></bio><bio xml:lang="en"><p>Kolomiets Larisa Alexandrovna, MD, Professor, Honored Scientist ofRussian Federation, Head of Department of Gynecology with the Group of Cancer Prevention, Tomsk Cancer Research Institute.</p><p>E-mail: kolomietsla@oncology.tomsk.ru. SPIN-код: 6316-1146.</p><p> </p></bio><email xlink:type="simple">kolomietsla@oncology.tomsk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Томский НИИ онкологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tomsk Cancer Research Institute</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Томский НИИ онкологии; &#13;
Сибирский государственный медицинский университет, Томск</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tomsk Cancer Research Institute; &#13;
Siberian State Medical University, Tomsk</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>20</day><month>02</month><year>2016</year></pub-date><volume>0</volume><issue>6</issue><fpage>68</fpage><lpage>75</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Молчанов С.В., Коломиец Л.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Молчанов С.В., Коломиец Л.А.</copyright-holder><copyright-holder xml:lang="en">Molchanov S.V., Kolomiets L.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/205">https://www.siboncoj.ru/jour/article/view/205</self-uri><abstract><p>В обзоре представлены данные литературы по вопросам лекарственной терапии рака яичников, в том числе неоадъювантной, интраперитонеальной, гипертермической интраперитонеальной химиотерапии. Обсуждаются перспективы использования таргетной терапии при данной патологии.</p></abstract><trans-abstract xml:lang="en"><p>The review presents data on drug therapy for ovarian cancer including neoadjuvant and intraperitoneal chemotherapy. The prospects of using targeted therapy for ovarian cancer are discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак яичников</kwd><kwd>неоадъювантная химиотерапия</kwd><kwd>интраперитонеальная химиотерапия</kwd><kwd>гипертермическая интраперитонеальная химиотерапия</kwd><kwd>таргетная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ovarian cancer</kwd><kwd>neoadjuvant chemotherapy</kwd><kwd>intraperitoneal chemotherapy</kwd><kwd>hyperthermic intraperitoneal chemotherapy</kwd><kwd>targeted therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гервас П.А., Литвяков Н.В., Попова Н.О., Добродеев А.Ю., Тарасова А.С., Юмов Е.Л., Иванова Ф.Г., Черемисина О.В., Афанасьев С.Г., Гольдберг В.Е., Чердынцева Н.В. Проблемы и перспективы совершенствования молекулярно-генетической диагностики для назначения таргетных препаратов в онкологии // Сибирский онкологический журнал. 2014. № 2. С. 46–55.</mixed-citation><mixed-citation xml:lang="en">Gervas P.A., Litviakov N.V., Popova N.O., Dobrodeev A.Yu., Tarasova A.S., Yumov E.L., Ivanova F.G., Cheremisina O.V., Afanasyev S.G., Goldberg V.E., Cherdyntseva N.V. Problem and perspective to improve molecular testing to choose appropriate target therapy // Sibirskij onkologicheskij zhurnal. 2014. № 2. P. 46–55. [in Russian]</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Злокачественные новообразования в России в 2009 году (заболеваемость и смертность) / Под ред. В.И. Чиссова, В.В. Старинского, Г.В. Петровой. М., 2011. 260 с.</mixed-citation><mixed-citation xml:lang="en">Malignant neoplasms in Russia in 2009 (morbidity and mortality) / Eds. V.I. Chissov, V.V. Starinskij, G.V. Petrova. M., 2011. 260 p. [in Russian]</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Молчанов С.В., Коломиец Л.А. Диссеминированный рак яичников: возможности хирургического лечения (обзор литературы) // Сибирский онкологический журнал. 2014. № 5. С. 54–59.</mixed-citation><mixed-citation xml:lang="en">Molchanov S.V., Kolomiets L.A. Disseminated ovarian cancer: surgical treatment (Literature review) // Sibirskij onkologicheskij zhurnal. 2014. № 5. P. 54–59. [in Russian]</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Молчанов С.В., Коломиец Л.А., Фролова И.Г., Вяткина Н.В., Бакланова Н.С. Перитонеальный канцероматоз при раке яичников: эхосемиотика, классификация // Вестник РОНЦ им. Н.Н. Блохина РАМН. 2014. Т. 25, № 1–2. С. 14–20.</mixed-citation><mixed-citation xml:lang="en">Molchanov S.V., Kolomiyets L.A., Frolova I.G., Vyatkina N.V.1, Baklanova N.S. Peritoneal carcinomatosis in patients with ovarian cancer: echosemiotics and classification // Vestnik RONC im. N. N. Blohina RAMN. 2014. Vol. 25 (1–2). P. 14–20. [in Russian]</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Тюляндин С.А., Покатаев И.А., Тюляндина А.С., Кузнецов В.В., Жорданиа К.И., Стенина М.Б. Лечение распространенного рака яичников: Итоги работы отделения клинической фармакологии и химиотерапии РОНЦ им. Н.Н. Блохина РАМН за 1999–2010 гг. // Вестник Российской академии медицинских наук. 2011. № 12. С. 4–9.</mixed-citation><mixed-citation xml:lang="en">Tjulandin S.A., Pokataev I.A., Tjulandina A.S., Kuznetsov V.V., Zhordania K.I., Stenina M.B. Treatment of advanced ovarian cancer: results of the department of clinical pharmacology and chemotherapy, N.N. Blokhin PORC in 1999– 2010 // Vestnik Rossijskoj akademii medicinskih nauk. 2011. № 12. P. 4–9. [in Russian]</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Armstrong D.K., Bundy B., Wenzel L., Huang H.Q., Baergen R., Lele S., Copeland L.J., Walker J.L., Burger R.A. Intraperitoneal cisplatin and paclitaxel in ovarian cancer // N. Engl. J. Med. 2006. Vol. 354 (1). P. 34–43.</mixed-citation><mixed-citation xml:lang="en">Armstrong D.K., Bundy B., Wenzel L., Huang H.Q., Baergen R., Lele S., Copeland L.J., Walker J.L., Burger R.A. Intraperitoneal cisplatin and paclitaxel in ovarian cancer // N. Engl. J. Med. 2006. Vol. 354 (1). P. 34–43.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bristow R.E., Chi D.S. Platinum-based neoadjuvant chemotherapy and interval surgical cytoreduction for advanced ovarian cancer: a metaanalysis // Gynecol. Oncol. 2006. Vol. 103 (3). P. 1070–1076.</mixed-citation><mixed-citation xml:lang="en">Bristow R.E., Chi D.S. Platinum-based neoadjuvant chemotherapy and interval surgical cytoreduction for advanced ovarian cancer: a metaanalysis // Gynecol. Oncol. 2006. Vol. 103 (3). P. 1070–1076.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Burger R.A., Brady M.F., Rhee J., Sovak M.A., Kong G., Nguyen H.P., Bookman M.A. Independent radiologic review of the Gynecologic Oncology Group Study 0218, a phase III trial of bevacizumab in the primary treatment of advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer // Gynecol. Oncol. 2013. Vol. 131 (1). P. 21–26. doi: 10.1016/j. ygyno.2013.07.100.</mixed-citation><mixed-citation xml:lang="en">Burger R.A., Brady M.F., Rhee J., Sovak M.A., Kong G., Nguyen H.P., Bookman M.A. Independent radiologic review of the Gynecologic Oncology Group Study 0218, a phase III trial of bevacizumab in the primary treatment of advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer // Gynecol. Oncol. 2013. Vol. 131 (1). P. 21–26. doi: 10.1016/j.ygyno.2013.07.100.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Burger R.A., Sill M.W., Monk B.J., Greer B.E., Sorosky J.I. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study // J. Clin. Oncol. 2007. Vol. 25 (33). P. 5165–5171.</mixed-citation><mixed-citation xml:lang="en">Burger R.A., Sill M.W., Monk B.J., Greer B.E., Sorosky J.I. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study // J. Clin. Oncol. 2007. Vol. 25 (33). P. 5165–5171.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Byrne A.T., Ross L., Holash J., Nakanishi M., Hu L., Hofmann J.I., Yancopoulos G.D., Jaffe R.B. Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model // Clin. Cancer Res. 2003. Vol. 9 (15). P. 5721–5728.</mixed-citation><mixed-citation xml:lang="en">Byrne A.T., Ross L., Holash J., Nakanishi M., Hu L., Hofmann J.I., Yancopoulos G.D., Jaffe R.B. Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model // Clin. Cancer Res. 2003. Vol. 9 (15). P. 5721–5728.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Cannistra S.A., Matulonis U.A., Penson R.T., Hambleton J., Dupont J., Mackey H., Douglas J., Burger R.A., Armstrong D., Wenham R., McGuire W. Phase II study of bevacizumab in patients with platinumresistant ovarian cancer or peritoneal serous cancer // J. Clin. Oncol. 2007. Vol. 25 (33). P. 5180–5186.</mixed-citation><mixed-citation xml:lang="en">Cannistra S.A., Matulonis U.A., Penson R.T., Hambleton J., Dupont J., Mackey H., Douglas J., Burger R.A., Armstrong D., Wenham R., McGuire W. Phase II study of bevacizumab in patients with platinumresistant ovarian cancer or peritoneal serous cancer // J. Clin. Oncol. 2007. Vol. 25 (33). P. 5180–5186.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">de Bree E., Tsiftsis D.D. Experimental and pharmacokinetic studies in intraperitoneal chemotherapy: From laboratory bench to bedside // Recent Results Cancer Res. 2007. Vol. 169. P. 53–73.</mixed-citation><mixed-citation xml:lang="en">de Bree E., Tsiftsis D.D. Experimental and pharmacokinetic studies in intraperitoneal chemotherapy: From laboratory bench to bedside // Recent Results Cancer Res. 2007. Vol. 169. P. 53–73.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Diaz-Montes T.P., Bristow R.E. Secondary cytoreduction for patients with recurrent ovarian cancer // Curr. Oncol. Rep. 2005. Vol. 7 (6). P. 451–458.</mixed-citation><mixed-citation xml:lang="en">Diaz-Montes T.P., Bristow R.E. Secondary cytoreduction for patients with recurrent ovarian cancer // Curr. Oncol. Rep. 2005. Vol. 7 (6). P. 451–458.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Friedlander M., Hancock K.C., Rischin D., Messing M.J., Stringer C.A., Matthys G.M., Ma B., Hodge J.P., Lager J.J. A phase II open-label study evaluating pazopanib in patients with recurrent ovarian cancer // Gynecol. Oncol. 2010. Vol. 119 (1). P. 32–37. doi: 10.1016/j.ygyno.2010.05.033.</mixed-citation><mixed-citation xml:lang="en">Friedlander M., Hancock K.C., Rischin D., Messing M.J., Stringer C.A., Matthys G.M., Ma B., Hodge J.P., Lager J.J. A phase II open-label study evaluating pazopanib in patients with recurrent ovarian cancer // Gynecol. Oncol. 2010. Vol. 119 (1). P. 32–37. doi: 10.1016/j.ygyno.2010.05.033.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Fujiwara K., Armstrong D., Morgan M., Markman M. Principles and practice of intraperitoneal chemotherapy for ovarian cancer // Int. J. Gynecol. Cancer. 2007. Vol. 17 (1). P. 1–20.</mixed-citation><mixed-citation xml:lang="en">Fujiwara K., Armstrong D., Morgan M., Markman M. Principles and practice of intraperitoneal chemotherapy for ovarian cancer // Int. J. Gynecol. Cancer. 2007. Vol. 17 (1). P. 1–20.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gelmon K.A., Tischkowitz M., Mackay H., Swenerton K., Robidoux A., Tonkin K., Hirte H., Huntsman D., Clemons M., Gilks B., Yerushalmi R., Macpherson E., Carmichael J., Oza A. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triplenegative breast cancer: a phase 2, multicentre, open-label, non-randomised study // Lancet Oncology. 2011. Vol. 12 (9). P. 852–861. doi: 10.1016/ S1470-2045(11)70214-5.</mixed-citation><mixed-citation xml:lang="en">Gelmon K.A., Tischkowitz M., Mackay H., Swenerton K., Robidoux A., Tonkin K., Hirte H., Huntsman D., Clemons M., Gilks B., Yerushalmi R., Macpherson E., Carmichael J., Oza A. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triplenegative breast cancer: a phase 2, multicentre, open-label, non-randomised study // Lancet Oncology. 2011. Vol. 12 (9). P. 852–861. doi: 10.1016/S1470-2045(11)70214-5.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Giannopoulos T., Butler-Manuel S., Taylor A., Ngeh N., Thomas H. Clinical outcomes of neoadjuvant chemotherapy and primary debulking surgery in advanced ovarian carcinoma // Eur. J. Gynecol. Oncol. 2006. Vol. 27 (1). P. 25–28.</mixed-citation><mixed-citation xml:lang="en">Giannopoulos T., Butler-Manuel S., Taylor A., Ngeh N., Thomas H. Clinical outcomes of neoadjuvant chemotherapy and primary debulking surgery in advanced ovarian carcinoma // Eur. J. Gynecol. Oncol. 2006. Vol. 27 (1). P. 25–28.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Gori J., Castano R., Toziano M., Häbich D., Staringer J., De Quirós D.G., Felci N. Intraperitoneal hyperthermic chemotherapy in ovarian cancer // Int. J. Gynecol. Cancer. 2005. Vol. 15 (2). P. 233–239.</mixed-citation><mixed-citation xml:lang="en">Gori J., Castano R., Toziano M., Häbich D., Staringer J., De Quirós D.G., Felci N. Intraperitoneal hyperthermic chemotherapy in ovarian cancer // Int. J. Gynecol. Cancer. 2005. Vol. 15 (2). P. 233–239.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Hainsworth J.D., Numnum T.M., Rao G.G. A randomized phase II study of paclitaxel/carboplatin with or without sorafenib in the first-line treatment of patients with stage III/IV epithelial ovarian cancer // J. Clin. Oncol. 2010. Vol. 28. Suppl. 15s. Abs. TPS257.</mixed-citation><mixed-citation xml:lang="en">Hainsworth J.D., Numnum T.M., Rao G.G. A randomized phase II study of paclitaxel/carboplatin with or without sorafenib in the first-line treatment of patients with stage III/IV epithelial ovarian cancer // J. Clin. Oncol. 2010. Vol. 28. Suppl. 15s. Abs. TPS257.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Helleday T. The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings // Mol. Oncol. 2011. Vol. 5 (4). P. 387–393. Doi: 10.1016/j.molonc.2011.07.001.</mixed-citation><mixed-citation xml:lang="en">Helleday T. The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings // Mol. Oncol. 2011. Vol. 5 (4). P. 387–393. Doi: 10.1016/j.molonc.2011.07.001.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Helm C.W., Richard S.D., Pan J., Bartlett D., Goodman M.D., Hoefer R., Lentz S.S., Levine E.A., Loggie B.W., Metzinger D.S., Miller B., Parker L., Spellman J.E., Sugarbaker P.H., Edwards R.P., Rai S.N. Hyperthermic intraperitoneal chemotherapy in ovarian cancer: first report of the HYPER-O registry // Int. J. Gynecol. Cancer. 2010. Vol. 20 (1). P. 61–69. doi: 10.1111/IGC.0b013e3181c50cde.</mixed-citation><mixed-citation xml:lang="en">Helm C.W., Richard S.D., Pan J., Bartlett D., Goodman M.D., Hoefer R., Lentz S.S., Levine E.A., Loggie B.W., Metzinger D.S., Miller B., Parker L., Spellman J.E., Sugarbaker P.H., Edwards R.P., Rai S.N. Hyperthermic intraperitoneal chemotherapy in ovarian cancer: first report of the HYPER-O registry // Int. J. Gynecol. Cancer. 2010. Vol. 20 (1). P. 61–69. doi: 10.1111/IGC.0b013e3181c50cde.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Hou J.Y., Kelly M.G., Yu H., McAlpine J.N., Azodi M., Rutherford T.J., Schwartz P.E. Neoadjuvant chemotherapy lessens surgical morbidity in advanced ovarian cancer and leads to improved survival in stage IV disease // Gynecol. Oncol. 2007. Vol. 105 (1). P. 211–217.</mixed-citation><mixed-citation xml:lang="en">Hou J.Y., Kelly M.G., Yu H., McAlpine J.N., Azodi M., Rutherford T.J., Schwartz P.E. Neoadjuvant chemotherapy lessens surgical morbidity in advanced ovarian cancer and leads to improved survival in stage IV disease // Gynecol. Oncol. 2007. Vol. 105 (1). P. 211–217.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kang S., Nam B.H. Does neoadjuvant chemotherapy increase optimal cytoreduction rate in advanced ovarian cancer? Meta-analysis of 21 studies // Ann. Surg. Oncol. 2009. Vol. 16 (8). P. 2315–2320. doi: 10.1245/s10434-009-0558-6.</mixed-citation><mixed-citation xml:lang="en">Kang S., Nam B.H. Does neoadjuvant chemotherapy increase optimal cytoreduction rate in advanced ovarian cancer? Meta-analysis of 21 studies // Ann. Surg. Oncol. 2009. Vol. 16 (8). P. 2315–2320. doi: 10.1245/s10434-009-0558-6.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar L., Hariprasad R., Kumar S. et al. Neoadjuvant chemotherapy in advanced epithelial ovarian oancer (EOC): a Phase III randomized study // J. Clin. Oncol. (Meeting Abstracts). 2006. Vol. 24. Suppl. 18. Abs. 15000.</mixed-citation><mixed-citation xml:lang="en">Kumar L., Hariprasad R., Kumar S. et al. Neoadjuvant chemotherapy in advanced epithelial ovarian oancer (EOC): a Phase III randomized study // J. Clin. Oncol. (Meeting Abstracts). 2006. Vol. 24. Suppl. 18. Abs. 15000.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Ledermann J.A., Harter P., Gourley C., Friedlander M., Vergote I., Rustin G., Scott C., Meier W., Shapira-Frommer R., Safra T., Matei D., Macpherson E., Watkins C., Carmichael J., Matulonis U. Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer // N. Engl. J. Med. 2012. Vol. 366 (15). P. 1382–1392. doi: 10.1056/NEJMoa1105535.</mixed-citation><mixed-citation xml:lang="en">Ledermann J.A., Harter P., Gourley C., Friedlander M., Vergote I., Rustin G., Scott C., Meier W., Shapira-Frommer R., Safra T., Matei D., Macpherson E., Watkins C., Carmichael J., Matulonis U. Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer // N. Engl. J. Med. 2012. Vol. 366 (15). P. 1382–1392. doi: 10.1056/NEJMoa1105535.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ledermann J.A., Rustin G.J., Hackshaw A. et al. A randomized phase II placebo controlled trial using maintenance therapy to evaluate the vascular targeting agent BIBF 1120 following treatment of relapsed ovarian cancer // J. Clin. Oncol. 2009. Vol. 27. Suppl. 15s. Abs. 5501.</mixed-citation><mixed-citation xml:lang="en">Ledermann J.A., Rustin G.J., Hackshaw A. et al. A randomized phase II placebo controlled trial using maintenance therapy to evaluate the vascular targeting agent BIBF 1120 following treatment of relapsed ovarian cancer // J. Clin. Oncol. 2009. Vol. 27. Suppl. 15s. Abs. 5501.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Matulonis U.A., Berlin S., Ivy P., Tyburski K., Krasner C., Zarwan C., Berkenblit A., Campos S., Horowitz N., Cannistra S.A., Lee H., Lee J., Roche M., Hill M., Whalen C., Sullivan L., Tran C., Humphreys B.D., Penson R.T. Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer // J. Clin. Oncol. 2009. Vol. 27 (33). P. 5601–5606. doi: 10.1200/JCO.2009.23.2777.</mixed-citation><mixed-citation xml:lang="en">Matulonis U.A., Berlin S., Ivy P., Tyburski K., Krasner C., Zarwan C., Berkenblit A., Campos S., Horowitz N., Cannistra S.A., Lee H., Lee J., Roche M., Hill M., Whalen C., Sullivan L., Tran C., Humphreys B.D., Penson R.T. Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer // J. Clin. Oncol. 2009. Vol. 27 (33). P. 5601–5606. doi: 10.1200/JCO.2009.23.2777.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Menczer J., Usviatzov I., Ben-Shem E., Golan A., Levy T. Neoadjuvant chemotherapy in ovarian, primary peritoneal and tubal carcinoma: can imaging results prior to interval debulking predict survival? // J. Gynecol. Oncol. 2011. Vol. 22 (3). P. 183–187. doi: 10.3802/jgo.2011.22.3.183.</mixed-citation><mixed-citation xml:lang="en">Menczer J., Usviatzov I., Ben-Shem E., Golan A., Levy T. Neoadjuvant chemotherapy in ovarian, primary peritoneal and tubal carcinoma: can imaging results prior to interval debulking predict survival? // J. Gynecol. Oncol. 2011. Vol. 22 (3). P. 183–187. doi: 10.3802/jgo.2011.22.3.183.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Micha J.P., Goldstein B.H., Rettenmaier M.A., Genesen M., Graham C., Bader K., Lopez K.L., Nickle M., Brown J.V. 3rd. A phase II study of outpatient fi rst-line paclitaxel, carboplatin, and bevacizumab for advancedstage epithelial ovarian, peritoneal, and fallopian tube cancer // Int. J. Gynecol. Cancer. 2007. Vol. 17 (4). P. 771–776.</mixed-citation><mixed-citation xml:lang="en">Micha J.P., Goldstein B.H., Rettenmaier M.A., Genesen M., Graham C., Bader K., Lopez K.L., Nickle M., Brown J.V. 3rd. A phase II study of outpatient fi rst-line paclitaxel, carboplatin, and bevacizumab for advancedstage epithelial ovarian, peritoneal, and fallopian tube cancer // Int. J. Gynecol. Cancer. 2007. Vol. 17 (4). P. 771–776.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Miyagi Y., Fujiwara K., Kigawa J., Itamochi H., Nagao S., Aotani E., Terakawa N., Kohno I. Intraperitoneal carboplatin infusion may be a pharmacologically more reasonable route than intravenous administration as a systemic chemotherapy: a comparative pharmacokinetic analysis of platinum using a new mathematical model after intraperitoneal vs intravenous infusion of carboplatin – a Sankai Gynecology Study Group (SGSG) study // Gynecol. Oncol. 2005. Vol. 99 (3). P. 591–596.</mixed-citation><mixed-citation xml:lang="en">Miyagi Y., Fujiwara K., Kigawa J., Itamochi H., Nagao S., Aotani E., Terakawa N., Kohno I. Intraperitoneal carboplatin infusion may be a pharmacologically more reasonable route than intravenous administration as a systemic chemotherapy: a comparative pharmacokinetic analysis of platinum using a new mathematical model after intraperitoneal vs intravenous infusion of carboplatin – a Sankai Gynecology Study Group (SGSG) study // Gynecol. Oncol. 2005. Vol. 99 (3). P. 591–596.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Onda T., Yoshikawa H. Neoadjuvant chemotherapy for advanced ovarian cancer: overview of outcomes and unanswered questions // Exp. Rev. Anticancer Ther. 2011. Vol. 11 (7). P. 1053–1067. doi: 10.1586/era.11.24.</mixed-citation><mixed-citation xml:lang="en">Onda T., Yoshikawa H. Neoadjuvant chemotherapy for advanced ovarian cancer: overview of outcomes and unanswered questions // Exp. Rev. Anticancer Ther. 2011. Vol. 11 (7). P. 1053–1067. doi: 10.1586/era.11.24.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Parson E.N., Lentz S., Russell G., Shen P., Levine E.A., Stewart J.H. 4th. Outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface dissemination from ovarian neoplasms // Am. J. Surg. 2011. Vol. 202 (4). P. 481–486. doi: 10.1016/j.amjsurg.2011.02.004.</mixed-citation><mixed-citation xml:lang="en">Parson E.N., Lentz S., Russell G., Shen P., Levine E.A., Stewart J.H. 4th. Outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface dissemination from ovarian neoplasms // Am. J. Surg. 2011. Vol. 202 (4). P. 481–486. doi: 10.1016/j.amjsurg.2011.02.004.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Perren T., Swart A.M., Pfisterer J. et al. ICON7: A phase III randomized gynecologic cancer intergroup trial of concurrent bevacizumab and chemotherapy followed by maintenance bevecizumab versus chemotherapy alone in women with new diagnosed epithelial ovarian, primary peritoneal or fallopian tube cancer // Ann. Oncol. 2010. Vol. 21. Suppl. 8. P. LBA4.</mixed-citation><mixed-citation xml:lang="en">Perren T., Swart A.M., Pfisterer J. et al. ICON7: A phase III randomized gynecologic cancer intergroup trial of concurrent bevacizumab and chemotherapy followed by maintenance bevecizumab versus chemotherapy alone in women with new diagnosed epithelial ovarian, primary peritoneal or fallopian tube cancer // Ann. Oncol. 2010. Vol. 21. Suppl. 8. P. LBA4.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Rose P.G., Drake R., Braly P.S. et al. Preliminary results of a phase II study of oxaliplatin, docetaxel, and bevacizumab as first-line therapy of advanced cancer of the ovary, peritoneum, and fallopian tube // J. Clin. Oncol. ASCO Annual Meeting. 2009. Vol. 27. Abs. 5546.</mixed-citation><mixed-citation xml:lang="en">Rose P.G., Drake R., Braly P.S. et al. Preliminary results of a phase II study of oxaliplatin, docetaxel, and bevacizumab as first-line therapy of advanced cancer of the ovary, peritoneum, and fallopian tube // J. Clin. Oncol. ASCO Annual Meeting. 2009. Vol. 27. Abs. 5546.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Roviello F., Pinto E., Corso G., Pedrazzani C., Caruso S., Filippeschi M., Petrioli R., Marsili S., Mazzei M.A., Marrelli D. Safety and potential benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in peritoneal carcinomatosis from primary or recurrent ovarian cancer // J. Surg. Oncol. 2010. Vol. 102 (6). P. 663–670. doi: 10.1002/jso.21682.</mixed-citation><mixed-citation xml:lang="en">Roviello F., Pinto E., Corso G., Pedrazzani C., Caruso S., Filippeschi M., Petrioli R., Marsili S., Mazzei M.A., Marrelli D. Safety and potential benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in peritoneal carcinomatosis from primary or recurrent ovarian cancer // J. Surg. Oncol. 2010. Vol. 102 (6). P. 663–670. doi: 10.1002/jso.21682.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Rufián S., Muñoz-Casares F.C., Briceño J., Díaz C.J., Rubio M.J., Ortega R., Ciria R., Morillo M., Aranda E., Muntané J., Pera C. Radical surgery-peritonectomy and intraoperative intraperitoneal chemotherapy for the treatment of peritoneal carcinomatosis in recurrent or primary ovarian cancer // J. Surg. Oncol. 2006. Vol. 94 (4). P. 316–324.</mixed-citation><mixed-citation xml:lang="en">Rufián S., Muñoz-Casares F.C., Briceño J., Díaz C.J., Rubio M.J., Ortega R., Ciria R., Morillo M., Aranda E., Muntané J., Pera C. Radical surgery-peritonectomy and intraoperative intraperitoneal chemotherapy for the treatment of peritoneal carcinomatosis in recurrent or primary ovarian cancer // J. Surg. Oncol. 2006. Vol. 94 (4). P. 316–324.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Ryu K.S., Kim J.H., Ko H.S., Kim J.W., Ahn W.S., Park Y.G., Kim S.J., Lee J.M. Effects of intraperitoneal hyperthermic chemotherapy in ovarian cancer // Gynecol. Oncol. 2004. Vol. 94 (2). P. 325–332.</mixed-citation><mixed-citation xml:lang="en">Ryu K.S., Kim J.H., Ko H.S., Kim J.W., Ahn W.S., Park Y.G., Kim S.J., Lee J.M. Effects of intraperitoneal hyperthermic chemotherapy in ovarian cancer // Gynecol. Oncol. 2004. Vol. 94 (2). P. 325–332.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Santillan A., Karam A. K., Li A.J., Giuntoli R. 2nd, Gardner G.J., Cass I. Karlan B.Y., Bristow R.E. Secondary cytoreductive surgery for isolated nodal recurrence in patients with epithelial ovarian cancer // Gynecol. Oncol. 2007. Vol. 104 (3). P. 686–690.</mixed-citation><mixed-citation xml:lang="en">Santillan A., Karam A. K., Li A.J., Giuntoli R. 2nd, Gardner G.J., Cass I. Karlan B.Y., Bristow R.E. Secondary cytoreductive surgery for isolated nodal recurrence in patients with epithelial ovarian cancer // Gynecol. Oncol. 2007. Vol. 104 (3). P. 686–690.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Shen G.H., Ghazizadeh M., Kawanami O., Shimizu H., Jin E., Araki T., Sugisaki Y. Prognostic significance of vascular endothelial growth factor expression in human ovarian carcinoma // Br. J. Cancer. 2000. Vol. 83 (2). P. 196–203.</mixed-citation><mixed-citation xml:lang="en">Shen G.H., Ghazizadeh M., Kawanami O., Shimizu H., Jin E., Araki T., Sugisaki Y. Prognostic significance of vascular endothelial growth factor expression in human ovarian carcinoma // Br. J. Cancer. 2000. Vol. 83 (2). P. 196–203.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Steed H., Oza A.M., Murphy J., Laframboise S., Lockwood G., Petrillo D.E., Sturgeon J., Rosen B. A retrospective analysis of neoadjuvant platinum-based chemotherapy versus up-front surgery in advanced ovarian cancer // Int. J. Gynecol. Cancer. 2006. Vol. 16. Suppl. 1. P. 47–53.</mixed-citation><mixed-citation xml:lang="en">Steed H., Oza A.M., Murphy J., Laframboise S., Lockwood G., Petrillo D.E., Sturgeon J., Rosen B. A retrospective analysis of neoadjuvant platinum-based chemotherapy versus up-front surgery in advanced ovarian cancer // Int. J. Gynecol. Cancer. 2006. Vol. 16. Suppl. 1. P. 47–53.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Sticca R.P., Dach B.W. Rationale for hyperthermia with intraoperative intraperitoneal chemotherapy agents // Surg. Oncol. Clin. N. Am. 2003. Vol. 12 (3). P. 689–701.</mixed-citation><mixed-citation xml:lang="en">Sticca R.P., Dach B.W. Rationale for hyperthermia with intraoperative intraperitoneal chemotherapy agents // Surg. Oncol. Clin. N. Am. 2003. Vol. 12 (3). P. 689–701.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Takemoto M., Kuroda M., Urano M., Nishimura Y., Kawasaki S., Kato H., Okumura Y., Akaki S., Kanazawa S., Asaumi J., Joja I., Hiraki Y. The effect of various chemotherapeutic agents given at mild hyperthermia on different types of tumors // Int. J. Hyperthermia. 2003. Vol. 19 (2). P. 193–203.</mixed-citation><mixed-citation xml:lang="en">Takemoto M., Kuroda M., Urano M., Nishimura Y., Kawasaki S., Kato H., Okumura Y., Akaki S., Kanazawa S., Asaumi J., Joja I., Hiraki Y. The effect of various chemotherapeutic agents given at mild hyperthermia on different types of tumors // Int. J. Hyperthermia. 2003. Vol. 19 (2). P. 193–203.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Trimble E.L., Christian M.C. National Cancer Institute – United States strategy regarding intraperitoneal chemotherapy for ovarian cancer // Int. J. Gynecol. Cancer. 2008. Vol. 18. Suppl. 1. P. 26–28. doi: 10.1111/j.1525-1438.2007.01100.x.</mixed-citation><mixed-citation xml:lang="en">Trimble E.L., Christian M.C. National Cancer Institute – United States strategy regarding intraperitoneal chemotherapy for ovarian cancer // Int. J. Gynecol. Cancer. 2008. Vol. 18. Suppl. 1. P. 26–28. doi: 10.1111/j.1525-1438.2007.01100.x.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Vasey P.A., Jayson G.C., Gordon A., Gabra H., Coleman R., Atkinson R., Parkin D., Paul J., Hay A., Kaye S.B. Phase III randomized trial of docetaxel-carboplatin versus paclitaxel-carboplatin as first-line chemotherapy for ovarian carcinoma // J. Natl. Cancer Inst. 2004. Vol. 96 (22). P. 1682–1691.</mixed-citation><mixed-citation xml:lang="en">Vasey P.A., Jayson G.C., Gordon A., Gabra H., Coleman R., Atkinson R., Parkin D., Paul J., Hay A., Kaye S.B. Phase III randomized trial of docetaxel-carboplatin versus paclitaxel-carboplatin as first-line chemotherapy for ovarian carcinoma // J. Natl. Cancer Inst. 2004. Vol. 96 (22). P. 1682–1691.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Vergote I., Tropé C.G., Amant F., Kristensen G.B., Ehlen T., Johnson N., Verheijen R.H., van der Burg M.E., Lacave A.J., Panici P.B., Kenter G.G., Casado A., Mendiola C., Coens C., Verleye L., Stuart G.C., Pecorelli S., Reed N.S. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Group; NCIC Clinical Trials Group. Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer // N. Engl. J. Med. 2010. Vol. 363 (10). P. 943–953. doi: 10.1056/NEJMoa0908806.</mixed-citation><mixed-citation xml:lang="en">Vergote I., Tropé C.G., Amant F., Kristensen G.B., Ehlen T., Johnson N., Verheijen R.H., van der Burg M.E., Lacave A.J., Panici P.B., Kenter G.G., Casado A., Mendiola C., Coens C., Verleye L., Stuart G.C., Pecorelli S., Reed N.S. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Group; NCIC Clinical Trials Group. Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer // N. Engl. J. Med. 2010. Vol. 363 (10). P. 943–953. doi: 10.1056/NEJMoa0908806.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Walker J.L., Armstrong D.K., Huang H.Q., Fowler J., Webster K., Burger R.A., Clarke-Pearson D. Intraperitoneal catheter outcomes in a phase III trial of intravenous versus intraperitoneal chemotherapy in optimal stage III ovarian and primary peritoneal cancer: a Gynecologic Oncology Group Study // Gynecol. Oncol. 2006. Vol. 100 (1). P. 27–32.</mixed-citation><mixed-citation xml:lang="en">Walker J.L., Armstrong D.K., Huang H.Q., Fowler J., Webster K., Burger R.A., Clarke-Pearson D. Intraperitoneal catheter outcomes in a phase III trial of intravenous versus intraperitoneal chemotherapy in optimal stage III ovarian and primary peritoneal cancer: a Gynecologic Oncology Group Study // Gynecol. Oncol. 2006. Vol. 100 (1). P. 27–32.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Weinberg L.E., Rodriguez G., Hurteau J.A. The role of neoadjuvant chemotherapy in treating advanced epithelial ovarian cancer // J. Surg. Oncol. 2010. Vol. 101 (4). P. 334–343. doi: 10.1002/jso.21482.</mixed-citation><mixed-citation xml:lang="en">Weinberg L.E., Rodriguez G., Hurteau J.A. The role of neoadjuvant chemotherapy in treating advanced epithelial ovarian cancer // J. Surg. Oncol. 2010. Vol. 101 (4). P. 334–343. doi: 10.1002/jso.21482.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
