oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2022-21-2-96-108oncotomsk-2095Research ArticleОБЗОРЫREVIEWSВопросы диагностики и лечения метастазов в позвоночник и длинные костиIssues of diagnosis and treatment of metastases in the spine and long boneshttps://orcid.org/0000-0002-2976-8895БухаровА. В.BukharovA. V.

 кандидат медицинских наук, заведующий, группа по лечению опухолей мягких тканей и костей

SPIN-код: 8349-0930

 Россия, 125284, г. Москва, 2-й Боткинский проезд, 3 

 MD, PhD, Head of the Department of Soft Tissue and Bone Tumors

31, 2-Nd Botkhinskii Proezd, 125284, Moscow, Russia

 

https://orcid.org/0000-0002-3501-036XЕринД. А.ErinD. A.

 врач-онколог, группа по лечению опухолей мягких тканей и костей

SPIN-код: 1769-2667

 Россия, 125284, г. Москва, 2-й Боткинский проезд, 3 

 MD, Oncologist, Department of Soft Tissue and Bone Tumors 

31, 2-Nd Botkhinskii Proezd, 125284, Moscow, Russia

erindmal@yandex.ruhttps://orcid.org/0000-0002-4385-9048ДержавинВ. А.DerzhavinV. A.

 кандидат медицинских наук, старший научный сотрудник, группа по лечению опухолей мягких тканей и костей

SPIN-код: 1811-2737

 Россия, 125284, г. Москва, 2-й Боткинский проезд, 3 

 MD, PhD, Senior Researcher, Department of Soft Tissue and Bone Tumors 

31, 2-Nd Botkhinskii Proezd, 125284, Moscow, Russia

https://orcid.org/0000-0002-7944-3108ЯдринаА. В.YadrinaA. V.

 кандидат медицинских наук, врач-онколог, группа по лечению опухолей мягких тканей и костей

SPIN-код: 9058-3922

 Россия, 125284, г. Москва, 2-й Боткинский проезд, 3 

 MD, PhD, Oncologist, Department of Soft Tissue and Bone Tumors 

31, 2-Nd Botkhinskii Proezd, 125284, Moscow, Russia

Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииРоссияP. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of Russia  Russian Federation20220605202221296108Copyright © Бухаров А.В., Ерин Д.А., Державин В.А., Ядрина А.В., 20222022Бухаров А.В., Ерин Д.А., Державин В.А., Ядрина А.В.Bukharov A.V., Erin D.A., Derzhavin V.A., Yadrina A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/2095

Цель исследования – провести систематический анализ данных, имеющихся в современной литературе, современных диагностических алгоритмов, прогностических факторов, выживаемости и вариантов хирургического лечения метастазов в позвоночник и длинные кости конечностей.

Материал и методы

Материал и методы. В обзор включены данные рандомизированных клинических исследований, оценивающих различные диагностические алгоритмы выявления метастатического поражения костей, частоту метастазов в позвоночный столб и длинные кости в зависимости от гистологической структуры первичной опухоли, их количество, в соответствии с этим и варианты хирургического или лучевого лечения, опубликованные за последние 10 лет. Также оценивались различные прогностические факторы, на основании которых можно определить ожидаемую продолжительность жизни пациента.

Результаты

Результаты. Опубликованы диагностические алгоритмы и шкалы, которые помогают выбрать оптимальную тактику лечения с учетом факторов прогноза заболевания. Благодаря этому улучшаются результаты лечения больных с метастатическим поражением позвоночника и длинных костей за счет индивидуализированного выбора тактики и объема хирургического вмешательства.

Заключение

Заключение. Необходимо продолжать научные исследования для выявления новых прогностических факторов, влияющих на онкологический прогноз при метастатическом поражении костей. Это приведет к оптимизации методик хирургического лечения пациентов с метастазами в кости и разработке новых алгоритмов выбора объема хирургических вмешательств.

Purpose

Purpose: to conducted a systematic analysis of data available in the current literature, modern diagnosticalgorithms, prognostic factors, survival and options for surgical treatment of metastases in the spine andlong bones of the extremities.

Material And Methods

Material And Methods. The review included data from randomized clinical trials evaluating various diagnostic algorithms for detecting bone metastases, the frequency of metastases to the vertebral column and long bones, their number, and options for surgical or radiation treatment published over the past 10 years. The review also evaluated various prognostic factors that can be used to determine the patient’s life expectancy.

Results

Results. Diagnostic algorithms and scales that help choose treatment strategy, taking into account prognostic factors, were published. The treatment outcomes in patients with spine and long bone metastases were shown to be improved due to personalized surgical treatment strategies.

Conclusion

Conclusion. Further studies are needed to identify new prognostic factors determining the oncological outcomes in patients with bone metastases. This will lead to the optimization of surgical treatment methods and the development of new algorithms for choosing the extent of surgery in patients with bone metastases.

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The authors declare that there are no conflicts of interest present.