oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2022-21-2-118-129oncotomsk-2097Research ArticleОБЗОРЫREVIEWSИммунотерапия в комплексном лечении опухолевых заболеванийImmunotherapy in the complex treatment of tumor diseaseshttps://orcid.org/0000-0002-4746-8853СеледцовВ. И.SeledtsovV. I.

 доктор медицинских наук, главный научный сотрудник

SPIN-код: 6469-9230

 Россия, 117593, г. Москва, Литовский бульвар, 1А 

 MD, DSc, Leading Researcher 

 1a, Litovsky Blvd., 117593, Moscow, Russia 

https://orcid.org/0000-0001-8072-6255СеледцоваГ. В.SeledtsovaG. V.

 доктор медицинских наук, главный научный сотрудник

SPIN-код: 1086-8579. Researcher ID (WOS): B-1085-2014

 Россия, 630099, г. Новосибирск, ул. Ядринцевская, 14 

 MD, DSc, Leading Researcher

Researcher ID (WOS): B-1085-2014 

 14, Yadrintsevskaya st., 630099, Novosibirsk, Russia 

galina-seledtsova@yandex.ruhttps://orcid.org/0000-0002-7109-4687ДоржиеваА. Б.DorzhievaA. B.

 аспирант

 Россия, 630099, г. Новосибирск, ул. Ядринцевская, 14 

 MD, Postgraduate 

 14, Yadrintsevskaya st., 630099, Novosibirsk, Russia 

https://orcid.org/0000-0003-1435-2616ИвановаИ. П.IvanovaI. P.

 кандидат медицинских наук, старший научный сотрудник

SPIN-код: 9322-2073. Researcher ID (WOS):D-9386-2014

 Россия, 630099, г. Новосибирск, ул. Ядринцевская, 14 

 MD, PhD, Senior Researcher

Researcher ID (WOS): D-9386-2014 

 14, Yadrintsevskaya st., 630099, Novosibirsk, Russia 

ФГБНУЗ «Центральная клиническая больница РАН»РоссияCentral Clinical Hospital of the Russian Academy of SciencesRussian FederationФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии»РоссияResearch Institute of Fundamental and Clinical ImmunologyRussian Federation202208052022212118129Copyright © Селедцов В.И., Селедцова Г.В., Доржиева А.Б., Иванова И.П., 20222022Селедцов В.И., Селедцова Г.В., Доржиева А.Б., Иванова И.П.Seledtsov V.I., Seledtsova G.V., Dorzhieva A.B., Ivanova I.P.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/2097

Цель исследования – проанализировать базу научной литературы с целью выявления и анализа возможностей противоопухолевой иммунотерапии, направленной на усиление способности иммунной системы противостоять развитию опухоли и(или) ослабление способности опухоли поддерживать свой рост.

Материал и методы

Материал и методы. Проведен поиск доступных литературных источников, опубликованных в базе данных Medline, Pubmed и др. Было найдено 215 источников, посвященных изучению формирования противоопухолевых механизмов и возможности их модуляции, из которых 57 были включены в данный обзор.

Результаты

Результаты. Обзор посвящен анализу литературы по супрессии опухолевого роста путем модуляции воспаления, коррекции концентрации факторов и ферментов, ингибирования формирования иммуносупрессорных клеток, усиления антительной цитотоксичности, стимуляции клеточной цитотоксичности. Оценены возможности противоопухолевой вакцинации.

Заключение

Заключение. Установлено, что разные иммунотерапевтические агенты могут усиливать противоопухолевое действие друг друга. На ранних стадиях болезни иммунотерапия может элиминировать опухолевые клетки, оставшиеся в организме после хирургического удаления первичной опухоли. На поздних стадиях заболевания комбинированное лечение, включающее в себя традиционное циторедуктивное и иммунотерапевтическое лечение, должно быть направлено на остановку или торможение развития болезни. Прогноз течения заболевания можно оценивать по воспалительной шкале, основанной на определении 3 параметров крови: содержания С-реактивного белка, лактат-дегидрогеназы и нейтрофил-лимфоцитарного соотношения.

The purpose of the study was to identify and analyze the potential of immunotherapy aimed at enhancing the immune system’s ability to resist tumor development and (or) weakening the ability of the tumor to maintain its growth.

Material and methods

Material and methods. A search for available literature sources published in Medline, Pubmed, etc. Databases was made. We found 215 publications regarding the study of the formation of antitumor mechanisms, of which 57 were included in this review.

Results

Results. The review was devoted to the analysis of the literature on tumor growth suppression by modulating inflammation, correcting the concentration of factors and enzymes, inhibiting the formation of immunosuppressive cells, enhancing antibody cytotoxicity, and stimulating cellular cytotoxicity. The feasibilities of antitumor vaccination were evaluated.

Conclusion

Conclusion. Different immunotherapeutic effects were found can enhance the antitumor effect of each other. In the early stages of the disease, immunotherapy can eliminate tumor cells remaining in the body after surgical removal of the primary tumor. In the advanced stages of the disease, combined treatment, including traditional cytoreductive and immunotherapeutic treatment, should be aimed at inhibiting the development of the disease. The prognosis of the disease can be assessed on an inflammatory scale based on the determination of 3 blood parameters: the content of c-reactive protein, the level of lactate dehydrogenase, and the determination of the neutrophil-lymphocyte ratio.

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The authors declare that there are no conflicts of interest present.