References

oncotomsk

Сибирский онкологический журнал

Siberian journal of oncology

1814-48612312-3168

Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences

oncotomsk-217

Research Article

ОБЗОРЫ

REVIEWS

ЛИМФОГЕННОЕ МЕТАСТАЗИРОВАНИЕ САРКОМ МЯГКИХ ТКАНЕЙ: ЧАСТОТА МЕТАСТАЗИРОВАНИЯ, ФАКТОРЫ РИСКА, МЕХАНИЗМЫ ВОЗНИКНОВЕНИЯ

LYMPH NODE METASTASIS FROM SOFT TISSUE SARCOMAS: INCIDENCE OF METASTATIC SPREAD, RISK FACTORS, MECHANISMS OF OCCURRENCE

Васильев

Н. В.

Vasilyev

N. V.

Васильев Николай Вольтович- кандидат медицинских наук, старший научный сотрудник лаборатории патологической анатомии и цитологии. Тел.: 8(3822) 41-80-81. Е-mail: vasilievasn@yandex.ru, SPIN-код: 1627-5226

Vasilyev Nikolai Voltovich - MD, PhD, Senior Researcher, Laboratory of Pathological Anatomy and Cytology.Phone: +7 3822 418081. E-mail: vasilievasn@yandex.ru. SPIN-code: 1627-5226

vasilievasn@yandex.ru

Томский национальный исследовательский онкологииРоссияTomsk Cancer Research InstituteRussian Federation

2015

20022016

136875

2016

Васильев Н.В.

Vasilyev N.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.siboncoj.ru/jour/article/view/217

В обзоре литературы представлены современные данные о частоте и особенностях патогенеза достаточно редкого клинического явления – лифмогенного метастазирования сарком мягких тканей.

The review presents the most recent data on the incidence and pathogenesis of lymph node metastasis from soft tissue sarcoma, a very rare clinical event.

саркомы мягких тканейлимфогенные метастазы

soft tissue sarcomalymph node metastasis

References1

Ковалев А.А. Метастатический каскад как терапевтическая и хирургическая мишень // Здоровье Украины. 2011. № 4 (17). С. 26–28.

Kovalev A.A. Метастатический каскад как терапевтическая и хирургическая мишень // Zdorov'e Ukrainy. 2011. № 4 (17). P. 26–28. [in Russian]

Манских В.Н., Перельмутер В.М. Коллатеральная презентация а н т и г е н о в к а к ф и з и о л о г и ч е с к и й п р о т о т и п л и м ф о г е н н о го метастазирования // Биохимия. 2013. Т. 78, вып. 3. С. 414–425.

Manskikh V.N., Perelmuter V.M. Collateral presentation of antigens as physiological prototype for lymph node metastases // Biochemistry (Moscow). 2013. Vol. 78 (3). P. 414–425. [in Russian]

Перельмутер В.М., Манских В.Н. Прениша как отсутствующее звено концепции метастатических ниш, объясняющее избирательное метастазирование злокачественных опухолей и форму метастатической болезни // Биохимия. 2012. Т. 77, вып. 1. С. 130–139.

Perelmuter V.M., Manskikh V.N. Preniche as missing link of the metastatic niche concept explaining organ-preferential metastasis of malignant tumors and the type of metastatic disease // Biochemistry (Moscow). 2012. Vol. 77 (1). P. 130–139. [in Russian]

Тришкин В.А., Столяров В.И., Волков О.Н. Особенности лимфогенного метастазирования злокачественных опухолей мягких тканей // Вопросы онкологии. 1979. Т. 25, № 9. С. 24–27.

Trishkin V.A., Stoljarov V.I., Volkov O.N. Особенно сти лимфогенного метастазирования злокачественных опухолей мягких тканей // Voprosy onkologii. 1979. Vol. 25 (9). P. 24–27. [in Russian]

Франк Г.А. Проблемы морфологической классификации и диагностики опухолей мягких тканей // Практическая онкология. 2004. Т. 5, № 4. С. 231–236.

Frank G.A. Проблемы морфологической классификации и диагностики опухолей мягких тканей // Prakticheskaja onkologija. 2004. Vol. 5 (4). P. 231–236. [in Russian]

Чехун В. Метастазирование – quo vadis? // Онкология. 2009. Т. 11, № 2. С. 84–85.

Chehun V. Метастазирование – quo vadis? // Onkologija. 2009. Vol. 11 (2). P. 84–85. [in Russian]

Aokage K., Ishii G., Ohtaki Y., Yamaguchi Y., Hishida T., Yoshida J., Nishimura M., Nagai K., Ochiai A. Dynamic molecular changes associated with Epithelial-Mesenchymal Transition and subsequent Mesenchymal– Epithelial Transition in the early phase of metastatic tumor formation // Int. J. Cancer. 2011. Vol. 128 (7). 1585–1595. doi: 10.1002/ijc.25500.

Ariel I.M. Incidence of Metastases to Lymph Nodes From Soft-Tissue Sarcomas // Semin. Surg. Oncol. 1988. Vol. 4 (1). P. 27–29.

Ariel I.M. Incidence of Metastases to Lymph Nodes From SoftTissue Sarcomas // Semin. Surg. Oncol. 1988. Vol. 4 (1). P. 27–29.

Atalay C., Altinok M., Seref B. The Impact of Lymph Node Metastases on Survival in Extremity Soft Tissue Sarcomas // World J. Surg. 2007. Vol. 31 (7). P. 1433–1437.

Babu L., Nandhara G., Baskaran K., Kumar P., Ng A., Paul A. Lymphatic spread and its significance in soft tissue sarcomas of the extremities // J. Bone Joint Surg. Br. 2006. Vol. 88-B. Suppl. II. P. 300–301.

Behranwala K.A., A’Hern R., Omar A.-M., Thomas J.M. Prognosis of Lymph Node Metastasis in Soft Tissue Sarcoma // Ann. Surg. Oncol. 2004. Vol. 11 (7). P. 714–719.

Blazer D.G., Sabel M.S., Sondak V.K. Is there a role for sentinel lymph node biopsy in the management of sarcoma? // Surg. Oncol. 2003. Vol. 12 (3). P. 201–206.

Cacciatore M., Dei Tos A.P. Challenging epithelioid mesenchymal neoplasms: mimics and traps // Pathology. 2014. Vol. 46 (2). P. 126–134. doi: 10.1097/PAT.0000000000000063.

Chen J., Alexander J.S., Orr A.W. Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis // Int. J. Cell Biol. Vol. 2012, Article ID 853703. 12 p. doi: 10.1155/2012/853703.

Dabbs D.J. Diagnostic immunohistochemistry: theranostic and genomic. 2010. 941 p.

Daigeler A., Kuhnen C., Moritz R., Stricker I., Goertz O., Tilkorn D., Steinstraesser L., Steinau H.U., Lehnhardt M. Lymph node metastases in soft tissue sarcomas: a single center analysis of 1,597 patients // Langenbecks Arch. Surg. 2009. Vol. 394 (2). P. 321–329. doi: 10.1007/ s00423-008-0371-x.

Dei Tos A.P., Wagner A.J., Modena P., Comandone A., Leyvraze S. Epithelioid Soft Tissue Tumors // Semin. Oncol. 2009. Vol. 36 (4). P. 347–357.

Deyrup A.T., Montag A.G. Epithelioid and epithelial neoplasms of bone // Arch. Pathol. Lab. Med. 2007. Vol. 131 (2). P. 205–216.

Fitzgerald M.P., Gourronc F., Teoh M.L.T., Provenzano M.J., Case J., Martin J.A., Domann F E. Human chondrosarcoma cells acquire an epithelial-like gene expression pattern via an epigenetic switch: evidence for mesenchymal-epithelial transition during sarcomagenesis // Sarcoma. 2011. Article id 598218, 11 p. doi: 10.1155/2011/598218.

Folpe A.L. Selected topics in the pathology of epithelioid soft tissue tumors // Mod. Pathol. 2014. Vol. 27. Suppl. 1. P. 64–79. doi: 10.1038/modpathol.2013.175.

Fotiadis C., Charalambopoulos A., Chatzikokolis S., Zografos G.C., Genetzakis M., Tringidou R. Extraskeletal myxoid chondrosarcoma metastatic to the pancreas: A case report // World J. Gastroenterol. 2005. Vol. 11 (14). P. 2203–2205.

Friedrichs N., Hahne J.C., Pepper M.S., Rommerscheidt-Fuss U., Stelzner F., Buettner R., Wernert N. Immunohistochemical quantification of lymph vessels, VEGF-C and VEGF receptor 3 in human sarcomas // Histopathology. 2006. Vol. 49 (1). P. 87–88.

Greene F., Page D., Fleming F. American Joint Committee On Cancer: Cancer staging manual. 6th ed. New York: Springer, 2002. P. 221–226.

Hugo H. Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression // J. Cell. Physiol. 2007. Vol. 213. P. 374–383.

Jasmin C., Coleman R.E., Coia L.R., Capanna R., Saillant G. Textbook of bone metastases. 2005. 555 р.

Johannesmeyer D., Smith V., Cole D.J., Esnaola N.F., Camp E.R. The impact of lymph node disease in extremity soft-tissue sarcomas: a population-based analysis // Am. J. Surg. 2013. Vol. 206 (3). P. 289–295. doi: 10.1016/j.amjsurg.2012.10.043.

Kilpatrick S.E., Geisinger K.R. Soft tissue sarcomas: the usefulness and limitations of fine-needle aspiration biopsy // Am. J. Clin. Pathol. 1998. Vol. 110. P. 50–68.

Koniaria K., Maherab H., Nikolaouc M., Chatzis O., Glezakou O., Magiasis V., Kiratzis G. Intraabdominal desmoplastic small round cell tumor: Report of a case and literature review // Int. J. Surg. Case Rep. 2011. Vol. 2 (8). P. 293–296. doi: 10.1016/j.ijscr.2011.08.013.

Lamyman M.J., Giele H.P., Critchley P., Whitwell D., Gibbons M., Athanasou N.A. Local recurrence and assessment of sentinel lymph node biopsy in deep soft tissue leiomyosarcoma of the extremities // Clin. Sarcoma Res. 2011. Vol. 1 (1). P. 7–15. doi: 10.1186/2045-3329-1-7.

Lee N.Y.-T., Moore T.M., Schwinn C.P. Metastasis of sarcomatous lesion in regional lymph node // J. Surg. Oncol. 1982. Vol. 20 (1). P. 53–58.

Leu A.J., Berk D.A., Lymboussaki A., Alitalo K., Jain R.K. Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation // Cancer Res. 2000. Vol. 60. P. 4324–4327.

Liberman B., Riad S., Griffin A.M., O’Sullivan B. Lymph Node Metastasis In Soft Tissue Sarcoma Of The Extremities // J. Bone Joint. Surg. Br. 2008. Vol. 90-B. Supp. 1. P. 87.

Mahendra G., Kliskey K., Williams K., Hollowood K., Jackson D., Athanasou N.A. Intratumoural lymphatics in benign and malignant soft tissue tumours // Virchows Arch. 2008. Vol. 453. P. 457–464.

Massi D., Gokoz O. The biological significance of lymphangiogenesis in human tumours // Diagnostic histopathology. 2010. Vol. 16 (6). P. 295–305.

Mazeron J.J., Suit H.D. Lymph nodes as sites of metastases from sarcomas of soft tissue // Cancer. 1987. Vol. 60. P. 1800–1808.

Nelen S.D., Vogelaar F.J., Gilissen F., Van der Linden J.C., Bosscha K. Lymph Node Metastasis after a Soft Tissue Sarcoma of the Leg: A Case Report and a Review of the Literature. Hindawi Publishing Corporation // Case Rep. Surg. 2013, Article ID 930361, 6 p. doi: 10.1155/2013/930361.

Niinaka Y., Harada K., Fujimuro M., Oda M., Haga A., Hosoki M., Uzawa N., Arai N., Yamaguchi S., Yamashiro M., Raz A. Osteosarcoma Pulmonary Metastasis Mesenchymal-to-Epithelial Transition and Suppression of Silencing of Autocrine Motility Factor Induces // Cancer Res. 2010. Vol. 70 (22). P. 9483–9493. doi: 10.1158/0008-5472.CAN-09-3880.

Ottaiano A., de Chiara A., Fazioli F., Talamanca A.A., Mori S., Botti G., Milano A., Apice G. Biological prognostic factors in adult soft tissue sarcomas // Anticancer Research. 2005. Vol. 25. P. 4519–4526.

Padera T.M., Kadambi A., di Tomaso E., Carreira C.M., Brown E.B., Boucher Y., Choi N.C., Mathisen D., Wain J., Mark E.J., Munn L.L., Jain R.K. Lymphatic metastasis in the absence of functional intratumor lymphatics // Science. 2002. Vol. 296 (5574). P. 1883–1886.

Pepper M.S., Skobe M. Lymphatic endothelium: morphological, molecular and functional properties // J. Cell Biol. 2003. Vol. 163. P. 209–213.

Riggi N., Stamenkovic I. The Biology of Ewing sarcoma // Cancer Lett. 2007. Vol. 254 (1). P. 1–10.

Rosciano A.E.P., Ruan J.M., Thome M.G.S., Ruiz G.C. et al. Impact of Lymph Node Metastasis Metachronous Vs Synchronous on the Prognosis of Soft Tissue Sarcomas. 2012. Session: Soft Tissue Sarcoma. Poster N. 122. 883 р.

Ryzewicz M., McLoughlin H.A., Freudenberger C., Williams A., Lindeque B. Unusual Metastases From Extremity Soft Tissue Sarcomas // Orthopedics. 2008. Vol. 31 (5). P. 1–11.

Saito T., Nagai M., Ladanyi M. SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by Snail and Slug: a potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma // Cancer Res. 2006. Vol. 66 (14). P. 6919–6927.

Sawamura C., Matsumoto S., Shimoji T., Ae K., Okawa A. Lymphadenectomy and histologic subtype affect overall Survival of soft tissue sarcoma patients with nodal metastases // Clin. Orthop. Relat. Res. 2013. Vol. 471 (3). P. 926–931. doi: 10.1007/s11999-012-2568-0.

Srinivasan B., Ethunandan M., Hussain K., Ilankovan V. Epitheloid Myxofibrosarcoma of the Parotid Gland // Case Rep. Pathol. 2011, Article ID 641621, 3 p.

Stelzner F., Steinau H.U., Friedrichs N., von Mallek D. Der Weg regionärer Lymphbahnmetastasen bei Weichgewebssarkomen // Chirurg. 2013. Bd. 84. S. 502–510.

Ulutin C., Bakkal B.H., Kuzhan O.A. Cohort Study of Adult Rhabdomyosarcoma: A Single Institution Experience // World J. Med. Sci. 2008. Vol. 3 (2). P. 54–59.

Ulutin C., Bakkal B.H. Kuzhan O.A. Cohort Study of Adult Rhabdomyosarcoma: A Single Institution Experience // World J. Med. Sci. 2008. Vol. 3 (2). P. 54–59.

Warren S., Meyer R.W. Lymph node metastasis of sarcoma // Am. J. Pathol. 1938. Vol. XIV. P. 605–619.

Weingrad D.N., Rosenberg S.A. Early lymphatic spread of osteogenic and soft-tissue sarcomas // Surgery. 1978. Vol. 84 (2). P. 231–240.

Weiss S.W., Goldblum J.R. Enzinger and Weiss’s soft tissue tumors. 5th ed. 2008. 1258 p.

WHO Classification of Tumours of Soft Tissue and Bone / Ed. C.D.M. Fletcher, J.A. Bridge, P.C.W. Hogendoorn, F. Mertens. Lyon: IARC, 2013. 468 p.

Yanagawa T., Saito K., Takagishi K. Risk Factors for Lymphatic Metastasis of Malignant Bone and Soft-Tissue Tumors: A Retrospective Cohort Study of 242 Patients // Medicine. 2014. Vol. 93 (27). P. 1–5. doi: 10.1097/MD.0000000000000225.

Yang J., Eddy J.A., Pan Y., Hategan A., Tabus I., Wang Y., Cogdell D., Price N.D., Pollock R.E., Lazar A.J.F., Hunt K.K., Trent J.C., Zhang W. Integrated proteomics and genomics analysis reveals a novel mesenchymal to epithelial reverting transition in leiomyosarcoma through regulation of slug // Mol. Cell. Proteomics. 2010. Vol. 9 (11). P. 2405–2413. doi: 10.1074/mcp.M110.000240.

Yang J., Du X., Wang G., Sun Y., Chen K., Zhu X., Lazar A.J.F., Hunt K.K., Pollock R.E., Zhang W. Mesenchymal to epithelial transition in sarcomas // Eur. J. Cancer. 2014. Vol. 50 (3). P. 593–601. doi: 10.1016/j.ejca.2013.11.006.

Yokoyama K., Chuman H., Sninohara N., Masuda S., Sugioka Y. A clinicopathologic study of soft tissue sarcomas with lymph nodes me-tastases // Orthoped. Traumatol. 1986. Vol. 35 (2). P. 414–416.

Yokoyama K., Chuman H., Sninohara N., Masuda S., Sugioka Y. A clinicopathologic study of soft tissue sarcomas with lymph nodes metastases // Orthoped. Traumatol. 1986. Vol. 35 (2). P. 414–416.

Yoo H., Yum S. K., Oh S.-J., Kim K.-M. Melanotic Neuroectodermal Tumor of Infancy Disseminated by a Ventriculoperitoneal Shunt and Diagnosed from the Inguinal // J. Pediatr. Hematol. Oncol. 2014. Vol. 36 (1). e61–64. doi: 10.1097/MPH.0b013e31829dd114.

Zagars G.K., Ballo M.T., Pisters P.W., Pollock R.E., Patel S.R., Benjamin R.S., Evans H.L. Prognostic Factors for Patients with Localized Soft-Tissue Sarcoma Treated with Conservation Surgery and Radiation Therapy. An Analysis of 1225 Patients // Cancer. 2003. Vol. 97. P. 2530–2543.

Zhao L., Anders K.H. Malignant perivascular epithelioid cell tumor of the gallbladder: a case report and review of literature // Arch. Pathol. Lab. Med. 2014. Vol. 138 (9). P. 1238–1241. doi: 10.5858/arpa.2013-0092-CR.

The authors declare that there are no conflicts of interest present.