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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21294/1814-4861-2022-21-4-165-169</article-id><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-2241</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАЙ ИЗ КЛИНИЧЕСКОЙ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Острый холецистит как первое проявление первичного плоскоклеточного рака желчного пузыря: клинический случай</article-title><trans-title-group xml:lang="en"><trans-title>Acute cholecystitis as the first manifestation of primary pure squamous cell carcinoma of the gallbladder; a case report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7106-9799</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Bahadoram</surname><given-names>M.</given-names></name><name name-style="western" xml:lang="en"><surname>Bahadoram</surname><given-names>M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Mohammad Bahadoram - научный сотрудник отделения радиационной онкологии и Центра развития клинических исследований Firoozgar, Иранский университет медицинских наук.</p><p>Hemat Highway, Тегеран, 14665-354.</p></bio><bio xml:lang="en"><p>Mohammad Bahadoram - MD, Researcher, Department of Radiation Oncology and Firoozgar Clinical Research Development Center, Iran University of Medical Sciences.</p><p>Hemat Highway, Tehran, Iran 14665-354.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0660-0069</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Barahman</surname><given-names>M.</given-names></name><name name-style="western" xml:lang="en"><surname>Barahman</surname><given-names>M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Maedeh Barahman - доцент отделения радиационной онкологии и Центра развития клинических исследований Firoozgar, Иранский университет медицинских наук.</p><p>Hemat Highway, Тегеран, 14665-354.</p></bio><bio xml:lang="en"><p>Maedeh Barahman - MD, Assistant Professor, Department of Radiation Oncology and Firoozgar Clinical Research Development Center, Iran University of Medical Sciences.</p><p>Hemat Highway, Tehran, Iran 14665-354.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7319-6196</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Davoodi</surname><given-names>M.</given-names></name><name name-style="western" xml:lang="en"><surname>Davoodi</surname><given-names>M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Mohammad Davoodi - доцент отделения радиологии, больница Шариати, Тегеранский университет медицинских наук.</p><p>Vali-e Asr Ave., Тегеран, 1416753955.</p></bio><bio xml:lang="en"><p>Mohammad Davoodi - MD, Associate Professor, Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences.</p><p>Vali-e Asr Ave., Tehran, Iran 1416753955.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5091-5191</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Hassanzadeh</surname><given-names>S.</given-names></name><name name-style="western" xml:lang="en"><surname>Hassanzadeh</surname><given-names>S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Shakiba Hassanzadeh - научный сотрудник отделения радиационной онкологии и Центра развития клинических исследований Firoozgar, Иранский университет медицинских наук.</p><p>Hemat Highway, Тегеран, 14665-354.</p></bio><bio xml:lang="en"><p>Shakiba Hassanzadeh - MD, Researcher, Department of Radiation Oncology and Firoozgar Clinical Research Development Center, Iran University of Medical Sciences.</p><p>Hemat Highway, Tehran, Iran 14665-354.</p></bio><email xlink:type="simple">shak.hassanzadeh@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Отделение радиационной онкологии и Центр развития клинических исследований Firoozgar, Иранский университет медицинских наук</institution><country>Иран</country></aff><aff xml:lang="en"><institution>Department of Radiation Oncology and Firoozgar Clinical Research Development Center, Iran University of Medical Sciences</institution><country>Islamic Republic of Iran</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Отделение радиологии, больница Шариати, Тегеранский университет медицинских наук</institution><country>Иран</country></aff><aff xml:lang="en"><institution>Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences</institution><country>Islamic Republic of Iran</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>02</day><month>09</month><year>2022</year></pub-date><volume>21</volume><issue>4</issue><fpage>165</fpage><lpage>169</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Bahadoram M., Barahman M., Davoodi M., Hassanzadeh S., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Bahadoram M., Barahman M., Davoodi M., Hassanzadeh S.</copyright-holder><copyright-holder xml:lang="en">Bahadoram M., Barahman M., Davoodi M., Hassanzadeh S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/2241">https://www.siboncoj.ru/jour/article/view/2241</self-uri><abstract><p>Актуальность. По сравнению с аденокарциномой плоскоклеточный рак желчного пузыря (ПРЖП) характеризуется более быстрым и инвазивным ростом с инфильтрацией соседних органов и более редким поражением лимфатических узлов. Это редкое новообразование, на долю которого приходится 1,4–12,7 % опухолей желчного пузыря. ПРЖП имеет плохой прогноз. Симптомы обычно появляются на поздних стадиях заболевания, в связи в чем пациенты часто умирают вскоре после постановки диагноза. Этиология ПРЖП сложная и в основном связана с наличием конкрементов в желчном пузыре. Описание случая. Пациент, 56 лет, поступил в стационар с жалобами на коликообразные боли в правом подреберье, которые возникли примерно за 2 нед до госпитализации; тошноты, рвоты, одышки, лихорадки, отсутствия аппетита или потери веса не отмечал. После обследования установлен диагноз острого холецистита и начата антибактериальная терапия, которая не дала положительных результатов, и пациенту была выполнена операция, при ревизии обнаружена опухоль желчного пузыря, что явилось показанием для холецистэктомии и расширенной правосторонней гемигепатэктомии. При гистологическом исследовании биопсийного материала выявлен плоскоклеточный рак. После операции назначена лучевая терапия и химиотерапия. При динамическом наблюдении в течение 2 лет отмечается полная ремиссия опухоли. Заключение. Представленный клинический случай подчеркивает необходимость дальнейшего изучения гистогенеза плоскоклеточного рака желчного пузыря.</p></abstract><trans-abstract xml:lang="en"><p>Background. SCC of the gallbladder is characterized by more rapid and invasive growth with infiltration of the adjacent organs and less spread to the lymph nodes compared to adenocarcinoma of the gallbladder. It is a rare neoplasm that accounts for 1.4–12.7 % of gallbladder tumors. SCC of the gallbladder has a poor prognosis. symptoms usually appear later when the disease has progressed and the malignancy has reached advanced stages. therefore, usually, the patients expire soon following the diagnosis. the etiology of the SCC of the gallbladder is complex and is mostly associated with gallstones. Case description. We report a case of a 56-year-old man that had been suffering from colicky abdominal pain in the right upper quadrant for about two weeks before his admission. He did not have nausea, vomiting, shortness of breath, fever, lack of appetite, or weight loss. after evaluation, a diagnosis of acute cholecystitis was established and antibiotic therapy was initiated. However, he did not respond to medical therapy and underwent surgery. A tumor mass was detected during surgery. therefore, cholecystectomy and extended right hepatectomy were performed. The pathological evaluation of the biopsy specimen revealed squamous cell carcinoma. consequently, he underwent radiotherapy and chemotherapy and was followed up for two years. He acquired complete tumor remission. Conclusion. The present case highlights the requirement of considering further investigation on the histogenesis of SCC of the gallbladder.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>первичный плоскоклеточный рак желчного пузыря</kwd><kwd>периодическая кислая реакция Шиффа</kwd><kwd>расширенная правосторонняя гепатэктомия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>primary squamous cell carcinoma of the gallbladder</kwd><kwd>periodic acid Schiff reaction</kwd><kwd>extended right hepatectomy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Rustagi T., Dasanu C.A. 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