oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciencesoncotomsk-226Research ArticleОБЗОРЫREVIEWSОСОБЕННОСТИ КАНЦЕРОГЕНЕЗА АДЕНОКАРЦИНОМЫ ТОЛСТОЙ КИШКИSPECIAL FEATURES OF CARCINOGENESIS OF COLON ADENOCARCINOMAРаскинГ. А.RaskinG. A.

Раскин Григорий Александрович, кандидат медицинских наук, ведущий научный сотрудник, Российский научный центр радиологии и хирургических технологий (г. Санкт-Петербург). 

E-mail: rasking@list.ru. SPIN-код: 4569-9756

Raskin Grigory Alexandrovich, DM, PhD, Leading Researcher, Russian Scientific Center of Radiology and Surgical Technologies (St-Petersburg).

E-mail: rasking@list.ru 

rasking@list.ruПетровС. В.PetrovS. V.

Петров Семен Венедиктович, доктор медицинских наук, профессор кафедры патологии. 

Petrov Semyen Venediktovich, MD, DSc, Professor, Pathology Department.

rasking@list.ruОрловаР. В.OrlovaR. V.

Орлова Рашида Вахидовна, доктор медицинских наук, профессор, заведующая кафедрой онкологии медицинского факультета,Санкт-Петербургский государственный университет.

SPIN-код: 9932-6170

Orlova Rashida Vakhidovna, DSc, Professor, Head of Oncology Department, Medical Faculty of St-Petersburg State University.

rasking@list.ruРоссийский научный центр радиологии и хирургических технологий, Санкт-Петербург; Санкт-Петербургский государственный университет, медицинский факультет, г. Санкт-ПетербургРоссияRussian Scientific Center of Radiology and Surgical Technologies, Saint-Petersburg; St-Petersburg State UniversityRussian FederationКазанский государственный медицинский университетРоссияKazan State Medical UniversityRussian Federation201521022016147379Copyright © Раскин Г.А., Петров С.В., Орлова Р.В., 20162016Раскин Г.А., Петров С.В., Орлова Р.В.Raskin G.A., Petrov S.V., Orlova R.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/226

Рак толстой кишки – одна из наиболее распространенных форм злокачественных опухолей, занимающая лидирующие в мире позиции по летальности от рака. Выделяют четыре основных пути канцерогенеза аденокарциномы толстой кишки: трансформация аденомы в карциному; HNPCC (наследственный неполипозный рак толстой кишки); развитие рака «de novo»; трансформация хронического колита. Во всех из них, кроме синдрома Линча, все больше внимания уделяют стволовым ткань-коммитированным клеткам как мишеням мутаций и источнику злокачественных опухолей. Впоследствии возникающие из них стволовые раковые клетки рассматривают как причину химиорезистентности опухолей, развития рецидивов и метастазов. Таким образом, изучение данной популяции клеток может кардинально изменить подходы к лечению пациентов с аденокарциномой толстой кишки.

Colorectal cancer is one of the most common malignancies and the leading cause of cancer-related death. There are 4 basic colon carcinogenic steps: malignant transformation of adenoma into carcinoma; HNPCC (hereditary nonpolyposis colon cancer); cancer «de novo»; chronic colitis malignant transformation. All of them, except for Lynch syndrome, are increasingly focused on stem tissue-committed cells as mutation targets and the source of malignancies. Subsequently, cancer stem cells are considered as the cause of chemoresistance of tumors, metastases and relapses. Thus, the study of the cell population can dramatically change approaches to the treatment of patients with colorectal adenocarcinoma.

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The authors declare that there are no conflicts of interest present.