oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciencesoncotomsk-227Research ArticleОБЗОРЫREVIEWSРОЛЬ НЕЙРЕГУЛИНОВ И ФАКТОРА РОСТА ГЕПАТОЦИТОВ В РАЗВИТИИ КАСТРАЦИОННО-РЕФРАКТЕРНОГО РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫROLE OF NEUREGULINS AND HEPATOCYTE GROWTH FACTOR IN THE DEVELOPMENT OF CASTRATION-RESISTANT PROSTATE CANCERСпиринаЛ. В.SpirinaL. V.

Спирина Людмила Викторовна, доктор медицинских наук, старший научный сотрудник лаборатории биохимии опухолей, Томский НИИ онкологии. 

E-mail: spirinalv@oncology.tomsk.ru. SPIN- код: 1336-8363 

Spirina Lyudmila Viktorovna, MD, DSc, Senior Researcher, Laboratory of Tumor Biochemistry, Tomsk Cancer Research Center. 

Phone: +7 (3822) 51-45-98. E-mail: spirinalv@oncology.tomsk.ru. SPIN-code: 1336-8363 

spirinalv@oncology.tomsk.ruУсынинЕ. А.UsyninE. A.

Усынин Евгений Анатольевич, кандидат медицинских наук, научный сотрудник отделения общей онкологии. 

Тел.: 8 (3822) 41-80-92. E-mail: gusi@list.ru. SPIN-код: 1804-0292 

Usynin Evgeny Anatolyevich, Md, PhD, Researcher, General Oncology Department. 

Phone: +7 (3822) 41-80-92. E-mail: gusi@list.ru. SPIN-code: 1804-0292 .

gusi@list.ruСлонимскаяЕ. М.SlonimskayaE. M.

Слонимская Елена Михайловна, доктор медицинских наук, профессор, руководитель отделения общей онкологии, Томский НИИ онкологии. 

E-mail: slonimskaya@yandex.ru. SPIN-код: 7763- 6417 

Slonimskaya Elena Mikhailovna, MD, DSC, Professor, Head of General Oncology Department, Tomsk Cancer Research Institute. 

Phone: +7 (3822) 41-80-92. E-mail: slonimskaya@rambler.ru. SPIN-code: 7763-6417 

КондаковаИ. В.KondakovaI. V.

Кондакова Ирина Викторовна, доктор медицинских наук, профессор, заведующий лабораторией биохимии опухолейю 

E-mail: kondakova@oncology.tomsk.ru. SPIN-код: 9338-4149 

Kondakova Irina Viktorovna, Tumor Biochemistry. 

Phone: +7 (3822) 51- 25-29. E-mail: kondakova@oncology.tomsk.ru. SPIN-code: 9338-4149 

kondakova@oncology.tomsk.ruГорбуновА. К.GorbunovA. K.

Горбунов Алексей Константинович, врач-ординатор. 

E-mail: goorbunov@gmail.com. SPIN-код: 3590-3479

Gorbunov Alexey Konstantinovich, intern, Tomsk Cancer Research Center. 

E-mail: goorbunov@gmail.com. SPIN-code: 3590-3479

goorbunov@gmail.comТомский НИИ онкологии; Сибирский государственный медицинский университет, ТомскРоссияTomsk Cancer research Institute; Siberian State Medical University, TomskRussian FederationТомский НИИ онкологииРоссияTomsk Cancer research InstituteRussian Federation201521022016148086Copyright © Спирина Л.В., Усынин Е.А., Слонимская Е.М., Кондакова И.В., Горбунов А.К., 20162016Спирина Л.В., Усынин Е.А., Слонимская Е.М., Кондакова И.В., Горбунов А.К.Spirina L.V., Usynin E.A., Slonimskaya E.M., Kondakova I.V., Gorbunov A.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/227

Развитие кастрационно-резистентного рака предстательной железы является важной проблемой современной онкологии, ухудшающей течение и качество жизни пациентов. Основное внимание в обзоре сосредоточено на системе ростовых факторов – нейрегулинов и факторе роста гепатоцитов (HGF) – непосредственных лигандов тирозиновых протеинкиназ ErbB и рецептора фактора роста гепатоцитов c-Met, активация которых запускает каскад сигнальных путей, завершающийся стимуляцией пролиферации раковых клеток, их миграцией в условиях развития нечувствительности к кастрационному лечению.

The development of castration-resistant prostate cancer is an important problem of modern oncology. The review is focused on the system of growth factors – neuregulins and hepatocyte growth factor (HGF), direct pathligands of ErbB tyrosine protein kinases and hepatocyte growth factor receptor, c-Met, the activation of which triggers a cascade of signaling pathways, ending by the stimulation of proliferation of cancer cells, their migration under conditions of the development of tolerance to the treatment of castration.

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The authors declare that there are no conflicts of interest present.