References

oncotomsk

Сибирский онкологический журнал

Siberian journal of oncology

1814-48612312-3168

Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences

10.21294/1814-4861-2022-21-5-123-134

oncotomsk-2315

Research Article

ОБЗОРЫ

REVIEWS

Наследственные злокачественные опухоли яичника

Hereditary ovarian cancer

https://orcid.org/0000-0002-0486-2404

Котив

Х. Б.

Kotiv

Kh. B.

Котив Христина Богдановна, кандидат медицинских наук, научный сотрудник отделения онкогинекологии; ассистент кафедры акушерства и гинекологии

SPIN-код: 3049-8250. Author ID (Scopus): 57193895371

Россия, 197758, г. Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

Россия, 191015, г. Санкт-Петербург, ул. Кирочная, 41

Khristina B. Kotiv, MD, PhD, Researcher of the Department of Gynecologic Oncology; Assistant of the Department of Obstetrics and Gynecology

Author ID (Scopus): 57193895371

68, Leningradskaya St., 197758, St. Petersburg, Russia

41, Kirochnaya St., 191015, St. Petersburg, Russia

kotiv.onc@gmail.com

https://orcid.org/0000-0003-1719-7498

Городнова

Т. В.

Gorodnova

T. V.

Городнова Татьяна Васильевна, кандидат медицинских наук, научный сотрудник

SPIN-код: 2661-9106. Author ID (Scopus): 36010503000

Россия, 197758, г. Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

Tatiana V. Gorodnova, MD, PhD, Researcher of the Department of Gynecologic Oncology

Author ID (Scopus): 36010503000

68, Leningradskaya St., 197758, St. Petersburg, Russia

https://orcid.org/0000-0001-6304-1609

Соколенко

А. П.

Sokolenko

A. P.

Соколенко Анна Петровна, кандидат медицинских наук, научный сотрудник отделения молекулярной онкологии; доцент кафедры общей и молекулярной медицинской генетики

Researcher ID (WOS): G-3123-2013. Author ID (Scopus):7004209770

Россия, 197758, г. Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

Россия, 194100, г. Санкт-Петербург, ул. Литовская, 2

Anna P. Sokolenko, MD, PhD, Researcher of the Department of Tumor Biology; Assistant Professor of the Department of General and Molecular Medical Genetic

Researcher ID (WOS): G-3123-2013. Author ID (Scopus): 7004209770

68, Leningradskaya St., 197758, St. Petersburg, Russia

2, Litovskaya St., 194100, St. Petersburg, Russia

Берлев

И. В.

Berlev

I. V.

Берлев Игорь Викторович, доктор медицинских наук, профессор, заведующий отделением онкогинекологии; заведующий кафедрой акушерства и гинекологии

Author ID (Scopus): 6603322008

Россия, 197758, г. Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

Россия, 191015, г. Санкт-Петербург, ул. Кирочная, 41

Igor V. Berlev, MD, Professor, Head of the Department of Gynecologic Oncology; Head of the Department of Obstetrics and Gynecology

Author ID (Scopus): 6603322008

68, Leningradskaya St., 197758, St. Petersburg, Russia

41, Kirochnaya St., 191015, St. Petersburg, Russia

https://orcid.org/0000-0003-4529-7891

Имянитов

Е. Н.

Imyanitov

E. N.

Имянитов Евгений Наумович, доктор медицинских наук, профессор, член-корреспондент РАН, заведующий научным отделом биологии опухолевого роста; заведующий кафедрой общей и молекулярной медицинской генетики

SPIN-код: 1909-7323. Author ID (Scopus): 7003644486

Россия, 197758, г. Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

Россия, 194100, г. Санкт-Петербург, ул. Литовская, 2

Evgeny N. Imyanitov, MD, Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Tumor Biology; Head of the Department of Tumor Biology

Author ID (Scopus): 7003644486

68, Leningradskaya St., 197758, St. Petersburg, Russia

2, Litovskaya St., 194100, St. Petersburg, Russia

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России; ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииРоссияN.N. Petrov National Medical Research Center of Oncology; I.I. Mechnikov North-Western State Medical UniversityRussian Federation

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава РоссииРоссияN.N. Petrov National Medical Research Center of OncologyRussian Federation

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России; ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава РоссииРоссияN.N. Petrov National Medical Research Center of Oncology; St. Petersburg State Pediatric Medical UniversityRussian Federation

2022

31102022

215123134

2022

Котив Х.Б., Городнова Т.В., Соколенко А.П., Берлев И.В., Имянитов Е.Н.

Kotiv K.B., Gorodnova T.V., Sokolenko A.P., Berlev I.V., Imyanitov E.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.siboncoj.ru/jour/article/view/2315

Введение. Наследственные дефекты генов – достоверный фактор риска злокачественной трансформации клеток и развития онкологических заболеваний. На долю наследственных форм приходится 15–25 % всех случаев карцином яичника. Цель исследования – обобщить имеющиеся данные о наследственных злокачественных опухолях яичников: ассоциированных генетических дефектах, особенностях клинического течения, лечения и профилактических мероприятий. Материал и методы. Поиск литературных источников выполнялся в базах PubMed, Medline, Cochrane Library, включались публикации с 1999 по 2021 г. Результаты. Описаны основные генетические дефекты и ассоциированные с ними опухолевые синдромы, предрасполагающие к развитию наследственных злокачественных опухолей яичника. Представлены особенности клинического течения и чувствительность к лекарственной терапии. Обобщены рекомендации профессиональных сообществ: Национальной онкологической сети США (National Comprehensive Cancer Network, NCCN), Американского общества клинической онкологии (American Society Of Clinical Oncology, ASCO), Рабочей группы по профилактике заболеваний в США (The U.S. Preventive Services Task Force), Европейского общества медицинской онкологии (European Society For Medical Oncology, ESMO), направленные на раннее выявление новообразований, и представлен комплекс профилактических мер для предотвращения развития злокачественных опухолей яичника у носителей герминальных мутаций. Заключение. Выявление наследственных опухолевых синдромов имеет важное значение для пациентов и их семей. Своевременное определение предрасположенности к развитию злокачественных опухолей позволяет оптимизировать программы скрининга и профилактики онкологических заболеваний.

Background. Hereditary genetic mutations are a significant risk factor for malignant transformation of cells and cancer development. Hereditary genetic mutations account for 15 to 25 % of all ovarian carcinomas. Purpose of the study: to summarize data on hereditary ovarian malignancies, namely: genetic defects, features of the clinical course, treatment options, and disease prevention. Material and methods. A systemic search was undertaken using PubMed, Medline, Cochrane Library databases for publications from 1999 to 2021. Results. The review describes the main genetic defects and hereditary cancer syndromes predisposing to the development of hereditary malignant ovarian tumors. The features of the clinical course and response to drug therapy have been presented. This article summarizes clinical guidelines of the professional communities (National Comprehensive Cancer Network (NCCN), American Society Of Clinical Oncology (ASCO), The U.S. Preventive Services Task Force, and European Society For Medical Oncology (ESMO). These guidelines contain early detection strategies and approaches to prevent the development of cancers in mutation carriers. Conclusion. Detection of hereditary cancer syndromes is important for patients and their families. Recognizing hereditary predisposition to cancer is important to allow timely surveillance and preventative interventions for both patients and family members.

наследственные злокачественные опухоли яичникаBRca мутациисиндром Линчамутации в генах MSH2MLH1MSH6PMS2EPCAMBRIP1RAD51CRAD51DАТМNBNSTK11PALB2

hereditary ovarian cancerBRca mutationslynch syndromemutations in the genes MSH2MLH1MSH6PMS2EPCAMBRIP1RAD51CRAD51DATMNBNSTK11PALB2

Работа выполнена при поддержке гранта РНФ №21-75-30015.

The study was supported by the Russian Science Foundation grant No. 21-75-30015.

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The authors declare that there are no conflicts of interest present.