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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-240</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>СОВРЕМЕНЫЕ ПРИНЦИПЫ КОМПЛЕКСНОГО ЛЕЧЕНИЯ ГЕНЕРАЛИЗОВАНОГО РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ (ОБЗОР ЛИТЕРАТУРЫ И АНАЛИЗ СОБСТВЕНОГО МАТЕРИАЛА)</article-title><trans-title-group xml:lang="en"><trans-title>Current aspects of comprehensive treatmentfor advanced breast cancer (literature review and analysis of original material)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пак</surname><given-names>Д. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Pak</surname><given-names>D. D.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Болотина</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bolotina</surname><given-names>L. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сухотько</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Suhotko</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">a.s.sykhotko@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Московский научно-исследовательский онкологический институт им. П.А. Герцена», г. Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>P.A. Gertsen Moscow Research Institute of Oncology, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>23</day><month>02</month><year>2016</year></pub-date><volume>0</volume><issue>5</issue><fpage>54</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пак Д.Д., Болотина Л.В., Сухотько А.С., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Пак Д.Д., Болотина Л.В., Сухотько А.С.</copyright-holder><copyright-holder xml:lang="en">Pak D.D., Bolotina L.V., Suhotko A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/240">https://www.siboncoj.ru/jour/article/view/240</self-uri><abstract><p>Обзор посвящен основным методам комплексного лечения генерализованного рака молочной железы. Проведен анализ международных исследований, целью которых явилась оценка эффективности хирургического лечения как этапа комплексного лечения больных раком молочной железы IV стадии. Рассмотрена роль современной лекарственной терапии как фактора, увеличивающего общую выживаемость</p></abstract><trans-abstract xml:lang="en"><p>The review is devoted to the treatment methods for advanced breast cancer. The analysis of international studies aimed to assess the efficacy of surgical treatment for stage IV breast cancer patients was carried out. The role of the current drug therapy as a factor contributing to increase in the overall survival was studied</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>комплексное лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>comprehensive treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Белохвостова А.С., Смирнова И.А., Енилеева А.А. Таргетная терапия в лечении HER2-позитивного рака молочной железы//Сибирский онкологический журнал. 2013. № 2 (56). С. 84-88</mixed-citation><mixed-citation xml:lang="en">Белохвостова А.С., Смирнова И.А., Енилеева А.А. Таргетная терапия в лечении HER2-позитивного рака молочной железы//Сибирский онкологический журнал. 2013. № 2 (56). 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