oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2023-22-1-141-150oncotomsk-2440Research ArticleОБЗОРЫREVIEWSЛечение солидных опухолей ингибиторами контрольных точек на фоне сопутствующей ВИЧ-инфекции: стоит ли рисковать?Immune checkpoint inhibitors for the treatment of solid tumors in HIV-infected patients: is it worth the risk?ДегтярёваЕ. А.DegtiarevaE. A.

Дегтярёва Екатерина Александровна, врач-онколог, аспирант научного отдела инновационных методов терапевтической онкологии и реабилитации

197758, г. Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

SPIN-код: 2273-1260

Ekaterina A. Degtiareva, MD, Oncologist, postgraduate student of the Scientific Department of Innovative Methods of Therapeutic Oncology and Rehabilitation

68, Leningradskaya St., 197758, St. Petersburg, Pesochny

degtyarevaekaterina@mail.ruhttps://orcid.org/0000-0002-5026-0009ПроценкоС. А.ProtsenkoS. A.

Проценко Светлана Анатольевна, доктор медицинских наук, ведущий научный сотрудник, заведующая отделением противоопухолевой лекарственной терапии

197758, г. Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

Svetlana A. Protsenko, MD, DSc, Head of the Department of Anticancer Drug Therapy

68, Leningradskaya St., 197758, St. Petersburg, Pesochny

https://orcid.org/0000-0003-4529-7891ИмянитовЕ. Н.ImyanitovE. N.

Имянитов Евгений Наумович, доктор медицинских наук, профессор, член-корреспондент РАН, руководитель научного отдела

197758, г. Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68

SPIN-код: 1909-7323

Evgeny N. Imyanitov, MD, DSc, Prof., Corresponding Member of the Russian Academy of Sciences, Head of the Department of Tumor Biology

68, Leningradskaya St., 197758, St. Petersburg, Pesochny

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава РоссииРоссияN.N. Petrov National Medical Research Center of Oncology of the Ministry of Health of the RussiaRussian Federation202323022023221141150Copyright © Дегтярёва Е.А., Проценко С.А., Имянитов Е.Н., 20232023Дегтярёва Е.А., Проценко С.А., Имянитов Е.Н.Degtiareva E.A., Protsenko S.A., Imyanitov E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/2440

Цель исследования ‒ представить имеющиеся данные о переносимости ингибиторов контрольных точек (ИКТ) у онкологических пациентов, отягощенных ВИЧ-инфекцией.

Материал и методы

Материал и методы. Проведен поиск литературных источников, опубликованных в базах данных PubMed, Cochrane Library и UpToDate по февраль 2022 г.

Результаты

Результаты. В статье изложены предпосылки и опыт применения ИКТ для лечения злокачественных опухолей у больных с сопутствующей ВИЧ-инфекцией.

Заключение

Заключение. До недавнего времени наличие вирусных заболеваний, в т.ч. ВИЧ-инфекции, являлось одним из ключевых противопоказаний для назначения иммунотерапии. Однако последние научные публикации демонстрируют эффективность и хорошую переносимость ИКТ у онкологических пациентов, отягощенных ВИЧ-инфекцией. Дальнейшие проспективные исследования позволят определить потенциал иммунотерапии в клинической практике у данной категории больных.

Objective

Objective. To present the available data regarding the tolerance of immune checkpoint inhibitors (ICIs) in cancer patients with concurrent HIV.

Material and Methods

Material and Methods. A literature search was conducted in the electronic databases PubMed, Cochrane Library and UpToDate up to February 2022.

Results

Results. The article outlines the background and experience of using ICIs for the treatment of malignant tumors in patients with concomitant HIV infection.

Conclusions

Conclusions. Until recently, the presence of chronic infections, including HIV infection, was one of the key contraindications for prescribing immunotherapy. However, the recent scientific publications demonstrate the efficacy and good tolerability of ICIs in cancer patients with concurrent HIV. Future prospective clinical trials will help to predetermine the potential of immunotherapy in clinical practice in this patients.

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The authors declare that there are no conflicts of interest present.