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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21294/1814-4861-2023-22-3-99-107</article-id><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-2585</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Искусственный интеллект при колоректальном раке: обзор</article-title><trans-title-group xml:lang="en"><trans-title>Artificial intelligence in colorectal cancer: a review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9826-3375</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Singh</surname><given-names>G.</given-names></name><name name-style="western" xml:lang="en"><surname>Singh</surname><given-names>G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Singh Gurjeet - Dr, PhD degree in Computer Science доцент, декан факультета информационных технологий Лордского университета.</p><p>Алвар, Раджастхан</p></bio><bio xml:lang="en"><p>Gurjeet Singh - Dr, PhD degree in Computer Science, Associate Professor, Dean in the department of Lords School of Computer Applications &amp; IT, Lords University.</p><p>Alwar, Rajasthan</p></bio><email xlink:type="simple">research.gurjeet@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Lords University</institution><country>Индия</country></aff><aff xml:lang="en"><institution>Lords University</institution><country>India</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2023</year></pub-date><volume>22</volume><issue>3</issue><fpage>99</fpage><lpage>107</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Singh G., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Singh G.</copyright-holder><copyright-holder xml:lang="en">Singh G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/2585">https://www.siboncoj.ru/jour/article/view/2585</self-uri><abstract><p>Цель исследования - оценка возможностей использования искусственного интеллекта (ИИ) в диагностике, лечении и прогнозировании колоректального рака (КРР), а также обсуждение потенциала ИИ в лечении КРР. Материал и методы. Проведен поиск научных публикаций в поисковых системах Web of Science, Scopus, PubMed, Medline и eLIBRARY. Было просмотрено более 100 источников по применению ИИ для диагностики, лечения и прогнозирования КРР. В обзор включены данные из 83 статей. Результаты. Проведен анализ литературы, посвященной применению искусственного интеллекта в медицине, особое внимание уделено его использованию при колоректальном раке. Обсуждаются этапы развития ИИ при КРР, включая молекулярную верификацию, лучевую диагностику, разработку лекарств и индивидуальное лечение. Подчеркнуты преимущества ИИ в анализе медицинских изображений, таких как КТ, МРТ и ПЭТ, что повышает точность диагностики. Рассматриваются такие проблемы развития ИИ, как стандартизация данных и интерпретируемость алгоритмов машинного обучения. Подчеркивается роль ИИ в выборе оптимальной тактики лечения и повышении эффективности хирургического вмешательства. Учитываются этические и нормативные аспекты ИИ, включая доверие пациентов, безопасность данных и ответственность в проведении операций с использованием ИИ. Обсуждаются преимущества ИИ в диагностике, лечении и прогнозировании колоректального рака, проблемы и перспективы улучшения результатов лечения.</p></abstract><trans-abstract xml:lang="en"><p>The study objective: the study objective is to examine the use of artificial intelligence (AI) in the diagnosis, treatment, and prognosis of Colorectal Cancer (CRC) and discuss the future potential of AI in CRC. Material and Methods. The Web of Science, Scopus, PubMed, Medline, and eLIBRARY databases were used to search for the publications. A study on the application of Artificial Intelligence (AI) to the diagnosis, treatment, and prognosis of Colorectal Cancer (CRC) was discovered in more than 100 sources. In the review, data from 83 articles were incorporated. Results. The review article explores the use of artificial intelligence (AI) in medicine, specifically focusing on its applications in colorectal cancer (CRC). It discusses the stages of AI development for CRC, including molecular understanding, image-based diagnosis, drug design, and individualized treatment. The benefits of AI in medical image analysis are highlighted, improving diagnosis accuracy and inspection quality. Challenges in AI development are addressed, such as data standardization and the interpretability of machine learning algorithms. The potential of AI in treatment decision support, precision medicine, and prognosis prediction is discussed, emphasizing the role of AI in selecting optimal treatments and improving surgical precision. Ethical and regulatory considerations in integrating AI are mentioned, including patient trust, data security, and liability in AI-assisted surgeries. The review emphasizes the importance of an AI standard system, dataset standardization, and integrating clinical knowledge into AI algorithms. Overall, the article provides an overview of the current research on AI in CRC diagnosis, treatment, and prognosis, discussing its benefits, challenges, and future prospects in improving medical outcomes.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>искусственный интеллект</kwd><kwd>глубокое обучение</kwd><kwd>машинное обучение</kwd><kwd>диагаостика</kwd><kwd>лечение</kwd><kwd>колоректальнй рак</kwd></kwd-group><kwd-group xml:lang="en"><kwd>artificial intelligence (AI)</kwd><kwd>deep learning (DL)</kwd><kwd>machine learning (ML)</kwd><kwd>diagnosis</kwd><kwd>treatment</kwd><kwd>CRC</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Acs B., Rantalainen M., Hartman J. Artificial intelligence as the next step towards precision pathology. J Intern Med. 2020; 288(1): 62-81. doi: 10.1111/joim.13030.</mixed-citation><mixed-citation xml:lang="en">Acs B., Rantalainen M., Hartman J. Artificial intelligence as the next step towards precision pathology. J Intern Med. 2020; 288(1): 62-81. doi: 10.1111/joim.13030.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">El Hajjar A., Rey J.F. Artificial intelligence in gastrointestinal endoscopy: general overview. Chin Med J (Engl). 2020; 133(3): 326-34. doi: 10.1097/CM9.0000000000000623.</mixed-citation><mixed-citation xml:lang="en">El Hajjar A., Rey J.F. Artificial intelligence in gastrointestinal endoscopy: general overview. Chin Med J (Engl). 2020; 133(3): 326-34. doi: 10.1097/CM9.0000000000000623.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Min J.K., Kwak M.S., Cha J.M. Overview of Deep Learning in Gastrointestinal Endoscopy. Gut Liver. 2019; 13(4): 388-93. doi: 10.5009/gnl18384.</mixed-citation><mixed-citation xml:lang="en">Min J.K., Kwak M.S., Cha J.M. Overview of Deep Learning in Gastrointestinal Endoscopy. Gut Liver. 2019; 13(4): 388-93. doi: 10.5009/gnl18384.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Onder D., Sarioglu S., Karacali B. Automated labelling of cancer textures in colorectal histopathology slides using quasi-supervised learning. Micron. 2013; 47: 33-42. doi: 10.1016/j.micron.2013.01.003.</mixed-citation><mixed-citation xml:lang="en">Onder D., Sarioglu S., Karacali B. Automated labelling of cancer textures in colorectal histopathology slides using quasi-supervised learning. Micron. 2013; 47: 33-42. doi: 10.1016/j.micron.2013.01.003.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Roadknight C., Aickelin U., Qiu G., Scholefield J., Durrant L. Supervised learning and anti-learning of colorectal cancer classes and survival rates from cellular biology parameters. Proceedings 2012 IEEE international conference on systems, man, and cybernetics. 2012: 797-802. doi: 10.1109/icsmc.2012.6377825.</mixed-citation><mixed-citation xml:lang="en">Roadknight C., Aickelin U., Qiu G., Scholefield J., Durrant L. Supervised learning and anti-learning of colorectal cancer classes and survival rates from cellular biology parameters. Proceedings 2012 IEEE international conference on systems, man, and cybernetics. 2012: 797-802. doi: 10.1109/icsmc.2012.6377825.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chen Y., Carroll R.J., Hinz E.R., Shah A., Eyler A.E., Denny J.C., Xu H. Applying active learning to high-throughput phenotyping algorithms for electronic health records data. J Am Med Inform Assoc. 2013; 20(2): 253-9. doi: 10.1136/amiajnl-2013-001945.</mixed-citation><mixed-citation xml:lang="en">Chen Y., Carroll R.J., Hinz E.R., Shah A., Eyler A.E., Denny J.C., Xu H. Applying active learning to high-throughput phenotyping algorithms for electronic health records data. J Am Med Inform Assoc. 2013; 20(2): 253-9. doi: 10.1136/amiajnl-2013-001945.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Le Berre C., Sandborn W.J., Aridhi S., Devignes M.D., Fournier L., Smail-TabboneM., Danese S., Peyrin-BirouletL. Application of Artificial Intelligence to Gastroenterology and Hepatology. Gastroenterology. 2020; 158(1): 76-94. doi: 10.1053/j.gastro.2019.08.058.</mixed-citation><mixed-citation xml:lang="en">Le Berre C., Sandborn W.J., Aridhi S., Devignes M.D., Fournier L., Smail-TabboneM., Danese S., Peyrin-BirouletL. Application of Artificial Intelligence to Gastroenterology and Hepatology. Gastroenterology. 2020; 158(1): 76-94. doi: 10.1053/j.gastro.2019.08.058.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Jagga Z., Gupta D. Machine learning for biomarker identification in cancer research - developments toward its clinical application. Per Med. 2015; 12(4): 371-87. doi: 10.2217/pme.15.5.</mixed-citation><mixed-citation xml:lang="en">Jagga Z., Gupta D. Machine learning for biomarker identification in cancer research - developments toward its clinical application. Per Med. 2015; 12(4): 371-87. doi: 10.2217/pme.15.5.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Low S.K., Nakamura Y. The road map of cancer precision medicine with the innovation of advanced cancer detection technology and personalized immunotherapy. Jpn J Clin Oncol. 2019; 49(7): 596-603. doi: 10.1093/jjco/hyz073.</mixed-citation><mixed-citation xml:lang="en">Low S.K., Nakamura Y. The road map of cancer precision medicine with the innovation of advanced cancer detection technology and personalized immunotherapy. Jpn J Clin Oncol. 2019; 49(7): 596-603. doi: 10.1093/jjco/hyz073.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Singh G., Nager P. A case Study on Nutek India Limited Regarding Deep Falling in Share Price. Researchers World--Journal of Arts, Science &amp; Commerce. 2012; 3(2): 64-8.</mixed-citation><mixed-citation xml:lang="en">Singh G., Nager P. A case Study on Nutek India Limited Regarding Deep Falling in Share Price. Researchers World--Journal of Arts, Science &amp; Commerce. 2012; 3(2): 64-8.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Nager P., Singh G. An Analysis of Outliers For Fraud Detection in Indian Stock Market. Researchers World--Journal of Arts, Science &amp; Commerce. 2012; 3(4): 10-5.</mixed-citation><mixed-citation xml:lang="en">Nager P., Singh G. An Analysis of Outliers For Fraud Detection in Indian Stock Market. Researchers World--Journal of Arts, Science &amp; Commerce. 2012; 3(4): 10-5.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Nagar P., Issar G.S. Detection of outliers in stock market using regression analysis. 2021. doi: 10.5281/zenodo.6047417.</mixed-citation><mixed-citation xml:lang="en">Nagar P., Issar G.S. Detection of outliers in stock market using regression analysis. 2021. doi: 10.5281/zenodo.6047417.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Singh G. Machine Learning Models in Stock Market Prediction. arXiv e-prints, arXiv-2202. 2022.</mixed-citation><mixed-citation xml:lang="en">Singh G. Machine Learning Models in Stock Market Prediction. arXiv e-prints, arXiv-2202. 2022.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Shi M., Zhang B. Semi-supervised learning improves gene expression-based prediction of cancer recurrence. Bioinformatics. 2011; 27(21): 3017-23. doi: 10.1093/bioinformatics/btr502.</mixed-citation><mixed-citation xml:lang="en">Shi M., Zhang B. Semi-supervised learning improves gene expression-based prediction of cancer recurrence. Bioinformatics. 2011; 27(21): 3017-23. doi: 10.1093/bioinformatics/btr502.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Gulati S., Patel M., Emmanuel A., Haji A., Hayee B., Neumann H. The future of endoscopy: Advances in endoscopic image innovations. Dig Endosc. 2020; 32(4): 512-22. doi: 10.1111/den.13481.</mixed-citation><mixed-citation xml:lang="en">Gulati S., Patel M., Emmanuel A., Haji A., Hayee B., Neumann H. The future of endoscopy: Advances in endoscopic image innovations. Dig Endosc. 2020; 32(4): 512-22. doi: 10.1111/den.13481.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Wang P., Berzin T.M., Glissen Brown J.R., Bharadwaj S., Becq A., Xiao X., Liu P., Li L., Song Y., Zhang D., Li Y., Xu G., Tu M., Liu X. Real-time automatic detection system increases colonoscopic polyp and adenoma detection rates: a prospective randomised controlled study. Gut. 2019; 68(10): 1813-9. doi: 10.1136/gutjnl-2018-317500.</mixed-citation><mixed-citation xml:lang="en">Wang P., Berzin T.M., Glissen Brown J.R., Bharadwaj S., Becq A., Xiao X., Liu P., Li L., Song Y., Zhang D., Li Y., Xu G., Tu M., Liu X. Real-time automatic detection system increases colonoscopic polyp and adenoma detection rates: a prospective randomised controlled study. Gut. 2019; 68(10): 1813-9. doi: 10.1136/gutjnl-2018-317500.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kang J., Gwak J. Ensemble of instance segmentation models for polyp segmentation in colonoscopy images. IEEE Access. 2019. 7: 26440-7. doi: 10.1109/access.2019.2900672.</mixed-citation><mixed-citation xml:lang="en">Kang J., Gwak J. Ensemble of instance segmentation models for polyp segmentation in colonoscopy images. IEEE Access. 2019. 7: 26440-7. doi: 10.1109/access.2019.2900672.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Eisner R., Greiner R., Tso V., Wang H., Fedorak R.N. A machine-learned predictor of colonic polyps based on urinary metabolomics. Biomed Res Int. 2013. doi: 10.1155/2013/303982.</mixed-citation><mixed-citation xml:lang="en">Eisner R., Greiner R., Tso V., Wang H., Fedorak R.N. A machine-learned predictor of colonic polyps based on urinary metabolomics. Biomed Res Int. 2013. doi: 10.1155/2013/303982.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Köküer M., Naguib R.N., Jancovic P, Younghusband H.B., Green R.C. Cancer risk analysis in families with hereditary nonpolyposis colorectal cancer. IEEE Trans Inf Technol Biomed. 2006; 10(3): 581-7. doi: 10.1109/titb.2006.872054.</mixed-citation><mixed-citation xml:lang="en">Köküer M., Naguib R.N., Jancovic P, Younghusband H.B., Green R.C. Cancer risk analysis in families with hereditary nonpolyposis colorectal cancer. IEEE Trans Inf Technol Biomed. 2006; 10(3): 581-7. doi: 10.1109/titb.2006.872054.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Bell C.S., Puerto G.A., Mariottini G.L., Valdastri P. Six DOF motion estimation for teleoperated flexible endoscopes using optical flow: A comparative study. 2014 IEEE international conference on robotics and automation (ICRA). 2014: 5386-92. doi: 10.1109/icra.2014.6907651.</mixed-citation><mixed-citation xml:lang="en">Bell C.S., Puerto G.A., Mariottini G.L., Valdastri P. Six DOF motion estimation for teleoperated flexible endoscopes using optical flow: A comparative study. 2014 IEEE international conference on robotics and automation (ICRA). 2014: 5386-92. doi: 10.1109/icra.2014.6907651.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Z., Wang S., Dong D., Wei J., Fang C., Zhou X., Sun K., Li L., Li B., Wang M., Tian J. The Applications of Radiomics in Precision Diagnosis and Treatment of Oncology: Opportunities and Challenges. Theranostics. 2019; 9(5): 1303-22. doi: 10.7150/thno.30309.</mixed-citation><mixed-citation xml:lang="en">Liu Z., Wang S., Dong D., Wei J., Fang C., Zhou X., Sun K., Li L., Li B., Wang M., Tian J. The Applications of Radiomics in Precision Diagnosis and Treatment of Oncology: Opportunities and Challenges. Theranostics. 2019; 9(5): 1303-22. doi: 10.7150/thno.30309.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Yang T., Liang N., Li J., Yang Y., Li Y., Huang Q., Li R., He X., Zhang H. Intelligent imaging technology in diagnosis of colorectal cancer using deep learning. IEEE Access 2019; 7: 178839-47. doi: 10.1109/access.2019.2958124.</mixed-citation><mixed-citation xml:lang="en">Yang T., Liang N., Li J., Yang Y., Li Y., Huang Q., Li R., He X., Zhang H. Intelligent imaging technology in diagnosis of colorectal cancer using deep learning. IEEE Access 2019; 7: 178839-47. doi: 10.1109/access.2019.2958124.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Dalca A., Danagoulian G., Kikinis R., Schmidt E., Golland P. Sparse classification for computer aided diagnosis using learned dictionaries. Medical Image Computing and Computer-Assisted Intervention. 2011; 537-45.</mixed-citation><mixed-citation xml:lang="en">Dalca A., Danagoulian G., Kikinis R., Schmidt E., Golland P. Sparse classification for computer aided diagnosis using learned dictionaries. Medical Image Computing and Computer-Assisted Intervention. 2011; 537-45.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Regge D., Halligan S. CAD: how it works, how to use it, performance. Eur J Radiol. 2013; 82(8): 1171-6. doi: 10.1016/j.ejrad.2012.04.022.</mixed-citation><mixed-citation xml:lang="en">Regge D., Halligan S. CAD: how it works, how to use it, performance. Eur J Radiol. 2013; 82(8): 1171-6. doi: 10.1016/j.ejrad.2012.04.022.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Summers R.M., Handwerker L.R., Pickhardt P.J., Van Uitert R.L., Deshpande K.K., Yeshwant S., Yao J., Franaszek M. Performance of a previously validated CT colonography computer-aided detection system in a new patient population. AJR Am J Roentgenol. 2008; 191(1): 168-74. doi: 10.2214/AJR.07.3354.</mixed-citation><mixed-citation xml:lang="en">Summers R.M., Handwerker L.R., Pickhardt P.J., Van Uitert R.L., Deshpande K.K., Yeshwant S., Yao J., Franaszek M. Performance of a previously validated CT colonography computer-aided detection system in a new patient population. AJR Am J Roentgenol. 2008; 191(1): 168-74. doi: 10.2214/AJR.07.3354.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Chowdhury T.A., Whelan P.F., Ghita O. A fully automatic CAD-CTC system based on curvature analysis for standard and low-dose CT data. IEEE Trans Biomed Eng. 2008; 55(3): 888-901. doi: 10.1109/TBME.2007.909506.</mixed-citation><mixed-citation xml:lang="en">Chowdhury T.A., Whelan P.F., Ghita O. A fully automatic CAD-CTC system based on curvature analysis for standard and low-dose CT data. IEEE Trans Biomed Eng. 2008; 55(3): 888-901. doi: 10.1109/TBME.2007.909506.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Nappi J.J., Hironaka T., Yoshida H. Detection of colorectal masses in CT colonography: Application of deep residual networks for differentiating masses from normal colon anatomy. Medical imaging 2018: Computer-aided diagnosis. Bellingham: Spie-Int Soc Optical Engineering. doi: 10.1117/12.2293848.</mixed-citation><mixed-citation xml:lang="en">Nappi J.J., Hironaka T., Yoshida H. Detection of colorectal masses in CT colonography: Application of deep residual networks for differentiating masses from normal colon anatomy. Medical imaging 2018: Computer-aided diagnosis. Bellingham: Spie-Int Soc Optical Engineering. doi: 10.1117/12.2293848.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor S.A., Iinuma G., Saito Y., Zhang J., Halligan S. CT colonography: computer-aided detection of morphologically flat T1 colonic carcinoma. Eur Radiol. 2008; 18(8): 1666-73. doi: 10.1007/s00330-008-0936-7.</mixed-citation><mixed-citation xml:lang="en">Taylor S.A., Iinuma G., Saito Y., Zhang J., Halligan S. CT colonography: computer-aided detection of morphologically flat T1 colonic carcinoma. Eur Radiol. 2008; 18(8): 1666-73. doi: 10.1007/s00330-008-0936-7.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Summers R.M. Current concepts in computer-aided detection for CT colonography. 2010 7th IEEE international symposium on biomedical imaging: From nano to macro. 2010: 269-72. doi: 10.1109/isbi.2010.5490363.</mixed-citation><mixed-citation xml:lang="en">Summers R.M. Current concepts in computer-aided detection for CT colonography. 2010 7th IEEE international symposium on biomedical imaging: From nano to macro. 2010: 269-72. doi: 10.1109/isbi.2010.5490363.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Lee J.G., Hyo Kim J., Hyung Kim S., Sun Park H., Ihn Choi B. A straightforward approach to computer-aided polyp detection using a polypspecific volumetric feature in CT colonography. Comput Biol Med. 2011; 41(9): 790-801. doi: 10.1016/j.compbiomed.2011.06.015.</mixed-citation><mixed-citation xml:lang="en">Lee J.G., Hyo Kim J., Hyung Kim S., Sun Park H., Ihn Choi B. A straightforward approach to computer-aided polyp detection using a polypspecific volumetric feature in CT colonography. Comput Biol Med. 2011; 41(9): 790-801. doi: 10.1016/j.compbiomed.2011.06.015.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Nappi J.J., Hironaka T., Regge D., Yoshida H. Deep transfer learning of virtual endoluminal views for the detection of polyps in CT colonography. Medical imaging 2016: Computer-aided diagnosis. Bellingham: Spie-Int Soc Optical Engineering, 2015. doi: 10.1117/12.2217260.</mixed-citation><mixed-citation xml:lang="en">Nappi J.J., Hironaka T., Regge D., Yoshida H. Deep transfer learning of virtual endoluminal views for the detection of polyps in CT colonography. Medical imaging 2016: Computer-aided diagnosis. Bellingham: Spie-Int Soc Optical Engineering, 2015. doi: 10.1117/12.2217260.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Näppi J., Frimmel H., Yoshida H. Virtual endoscopic visualization of the colon by shape-scale signatures. IEEE Trans Inf Technol Biomed. 2005; 9(1): 120-31. doi: 10.1109/titb.2004.837834.</mixed-citation><mixed-citation xml:lang="en">Näppi J., Frimmel H., Yoshida H. Virtual endoscopic visualization of the colon by shape-scale signatures. IEEE Trans Inf Technol Biomed. 2005; 9(1): 120-31. doi: 10.1109/titb.2004.837834.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">van Wijk C., van Ravesteijn V.F., Vos F.M., van Vliet L.J. Detection and segmentation of colonic polyps on implicit isosurfaces by second principal curvature flow. IEEE Trans Med Imaging. 2010; 29(3): 688-98. doi: 10.1109/TMI.2009.2031323.</mixed-citation><mixed-citation xml:lang="en">van Wijk C., van Ravesteijn V.F., Vos F.M., van Vliet L.J. Detection and segmentation of colonic polyps on implicit isosurfaces by second principal curvature flow. IEEE Trans Med Imaging. 2010; 29(3): 688-98. doi: 10.1109/TMI.2009.2031323.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Kim S.H., Lee J.M., Lee J.G., Kim J.H., Lefere P.A., Han J.K., Choi B.I. Computer-aided detection of colonic polyps at CT colonography using a Hessian matrix-based algorithm: preliminary study. AJR Am J Roentgenol. 2007; 189(1): 41-51. doi: 10.2214/AJR.07.2072.</mixed-citation><mixed-citation xml:lang="en">Kim S.H., Lee J.M., Lee J.G., Kim J.H., Lefere P.A., Han J.K., Choi B.I. Computer-aided detection of colonic polyps at CT colonography using a Hessian matrix-based algorithm: preliminary study. AJR Am J Roentgenol. 2007; 189(1): 41-51. doi: 10.2214/AJR.07.2072.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Nappi J.J., Pickhardt P., Kim D.H., Hironaka T., Yoshida H. Deep learning of contrast-coated serrated polyps for computer-aided detection in CT colonography. Medical imaging 2017: Computer-aided diagnosis. 2017. doi: 10.1117/12.2255634.</mixed-citation><mixed-citation xml:lang="en">Nappi J.J., Pickhardt P., Kim D.H., Hironaka T., Yoshida H. Deep learning of contrast-coated serrated polyps for computer-aided detection in CT colonography. Medical imaging 2017: Computer-aided diagnosis. 2017. doi: 10.1117/12.2255634.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Ma J., Dercle L., Lichtenstein P., Wang D., Chen A., Zhu J., Piessevaux H., Zhao J., Schwartz L.H., Lu L., Zhao B. Automated Identification of Optimal Portal Venous Phase Timing with Convolutional Neural Networks. Acad Radiol. 2020; 27(2): 10-18. doi: 10.1016/j.acra.2019.02.024.</mixed-citation><mixed-citation xml:lang="en">Ma J., Dercle L., Lichtenstein P., Wang D., Chen A., Zhu J., Piessevaux H., Zhao J., Schwartz L.H., Lu L., Zhao B. Automated Identification of Optimal Portal Venous Phase Timing with Convolutional Neural Networks. Acad Radiol. 2020; 27(2): 10-18. doi: 10.1016/j.acra.2019.02.024.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Soomro M.H., De Cola G., Conforto S., Schmid M., Giunta G., Guidi E., Neri E., Caruso D., Ciolina M., Laghi A. Automatic segmentation of colorectal cancer in 3D MRI by combining deep learning and 3D level-set algorithm-a preliminary study. 2018 IEEE 4th middle east conference on biomedical engineering. 2018; 198-203. doi: 10.1109/mecbme.2018.8402433.</mixed-citation><mixed-citation xml:lang="en">Soomro M.H., De Cola G., Conforto S., Schmid M., Giunta G., Guidi E., Neri E., Caruso D., Ciolina M., Laghi A. Automatic segmentation of colorectal cancer in 3D MRI by combining deep learning and 3D level-set algorithm-a preliminary study. 2018 IEEE 4th middle east conference on biomedical engineering. 2018; 198-203. doi: 10.1109/mecbme.2018.8402433.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Soomro M.H., Coppotelli M., Conforto S., Schmid M., Giunta G., Del Secco L., Neri E., Caruso D., Rengo M., Laghi A. Automated Segmentation of Colorectal Tumor in 3D MRI Using 3D Multiscale Densely Connected Convolutional Neural Network. J Healthc Eng. 2019. doi: 10.1155/2019/1075434.</mixed-citation><mixed-citation xml:lang="en">Soomro M.H., Coppotelli M., Conforto S., Schmid M., Giunta G., Del Secco L., Neri E., Caruso D., Rengo M., Laghi A. Automated Segmentation of Colorectal Tumor in 3D MRI Using 3D Multiscale Densely Connected Convolutional Neural Network. J Healthc Eng. 2019. doi: 10.1155/2019/1075434.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Wang D., Xu J., Zhang Z., Li S., Zhang X., Zhou Y., Zhang X., Lu Y. Evaluation of Rectal Cancer Circumferential Resection Margin Using Faster Region-Based Convolutional Neural Network in High-Resolution Magnetic Resonance Images. Dis Colon Rectum. 2020; 63(2): 143-51. doi: 10.1097/DCR.0000000000001519.</mixed-citation><mixed-citation xml:lang="en">Wang D., Xu J., Zhang Z., Li S., Zhang X., Zhou Y., Zhang X., Lu Y. Evaluation of Rectal Cancer Circumferential Resection Margin Using Faster Region-Based Convolutional Neural Network in High-Resolution Magnetic Resonance Images. Dis Colon Rectum. 2020; 63(2): 143-51. doi: 10.1097/DCR.0000000000001519.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Q.Y., Liu S.L., Sun P., Li Y., Liu G.W., Liu S.S., Hu J.L., Niu T.Y., Lu Y. Establishment and clinical application value of an automatic diagnosis platform for rectal cancer T-staging based on a deep neural network. Chin Med J (Engl). 2021; 134(7): 821-8. doi: 10.1097/CM9.0000000000001401.</mixed-citation><mixed-citation xml:lang="en">Wu Q.Y., Liu S.L., Sun P., Li Y., Liu G.W., Liu S.S., Hu J.L., Niu T.Y., Lu Y. Establishment and clinical application value of an automatic diagnosis platform for rectal cancer T-staging based on a deep neural network. Chin Med J (Engl). 2021; 134(7): 821-8. doi: 10.1097/CM9.0000000000001401.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Joshi N., Bond S., Brady M. The segmentation of colorectal MRI images. Med Image Anal. 2010; 14(4): 494-509. doi: 10.1016/j.media.2010.03.002.</mixed-citation><mixed-citation xml:lang="en">Joshi N., Bond S., Brady M. The segmentation of colorectal MRI images. Med Image Anal. 2010; 14(4): 494-509. doi: 10.1016/j.media.2010.03.002.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Dabass M., Vashisth S., Vig R. Review of classification techniques using deep learning for colorectal cancer imaging modalities. 2019 6th International Conference on Signal Processing and Integrated Networks. 2019; 105-10. doi: 10.1109/spin.2019.8711776.</mixed-citation><mixed-citation xml:lang="en">Dabass M., Vashisth S., Vig R. Review of classification techniques using deep learning for colorectal cancer imaging modalities. 2019 6th International Conference on Signal Processing and Integrated Networks. 2019; 105-10. doi: 10.1109/spin.2019.8711776.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Shiraishi T., Shinto E., Nearchou I.P., Tsuda H., Kajiwara Y., Einama T., Caie P.D., Kishi Y., Ueno H. Prognostic significance of mesothelin expression in colorectal cancer disclosed by area-specific four-point tissue microarrays. Virchows Arch. 2020; 477(3): 409-20. doi: 10.1007/s00428-020-02775-y.</mixed-citation><mixed-citation xml:lang="en">Shiraishi T., Shinto E., Nearchou I.P., Tsuda H., Kajiwara Y., Einama T., Caie P.D., Kishi Y., Ueno H. Prognostic significance of mesothelin expression in colorectal cancer disclosed by area-specific four-point tissue microarrays. Virchows Arch. 2020; 477(3): 409-20. doi: 10.1007/s00428-020-02775-y.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Pham T.D. Scaling of texture in training autoencoders for classification of histological images of colorectal cancer. Advances in neural networks. 2017; 524-32. doi: 10.1007/978-3-319-59081-3_61.</mixed-citation><mixed-citation xml:lang="en">Pham T.D. Scaling of texture in training autoencoders for classification of histological images of colorectal cancer. Advances in neural networks. 2017; 524-32. doi: 10.1007/978-3-319-59081-3_61.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Tiwari S. An analysis in tissue classification for colorectal cancer histology using convolution neural network and colour models. IJISMD. 2018; 9: 1-19. doi: 10.4018/ijismd.2018100101.</mixed-citation><mixed-citation xml:lang="en">Tiwari S. An analysis in tissue classification for colorectal cancer histology using convolution neural network and colour models. IJISMD. 2018; 9: 1-19. doi: 10.4018/ijismd.2018100101.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Sirinukunwattana K., Ahmed Raza S.E., Tsang Y.W., Snead D.R., Cree I.A., Rajpoot N.M. Locality Sensitive Deep Learning for Detection and Classification of Nuclei in Routine Colon Cancer Histology Images. IEEE Trans Med Imaging. 2016; 35(5): 1196-206. doi: 10.1109/TMI.2016.2525803.</mixed-citation><mixed-citation xml:lang="en">Sirinukunwattana K., Ahmed Raza S.E., Tsang Y.W., Snead D.R., Cree I.A., Rajpoot N.M. Locality Sensitive Deep Learning for Detection and Classification of Nuclei in Routine Colon Cancer Histology Images. IEEE Trans Med Imaging. 2016; 35(5): 1196-206. doi: 10.1109/TMI.2016.2525803.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Koohababni N.A., Jahanifar M., Gooya A., Rajpoot N. Nuclei detection using mixture density networks. Machine learning in medical imaging. 2018; 241-8. doi: 10.1007/978-3-030-00919-9_28.</mixed-citation><mixed-citation xml:lang="en">Koohababni N.A., Jahanifar M., Gooya A., Rajpoot N. Nuclei detection using mixture density networks. Machine learning in medical imaging. 2018; 241-8. doi: 10.1007/978-3-030-00919-9_28.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang X., Chen G., Saruta K., Terata Y. An end-to-end cells detection approach for colon cancer histology images. 10th international conference on digital image processing. 2018. doi: 10.1117/12.2503067.</mixed-citation><mixed-citation xml:lang="en">Zhang X., Chen G., Saruta K., Terata Y. An end-to-end cells detection approach for colon cancer histology images. 10th international conference on digital image processing. 2018. doi: 10.1117/12.2503067.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Xu J., Luo X., Wang G., Gilmore H., Madabhushi A. A Deep Convolutional Neural Network for segmenting and classifying epithelial and stromal regions in histopathological images. Neurocomputing. 2016; 191: 214-23. doi: 10.1016/j.neucom.2016.01.034.</mixed-citation><mixed-citation xml:lang="en">Xu J., Luo X., Wang G., Gilmore H., Madabhushi A. A Deep Convolutional Neural Network for segmenting and classifying epithelial and stromal regions in histopathological images. Neurocomputing. 2016; 191: 214-23. doi: 10.1016/j.neucom.2016.01.034.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Chen H., Qi X., Yu L., Dou Q., Qin J., Heng P.A. DCAN: Deep contour-aware networks for object instance segmentation from histology images. Med Image Anal. 2017; 36: 135-46. doi: 10.1016/j.media.2016.11.004.</mixed-citation><mixed-citation xml:lang="en">Chen H., Qi X., Yu L., Dou Q., Qin J., Heng P.A. DCAN: Deep contour-aware networks for object instance segmentation from histology images. Med Image Anal. 2017; 36: 135-46. doi: 10.1016/j.media.2016.11.004.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshida H., Yamashita Y., Shimazu T., Cosatto E., Kiyuna T., Taniguchi H., Sekine S., Ochiai A. Automated histological classification of whole slide images of colorectal biopsy specimens. Oncotarget. 2017; 8(53): 90719-29. doi: 10.18632/oncotarget.21819.</mixed-citation><mixed-citation xml:lang="en">Yoshida H., Yamashita Y., Shimazu T., Cosatto E., Kiyuna T., Taniguchi H., Sekine S., Ochiai A. Automated histological classification of whole slide images of colorectal biopsy specimens. Oncotarget. 2017; 8(53): 90719-29. doi: 10.18632/oncotarget.21819.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Saito A., Cosatto E., Kiyuna T., Sakamoto M. Dawn of the digital diagnosis assisting system, can it open a new age for pathology? Medical imaging. Digital pathology. 2013. doi: 10.1117/12.2008967.</mixed-citation><mixed-citation xml:lang="en">Saito A., Cosatto E., Kiyuna T., Sakamoto M. Dawn of the digital diagnosis assisting system, can it open a new age for pathology? Medical imaging. Digital pathology. 2013. doi: 10.1117/12.2008967.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Jin Y., Zhou C., Teng X., Ji J., Wu H., Liao J. Pai-wsit: An AI service platform with support for storing and sharing whole-slide images with metadata and annotations. IEEE Access. 2019; 7: 54780-6. doi: 10.1109/access.2019.2913255.</mixed-citation><mixed-citation xml:lang="en">Jin Y., Zhou C., Teng X., Ji J., Wu H., Liao J. Pai-wsit: An AI service platform with support for storing and sharing whole-slide images with metadata and annotations. IEEE Access. 2019; 7: 54780-6. doi: 10.1109/access.2019.2913255.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Qaiser T., Tsang Y.W., Taniyama D., Sakamoto N., Nakane K., Epstein D., Rajpoot N. Fast and accurate tumor segmentation of histology images using persistent homology and deep convolutional features. Med Image Anal. 2019; 55: 1-14. doi: 10.1016/j.media.2019.03.014.</mixed-citation><mixed-citation xml:lang="en">Qaiser T., Tsang Y.W., Taniyama D., Sakamoto N., Nakane K., Epstein D., Rajpoot N. Fast and accurate tumor segmentation of histology images using persistent homology and deep convolutional features. Med Image Anal. 2019; 55: 1-14. doi: 10.1016/j.media.2019.03.014.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Chao W.L., Manickavasagan H., Krishna S.G. Application of Artificial Intelligence in the Detection and Differentiation of Colon Polyps: A Technical Review for Physicians. Diagnostics (Basel). 2019; 9(3): 99. doi: 10.3390/diagnostics9030099.</mixed-citation><mixed-citation xml:lang="en">Chao W.L., Manickavasagan H., Krishna S.G. Application of Artificial Intelligence in the Detection and Differentiation of Colon Polyps: A Technical Review for Physicians. Diagnostics (Basel). 2019; 9(3): 99. doi: 10.3390/diagnostics9030099.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou J., Wu L., Wan X., Shen L., Liu J., Zhang J., Jiang X., Wang Z., Yu S., Kang J., Li M., Hu S., Hu X., Gong D., Chen D., Yao L., Zhu Y., Yu H. A novel artificial intelligence system for the assessment of bowel preparation (with video). Gastrointest Endosc. 2020; 91(2): 428-35. doi: 10.1016/j.gie.2019.11.026.</mixed-citation><mixed-citation xml:lang="en">Zhou J., Wu L., Wan X., Shen L., Liu J., Zhang J., Jiang X., Wang Z., Yu S., Kang J., Li M., Hu S., Hu X., Gong D., Chen D., Yao L., Zhu Y., Yu H. A novel artificial intelligence system for the assessment of bowel preparation (with video). Gastrointest Endosc. 2020; 91(2): 428-35. doi: 10.1016/j.gie.2019.11.026.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">de Almeida Thomaz V., Sierra-Franco C.A., Raposo A.B. Training data enhancements for robust polyp segmentation in colonoscopy images. 2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS). 2019; 192-7. doi: 10.1109/cbms.2019.00047.</mixed-citation><mixed-citation xml:lang="en">de Almeida Thomaz V., Sierra-Franco C.A., Raposo A.B. Training data enhancements for robust polyp segmentation in colonoscopy images. 2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS). 2019; 192-7. doi: 10.1109/cbms.2019.00047.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Azer S.A. Challenges Facing the Detection of Colonic Polyps: What Can Deep Learning Do? Medicina (Kaunas). 2019; 55(8): 473. doi: 10.3390/medicina55080473.</mixed-citation><mixed-citation xml:lang="en">Azer S.A. Challenges Facing the Detection of Colonic Polyps: What Can Deep Learning Do? Medicina (Kaunas). 2019; 55(8): 473. doi: 10.3390/medicina55080473.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Taha B., Dias J., Werghi N. Convolutional neural network as a feature extractor for automatic polyp detection. 2017 24th IEEE international conference on image processing. 2017; 2060-4. doi: 10.1109/icip.2017.8296644.</mixed-citation><mixed-citation xml:lang="en">Taha B., Dias J., Werghi N. Convolutional neural network as a feature extractor for automatic polyp detection. 2017 24th IEEE international conference on image processing. 2017; 2060-4. doi: 10.1109/icip.2017.8296644.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Yao H., Stidham R.W., Soroushmehr R., Gryak J., Najarian K. Automated Detection of Non-Informative Frames for Colonoscopy Through a Combination of Deep Learning and Feature Extraction. Annu Int Conf IEEE Eng Med Biol Soc. 2019; 2402-6. doi: 10.1109/EMBC.2019.8856625.</mixed-citation><mixed-citation xml:lang="en">Yao H., Stidham R.W., Soroushmehr R., Gryak J., Najarian K. Automated Detection of Non-Informative Frames for Colonoscopy Through a Combination of Deep Learning and Feature Extraction. Annu Int Conf IEEE Eng Med Biol Soc. 2019; 2402-6. doi: 10.1109/EMBC.2019.8856625.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">McNeil M.B., Gross S.A. Siri here, cecum reached, but please wash that fold: Will artificial intelligence improve gastroenterology? Gastrointest Endosc. 2020; 91(2): 425-7. doi: 10.1016/j.gie.2019.10.027. Erratum in: Gastrointest Endosc. 2021; 93(2): 538.</mixed-citation><mixed-citation xml:lang="en">McNeil M.B., Gross S.A. Siri here, cecum reached, but please wash that fold: Will artificial intelligence improve gastroenterology? Gastrointest Endosc. 2020; 91(2): 425-7. doi: 10.1016/j.gie.2019.10.027. Erratum in: Gastrointest Endosc. 2021; 93(2): 538.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Bravo D., Ruano J., Gomez M., Romero E. Automatic detection of colorectal polyps larger than 5 mm during colonoscopy procedures using visual descriptors. 14th international symposium on medical information processing and analysis. 2018. doi: 10.1117/12.2511577.</mixed-citation><mixed-citation xml:lang="en">Bravo D., Ruano J., Gomez M., Romero E. Automatic detection of colorectal polyps larger than 5 mm during colonoscopy procedures using visual descriptors. 14th international symposium on medical information processing and analysis. 2018. doi: 10.1117/12.2511577.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">de Lange T., Halvorsen P., Riegler M. Methodology to develop machine learning algorithms to improve performance in gastrointestinal endoscopy. World J Gastroenterol. 2018; 24(45): 5057-62. doi: 10.3748/wjg.v24.i45.5057.</mixed-citation><mixed-citation xml:lang="en">de Lange T., Halvorsen P., Riegler M. Methodology to develop machine learning algorithms to improve performance in gastrointestinal endoscopy. World J Gastroenterol. 2018; 24(45): 5057-62. doi: 10.3748/wjg.v24.i45.5057.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Mahmood F., Durr N.J. Deep learning-based depth estimation from a synthetic endoscopy image training set. Medical imaging 2018: Image processing. Bellingham: Spie-Int Soc Optical Engineering. 2018. doi: 10.1117/12.2293785.</mixed-citation><mixed-citation xml:lang="en">Mahmood F., Durr N.J. Deep learning-based depth estimation from a synthetic endoscopy image training set. Medical imaging 2018: Image processing. Bellingham: Spie-Int Soc Optical Engineering. 2018. doi: 10.1117/12.2293785.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Mo X., Tao K., Wang Q., Wang G. An efficient approach for polyps detection in endoscopic videos based on faster R-CNN. 2018 24th international conference on pattern recognition. 2018; 3929-34. doi: 10.1109/icpr.2018.8545174.</mixed-citation><mixed-citation xml:lang="en">Mo X., Tao K., Wang Q., Wang G. An efficient approach for polyps detection in endoscopic videos based on faster R-CNN. 2018 24th international conference on pattern recognition. 2018; 3929-34. doi: 10.1109/icpr.2018.8545174.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Zhu H., Fan Y., Lu H., Liang Z. Improving initial polyp candidate extraction for CT colonography. Phys Med Biol. 2010; 55(7): 2087-102. doi: 10.1088/0031-9155/55/7/019.</mixed-citation><mixed-citation xml:lang="en">Zhu H., Fan Y., Lu H., Liang Z. Improving initial polyp candidate extraction for CT colonography. Phys Med Biol. 2010; 55(7): 2087-102. doi: 10.1088/0031-9155/55/7/019.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Komeda Y., Handa H., Watanabe T., Nomura T., Kitahashi M., Sakurai T., Okamoto A., Minami T., Kono M., Arizumi T., Takenaka M., Hagiwara S., Matsui S., Nishida N., Kashida H., Kudo M. Computer-Aided Diagnosis Based on Convolutional Neural Network System for Colorectal Polyp Classification: Preliminary Experience. Oncology. 2017; 93s1: 30-4. doi: 10.1159/000481227.</mixed-citation><mixed-citation xml:lang="en">Komeda Y., Handa H., Watanabe T., Nomura T., Kitahashi M., Sakurai T., Okamoto A., Minami T., Kono M., Arizumi T., Takenaka M., Hagiwara S., Matsui S., Nishida N., Kashida H., Kudo M. Computer-Aided Diagnosis Based on Convolutional Neural Network System for Colorectal Polyp Classification: Preliminary Experience. Oncology. 2017; 93s1: 30-4. doi: 10.1159/000481227.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang R., Zheng Y., Poon C.C.Y., Shen D., Lau J.Y.W. Polyp detection during colonoscopy using a regression-based convolutional neural network with a tracker. Pattern Recognit. 2018; 83: 209-19. doi: 10.1016/j.patcog.2018.05.026.</mixed-citation><mixed-citation xml:lang="en">Zhang R., Zheng Y., Poon C.C.Y., Shen D., Lau J.Y.W. Polyp detection during colonoscopy using a regression-based convolutional neural network with a tracker. Pattern Recognit. 2018; 83: 209-19. doi: 10.1016/j.patcog.2018.05.026.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Zhu X., Nemoto D., Mizuno T., Nakajima Y., Utano K., Aizawa M., Takezawa T., Sagara Y., Hayashi Y., Katsuki S., Yamamoto H., Hewett D.G., Togashi K. Identification of deeply invasive colorectal cancer on nonmagnified endoscopic images using artificial intelligence. Gastrointest Endosc. 2019.</mixed-citation><mixed-citation xml:lang="en">Zhu X., Nemoto D., Mizuno T., Nakajima Y., Utano K., Aizawa M., Takezawa T., Sagara Y., Hayashi Y., Katsuki S., Yamamoto H., Hewett D.G., Togashi K. Identification of deeply invasive colorectal cancer on nonmagnified endoscopic images using artificial intelligence. Gastrointest Endosc. 2019.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Akbari M., Mohrekesh M., Nasr-Esfahani E., Soroushmehr S.M.R., Karimi N., Samavi S., Najarian K. Polyp Segmentation in Colonoscopy Images Using Fully Convolutional Network. Annu Int Conf IEEE Eng Med Biol Soc. 2018; 69-72. doi: 10.1109/EMBC.2018.8512197.</mixed-citation><mixed-citation xml:lang="en">Akbari M., Mohrekesh M., Nasr-Esfahani E., Soroushmehr S.M.R., Karimi N., Samavi S., Najarian K. Polyp Segmentation in Colonoscopy Images Using Fully Convolutional Network. Annu Int Conf IEEE Eng Med Biol Soc. 2018; 69-72. doi: 10.1109/EMBC.2018.8512197.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Yu L., Chen H., Dou Q., Qin J., Heng P.A. Integrating Online and Offline Three-Dimensional Deep Learning for Automated Polyp Detection in Colonoscopy Videos. IEEE J Biomed Health Inform. 2017; 21(1): 65-75. doi: 10.1109/JBHI.2016.2637004.</mixed-citation><mixed-citation xml:lang="en">Yu L., Chen H., Dou Q., Qin J., Heng P.A. Integrating Online and Offline Three-Dimensional Deep Learning for Automated Polyp Detection in Colonoscopy Videos. IEEE J Biomed Health Inform. 2017; 21(1): 65-75. doi: 10.1109/JBHI.2016.2637004.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada M., Saito Y., Imaoka H., Saiko M., Yamada S., Kondo H., Takamaru H., Sakamoto T., Sese J., Kuchiba A., Shibata T., Hamamoto R. Development of a real-time endoscopic image diagnosis support system using deep learning technology in colonoscopy. Sci Rep. 2019; 9(1): 14465. doi: 10.1038/s41598-019-50567-5.</mixed-citation><mixed-citation xml:lang="en">Yamada M., Saito Y., Imaoka H., Saiko M., Yamada S., Kondo H., Takamaru H., Sakamoto T., Sese J., Kuchiba A., Shibata T., Hamamoto R. Development of a real-time endoscopic image diagnosis support system using deep learning technology in colonoscopy. Sci Rep. 2019; 9(1): 14465. doi: 10.1038/s41598-019-50567-5.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Allescher H.D., Weingart V. Optimizing Screening Colonoscopy: Strategies and Alternatives. Visc Med. 2019; 35(4): 215-25. doi: 10.1159/000501835.</mixed-citation><mixed-citation xml:lang="en">Allescher H.D., Weingart V. Optimizing Screening Colonoscopy: Strategies and Alternatives. Visc Med. 2019; 35(4): 215-25. doi: 10.1159/000501835.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Lund Henriksen F., Jensen R., Kvale Stensland H., Johansen D., Riegler M.A., Halvorsen P. Performance of data enhancements and training optimization for neural network: A polyp detection case study. 2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS), 2019. 287-93. doi: 10.1109/cbms.2019.00067.</mixed-citation><mixed-citation xml:lang="en">Lund Henriksen F., Jensen R., Kvale Stensland H., Johansen D., Riegler M.A., Halvorsen P. Performance of data enhancements and training optimization for neural network: A polyp detection case study. 2019 IEEE 32nd International Symposium on Computer-Based Medical Systems (CBMS), 2019. 287-93. doi: 10.1109/cbms.2019.00067.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmad O.F., Soares A.S., Mazomenos E., Brandao P., Vega R., Seward E., Stoyanov D., Chand M., Lovat L.B. Artificial intelligence and computer-aided diagnosis in colonoscopy: current evidence and future directions. Lancet Gastroenterol Hepatol. 2019; 4(1): 71-80. doi: 10.1016/S2468-1253(18)30282-6.</mixed-citation><mixed-citation xml:lang="en">Ahmad O.F., Soares A.S., Mazomenos E., Brandao P., Vega R., Seward E., Stoyanov D., Chand M., Lovat L.B. Artificial intelligence and computer-aided diagnosis in colonoscopy: current evidence and future directions. Lancet Gastroenterol Hepatol. 2019; 4(1): 71-80. doi: 10.1016/S2468-1253(18)30282-6.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Takamaru H., Wu S.Y.S., Saito Y. Endocytoscopy: technology and clinical application in the lower GI tract. Transl Gastroenterol Hepatol. 2020; 5: 40. doi: 10.21037/tgh.2019.12.04.</mixed-citation><mixed-citation xml:lang="en">Takamaru H., Wu S.Y.S., Saito Y. Endocytoscopy: technology and clinical application in the lower GI tract. Transl Gastroenterol Hepatol. 2020; 5: 40. doi: 10.21037/tgh.2019.12.04.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Rath T., Morgenstern N., Vitali F., Atreya R., Neurath M.F. Advanced Endoscopic Imaging in Colonic Neoplasia. Visc Med. 2020; 36(1): 48-59. doi: 10.1159/000505411.</mixed-citation><mixed-citation xml:lang="en">Rath T., Morgenstern N., Vitali F., Atreya R., Neurath M.F. Advanced Endoscopic Imaging in Colonic Neoplasia. Visc Med. 2020; 36(1): 48-59. doi: 10.1159/000505411.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Shahidi N., Rex D.K., Kaltenbach T., Rastogi A., Ghalehjegh S.H., Byrne M.F. Use of Endoscopic Impression, Artificial Intelligence, and Pathologist Interpretation to Resolve Discrepancies Between Endoscopy and Pathology Analyses of Diminutive Colorectal Polyps. Gastroenterology. 2020; 158(3): 783-5. doi: 10.1053/j.gastro.2019.10.024.</mixed-citation><mixed-citation xml:lang="en">Shahidi N., Rex D.K., Kaltenbach T., Rastogi A., Ghalehjegh S.H., Byrne M.F. Use of Endoscopic Impression, Artificial Intelligence, and Pathologist Interpretation to Resolve Discrepancies Between Endoscopy and Pathology Analyses of Diminutive Colorectal Polyps. Gastroenterology. 2020; 158(3): 783-5. doi: 10.1053/j.gastro.2019.10.024.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Djinbachian R., Dube AJ., von Rentein D. Optical Diagnosis of Colorectal Polyps: Recent Developments. Curr Treat Options Gastroenterol. 2019; 17(1): 99-114. doi: 10.1007/s11938-019-00220-x.</mixed-citation><mixed-citation xml:lang="en">Djinbachian R., Dube AJ., von Rentein D. Optical Diagnosis of Colorectal Polyps: Recent Developments. Curr Treat Options Gastroenterol. 2019; 17(1): 99-114. doi: 10.1007/s11938-019-00220-x.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Kudo S.E., Misawa M., Mori Y., Hotta K., Ohtsuka K., Ikematsu H., Saito Y., Takeda K., Nakamura H., Ichimasa K., Ishigaki T., Toyoshima N., Kudo T., Hayashi T., Wakamura K., Baba T., Ishida F., Inoue H., Itoh H., Oda M., Mori K. Artificial Intelligence-assisted System Improves Endoscopic Identification of Colorectal Neoplasms. Clin Gastroenterol Hepatol. 2020; 18(8): 1874-81. doi: 10.1016/j.cgh.2019.09.009.</mixed-citation><mixed-citation xml:lang="en">Kudo S.E., Misawa M., Mori Y., Hotta K., Ohtsuka K., Ikematsu H., Saito Y., Takeda K., Nakamura H., Ichimasa K., Ishigaki T., Toyoshima N., Kudo T., Hayashi T., Wakamura K., Baba T., Ishida F., Inoue H., Itoh H., Oda M., Mori K. Artificial Intelligence-assisted System Improves Endoscopic Identification of Colorectal Neoplasms. Clin Gastroenterol Hepatol. 2020; 18(8): 1874-81. doi: 10.1016/j.cgh.2019.09.009.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y., He X., Nie H., Zhou J., Cao P., Ou C. Application of artificial intelligence to the diagnosis and therapy of colorectal cancer. Am J Cancer Res. 2020; 10(11): 3575-98.</mixed-citation><mixed-citation xml:lang="en">Wang Y., He X., Nie H., Zhou J., Cao P., Ou C. Application of artificial intelligence to the diagnosis and therapy of colorectal cancer. Am J Cancer Res. 2020; 10(11): 3575-98.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">O'Sullivan S., Nevejans N., Allen C., Blyth A., Leonard S., Pagallo U., Holzinger K., Holzinger A., Sajid M.I., Ashrafian H. Legal, regulatory, and ethical frameworks for development of standards in artificial intelligence (AI) and autonomous robotic surgery. Int J Med Robot. 2019; 15(1). doi: 10.1002/rcs.1968.</mixed-citation><mixed-citation xml:lang="en">O'Sullivan S., Nevejans N., Allen C., Blyth A., Leonard S., Pagallo U., Holzinger K., Holzinger A., Sajid M.I., Ashrafian H. Legal, regulatory, and ethical frameworks for development of standards in artificial intelligence (AI) and autonomous robotic surgery. Int J Med Robot. 2019; 15(1). doi: 10.1002/rcs.1968.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Felfoul O., Mohammadi M., Taherkhani S., de Lanauze D., Zhong Xu Y., Loghin D., Essa S., Jancik S., Houle D., Lafleur M., Gabou-ry L., Tabrizian M., Kaou N., Atkin M., Vuong T., Batist G., Beauchemin N., Radzioch D., Martel S. Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions. Nat Nanotechnol. 2016; 11(11): 941-7. doi: 10.1038/nnano.2016.137.</mixed-citation><mixed-citation xml:lang="en">Felfoul O., Mohammadi M., Taherkhani S., de Lanauze D., Zhong Xu Y., Loghin D., Essa S., Jancik S., Houle D., Lafleur M., Gabou-ry L., Tabrizian M., Kaou N., Atkin M., Vuong T., Batist G., Beauchemin N., Radzioch D., Martel S. Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions. Nat Nanotechnol. 2016; 11(11): 941-7. doi: 10.1038/nnano.2016.137.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
