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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21294/1814-4861-2023-22-5-173-179</article-id><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-2771</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАЙ ИЗ КЛИНИЧЕСКОЙ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Случай раннего выявления метастазов в бедренной кости у больного раком полового члена</article-title><trans-title-group xml:lang="en"><trans-title>A case report of early detection of rare femoral shaft bone metastasis in a penis cancer patient</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9220-1947</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ajay</surname><given-names>Kumar Yadav</given-names></name><name name-style="western" xml:lang="en"><surname>Ajay</surname><given-names>Kumar Yadav</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ajay Kumar Yadav - M.Sc, PhD, отделение лучевой диагностики и ядерной медицины.</p><p>Бхаратпур</p></bio><bio xml:lang="en"><p>Ajay Kumar Yadav - M.Sc, PhD, Department of Radio-diagnosis, Imaging and Nuclear Medicine.</p><p>Bharatpur</p></bio><email xlink:type="simple">ajay_bpkmch@hotmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Sandip</surname><given-names>Kumar Mandal</given-names></name><name name-style="western" xml:lang="en"><surname>Sandip</surname><given-names>Kumar Mandal</given-names></name></name-alternatives><bio xml:lang="ru"><p>Sandip Kumar Mandal - B.Sc., отделение лучевой диагностики и ядерной медицины.</p><p>Бхаратпур</p></bio><bio xml:lang="en"><p>Sandip Kumar Mandal - B.Sc., Department of Radio-diagnosis, Imaging and Nuclear Medicine.</p><p>Bharatpur</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Suman</surname><given-names>Gnawali</given-names></name><name name-style="western" xml:lang="en"><surname>Suman</surname><given-names>Gnawali</given-names></name></name-alternatives><bio xml:lang="ru"><p>Suman Gnawali - B.Sc., отделение лучевой диагностики и ядерной медицины.</p><p>Бхаратпур</p></bio><bio xml:lang="en"><p>Suman Gnawali - B.Sc., Department of Radio-diagnosis, Imaging and Nuclear Medicine.</p><p>Bharatpur</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ganga</surname><given-names>Dutta Adhikari</given-names></name><name name-style="western" xml:lang="en"><surname>Ganga</surname><given-names>Dutta Adhikari</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ganga Dutta Adhikari - MD, отделение лучевой диагностики и ядерной медицины.</p><p>Бхаратпур</p></bio><bio xml:lang="en"><p>Ganga Dutta Adhikari - MD, Department of Radio-diagnosis, Imaging and Nuclear Medicine.</p><p>Bharatpur</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Nitu</surname><given-names>Sharma</given-names></name><name name-style="western" xml:lang="en"><surname>Nitu</surname><given-names>Sharma</given-names></name></name-alternatives><bio xml:lang="ru"><p>Nitu Sharma - MD, MD, отделение лучевой диагностики и ядерной медицины.</p><p>Бхаратпур</p></bio><bio xml:lang="en"><p>Nitu Sharma - MD, Department of Radio-diagnosis, Imaging and Nuclear Medicine.</p><p>Bharatpur</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Pandey</surname><given-names>Shailesh Kumar</given-names></name><name name-style="western" xml:lang="en"><surname>Pandey</surname><given-names>Shailesh Kumar</given-names></name></name-alternatives><bio xml:lang="ru"><p>Pandey Shailesh Kumar - MD, отделение лучевой диагностики и ядерной медицины.</p><p>Бхаратпур</p></bio><bio xml:lang="en"><p>Pandey Shailesh Kumar - MD, Department of Radio-diagnosis, Imaging and Nuclear Medicine.</p><p>Bharatpur</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Dhakal</surname><given-names>Deepika</given-names></name><name name-style="western" xml:lang="en"><surname>Dhakal</surname><given-names>Deepika</given-names></name></name-alternatives><bio xml:lang="ru"><p>Dhakal Deepika - MD, отделение лучевой диагностики и ядерной медицины.</p><p>Бхаратпур</p></bio><bio xml:lang="en"><p>Dhakal Deepika, MD, Department of Radio-diagnosis, Imaging and Nuclear Medicine.</p><p>Bharatpur</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-2912-9446</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Anil</surname><given-names>Pandit</given-names></name><name name-style="western" xml:lang="en"><surname>Anil</surname><given-names>Pandit</given-names></name></name-alternatives><bio xml:lang="ru"><p>Anil Pandit - M.Sc., отделение лучевой диагностики и ядерной медицины.</p><p>Бхаратпур</p></bio><bio xml:lang="en"><p>Anil Pandit - M.Sc., Department of Radio-diagnosis, Imaging and Nuclear Medicine.</p><p>Bharatpur</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Мемориальный онкологический госпиталь Bp Koirala<country>Непал</country></aff><aff xml:lang="en">Bp Koirala Memorial Cancer Hospital<country>Nepal</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>16</day><month>11</month><year>2023</year></pub-date><volume>22</volume><issue>5</issue><fpage>173</fpage><lpage>179</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ajay K., Sandip K., Suman G., Ganga D., Nitu S., Pandey S., Dhakal D., Anil P., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Ajay K., Sandip K., Suman G., Ganga D., Nitu S., Pandey S., Dhakal D., Anil P.</copyright-holder><copyright-holder xml:lang="en">Ajay K., Sandip K., Suman G., Ganga D., Nitu S., Pandey S., Dhakal D., Anil P.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/2771">https://www.siboncoj.ru/jour/article/view/2771</self-uri><abstract><p>Аннотация Метастазы в кости часто встречаются на поздних стадиях разных злокачественных новообразований. Для рака полового члена характерно лимфогенное метастазирование, костные метастазы встречаются очень редко. На данный момент в мировой литературе зарегистрировано лишь несколько случаев рака полового члена с метастазами в кости.</p><p>Описание клинического случая. Мы представляем описание клинического случая плоскоклеточного рака полового члена у 51-летнего мужчины из Непала. Компьютерная томография (КТ) выявила рак полового члена, локализованный на головке и крайней плоти с двусторонней паховой лимфаденопатией. Пациенту выполнена частичная пенэктомия, двусторонняя паховая лимфаденэктомия, проведено 6 курсов адъювантной химиотерапии. Через один год после завершения лечения у пациента появились боли в бедре и головная боль, рекомендована МРТ головного мозга, сканирование костей скелета с 99mTc-MDP и КТ таза и бедра. Обследование показало наличие склеротических изменений в теменной кости черепа и умеренное накопление 99mTc-MDP в проксимальном отделе правом бедренной кости ниже шейки. Гистологическое исследование биоптата, взятого из очага в бедренной кости, выявило метастаз ороговевающего плоскоклеточного рака, что является редким случаем метастазирования рака полового члена в диафиз бедренной кости. Пациент был направлен на хирургическую реконструкцию бедренной кости. Согласно обзору клинических исследований, метастазы в диафизе бедренной кости при раке полового члена встречаются крайне редко.</p><p>Заключение. Представлен первый случай раннего выявления костных метастазов в диафизе бедренной кости у пациента с раком полового члена. Ранняя диагностика помогает как радикальному, так и паллиативному лечению. Хирургическое вмешательство является предпочтительным вариантом лечения, особенно при метастатических очагах в длинных костях.</p></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Bone metastasis is very common in the advanced stage of numerous carcinomas. In penile carcinoma, lymph nodes metastasis is somehow common but it is very rare reported to be secondary from penile cancer. till the date, there are only few cases of penis carcinoma reported bone metastasis in literature worldwide.</p></sec><sec><title>Case Presentation</title><p>Case Presentation. Herein, We presented a 51-year-old Nepalese male with squamous cell carcinoma of penis. computed tomography (ct) scan of the patient revealed that there was carcinoma involving glans penis and precure with bilateral external &amp; internal inguinal lymphadenopathies. After then, the patient was under gone for partial penectomy and bilateral inguinal lymphadenectomy and complete 6-cycle chemotherapy. After one year of treatment, patient developed thigh pain and headache and he advised to have magnetic Resonance imaging (mRi) of brain, 99mTc-MDP whole body bone scan and ct scan of pelvis and thigh. The examination report reveals that there was a sclerotic change in vertex of skull bone and moderate 99mTc-MDP uptake in right proximal shaft of femur just below the neck d/d metastasis. The histopathological examination of the true cut biopsy taken from the lesion of the femur showed metastatic keratinizing squamous cell carcinoma which is rare case of femoral shaft bone metastasis secondary from penile carcinoma. Then patient was sent for surgical reconstruction of femur. Based on the case studies review femur shaft bone metastasis from penile cancer is extremely rare.</p></sec><sec><title>Conclusion</title><p>Conclusion. The best of our knowledge; this is the first early detected bone metastases to shaft of the femur in a patient with penile cancer. early diagnosis helps to radical treatment as well as palliative treatment. surgery is the preferred option of the treatments, especially for metastatic foci in the long bones.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>костные метастазы</kwd><kwd>рак полового члена</kwd><kwd>бедренная кость</kwd><kwd>комбинированное лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>skeletal metastasis</kwd><kwd>penis cancer</kwd><kwd>femoral shaft</kwd><kwd>comprehensive management</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Diorio G.J., Leone A.R., Spiess P.E. Management of Penile Cancer. Urology. 2016; 96: 15–21. doi: 10.1016/j.urology.2015.12.041.</mixed-citation><mixed-citation xml:lang="en">Diorio G.J., Leone A.R., Spiess P.E. 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Urol Case Rep. 2021; 38. doi: 10.1016/j.eucr.2021.101692.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
