<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21294/1814-4861-2023-22-5-190-196</article-id><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-2773</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАЙ ИЗ КЛИНИЧЕСКОЙ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Место роботической хирургии в лечении рака ротоглотки. Клиническое наблюдение</article-title><trans-title-group xml:lang="en"><trans-title>Robotic surgery in the treatment of oropharyngeal cancer: a case report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2283-1812</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Саприна</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Saprina</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Саприна Оксана Александровна - кандидат медицинских наук, старший научный сотрудник онкологического отделения хирургических методов лечения опухолей головы и шеи № 10.</p><p>115448, Москва, Каширское шоссе, 23</p></bio><bio xml:lang="en"><p>Oxana A. Saprina - MD, PhD, Senior Researcher, Department of Head and Neck Cancer Surgery.</p><p>23, Kashirskoe shosse, Moscow, 1154786</p></bio><email xlink:type="simple">isabekian@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9132-3416</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кропотов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kropotov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кропотов Михаил Алексеевич - доктор медицинских наук, заведующий онкологическим отделением хирургических методов лечения опухолей головы и шеи № 10.</p><p>115448, Москва, Каширское шоссе, 23</p></bio><bio xml:lang="en"><p>Mikhael A. Kropotov - MD, DSc, Head of Department of Head and Neck Cancer Surgery.</p><p>23, Kashirskoe shosse, Moscow, 1154786</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Занозина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zanozina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Занозина Екатерина Алексеевна - клинический ординатор.</p><p>115448, Москва, Каширское шоссе, 23</p></bio><bio xml:lang="en"><p>Ekaterina A. Zanozina - MD, Resident.</p><p>23, Kashirskoe shosse, Moscow, 1154786</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России<country>Россия</country></aff><aff xml:lang="en">N.N. Blokhin National medical Research centre of oncology<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>16</day><month>11</month><year>2023</year></pub-date><volume>22</volume><issue>5</issue><fpage>190</fpage><lpage>196</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Саприна О.А., Кропотов М.А., Занозина Е.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Саприна О.А., Кропотов М.А., Занозина Е.А.</copyright-holder><copyright-holder xml:lang="en">Saprina O.A., Kropotov M.A., Zanozina E.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/2773">https://www.siboncoj.ru/jour/article/view/2773</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Заболеваемость плоскоклеточным раком ротоглотки растет, и связано это с увеличением частоты инфицирования вирусом папилломы человека (ВПЧ). Учитывая лучший прогноз у пациентов с ВПЧ-позитивным раком по сравнению с ВПЧ-негативным, предприняты попытки уменьшить терапевтическое воздействие с целью улучшения качества жизни у пациентов с ранними стадиями. При ранних стадиях рака ротоглотки возможно применение как лучевого, так и хирургического методов лечения в самостоятельном варианте или в комбинации. На современном этапе понятие «трансоральная хирургия» включает в себя как трансоральную лазерную микрохирургию, так и робот-ассистированные операции (da Vinci, medrobotic Flex system). Описание клинического случая. В статье представлен один из клинических случаев использования робот-ассистированной системы da Vinci в комбинированном лечении рака ротоглотки. После операции пациент получил адъювантное химиолучевое лечение. Срок наблюдения за пациентом составил 10 мес. При контрольном обследовании – без признаков рецидива заболевания. Жалоб со стороны органов полости рта, ротоглотки не предъявляет, глотание любой пищи безболезненное.</p></sec><sec><title>Заключение</title><p>Заключение. Использование робот-ассистированной системы da Vinci в комбинированном лечении рака ротоглотки, особенно в такой труднодоступной зоне, как корень языка, позволяет лучше визуализировать и определить границы поражения с последующим удалением в едином блоке в пределах здоровых тканей в ограниченном пространстве, а также улучшить функциональные и эстетические результаты. Однако необходим тщательный отбор пациентов для данного вида лечения.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. The incidence of HpV-associated oropharyngeal squamous cell carcinoma (oscc) is steadily increasing. given the better prognosis in patients with HpV-positive cancer compared to HpV-negative cancer, attempts were made to reduce the therapeutic effect in patients with early-stage oscc to improve the quality of life of these patients. early-stage oscc can currently been treated with radiation therapy or surgery used alone or in combination. Currently, the concept of transoral surgery includes both transoral laser microsurgery and robot-assisted surgeries (da Vinci, medrobotics Flex system). Case description. We report a case of using the da Vinci robot-assisted system in the combined modality treatment of oropharyngeal cancer. The patient underwent surgery followed by chemoradiotherapy. At a follow-up of 10 months, no evidence of disease progression was found. The patient experienced no any pain on swallowing.</p></sec><sec><title>Conclusion</title><p>Conclusion. The use of the da Vinci robot-assisted surgical system in the combined modality treatment of oropharyngeal cancer, especially in such a hard-to-reach area as the root of the tongue, makes it possible to better visualize and determine the boundaries of the lesion, followed by en block resection, as well as to improve functional and aesthetic results. However, careful selection of patients for this type of treatment is necessary.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>рак ротоглотки</kwd><kwd>ВПЧ-позитивный рак</kwd><kwd>трансоральная хирургия</kwd><kwd>роботическая хирургия</kwd><kwd>da Vinci</kwd></kwd-group><kwd-group xml:lang="en"><kwd>oropharyngeal cancer</kwd><kwd>HPV-positive cancer</kwd><kwd>transoral surgery</kwd><kwd>robotic surgery</kwd><kwd>da Vinci</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Злокачественные новообразования в России в 2021 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, А.О. Шахзадовой. М., 2022. 252 с.</mixed-citation><mixed-citation xml:lang="en">Malignant tumors in Russia in 2021 (morbidity and mortality). Ed. by A.D. Kaprin, V.V. Starinsky, A.O. Shakhzadova. Moscow, 2022. 252 p. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Cancer of the Oropharynx. Version 2.2018.</mixed-citation><mixed-citation xml:lang="en">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Cancer of the Oropharynx. Version 2.2018.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ragin C.C., Taioli E. Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer. 2007; 121(8): 1813–20. doi: 10.1002/ijc.22851.</mixed-citation><mixed-citation xml:lang="en">Ragin C.C., Taioli E. Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer. 2007; 121(8): 1813–20. doi: 10.1002/ijc.22851.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Allen C.T., Lewis J.S., El-Mofty S.K., Haughey B.H., Nussenbaum B. Human papillomavirus and oropharynx cancer: biology, detection and clinical implications. Laryngoscope. 2010; 120(9): 1756–72. doi: 10.1002/lary.20936.</mixed-citation><mixed-citation xml:lang="en">Allen C.T., Lewis J.S., El-Mofty S.K., Haughey B.H., Nussenbaum B. Human papillomavirus and oropharynx cancer: biology, detection and clinical implications. Laryngoscope. 2010; 120(9): 1756–72. doi: 10.1002/lary.20936.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Moore E.J., Olsen S.M., Laborde R.R., García J.J., Walsh F.J., Price D.L., Janus J.R., Kasperbauer J.L., Olsen K.D. Long-term functional and oncologic results of transoral robotic surgery for oropharyngeal squamous cell carcinoma. Mayo Clin Proc. 2012; 87(3): 219–25. doi: 10.1016/j.mayocp.2011.10.007.</mixed-citation><mixed-citation xml:lang="en">Moore E.J., Olsen S.M., Laborde R.R., García J.J., Walsh F.J., Price D.L., Janus J.R., Kasperbauer J.L., Olsen K.D. Long-term functional and oncologic results of transoral robotic surgery for oropharyngeal squamous cell carcinoma. Mayo Clin Proc. 2012; 87(3): 219–25. doi: 10.1016/j.mayocp.2011.10.007.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Grant D.G., Hinni M.L., Salassa J.R., Perry W.C., Hayden R.E., Casler J.D. Oropharyngeal cancer: a case for single modality treatment with transoral laser microsurgery. Arch Otolaryngol Head Neck Surg. 2009; 135(12): 1225–30. doi: 10.1001/archoto.2009.185.</mixed-citation><mixed-citation xml:lang="en">Grant D.G., Hinni M.L., Salassa J.R., Perry W.C., Hayden R.E., Casler J.D. Oropharyngeal cancer: a case for single modality treatment with transoral laser microsurgery. Arch Otolaryngol Head Neck Surg. 2009; 135(12): 1225–30. doi: 10.1001/archoto.2009.185.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Haughey B.H., Hinni M.L., Salassa J.R., Hayden R.E., Grant D.G., Rich J.T., Milov S., Lewis J.S., Krishna M. Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer: a United States multicenter study. Head Neck. 2011; 33(12): 1683–94. doi: 10.1002/hed.21669.</mixed-citation><mixed-citation xml:lang="en">Haughey B.H., Hinni M.L., Salassa J.R., Hayden R.E., Grant D.G., Rich J.T., Milov S., Lewis J.S., Krishna M. Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer: a United States multicenter study. Head Neck. 2011; 33(12): 1683–94. doi: 10.1002/hed.21669.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Smith R.V., Schiff B.A., Garg M., Haigentz M. The impact of transoral robotic surgery on the overall treatment of oropharyngeal cancer patients. Laryngoscope. 2015; 125(s10): 610–5. doi: 10.1002/lary.25534.</mixed-citation><mixed-citation xml:lang="en">Smith R.V., Schiff B.A., Garg M., Haigentz M. The impact of transoral robotic surgery on the overall treatment of oropharyngeal cancer patients. Laryngoscope. 2015; 125(s10): 610–5. doi: 10.1002/lary.25534.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Steiner W., Fierek O., Ambrosch P., Hommerich C.P., Kron M. Transoral laser microsurgery for squamous cell carcinoma of the base of the tongue. Arch Otolaryngol Head Neck Surg. 2003; 129(1): 36–43. doi: 10.1001/archotol.129.1.36.</mixed-citation><mixed-citation xml:lang="en">Steiner W., Fierek O., Ambrosch P., Hommerich C.P., Kron M. Transoral laser microsurgery for squamous cell carcinoma of the base of the tongue. Arch Otolaryngol Head Neck Surg. 2003; 129(1): 36–43. doi: 10.1001/archotol.129.1.36.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Mirghani H., Blanchard P. Treatment de-escalation for HPV-driven oropharyngeal cancer: Where do we stand? Clin Transl Radiat Oncol. 2017; 8: 4–11. doi: 10.1016/j.ctro.2017.10.005.</mixed-citation><mixed-citation xml:lang="en">Mirghani H., Blanchard P. Treatment de-escalation for HPV-driven oropharyngeal cancer: Where do we stand? Clin Transl Radiat Oncol. 2017; 8: 4–11. doi: 10.1016/j.ctro.2017.10.005.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
