oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2023-22-6-130-137oncotomsk-2843Research ArticleОБЗОРЫREVIEWSРоль Е-кадгерина и β-катенина при плоскоклеточном раке органов головы и шеиRole of E-cadherin and β-catenin in head and neck squamous cell carcinomahttps://orcid.org/0000-0003-4258-6196ПетроваА. А.PetrovaA. A.

Петрова Арина Алексеевна - аспирант, старший лаборант кафедры онкологии, радиотерапии и реконструктивной хирургии,

119991, г. Москва, ул. Трубецкая, 8/2

Arina A. Petrova - MD, Postgraduate, Senior Laboratory Assistant, Department of Oncology, Radiotherapy and Reconstructive Surgery, 

8/2, Trubetskaya St., Moscow, 119991

AAPetrova.sechenov@yandex.ruhttps://orcid.org/0000-0003-4598-8625СамойловаС. И.SamoylovaS. I.

Самойлова Светлана Ивановна, кандидат медицинских наук, доцент кафедры онкологии, радиотерапии и пластической хирургии Института клинической медицины им. Н.В. Склифосовского, 

 119991, г. Москва, ул. Трубецкая, 8/2

Svetlana I. Samoylova - MD, PhD, Associate Professor, Department of Oncology, Radiotherapy and Plastic Surgery, N.V. Sklifosovsky Institute of Clinical Medicine, 

8/2, Trubetskaya St., Moscow, 119991

https://orcid.org/0000-0002-8725-5246МагомедкеримоваЛ. В.MagomedkerimovaL. V.

Магомедкеримова Луиза Вагифовна, аспирант, 

119991, г. Москва, ул. Трубецкая, 8/2

Luiza V. Magomedkerimova - MD, Postgraduate,

8/2, Trubetskaya St., Moscow, 119991

https://orcid.org/0009-0003-9954-4584ПартсС. А.PartsS. A.

Партс Сергей Адольфович - кандидат медицинских наук, заместитель главного врача по медицинской части, 

117152, г. Москва, Загородное шоссе, 18А/7

Sergey A. Parts - MD, PhD, Deputy Chief Physician,

18A/7, Zagorodnoe hwy, Moscow, 117152

https://orcid.org/0000-0002-0909-6278РешетовИ. В.ReshetovI. V.

Решетов Игорь Владимирович - доктор медицинских наук, профессор, академик РАН, директор Института кластерной онкологии им. профессора Л.Л. Левшина, заведующий кафедрой онкологии, радиотерапии и пластической хирургии Института клинической медицины им. Н.В. Склифосовского, 

119991, г. Москва, ул. Трубецкая, 8/2

Igor V. Reshetov - MD, DSc, Professor, Academician of the Russian Academy of Sciences, Director, L.L. Levshin Institute of Cluster Oncology, Head of the Department of Oncology, Radiotherapy and Plastic Surgery, N.V. Sklifosovsky Institute of Clinical Medicine, 

8/2, Trubetskaya St., Moscow, 119991

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава РоссииРоссияI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the RussiaRussian FederationГБУЗ «Городская клиническая онкологическая больница № 1 ДЗМ»РоссияMoscow Clinical Oncology Hospital No. 1Russian Federation202303012024226130137Copyright © Петрова А.А., Самойлова С.И., Магомедкеримова Л.В., Партс С.А., Решетов И.В., 20242024Петрова А.А., Самойлова С.И., Магомедкеримова Л.В., Партс С.А., Решетов И.В.Petrova A.A., Samoylova S.I., Magomedkerimova L.V., Parts S.A., Reshetov I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/2843

Цель исследования – представить и обобщить имеющиеся в современной литературе данные о прогностическом значении маркеров E-кадгерина и β-катенина для плоскоклеточного рака органов головы и шеи, обосновать потенциальную пользу внедрения исследований данной области в клиническую практику в рамках персонализированного подхода к лечению плоскоклеточного рака органов головы и шеи.

Материал и методы

Материал и методы. Выполнен поиск и обзор литературы в базах данных Pubmed, Scopus, Google Scholar и РИНЦ на предмет связи уровня данных маркеров с прогнозом и клинической картиной заболевания, а также агрессивностью поведения опухоли и ответом на лечение.

Результаты

Результаты. Представлена подробная информация о функциях и механизмах работы белков Е-кадгерина и β-катенина, описаны патогенетические пути, лежащие в основе эпителиально-мезенхимального перехода в рамках опухолевых процессов в целом. Собраны и обобщены результаты исследований связи уровня экспрессии β-катенина и Е-кадгерина с прогнозом плоскоклеточного рака органов головы и шеи. Высокий уровень экспрессии β-катенина и Е-кадгерина ассоциируется с быстрым метастазированием в лимфатические узлы, худшим прогнозом течения заболевания и худшим ответом на лечение.

Заключение

Заключение. Уровень экспрессии β-катенина и Е-кадгерина коррелирует с такими опухолевыми паттернами, как степень инвазии и метастазирование в регионарные лимфоузлы, что предполагает их использование в качестве потенциальных маркеров прогноза течения заболевания и ответа на терапию для плоскоклеточных опухолей головы и шеи. Определенный потенциал имеет изучение коэкспрессии Е-кадгерина, β-катенина и ассоциированных с плоскоклеточным раком маркеров, влияние их комбинации на прогноз и ответ на лечение, а также их прогностического значения.

Aim of the study

Aim of the study: to present and summarize current data on the prognostic value of E-cadherin and β-catenin markers for head and neck squamous cell carcinoma, as well as to substantiate the potential benefit from implementing research results into clinical practice within the framework of a personalized approach to the treatment of head and neck squamous cell carcinoma.

Material and Methods

Material and Methods. We performed a literature search and review in Pubmed, Scopus, Google Scholar and RSCI databases regarding the association of the level of E-cadherin and β-catenin markers with disease prognosis, aggressiveness of tumor behavior and response to treatment.

Results

Results. Detailed information on the functions and mechanisms of E-cadherin and β-catenin proteins were presented and pathogenetic pathways involved in epithelial-mesenchymal transition were described. The results of studies on the association of β-catenin and E-cadherin expression levels with the prognosis of head and neck squamous cell carcinoma are collected and summarized. High expression levels of β-catenin and E-cadherin are associated with lymph node metastasis, poor prognosis and poor response to treatment.

Conclusion

Conclusion. The expression levels of β-catenin and E-cadherin correlate with tumor invasion and lymph node metastasis, thus suggesting that β-catenin and E-cadherin can be used as potential markers of prognosis and treatment response in patients with head and neck squamous cell carcinoma. Further studies are needed to evaluate the co-expression of E-cadherin, β-catenin and other squamous cell carcinoma-associated markers, their impact on prognosis and treatment response, as well as their prognostic value.

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The authors declare that there are no conflicts of interest present.