oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciencesoncotomsk-286Research ArticleОБЗОРЫREVIEWSОСНОВНЫЕ МОЛЕКУЛЯРНЫЕ МИШЕНИ ДЛЯ ТЕРАПИИ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫMAIN MOLECULAR TARGETS FOR PROSTATE CANCER THERAPYКрасновГ. С.KrasnovG. S.

119991, г. Москва, ул. Вавилова, 32

32, Vavilova Street, 119991-Moscow

rhizamoeba@mail.ruДмитриевА. А.DmitrievA. A.rhizamoeba@mail.ruВолченкоН. Н.VolchenkoN. N.ДаниловаТ. В.DanilovaT. V.СадритдиноваА. Ф.SadritdinovaA. F.rhizamoeba@mail.ruСнежкинаА. В.SnezhkinaA. V.rhizamoeba@mail.ruМельниковаН. В.MelnikovaN. V.rhizamoeba@mail.ruФедороваМ. С.FedorovaM. S.rhizamoeba@mail.ruЛакунинаВ. А.LakuninaV. A.rhizamoeba@mail.ruБеловаА. А.BelovaA. A.rhizamoeba@mail.ruАлексеевБ. Я.AlekseevB. Y.КапринА. Д.KaprinA. D.КудрявцеваА. В.KudryavtsevaA. V.rhizamoeba@mail.ruФГБУН «Институт молекулярной биологии им. В.А. Энгельгардта» РАН, г. Москва Московский научно-исследовательский онкологический институт имени П.А. Герцена Минздрава РФ, г. Москва ФГБУ «Научно-исследовательский институт биомедицинской химии» им. В.Н. Ореховича РАМН, г. МоскваРоссияEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow P.A. Herzen Moscow Cancer Research Institute, Ministry of Healthcare of the Russian Federation, Moscow V. N. Orekhovich Institute of Biomedical Chemistry of the Russian Academy of Medical Sciences, MoscowRussian FederationМосковский научно-исследовательский онкологический институт имени П.А. Герцена Минздрава РФ, г. Москва ФГБУ «Научно-исследовательский институт биомедицинской химии» им. В.Н. Ореховича РАМН, г. МоскваРоссияP.A. Herzen Moscow Cancer Research Institute, Ministry of Healthcare of the Russian Federation, Moscow V. N. Orekhovich Institute of Biomedical Chemistry of the Russian Academy of Medical Sciences, MoscowRussian FederationФГБУ «Научно-исследовательский институт биомедицинской химии» им. В.Н. Ореховича РАМН, г. МоскваРоссияV. N. Orekhovich Institute of Biomedical Chemistry of the Russian Academy of Medical Sciences, MoscowRussian FederationФГБУН «Институт молекулярной биологии им. В.А. Энгельгардта» РАН, г. МоскваРоссияEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, MoscowRussian FederationМосковский научно-исследовательский онкологический институт имени П.А. Герцена Минздрава РФ, г. МоскваРоссияP.A. Herzen Moscow Cancer Research Institute, Ministry of Healthcare of the Russian Federation, MoscowRussian FederationФГБУН «Институт молекулярной биологии им. В.А. Энгельгардта» РАН, г. Москва Московский научно-исследовательский онкологический институт имени П.А. Герцена Минздрава РФ, г. МоскваРоссияEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow P.A. Herzen Moscow Cancer Research Institute, Ministry of Healthcare of the Russian Federation, MoscowRussian Federation201428022016064553Copyright © Краснов Г.С., Дмитриев А.А., Волченко Н.Н., Данилова Т.В., Садритдинова А.Ф., Снежкина А.В., Мельникова Н.В., Федорова М.С., Лакунина В.А., Белова А.А., Алексеев Б.Я., Каприн А.Д., Кудрявцева А.В., 20162016Краснов Г.С., Дмитриев А.А., Волченко Н.Н., Данилова Т.В., Садритдинова А.Ф., Снежкина А.В., Мельникова Н.В., Федорова М.С., Лакунина В.А., Белова А.А., Алексеев Б.Я., Каприн А.Д., Кудрявцева А.В.Krasnov G.S., Dmitriev A.A., Volchenko N.N., Danilova T.V., Sadritdinova A.F., Snezhkina A.V., Melnikova N.V., Fedorova M.S., Lakunina V.A., Belova A.A., Alekseev B.Y., Kaprin A.D., Kudryavtseva A.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/286

Андрогенный путь играет главную роль в развитии доброкачественных и злокачественных новообразований предстательной железы. Подавляющее большинство опухолей простаты на момент начала лечения являются гормон-зависимыми. Терапевтические меры, направленные на снижение уровня тестостерона в крови, позволяют остановить развитие заболевания. Однако со временем опухоль практически неизбежно начинает прогрессировать, переходя в кастрационно-резистентную форму (КРРПЖ), представляющую серьёзную проблему онкоурологии. В течение последних лет возможности терапии КРРПЖ значительно расширились – в клинической практике стал доступен ряд новых препаратов, позволяющих эффективно затормозить развитие кастрационно-резистентных опухолей и значительно отодвинуть время начала химиотерапии. В обзоре описаны основные лекарственные мишени и механизмы действия абиратерона, энзалутамида, галетерона, VT-464 и других одобренных и перспективных средств терапии КРРПЖ.

Androgenic pathway plays a pivotal role in the development of benign and malignant prostate tumors. Most of the prostate neoplasms are hormone-dependent at the time of diagnosis. Therapeutic interventions aimed at reducing the level of testosterone in the blood allow to stop progression of the disease. But over time, the tumor almost inevitably starts to progress, moving in the castration-resistant state (CRPC), representing a serious problem of oncourology. In recent years, the possibility of CRRPC therapy increased significantly – there was developed a number of new drugs that effectively inhibit the development of castration-resistant tumors and significantly push back the start of chemotherapy. This review describes the major drug targets and mechanisms of action of abiraterone, enzalutamide, galeterone, VT-464 and other approved and promising CRPC therapies.

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The authors declare that there are no conflicts of interest present.