oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2024-23-3-159-167oncotomsk-3126Research ArticleОБЗОРЫREVIEWSОбзор современных возможностей эндокринной терапии гормонозависимых злокачественных опухолей молочной железыA review of endocrine therapy for hormone-dependent breast cancerhttps://orcid.org/0000-0003-0725-5455УсеиноваА. Н.UseinovaA. N.

Усеинова Асие Наримановна, кандидат медицинских наук, доцент кафедры базисной и клинической фармакологии

Россия, 295051, г. Симферополь, бульв. Ленина, 5/7 

Asie N. Useinova, MD, PhD, Associate Professor, Department of Basic and Clinical Pharmacology

 5/7, lenin Blv, simferopol, 295051, Russia 

https://orcid.org/0000-0003-1693-3190КалиберденкоВ. Б.KaliberdenkoV. B.

Калиберденко Виталий Борисович, кандидат медицинских наук, доцент кафедры внутренней медицины № 2

Россия, 295051, г. Симферополь, бульв. Ленина, 5/7 

Vitaliy B. Kaliberdenko, MD, PhD, Associate Professor, Department of Internal Medicine No. 2

 5/7, lenin Blv, simferopol, 295051, Russia 

https://orcid.org/0000-0003-0765-5336МарьяненкоС. П.MaryanenkoS. P.

Марьяненко София Павловна, студентка 6-го курса, Ордена Трудового Красного Знамени Медицинский институт  им. С.И. Георгиевского 

 

Россия, 295051, г. Симферополь, бульв. Ленина, 5/7 

 Sofia P. Maryanenko, 6th year student

 5/7, lenin Blv, simferopol, 295051, Russia 

sofiya-maryanenko@mail.ruhttps://orcid.org/0000-0003-2121-6735Аль-НсоурДж. М.Al-NsourJ. M.

Аль-Нсоур Джамал Мустафа, кандидат медицинских наук, доцент кафедры онкологии 

Россия, 295051, г. Симферополь, бульв. Ленина, 5/7 

 Jamal M. Al-Nsour, MD, PhD, Associate Professor, Department of Oncology 

 5/7, lenin Blv, simferopol, 295051, Russia 

https://orcid.org/0009-0007-9845-2484КореньковаА. А.KorenkovaA. A.

Коренькова Анастасия Андреевна, студентка 6-го курса

Россия, 295051, г. Симферополь, бульв. Ленина, 5/7 

 Anastasia A. Korenkova, 6th year student 

 5/7, lenin Blv, simferopol, 295051, Russia 

Ордена Трудового Красного Знамени Медицинский институт им. С.И. Георгиевского, ФГАОУ ВО «Крымский федеральный университет им. В.И. Вернадского»РоссияS.I. Georgievsky Medical Institute of Order of the Red Banner of Labor, Vernadsky Crimean Federal UniversityRussian FederationОрдена Трудового Красного Знамени Медицинский институт им. С.И. Георгиевского, ФГАОУ ВО «Крымский федеральный университет им. В.И. Вернадского»РоссияS.I. Georgievsky Medical Institute of Order of the Red Banner of Labor, Vernadsky Crimean Federal University Russian Federation202407072024233159167Copyright © Усеинова А.Н., Калиберденко В.Б., Марьяненко С.П., Аль-Нсоур Д.М., Коренькова А.А., 20242024Усеинова А.Н., Калиберденко В.Б., Марьяненко С.П., Аль-Нсоур Д.М., Коренькова А.А.Useinova A.N., Kaliberdenko V.B., Maryanenko S.P., Al-Nsour J.M., Korenkova A.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/3126

Цель исследования – представить современные данные о фармакотерапии гормонозависимого рака молочной железы (гРМЖ) и рассмотреть возможность внедрения в практику новых лекарственных средств в составе гормонотерапии РМЖ. Материал и методы. Проведен поиск литературных источников в базах данных Pubmed, Springer, Cochrane Library и др. За последние 10 лет найдено 80 публикаций, посвященных изучению фармакологических свойств различных групп лекарственных препаратов при лечении гРМЖ на разных стадиях, из которых 49 включены в данный обзор. Результаты. На данный момент существует несколько линий лечения гРМЖ. Наиболее изученными и часто применяемыми группами препаратов являются селективные модуляторы рецепторов эстрогена и ингибиторы ароматазы. Ингибиторы циклин-зависимых киназ 4/6 в протоколах могут присутствовать как в первой, так и во второй линии терапии. Пристальное внимание уделяется разработке новых препаратов на основе геномного профилирования опухоли, что является стандартом лечения гРМЖ и способствует персонализации терапии. Заключение. Разработка лекарственных препаратов открывает большие перспективы для увеличения общей выживаемости и более точного прогнозирования ответа на общепринятую системную терапию и индивидуализации фармакотерапии гРМЖ. Наиболее перспективными направлениями являются внедрение в практику пероральных селективных деструкторов рецепторов эстрогена и разработка новых средств, блокирующих эстроген-зависимую и независимую передачу сигналов рецепторам эстрогена.

Purpose of the study: to provide current data on pharmacotherapy of hormone-dependent breast cancer (hdBC) and to consider the feasibility of introducing new hormone therapy drugs for breast cancer into clinical practice. Material and Methods. We analyzed 80 publications available Pubmed, Springer, Cochrane Library, etc. concerning the study of pharmacological characteristics of various groups of drugs for the treatment of hdBC, of which 49 were included in this review. Results. Currently, there are several approaches to the treatment of hdBC. Selective estrogen receptor modulators and aromatase inhibitors are the most studied and frequently used drugs. The cyclin-dependent kinase 4/6 inhibitors can be present in both the first- and second-line therapy. Currently, close attention is paid to the development of new drugs based on genomic profiling of the tumor, which is the standard of treatment for hdBC, and contributes to the personalization of therapy. Conclusion. Further development of drugs holds great promise for increasing overall survival and more accurate prognosis, response to conventional systemic therapy, and individualization of pharmacotherapy for hdBC. However, further research and development of new drugs is required. In this regard, the introduction of oral selective estrogen receptor degraders into practice and the development of new drugs that block estrogen-dependent and independent signaling to estrogen receptors are the most promising trends.

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The authors declare that there are no conflicts of interest present.