<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21294/1814-4861-2024-23-5-185-191</article-id><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-3288</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАЙ ИЗ КЛИНИЧЕСКОЙ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Метастатическое поражение глазницы при раке молочной железы: три редких клинических наблюдения</article-title><trans-title-group xml:lang="en"><trans-title>Orbital metastases from breast cancer: three case reports</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0060-4061</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Данилова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Danilova</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Данилова Людмила Алексеевна, кандидат медицинских наук, первый заместитель главного врача, 432017, г. Ульяновск, ул. 12 Сентября, 90;</p><p>доцент кафедры онкологии и лучевой диагностики, медицинский факультет им. Т.З. Биктимирова, Институт медицины, экологии и физической культуры, г. Ульяновск, 432017, ул. Льва Толстого, 42</p></bio><bio xml:lang="en"><p>Lyudmila A. Danilova, MD, PhD, Deputy Chief Physician, 90, 12 September St., Ulyanovsk, 4320171;</p><p>Associate Professor, Department of Oncology and Diagnostic Imaging, Faculty of Medicine named after T.Z. Biktimirova, Institute of Medicine, Ecology and Physical Culture, 42, Lev Tolstoy St., Ulyanovsk, 432017</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8121-4654</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анохина</surname><given-names>Е. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Anokhina</surname><given-names>E. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анохина Екатерина Павловна, онколог отделения химиотерапии № 1, </p><p>432017, г. Ульяновск, ул. 12 Сентября, 90</p></bio><bio xml:lang="en"><p>Ekaterina P. Anokhina, MD, Oncologist, Chemotherapy Department No. 1,</p><p>90, 12 September St., Ulyanovsk, 4320171</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8590-2350</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тонеев</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Toneev</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тонеев Евгений Александрович, кандидат медицинских наук, торакальный хирург хирургического отделения торакальной онкологии, 432017, г. Ульяновск, ул. 12 Сентября, 90;</p><p>доцент кафедры факультетской хирургии, медицинский факультет им. Т.З. Биктимирова, Институт медицины, экологии и физической культуры, г. Ульяновск, 432017, ул. Льва Толстого, 42</p></bio><bio xml:lang="en"><p>Evgeny A. Toneev, MD, PhD, Thoracic Surgeon, Thoracic Oncology Department, 90, 12 September St., Ulyanovsk, 4320171;</p><p>Associate Professor, Department of Faculty Surgery, Faculty of Medicine named after T.Z. Biktimirova, Institute of Medicine, Ecology and Physical Culture, 42, Lev Tolstoy St., Ulyanovsk, 432017</p></bio><email xlink:type="simple">e.toneev@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-0218-666X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шагдалеев</surname><given-names>Р. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Shagdaleev</surname><given-names>R. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шагдалеев Роман Фатыхович, ординатор кафедры госпитальной хирургии, анестезиологии, реаниматологии, урологии, травматологии и ортопедии, факультет стоматологии, фармации и последипломного медицинского образования, Институтмедицины, экологии и физической культуры, </p><p>г. Ульяновск, 432017, ул. Льва Толстого, 42</p></bio><bio xml:lang="en"><p>Roman F. Shagdaleev, MD, Resident, Department of Hospital Surgery, Anesthesiology, Resuscitation, Urology, Traumatology and Orthopedics, Faculty of Dentistry, Pharmacy and Postgraduate Medical Education, Institute of Medicine, Ecology and Physical Culture, </p><p>42, Lev Tolstoy St., Ulyanovsk, 432017</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1190-3112</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пономаренко</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Ponomarenko</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пономаренко Анна Михайловна, рентгенолог отделения рентгенодиагностики, </p><p>432017, г. Ульяновск, ул. 12 Сентября, 90</p></bio><bio xml:lang="en"><p>Anna M. Ponomarenko, MD, Radiologist, X-ray Diagnostics Department,</p><p>90, 12 September St., Ulyanovsk, 4320171</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-3679-7187</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глумнушина</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Glumnushina</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Глумнушина Дарья Валериевна, студентка медицинского факультета им. Т.З. Биктимирова, Институт медицины, экологии и физической культуры, </p><p>г. Ульяновск, 432017, ул. Льва Толстого, 42</p></bio><bio xml:lang="en"><p>Daria V. Glumnushina, Student, Faculty of Medicine named after T.Z. Biktimirova, Institute of Medicine, Ecology and Physical Culture, </p><p>42, Lev Tolstoy St., Ulyanovsk, 432017</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-0777-0142</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крымзалова</surname><given-names>Н. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Krymzalova</surname><given-names>N. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крымзалова Наталия Дмитриевна, студентка медицинского факультета им. Т.З. Биктимирова, Институт медицины, экологии и физической культуры, </p><p>г. Ульяновск, 432017, ул. Льва Толстого, 42</p></bio><bio xml:lang="en"><p>Natalia D. Krymzalova, Student, Faculty of Medicine named after T.Z. Biktimirova, Institute of Medicine, Ecology and Physical Culture,</p><p>42, Lev Tolstoy St., Ulyanovsk, 432017</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГУЗ «Областной клинический онкологический диспансер»;&#13;
ФГБОУ ВО «Ульяновский государственный университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Clinical Oncology Center;&#13;
Ulyanovsk State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГУЗ «Областной клинический онкологический диспансер»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Clinical Oncology Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Ульяновский государственный университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ulyanovsk State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>17</day><month>11</month><year>2024</year></pub-date><volume>23</volume><issue>5</issue><fpage>185</fpage><lpage>191</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Данилова Л.А., Анохина Е.П., Тонеев Е.А., Шагдалеев Р.Ф., Пономаренко А.М., Глумнушина Д.В., Крымзалова Н.Д., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Данилова Л.А., Анохина Е.П., Тонеев Е.А., Шагдалеев Р.Ф., Пономаренко А.М., Глумнушина Д.В., Крымзалова Н.Д.</copyright-holder><copyright-holder xml:lang="en">Danilova L.A., Anokhina E.P., Toneev E.A., Shagdaleev R.F., Ponomarenko A.M., Glumnushina D.V., Krymzalova N.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/3288">https://www.siboncoj.ru/jour/article/view/3288</self-uri><abstract><p>Цель исследования – анализ редких случаев метастатического поражения глазницы при раке молочной железы.</p><sec><title>Материал и методы</title><p>Материал и методы. В период с 01.01.18 по 01.05.24 выявлены и изучены 3 случая лечения рака молочной железы (РМЖ) с метастазированием в глазницу и подтвержденным молекулярно-биологическим подтипом опухоли Люминальный А(1), В(2). Метастазирование в орбиту выявлено через 5 лет, 2 года и 1,5 года после радикального лечения РМЖ. По поводу метастатического поражения глазницы больные получали лекарственное лечение и лучевую терапию.</p></sec><sec><title>Результаты</title><p>Результаты. Установлено, что метастатическое поражение глазницы при РМЖ встречается редко, однако эти случаи могут быть связаны с длительным периодом времени между диагностикой рака и началом лечения. Важными факторами предотвращения данного осложнения являются раннее выявление и активное лечение рака молочной железы.</p></sec><sec><title>Заключение</title><p>Заключение. После радикального лечения рака молочной железы необходимо динамическое наблюдение пациенток, так как возможно метастатическое поражение других органов, в частности глазницы. Комплексный подход к лечению метастазов при РМЖ позволяет добиться длительного контроля над заболеванием.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose: to describe rare cases of orbital metastases from breast cancer.</p></sec><sec><title>Material and Methods</title><p>Material and Methods. Three cases of Luminal A(1) and B(2) breast cancer with orbital metastases were identified and studied during the period from 01.01.2018 to 01.05.2024. Metastasis to the orbit was detected 5, 2 and 1.5 years after radical mastectomy for breast cancer. Patients received chemotherapy and radiation therapy.</p></sec><sec><title>Results</title><p>Results. Cases of orbital metastasis originating from breast cancer were found to have a low frequency, but may be associated with a long period between cancer diagnosis and initiation of treatment. Early detection of breast cancer and its active treatment with chemotherapy and radiation therapy are important factors in preventing orbital metastasis.</p></sec><sec><title>Conclusion</title><p>Conclusion. A routine follow-up surveillance after radical treatment of breast cancer is important because there is an increase risk of developing orbital metastasis. Comprehensive strategies for treating breast cancer metastases can provide long-term disease control.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>метастаз в глазницу</kwd></kwd-group><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>orbital metastases</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wilkinson L., Gathani T. Understanding breast cancer as a global health concern. Br J Radiol. 2022; 95(1130). doi: 10.1259/bjr.20211033.</mixed-citation><mixed-citation xml:lang="en">Wilkinson L., Gathani T. Understanding breast cancer as a global health concern. Br J Radiol. 2022; 95(1130). doi: 10.1259/bjr.20211033.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">ОНКО-ONCO: Онкологические заболевания в России и мире. Мониторинго-экспертные исследования: знать и победить рак. Научн. рук. З.А. Саидова; гл. ред. Комарова А.И. Вып. 55. Том 846(888). М., 2022. 19 с.</mixed-citation><mixed-citation xml:lang="en">CANCER IN RUSSIA AND WORLDWIDE. Monitoring and expert studies: know and defeat cancer. Issue 55. Superviser: Z.A. Saidova; editor-inchief: A.I. Komarova. Vol. 846(888). Moscow, 2022. 19 p. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Saad E.S.P., Bakri H.M., Rayan A., Barakat D., Khalel M.M. Eye metastasis in breast cancer: case report and review of literature. Ecancermedicalscience. 2022; 16: 1353. doi: 10.3332/ecancer.2022.1353.</mixed-citation><mixed-citation xml:lang="en">Saad E.S.P., Bakri H.M., Rayan A., Barakat D., Khalel M.M. Eye metastasis in breast cancer: case report and review of literature. Ecancermedicalscience. 2022; 16: 1353. doi: 10.3332/ecancer.2022.1353.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Злокачественные новообразования в России в 2020 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, А.О. Шахзадовой. М., 2021. 252 с.</mixed-citation><mixed-citation xml:lang="en">Malignant tumors in Russia in 2020 (morbidity and mortality). Ed. by A.D. Kaprin, V.V. Starinsky, A.O. Shakhzadova. Moscow, 2021. 252 p. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson C.C., Hertzberg B.S., Klintworth G.K. A histo-pathologic study of 716 unselected eyes in patients with cancer at the time of death. Am J Ophthalmol. 1983; 95(6): 788–93. doi: 10.1016/0002-9394(83)90066-1.</mixed-citation><mixed-citation xml:lang="en">Nelson C.C., Hertzberg B.S., Klintworth G.K. A histo-pathologic study of 716 unselected eyes in patients with cancer at the time of death. Am J Ophthalmol. 1983; 95(6): 788–93. doi: 10.1016/0002-9394(83)90066-1.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Eliassi-Rad B., Albert D.M., Green W.R. Frequency of ocular metastases in patients dying of cancer in eye bank populations. Br J Ophthalmol. 1996; 80(2): 125–8. doi: 10.1136/bjo.80.2.125.</mixed-citation><mixed-citation xml:lang="en">Eliassi-Rad B., Albert D.M., Green W.R. Frequency of ocular metastases in patients dying of cancer in eye bank populations. Br J Ophthalmol. 1996; 80(2): 125–8. doi: 10.1136/bjo.80.2.125.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Гришина Е.Е. Метастатическое поражение органа зрения. РМЖ. Клиническая офтальмология. 2001; 2(1): 15–17.</mixed-citation><mixed-citation xml:lang="en">Grishina E.E. Ocular metastases. RMJ. Clinical Ophthalmology. 2001; 2(1): 15–17. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pierson T.M., Tebit E.V., El Sayed A., Smolkin M.E., Dillon P.M. Orbital Metastases from Breast Cancer: Retrospective Analysis at an Academic Cancer Center. Breast J. 2016; 22(4): 447–50. doi: 10.1111/tbj.12604.</mixed-citation><mixed-citation xml:lang="en">Pierson T.M., Tebit E.V., El Sayed A., Smolkin M.E., Dillon P.M. Orbital Metastases from Breast Cancer: Retrospective Analysis at an Academic Cancer Center. Breast J. 2016; 22(4): 447–50. doi: 10.1111/tbj.12604.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Grajales-Alvarez R., Gutierrez-Mata A. Orbital metastases from breast cancer: A retrospective analysis of 28 cases. Cancer Treat Res Commun. 2020. doi: 10.1016/j.ctarc.2020.100184.</mixed-citation><mixed-citation xml:lang="en">Grajales-Alvarez R., Gutierrez-Mata A. Orbital metastases from breast cancer: A retrospective analysis of 28 cases. Cancer Treat Res Commun. 2020. doi: 10.1016/j.ctarc.2020.100184.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Aralikatti D.A., Nylander A.G. Orbital metastasis from squamous cell carcinoma of the esophagus. Eur J Ophthalmol. 2006; 16(3): 458–60. doi: 10.1177/112067210601600316.</mixed-citation><mixed-citation xml:lang="en">Aralikatti D.A., Nylander A.G. Orbital metastasis from squamous cell carcinoma of the esophagus. Eur J Ophthalmol. 2006; 16(3): 458–60. doi: 10.1177/112067210601600316.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">González F., López-Couto C. Metástasis orbitarias. Serie de cuatro casos y revisión de la literatura [Orbital metastases. A report of four cases and a review of the literature]. Arch Soc Esp Oftalmol. 2006; 81(8): 451–62. Spanish. doi: 10.4321/s0365-66912006000800006.</mixed-citation><mixed-citation xml:lang="en">González F., López-Couto C. Metástasis orbitarias. Serie de cuatro casos y revisión de la literatura [Orbital metastases. A report of four cases and a review of the literature]. Arch Soc Esp Oftalmol. 2006; 81(8): 451–62. Spanish. doi: 10.4321/s0365-66912006000800006.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Freedman M.I., Folk J.C. Metastatic tumors to the eye and orbit. Patient survival and clinical characteristics. Arch Ophthalmol. 1987; 105(9): 1215–9. doi: 10.1001/archopht.1987.01060090073031.</mixed-citation><mixed-citation xml:lang="en">Freedman M.I., Folk J.C. Metastatic tumors to the eye and orbit. Patient survival and clinical characteristics. Arch Ophthalmol. 1987; 105(9): 1215–9. doi: 10.1001/archopht.1987.01060090073031.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Schick U., Lermen O., Hassler W. Management of orbital metastases. Zentralbl Neurochir. 2006; 67(1): 1–7. doi: 10.1055/s2005-836922.</mixed-citation><mixed-citation xml:lang="en">Schick U., Lermen O., Hassler W. Management of orbital metastases. Zentralbl Neurochir. 2006; 67(1): 1–7. doi: 10.1055/s2005-836922.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Shields J.A., Shields C.L., Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1. Ophthalmology. 2004; 111(5): 997–1008. doi: 10.1016/j.ophtha.2003.01.002.</mixed-citation><mixed-citation xml:lang="en">Shields J.A., Shields C.L., Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1. Ophthalmology. 2004; 111(5): 997–1008. doi: 10.1016/j.ophtha.2003.01.002.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Günalp I., Gündüz K. Metastatic orbital tumors. Jpn J Ophthalmol. 1995; 39(1): 65–70.</mixed-citation><mixed-citation xml:lang="en">Günalp I., Gündüz K. Metastatic orbital tumors. Jpn J Ophthalmol. 1995; 39(1): 65–70.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Holland D., Maune S., Kovács G., Behrendt S. Metastatic tumors of the orbit: a retrospective study. Orbit. 2003; 22(1): 15–24. doi: 10.1076/orbi.22.1.15.14007.</mixed-citation><mixed-citation xml:lang="en">Holland D., Maune S., Kovács G., Behrendt S. Metastatic tumors of the orbit: a retrospective study. Orbit. 2003; 22(1): 15–24. doi: 10.1076/orbi.22.1.15.14007.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
