oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciencesoncotomsk-33Research ArticleОБЗОРЫREVIEWSРАК ЖЕЛУДКА: СОВРЕМЕННЫЕ МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ ДАННЫЕ (ОБЗОР ЛИТЕРАТУРЫ)GASTRIC CANCER: MOLECULAR AND GENETIC DATA (LITERATURE REVIEW)БелковецА. В.BelkovetsA. V.belkovets@gmx.deРешетниковО. В.ReschetnikovO. V.belkovets@gmx.deКуриловичС. A.KurilovichS. A.

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

175/1, B. Bogatkova st., 630089-Novosibirsk

belkovets@gmx.deМаксимовВ. Н.MaksimovV. N.belkovets@gmx.deФГБУ «НИИ терапии и профилактической медицины» СО РАМН, г. НовосибирскРоссияInstitute of Internal and Prophylactic Medicine of SB RAMS, NovosibirskRussian FederationФГБУ «НИИ терапии и профилактической медицины» СО РАМН, г. Новосибирск ГБОУ ВПО «Новосибирский государственный медицинский университет», г. НовосибирсРоссияInstitute of Internal and Prophylactic Medicine of SB RAMS, Novosibirsk Novosibirsk State Medical University, Novosibirsk, Russian Federation2Russian Federation201407022016025664Copyright © Белковец А.В., Решетников О.В., Курилович С.A., Максимов В.Н., 20162016Белковец А.В., Решетников О.В., Курилович С.A., Максимов В.Н.Belkovets A.V., Reschetnikov O.V., Kurilovich S.A., Maksimov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/33

Обобщены современные данные о молекулярно-генетических поломках, выявленных при разных морфологических вариантах рака желудка в популяционных и семейных исследованиях. Приводятся сведения о множественных генетических и эпигенетических поломках в онкогенах, генах-супрессорах опухолей, регуляторах клеточного цикла, адгезивных молекулах, генах репарации ДНК, а также генетической нестабильности и активации теломераз, вовлеченных в многоступенчатый процесс канцерогенеза и вносящих вклад в скорость опухолевого роста и метастазирования. Обсуждаются возможности использования специфических молекулярных маркеров для ранней диагностики рака желудка и прогноза выживаемости.

In the review a data about molecular and genetic aspects of different morphological variants of gastric cancer in population and family studies are generalized. Data about multiple genetic and epigenetic damages in oncogenes, tumor suppressor genes, cell cycle regulators, adhesion molecules, DNA repair genes as well as genetic instability and telomerase activation involved in the multistep process of carcinogenesis and making a contribution to uncontrolled growth and ability to form metastases are included in the review. In article possibilities of use of specific molecular markers for early GC diagnostics are discussed.

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The authors declare that there are no conflicts of interest present.