References

oncotomsk

Сибирский онкологический журнал

Siberian journal of oncology

1814-48612312-3168

Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences

10.21294/1814-4861-2016-15-2-90-100

oncotomsk-338

Research Article

ОБЗОРЫ

REVIEWS

СОВРЕМЕННЫЕ МЕТОДЫ ЛЕЧЕНИЯ РЕЦИДИВНОГО НЕОПЕРАБЕЛЬНОГО ПЛОСКОКЛЕТОЧНОГО РАКА ГОРТАНИ (ОБЗОР ЛИТЕРАТУРЫ)

MODERN METHODS OF TREATMENT OF RECURRENT UNRESECTABLE SQUAMOUS CELL CARCINOMA OF LARYNX (LITERATURE REVIEW)

Рожнов

В. А.

Rozhnov

V. A.

доктор медицинских наук, ведущий научный сотрудник отделения лучевого и хирургического лечения заболеваний верхних дыхательных путей, Медицинский радиологический научный центр им. А.Ф. Цыба – филиал федерального государственного бюджетного учреждения «Национальный медицинский исследовательский радиологический центр» (г. Обнинск, Калужская область, Российская Федерация). SPIN-код: 2122-4410.

MD, DSc, Leading Researcher, Department of Radiotherapy and Surgery for Diseases of the Upper Respiratory Tract, A.F. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre (Obninsk, Kaluga region, Russian Federation). SPIN-code: 2122-4410.

vit@mrrc.obninsk.ru

Андреев

В. Г.

Andreev

V. G.

доктор медицинских наук, профессор, ведущий научный сотрудник, заведующий отделением лучевого и хирургического лечения заболеваний верхних дыхательных путей, Медицинский радиологический научный центр им. А.Ф. Цыба – филиал федерального государственного бюджетного учреждения «Национальный медицинский исследовательский радиологический центр» (г. Обнинск, Калужская область, Российская Федерация). SPIN-код: 9163-8490.

MD, DSc, Professor, Leading Researcher, Head of the Department of Radiotherapy and Surgery for Diseases of the Upper Respiratory Tract, A.F. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre (Obninsk, Kaluga region, Russian Federation). SPIN-code: 9163-8490.

andreev@mrrc.obninsk.ru

Гордон

К. Б.

Gordon

K. B.

научный сотрудник, врач-радиолог отделения дистанционной лучевой терапии, Медицинский радиологический научный центр им. А.Ф. Цыба – филиал федерального государственного бюджетного учреждения «Национальный медицинский исследовательский радиологический центр» (г. Обнинск, Калужская область, Российская Федерация). SPIN-код: 2045-4565.

Researcher, Radiologist, Department of Distant Beam Radiation Therapy, A.F. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre (Obninsk, Kaluga region, Russian Federation). SPIN-code: 2045-4565.

gordon@mrrc.obninsk.ru

Гулидов

И. А.

Gulidov

I. A.

доктор медицинских наук, профессор, заведующий отделением дистанционной лучевой терапии, Медицинский радиологический научный центр им. А.Ф. Цыба – филиал федерального государственного бюджетного учреждения «Национальный медицинский исследовательский радиологический центр» (г. Обнинск, Калужская область, Российская Федерация). SPIN-код: 2492-5581.

MD, Professor, Head of the Department of Distant Beam Radiation Therapy, A.F. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre (Obninsk, Kaluga region, Russian Federation). SPIN-code: 2492-5581.

i.a.gulidov@mrrc.obninsk.ru

Акки

Э. Д.

Akki

E. D.

научный сотрудник отделения лучевого и хирургического лечения заболеваний верхних дыхательных путей, Медицинский радиологический научный центр им. А.Ф. Цыба – филиал федерального государственного бюджетного учреждения «Национальный медицинский исследовательский радиологический центр» (г. Обнинск, Калужская область, Российская Федерация). SPIN-код: 3225-2078.

Researcher, Department of Radiotherapy and Surgery for Diseases of the Upper Respiratory Tract, A.F. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre (Obninsk, Kaluga region, Russian Federation). SPIN-code: 3225-2078.

erni_81@mail.ru

Медицинский радиологический научный центр им. А.Ф. Цыба – филиал федерального государственного бюджетного учреждения «Национальный медицинский исследовательский радиологический центр» Министерства здравоохранения Российской Федерации, 249036, ул. Королева, 4, Калужская область, г. ОбнинскРоссияA.F. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre, 4, Koroleva Street, 249036-Obninsk, Kaluga region, Russia.Russian Federation

2016

15072016

15290100

2016

Рожнов В.А., Андреев В.Г., Гордон К.Б., Гулидов И.А., Акки Э.Д.

Rozhnov V.A., Andreev V.G., Gordon K.B., Gulidov I.A., Akki E.D.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.siboncoj.ru/jour/article/view/338

В обзоре литературы представлены данные о современных методах лечения неоперабельного рецидивного плоскоклеточного рака гортани. Рассматриваются вопросы применения лучевой и лекарственной терапии.

The literature review presents the modern methods of treatment of inoperable recurrent squamous cell cancer of the larynx. The application of radiation and chemotherapy.

неоперабельный рак гортанирецидивпаллиативное лечениелучевая терапияхимиотерапия

inoperable cancer of the larynxrelapsepalliative careradiotherapychemotherapy

References1

Андреев В.Г., Мардынский Ю.С. Лучевое и комбинированное лечение рака гортани. М., 1998. 116 с.

Andreev V.G., Mardynskij Ju.S. Radiotherapy and combined treatment of laryngeal cancer. M., 1998. 116 p. [in Russian]

Гервас П.А., Литвяков Н.В., Попова Н.О., Добродеев А.Ю., Тарасова А.С., Юмов Е.Л., Иванова Ф.Г., Черемисина О.В., Афанасьев С.Г., Гольдберг В.Е., Чердынцева Н.В. Проблемы и перспективы

Gervas P.A., Litviakov N.V., Popova N.O., Dobrodeev A.Yu., Tarasova A.S., Yumov E.L., Ivanova F.G., Cheremisina O.V., Afanasyev S.G., Goldberg V.E., Cherdyntseva N.V. Problem and perspective to improve molecular testing to choose appropriate target therapy // Sibirskij onkologicheskij zhurnal. 2014. № 2. P. 46–55. [in Russian]

совершенствования молекулярно-генетической диагностики для назначения таргетных препаратов в онкологии // Сибирский онкологический журнал. 2014. № 2. С. 46–55.

Goldobenko G.V., Tkachev S.I., Matjakin E.G., Romanov I.G., Makarov S.P., Orlik O.P., Klimakov B.D. Thermoradiotherapy treatment of recurrent metastatic cancer of the upper respiratory tract and pischeprovodnyh in lymph nodes // Rossijskij onkologicheskij zhurnal. 1997. № 6. P. 9–11. [in Russian]

Голдобенко Г.В., Ткачев С.И., Матякин Е.Г., Романов И.Г., Макаров С.П., Орлик О.П., Климаков Б.Д. Термолучевая терапия рецидивных метастазов рака верхних дыхательных и пищепроводных путей в лимфатических узлах // Российский онкологический журнал. 1997. № 6. С. 9–11.

Darij V.A. Prophylactics of locoregional metastases of laryngeal cancer // Materialy III s’ezda onkologov i radiologov SNG. Minsk, 2004. Part. II. P. 10. [in Russian]

Дарий В.А. Профилактика регионарных метастазов при раке гортани // Материалы III съезда онкологов и радиологов СНГ. Минск, 2004. Часть II. С. 10.

Zav’jalov A.A., Musabaeva L.I., Lisin V.A., Chojnzonov E.L., Novikov V.A., Kolomiec L.A., Tuzikov S.A.. Afanas’ev S.G., Dubskij S.V., Anisenja I.I., Tjukalov Ju.I., Miller S.V., Dobrodeev A.Ju., Chivchish L.N., Nechitajlo M.N., Zheravin A.A. A 15-year experience in using intraoperative radiation therapy // Sibirskij onkologicheskij zhurnal. 2004. № 2–3. P. 75–84. [in Russian]

Завьялов А.А., Мусабаева Л.И., Лисин В.А., Чойнзонов Е.Л., Новиков В.А., Коломиец Л.А., Тузиков С.А., Афанасьев С.Г., Дубский С.В., Анисеня И.И., Тюкалов Ю.И., Миллер С.В., Добродеев А.Ю., Чивчиш Л.Н., Нечитайло М.Н., Жеравин А.А. Пятнадцатилетний опыт применения интраоперационной лучевой терапии // Сибирский онкологический журнал. 2004. № 2–3. С. 75–84.

Malignant neoplasms in Russia in 2011 (morbidity and mortality) / Eds. V.I. Chissov, V.V. Starinskij, G.V. Petrova. M., 2013. 289 p. [in Russian]

Злокачественные новообразования в России в 2012 году (заболеваемость и смертность) / Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М., 2014. 250 с.

Kislichko A.G. Continuous infusion intra-arterial chemotherapy combined with local hyperthermia in the treatment of unresectable cancer oropharyngeal // Palliativnaja medicina i reabilitacija. 1999. № 2. P. 21. [in Russian]

Кисличко А.Г. Длительная внутриартериальная инфузионная химиотерапия в сочетании с локальной гипертермией при лечении нерезектабельного рака орофарингеальной зоны // Паллиативная медицина и реабилитация. 1999. № 2. С. 21.

Muhamedov M.R., Cheremisina O.V., Choynzonov E.L., Kulbakin D.E., Balatskaya L.N., Vasiliev N.V., Gunther V.E. The modern view on complex approach when diagnosing, treating and aftercaring in larynx cancer patients // Rossijskaja otorinolaringologija. 2012. № 3. P. 78–84. [in Russian]

Мухамедов М.Р., Черемисина О.В., Чойнзонов Е.Л., Кульбакин Д.Е., Балацкая Л.Н., Васильев Н.В., Гюнтер В.Э. Современный взгляд на комплексный подход к диагностике, лечению и реабилитации больных раком гортани // Российская оториноларингология. 2012. № 3. С. 78–84.

Paches A.I. Tumors of head and neck. M., 2000. 480 p. [in Russian] 10. Sdvizhkov A.M., Borisov V.I., Soldatov I.V., Umerenkov A.G. Using of intraarterial regional chemotherapy in complex and palliative treatment of patients with head and neck cancer // Palliativnaja medicina i reabilitacija. 2001. № 2–3. P. 38. [in Russian]

Пачес А.И. Опухоли головы и шеи. М., 2000. 480 с.

Tkachev S.I., Ljubaev V.L., Matjakin E.G., Kondrat’eva A.P., Alieva S.B., Zimina N.A. Chemoradiotherapy of squamous cell head and neck cancer // Materialy VII Rossijskoj onkologicheskoj konferencii. M., 2003. P. 25–27. [in Russian]

Сдвижков А.М., Борисов В.И., Солдатов И.В., Умеренков А.Г. Использование внутриартериальной регионарной химиотерапии в комплексном и паллиативном лечении больных с опухолями головы и шеи // Паллиативная медицина и реабилитация. 2001. № 2–3. С. 38.

Chernichenko A.V., Reshetov I.V., Edemskaja O.V. The results of research about using of intraoperative radiotherapy in patients with localadvanced primary and recurrent head and neck tumors // Onkohirurgija. 2008. № 2. P. 102. [in Russian]

Ткачев С.И., Любаев В.Л., Матякин Е.Г., Кондратьева А.П., Алиева С.Б., Зимина Н.А. Химиолучевая терапия плоскоклеточного рака головы и шеи // Материалы VII Российской онкологической конференции. М., 2003. С. 25–27.

Choynzonov E.L., Startseva Zh.A., Mukhamedov M.R., Spivakova I.O., Cheremisina O.V., Gribova O.V., Kul’bakin D.E. Local hyperthermia in the combined treatment of patients with cancer of the larynx and hypopharynx // Sibirskij onkologicheskij zhurnal. 2014. № 5. P. 5–12. [in Russian]

Черниченко А.В., Решетов И.В., Едемская О.В. Результаты исследования по использованию метода интраоперационной лучевой терапии у больных злокачественными первичными и рецидивными местнораспространенными опухолями головы и шеи // Онкохирургия. 2008. № 2. С. 102.

Shackaja N.H., Sdvizhkov A.M., Bjahov M.Ju. Features the symptomatic treatment of patients IV clinical group with head and neck tumors // Palliativnaja medicina i reabilitacija. 1999. № 2. P. 10. [in Russian]

Чойнзонов Е.Л., Старцева Ж.А., Мухамедов М.Р., Спивакова И.О., Черемисина О.В., Грибова О.В., Кульбакин Д.Е., Суркова П.В. Локальная гипертермия в комбинированном лечении рака гортани и гортаноглотки // Сибирский онкологический журнал. 2014. № 5. С. 5–12.

Argiris A., Karamouzis M.V., Gooding W.E., Branstetter B.F., Zhong S., Raez L.E., Savvides P., Romkes M. Phase II trial of pemetrexed and bevacizumab in patients with recurrent or metastatic head and neck cancer // J. Clin. Oncol. 2011. Vol. 29 (9). P.1140–1145 . doi: 10.1200/JCO.2010.33.3591.

Шацкая Н.Х., Сдвижков А.М., Бяхов М.Ю. Возможности симптоматического лечения больных IV клинической группы с опухолями головы и шеи // Паллиативная медицина и реабилитация. 1999. № 2. С. 10.

Armand J.P., Couteau C., Ramires Cintra F.J. ESMO meeting. Lisbon, 1994. P. 119–129.

Baselga J., Trigo J.M., Bourhis J., Tortochaux J., Cortés-Funes H., Hitt R., Gascón P., Amellal N., Harstrick A., Eckardt A. Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinumrefractory metastatic and/or recurrent squamous cell carcinoma of the head and neck // J. Clin. Oncol. 2005. Vol. 23 (24). P. 5568–5577.

Armand J.P., Couteau C., Ramires Cintra F.J. ESMO meeting. Lisbon, 1994. P. 119–129.

Benazzo M., Merlano M., Corvo R., Sanguineti G. Alternating concomitant chemoradiotherapy with gemcitabine and cisplatin in advanced squamous cell carcinoma of head and neck; a feasibility study // Eighth Congress on AntiCancer Treatment. Paris. France, 1998. P. 92.

Biagioli M.C., Harvey M., Roman E., Raez L.E., Wolfson A.H., Mutyala S., Han H.S., Markoe A. Intensity-modulated radiotherapy with concurrent chemotherapy for previously irradiated, recurrent head and neck cancer // Int. J. Radiat. Oncol. Biol. Phys. 2007. Vol. 69 (4). P. 1067–1073.

Bollet M.A., Lapeyre M., Marchal C., Hoffstetter S., Peiffert D., Cornes P.G., Luporsi E., Bey P. Cervical lymph node relapses of head and neck squamous cell carcinoma: is brachytherapy a therapeutic option? // Int. J. Radiat. Oncol. Biol. Phys. 2001. Vol. 51 (5). P. 1305–1312.

Bourhis J., Rivera F., Mesia R., Awada A., Geoffrois L., Borel C., Humblet Y., Lopez-Pousa A., Hitt R., Vega Villegas M.E., Duck L., Rosine D., Amellal N., Schueler A., Harstrick A. Phase I/II study of cetuximab in combination with cisplatin or carboplatin and fluorouracil in patients with recurrent or metastatic squamous cell carcinoma of the head and neck // J. Clin. Oncol. 2006. Vol. 24 (18). P. 2866–2872.

Brockstein B., Haraf D.J., Rademaker A.W., Kies M.S., Stenson K.M., Rosen F., Mittal B.B., Pelzer H., Fung B.B., Witt M.E., Wenig B., Portugal L., Weichselbaum R.W., Vokes E.E. Patterns of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy: A 9-year, 337-patient, multi-institutional experience // Ann. Oncol. 2004. Vol. 15 (8). P. 1179–1186.

Burtness B., Goldwasser M.A., Mattar B., Forastiere A.A. Phase III Randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group Study // J. Clin. Oncol. 2005. Vol. 23 (34). P. 8346–8654.

Chin R.K., Daly M.E., Maxim P.G. Salvage Re-irradiation using Intensity-modulated Radiotherapy for Squamous Cell Carcinoma of the Head and Neck // J. Radiat. Oncol. Biol. Phys. 2008. Vol. 72 (1). P. 420.

Choe K.S., Haraf D.J., Solanki A., Cohen E.E., Seiwert T.Y., Stenson K.M., Blair E.A., Portugal L., Villaflor V.M., Witt M.E., Vokes E.E., Salama J.K. Prior chemoradiotherapy adversely impacts outcomes of recurrent and second primary head and neck cancer treated with concurrent chemotherapy and reirradiation // Cancer. 2011. Vol. 117 (20). P. 4671–4678. doi: 10.1002/cncr.26084.

Choe K.S., Solanki F., Haraf D.J. Previous Chemoradiotherapy Predicts for Worse Survival in Patients Undergoing Chemo-reirradiation for Recurrent and Second Head and Neck Cancer // J. Radiat. Oncol. Biol. Phys. 2008. Vol. 72 (1). P. 378.

Cohen E.E. Novel therapeutic targets in squamous cell carcinoma of the head and neck // Semin. Oncol. 2004. Vol. 31 (6). P. 775–768.

Cohen E.E. Role of epidermal growth factor receptor pathway – targeted therapy in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck // J. Clin. Oncol. 2006. Vol. 24 (17). P. 2659–2665.

Cohen E.E. Novel therapeutic targets in squamous cell carcinoma of the head and neck // Semin. Oncol. 2004. Vol. 31 (6). P. 775–768.

Cohen E.E., Lingen M.W., Vokes E.E. The expanding role of chemotherapy in head and neck cancers // J. Clin. Oncol. 2004. Vol. 22 (9). P.1743–1752.

Colevas A.D. Chemotherapy options for patients with metastatic or recurrent squamous cell carcinoma of the head and neck // J. Clin. Oncol. 2006. Vol. 24 (17). P. 2644–2652.

Cohen E.E., Lingen M.W., Vokes E.E. The expanding role of chemotherapy in head and neck cancers // J. Clin. Oncol. 2004. Vol. 22 (9). P.1743–1752.

Cornes P.G., Cox H.J., Rhys-Evans P.R., Breach N.M., Henk J.M. Salvage treatment for inoperable neck nodes in head and neck cancer using combined iridium-192 brachytherapy and surgical reconstruction // Br. J. Surg. 1996. Vol. 83 (11). P. 1620–1622.

Colevas A.D. Chemotherapy options for patients with metastatic or recurrent squamous cell carcinoma of the head and neck // J. Clin. Oncol. 2006. Vol. 24 (17). P. 2644–2652.

Dawson L.A., Myers L.L., Bradford C.R., Chepeha D.B., Hogikyan N.D., Teknos T.N., Terrell J.E., Wolf G.T., Eisbruch A. Conformal re-irradiation of recurrent and new primary head-and-neck cancer // Int. J. Radiat. Oncol. Biol. Phys. 2001. Vol. 50 (2). P. 377–385.

Domenge C., Pignon J.P., Sancho-Gamier H. Chemotherapy in locally advanced head and neck squamous cell carcinoma: results of a metaanalysis asing individual patient data of randomized trials // VIII Internal Congress on Anti-Cancer Treatment. Paris, France, 1998. P. 92.

Forastiere A.A., Shank D., Neuberg D., Taylor S.G. 4th, DeConti R.C., Adams G. Final report of a phase II evaluation of paclitaxel in patients with advanced squamous cell carcinoma of the head and neck: An Eastern Cooperative Oncology Group trial (PA390) // Cancer. 1998. Vol. 82 (11). P. 2270–2274.

Fury M.G., Sherman E., Lisa D., Algazy K., Brockstein B., Langer C., Lim D., Mehra R., Rajan S.K., Korte S., Lipson B., Yunus F., Tanvetyanon T., Smith-Marrone S., Ng K., Xiao H., Haque S., Pfister D.G. A randomized phase II study of cetuximab every 2 weeks at either 500 or 750 mg/m2 for patients with recurrent or metastatic head and neck squamous cell cancer // J. Natl. Compr. Canc. Netw. 2012. Vol. 10 (11). P. 1391–1398.

Gibson M.K., Li Y., Murphy B., Hussain M.H., DeConti R.C., Ensley J., Forastiere A.A. Randomized phase III evaluation of cisplatin plus fluorouracil versus cisplatin plus paclitaxel in advanced head and neck cancer (E1395): an intergroup trail of the Eastern Cooperative Oncology Group // J. Clin. Oncol. 2005. Vol. 23 (15). P. 3562–3567.

Grau J.J., Caballero M., Verger E., Monzó M., Blanch J.L. Weekly paclitaxel for platin-resistant stage IV head and neck cancer patients // Acta Otolaryngol. 2009. Vol. 129 (11). P. 1294–1299. doi: 10.3109/00016480802590451.

Grimard L., Esche B., Lamothe A., Cygler J., Spaans J. Interstitial low-dose-rate brachytherapy in the treatment of recurrent head and neck malignancies // Head Neck. 2006. Vol. 28 (1). P. 888–895.

Herbst R.S., Arquette M., Shin D.M., Dicke K., Vokes E.E., Azarnia N., Hong W.K., Kies M.S. Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck // J. Clin. Oncol. 2005. Vol. 23 (24). P. 5578–5587.

Grimard L., Esche B., Lamothe A., Cygler J., Spaans J. Interstitial low-dose-rate brachytherapy in the treatment of recurrent head and neck malignancies // Head Neck. 2006. Vol. 28 (1). P. 888–895.

Hitt R., Amador M.L., Quintela-Fandino M., Jimeno A., del Val O., Hernando S., Cortes-Funes H. Weekly docetaxel in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck // Cancer. 2006. Vol. 106 (1). P. 106–111.

Horowitz E.M., Harris J., Langer C.J. Concurrent split course hyperfractionated radiotherapy, cisplatin, and paclitaxel in patients with recurrent, previously irradiated squamous cell carcinoma of the head and neck: Update of RTOG 9911 // J. Clin. Oncol. 2005. Vol. 23. P. 519.

Hunter K.D., Parkinson E.K., Harrison P.R. Profiling early head and neck cancer // Nat Rev Cancer. 2005. Vol. 5 (2). P. 127–135.

Jacobs C., Lyman G., Velez-Garcia E., Sridhar K.S., Knight W., Hochster H., Goodnough L.T., Mortimer J.E., Einhorn L.H., Schacter L. A phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck // J. Clin. Oncol. 1992. Vol. 10 (2). P. 257–263.

Hunter K.D., Parkinson E.K., Harrison P.R. Profiling early head and neck cancer // Nat Rev Cancer. 2005. Vol. 5 (2). P. 127–135.

Kasperts N., Slotman B., Leemans C.R., Langendijk J.A. A review on re-irradiation for recurrent and second primary head and neck cancer // Oral Oncol. 2005. Vol. 41 (3). P.225–243.

Kawecki A., Jagielska B., Falkowski S. Chemotherapy for metastatic or recurrent laryngeal cancer: tolerance and early results // Otolaryngol. Pol. 2000. Vol. 54. Suppl. 31. P. 21–23.

Kasperts N., Slotman B., Leemans C.R., Langendijk J.A. A review on re-irradiation for recurrent and second primary head and neck cancer // Oral Oncol. 2005. Vol. 41 (3). P.225–243.

Kramer N.M., Horwitz E.M., Cheng J., Ridge J.A., Feigenberg S.J., Cohen R.B., Nicolaou N., Sherman E.J., Babb J.S., Damsker J.A., Langer C.J. Toxicity and outcome analysis of patients with recurrent head and neck cancer treated with hyperfractionated split-course reirradiation and concurrent cisplatin and paclitaxel chemotherapy from two prospective phase I and II studies // Head Neck. 2005. Vol. 27 (5). P. 406–414.

Kawecki A., Jagielska B., Falkowski S. Chemotherapy for metastatic or recurrent laryngeal cancer: tolerance and early results // Otolaryngol. Pol. 2000. Vol. 54. Suppl. 31. P. 21–23.

Langendijk J.A., Bourhis J. Reirradiation in squamous cell head and neck cancer: recent developments and future directions // Curr. Opin. Oncol. 2007. Vol. 19 (3). P. 202–209.

Latham M.M., Smart G.P., Hedland-Thomas B., Harper C.S. Endoluminal brachytherapy for recurrent laryngeal carcinoma // Australas Radiol. 1997. Vol. 41 (4). P. 357–360.

Langendijk J.A., Bourhis J. Reirradiation in squamous cell head and neck cancer: recent developments and future directions // Curr. Opin. Oncol. 2007. Vol. 19 (3). P. 202–209.

Lee N., Chan K., Bekelman J.E., Zhung J., Zhung J., Mechalakos J., Narayana A., Wolden S., Venkatraman E.S., Pfister D., Kraus D., Shah J., Zelefsky M.J. Salvage re-irradiation for recurrent head and neck cancer // Int. J. Radiat. Oncol. Biol. Phys. 2007. Vol. 68 (3). P. 731–740.

Latham M.M., Smart G.P., Hedland-Thomas B., Harper C.S. Endoluminal brachytherapy for recurrent laryngeal carcinoma // Australas Radiol. 1997. Vol. 41 (4). P. 357–360.

Leon X., Hitt R., Constenla M., Rocca A., Stupp R., Kovács A.F., Amellal N., Bessa E.H., Bourhis J. A retrospective analysis of the outcome of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck refractory to platinum-based chemotherapy // Clin. Oncol. 2005. Vol. 17 (6). P. 418–424.

Levendaag P.C., Meeuwis C.A., Visser G.A. Reirradiation of recurrent head and neck cancers: external and/or interstitial radiation therapy // Radiother. Oncol. 1992. Vol. 23. P. 6–15.

Licitra L., Felip E. ESMO Guidelines Working Group. Squamous cell carcinoma of the head and neck: ESMO clinical recommendations for diagnosis, treatment and follow-up // Ann. Oncol. 2009. Vol. 20 (Suppl. 4). P. 121–122.

Levendaag P.C., Meeuwis C.A., Visser G.A. Reirradiation of recurrent head and neck cancers: external and/or interstitial radiation therapy // Radiother. Oncol. 1992. Vol. 23. P. 6–15.

Martinez-Trufero J., Isla D., Adansa J.C. Phase II study of capecitabine as palliative treatment for patients with squamous head and neck cancer with locoregional and/or metastatic relapse after previous platinumbased treatment: final results of Spanish Head and Neck Cancer Group // J. Clin. Oncol. 2009. Vol. 27 (15 Suppl). P. 312. (Abstr. 6047).

McLaughlin M.P., Parsons J.T., Fein D.A., Stringer S.P., Cassisi N.J., Mendenhall W.M., Million R.R. Salvage surgery after radiotherapy failure in T1-T2 squamous cell carcinoma of the glottic larynx // Head Neck. 1996. Vol. 18 (3). P. 229–235.

Misiukiewicz K., Bonomi M., Demicco E., Posner M. Controversies and role of HPV16 in recurrent/metastatic squamous cell cancers of the head and neck // Ann. Oncol. 2014. Vol. 25 (8). P. 1667–1668. doi: 10.1093/annonc/mdu194.

Murar S., Forastiere A.A. Head and neck cancer: changing epidemiology, diagnosis, and treatment // Mayo Clin Proc. 2008. Vol. 83 (4). P. 489–501. doi: 10.4065/83.4.489.

Murphy B.A. Topoisomerases in the treatment of metastatic or recurrent squamous carcinoma of the head and neck // Expert Opin. Pharmacother. 2005. Vol. 6 (1). P. 85–92.

Murar S., Forastiere A.A. Head and neck cancer: changing epidemiology, diagnosis, and treatment // Mayo Clin Proc. 2008. Vol. 83 (4). P. 489–501. doi: 10.4065/83.4.489.

Nag S., Schuller D.E., Martinez-Monge R., Rodriguez-Villalba S., Grecula J., Bauer C. Intraoperative electron beam radiotherapy for previously

Murphy B.A. Topoisomerases in the treatment of metastatic or recurrent squamous carcinoma of the head and neck // Expert Opin. Pharmacother. 2005. Vol. 6 (1). P. 85–92.

irradiated advanced head and neck malignancies // Int. J. Radiat. Oncol. Biol. Phys. 1998. Vol. 42 (5). P. 1085–1089.

Nag S., Schuller D.E., Martinez-Monge R., Rodriguez-Villalba S., Grecula J., Bauer C. Intraoperative electron beam radiotherapy for previously irradiated advanced head and neck malignancies // Int. J. Radiat. Oncol. Biol. Phys. 1998. Vol. 42 (5). P. 1085–1089.

Nishino H., Tanaka H., Ishikawa K., Kanazawa T., Miyata M., Kitamura K. Combined chemotherapy with low-dose cisplatin, tegafur and uracil in a case with neck recurrence of laryngeal cancer // Gan To Kagaku Ryoho. 1998. Vol. 25 (12). P. 1973–1975.

Norris C.M., Peale A.R. Partial laryngectomy for irradiation failure // Arch. Otolaryngol. 1996. Vol. 84. P. 558–562.

Ohizumi Y., Tamai Y., Imamiya S., Akiba T. Complications following reirradiation for head and neck cancer // Am. J. Otol. 2002. Vol. 23 (4). P. 215–221.

Park S., Lee S., Park J. Phase II study of oral S-1 in pretreated patients with recurrent or metastatic head and neck cancer // J. Clin. Oncol. 2008. Vol. 26 (15 Suppl). P. 692 (Abstr. 17007).

Patel P.R., Salama J.K. Reirradiation for recurrent head and neck cancer // Expert Rev. Anticancer Ther. 2012. Vol. 12 (9). P. 1177–1189. doi: 10.1586/era.12.97.

Pazdur R., Coia R., Hoskins W. Cancer management: A multidisciplinary approach. Lawrence, KS: CMP Healthcare Media. 2005. P. 43–90.

Perry D.J., Chan K., Wolden S., Zelefsky M.J., Chiu J., Cohen G., Zaider M., Kraus D., Shah J., Lee N. High-dose-rate intraoperative radiation therapy for recurrent head-and-neck cancer // Int. J. Radiat. Oncol. Biol. Phys. 2010. Vol. 76 (4). P. 1140–1146. doi: 10.1016/j.ijrobp.2009.03.025.

Rate W., Garrett P., Hamaker R., Singer M., Pugh N., Ross D., Haerr R., Charles G. Intraoperative radiation therapy for recurrent head and neck cancer // Cancer. 1991. Vol. 67 (11). P.2738–2740.

Rwigema J.C., Heron D.E., Ferris R.L., Gibson M., Quinn A., Yang Y., Ozhasoglu C., Burton S. Fractionated stereotactic body radiation therapy in the treatment of previously-irradiated recurrent head and neck carcinoma: updated report of the University of Pittsburgh experience // Am. J. Clin. Oncol. 2010. Vol. 33 (3). P. 286–293. doi: 10.1097/COC.0b013e3181aacba5.

Salama J.K., Vokes E.E., Chmura S.J., Milano M.T., Kao J., Stenson K.M., Witt M.E., Haraf D.J. Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary headand-neck squamous cell carcinoma // Int. J. Radiat. Oncol. Biol. Phys. 2006. Vol. 64 (2). P. 382–391.

Samlowski W.E., Moon J., Kuebler J.P., Nichols C.R., Gandara D.R., Ozer H., Williamson S.K., Atkins J.N., Schuller D.E., Ensley J.F. Evaluation of the combination of docetaxel/carboplatin in patients with metastatic or recurrent squamous cell carcinoma of the head and neck (SCCHN): a Southwest Oncology Group phase II study // Cancer Invest. 2007. Vol. 25 (3). P. 182–188.

Schrijvers D., Vermorken J.B. Taxanes in the treatment of head and neck cancer // Curr Opin Oncol. 2005. Vol. 17. P.218–224.

Seiwert T.Y., Salama J.K., Vokes E.E. The concurrent chemoradiation paradigm-general principles // Nat. Clin. Pract. Oncol. 2007. Vol. 4 (2). P. 86–100.

Seiwert T.Y., Salama J.K., Vokes E.E. The concurrent chemoradiation paradigm--general principles // Nat. Clin. Pract. Oncol. 2007. Vol. 4 (2). P. 86–100.

Specenier P., Vermorken J.B. Targeted therapies in head and neck cancer // Target Oncol. 2007. Vol. 2. P. 73–78.

Spencer S.A., Harris J., Wheeler R.H., Machtay M., Schultz C., Spanos W., Rotman M., Meredith R. RTOG 96-10: Reirradiation with concurrent hydroxyurea and 5 FU in patients with squamous cell cancer of head and neck // Int. J. Radiat. Oncol. Biol. Phys. 2001. Vol. 51 (5). P. 1299–1304.

Stewart J.S., Cohen E.E., Licitra L., Van Herpen C.M., Khorprasert C., Soulieres D., Vodvarka P., Rischin D., Garin A.M., Hirsch F.R., Varella-Garcia M., Ghiorghiu S., Hargreaves L., Armour A., Speake G., Swaisland A., Vokes E.E. Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck [corrected] // J. Clin. Oncol. 2009. Vol. 27 (6). P. 1864–1871. doi: 10.1200/JCO.2008.17.0530.

Sulman E.P., Schwartz D.L., Le T.T., Ang K.K., Morrison W.H., Rosenthal D.I., Ahamad A., Kies M., Glisson B., Weber R., Garden A.S. IMRT reirradiation of head and neck cancer-disease control and morbidity outcomes // Int. J. Radiat. Oncol. Biol. Phys. 2009. Vol. 73 (2). P. 399–409. doi: 10.1016/j.ijrobp.2008.04.021.

Trigo J., Hitt R., Korawalewski P. Cetuximab monotherapy is active in patients (pts) with platinum-refractory recurrent/metastatic squamous cell carcinoma of the nead and neck (SCCHN): result of a phase II study // Proc. ASCO. 2004. Vol. 23. P. 5502–5514.

Vargo J.A., Wegner R.E., Heron D.E., Ferris R.L., Rwigema J.C., Quinn A., Gigliotti P., Ohr J., Kubicek G.J., Burton S. Stereotactic body radiation therapy for locally recurrent, previously irradiated nonsquamous cell cancers of the head and neck // Head Neck. 2012. Vol. 34 (8). P. 1153–1161. doi: 10.1002/hed.21889.

Vermorken J.B., Psyrri A., Mesía R., Peyrade F., Beier F., de Blas B., Celik I., Licitra L. Impact of tumor HPV status on outcome in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck receiving chemotherapy with or without cetuximab: retrospective analysis of the phase III EXTREME trial // Ann. Oncol. 2014. Vol. 25 (4). P. 801–807. doi: 10.1093/annonc/mdt574.

Vermorken J.B., Trigo J., Hitt R., Koralewski P., Diaz-Rubio E., Rolland F., Knecht R., Amellal N., Schueler A., Baselga J. Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy // J. Clin. Oncol. 2007. Vol. 25 (16). P. 2171–2177.

Viani L., Stell P.M., Dalby J.E. Recurrence after radiotherapy for glottic carcinoma // Cancer. 1991. Vol. 67 (3). P. 577–584. 81. Watson J.C., Ridge J.A. Surgical management of local and regional recurrent head and neck squamous cell carcinoma // Curr. Opin. Oncol. 1998. Vol. 10 (3). P. 207–212.

Viani L., Stell P.M., Dalby J.E. Recurrence after radiotherapy for glottic carcinoma // Cancer. 1991. Vol. 67 (3). P. 577–584.

Wenig B.L., Werner J.A., Castro D.J., Sridhar K.S., Garewal H.S., Kehrl W., Pluzanska A., Arndt O., Costantino P.D., Mills G.M., Dunphy F.R. 2nd, Orenberg E.K., Leavitt R.D. The Role of Intratumoral Therapy With Cisplatin/Epinephrine Injectable Gel in the Management of Advanced Squamous Cell Carcinoma of the Head and Neck // Arch. Otolaryngol. Head Neck Surg. 2002. Vol. 128 (8). P. 880–885.

Watson J.C., Ridge J.A. Surgical management of local and regional recurrent head and neck squamous cell carcinoma // Curr. Opin. Oncol. 1998. Vol. 10 (3). P. 207–212.

Wong S.J., Machtay M., Li Y. Locally recurrent, previously irradiated head and neck cancer: Concurrent re-irradiation and chemotherapy, or chemotherapy alone? // J. Clin. Oncol. 2006. Vol. 24 (17). P. 2653–2658.

The authors declare that there are no conflicts of interest present.