oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2025-24-1-142-149oncotomsk-3454Research ArticleОБЗОРЫREVIEWSФармацевтические и экспериментально-клинические аспекты комбинированной фотодинамической терапии злокачественных опухолей и предраков с применением химиотерапииPharmaceutical and experimental-clinical aspects of photodynamic therapy combined with chemotherapy for malignant and premalignant tumorshttps://orcid.org/0000-0001-8797-5932РоманкоЮ. С.RomankoYu. S.

Романко Юрий Сергеевич - доктор медицинских наук, профессор кафедры, ФГАОУ ВО «ПМГМУ им. И.М. Сеченова» Минздрава России; профессор кафедры, Академия постдипломного образования ФГБУ ФНКЦ ФМБА России.

119991, Москва, ул. Трубецкая, 8/2; 125371, Москва, Волоколамское шоссе, 91

Researcher ID (WOS) L-5965-2014, Author ID (Scopus) 7801463724

Yuri S. Romanko - MD, DSc, Professor of the Department, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia; Professor of the Department, Academy of Postgraduate Education, FSCC of FMBA of Russia.

8/2, Trubetskaya St., Moscow, 119991; 91, Volokolamskoe Shosse, Moscow, 125371

Researcher ID (WOS) L-5965-2014, Author ID (Scopus) 7801463724

romanko_yu_s@staff.sechenov.ruhttps://orcid.org/0000-0002-0909-6278РешетовИ. В.ReshetovI. V.

Решетов Игорь Владимирович - доктор медицинских наук, профессор, академик РАН, директор института, ФГАОУ ВО «ПМГМУ им. И.М. Сеченова» Минздрава России; заведующий кафедрой, Академия постдипломного образования ФГБУ ФНКЦ ФМБА России; научный руководитель факультета, ЧОУВО «МУ им. С.Ю. Витте».

119991, Москва, ул. Трубецкая, 8/2; 125371, Москва, Волоколамское шоссе, 91; 115432, Москва, 2-й Кожуховский пр-д, 12/1

Author ID (Scopus) 6701353127

Igor V. Reshetov - MD, DSc, Professor, Full Member of RAS, Director of the Institute, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia; Head of the Department, Academy of Postgraduate Education, FSCC of FMBA of Russia; Scientific Director of the faculty, S.Y. Witte Moscow University.

8/2, Trubetskaya St., Moscow, 119991; 91, Volokolamskoe Shosse, Moscow, 125371; 12/1, 2nd Kozhukhovsky Drive, Moscow, 115432

Author ID (Scopus) 6701353127

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России; Академия постдипломного образования ФГБУ ФНКЦ ФМБА РоссииРоссияI.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia; Academy of Postgraduate Education, FSCC of FMBA of RussiaRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России; Академия постдипломного образования ФГБУ ФНКЦ ФМБА России; ЧОУВО «Московский университет им. С.Ю. Витте»РоссияI.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia; Academy of Postgraduate Education, FSCC of FMBA of Russia; S.Y. Witte Moscow UniversityRussian Federation202518032025241142149Copyright © Романко Ю.С., Решетов И.В., 20252025Романко Ю.С., Решетов И.В.Romanko Y.S., Reshetov I.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/3454

Цель исследования – анализ эффективности экспериментальной и клинической комбинированной фотодинамической терапии злокачественных опухолей и предопухолевых заболеваний с использованием химиотерапии. Материал и методы. По данной проблеме был проведен поиск в базах данных WoS, Scopus, MedLine, РИНЦ, в основном за последние 7 лет. Мы нашли 288 публикаций о фармацевтических и экспериментально-клинических исследованиях комбинированной фотодинамической терапии в сочетании с химиотерапией для сравнения терапевтических эффектов комбинированной терапии и монотерапии, из которых 50 включили в обзор. Результаты. Фотодинамическая терапия представляет собой новую технологию лечения рака, которая в последние годы становится все более распространенной. В ряде случаев она является альтернативным методом лечения онкологических заболеваний, когда есть высокий риск развития побочных эффектов и осложнений при использовании традиционных методов лечения, таких как хирургическое вмешательство, лучевая терапия и химиотерапия. В обзоре рассматриваются современные фармацевтические и экспериментально-клинические аспекты комбинированной фотодинамической терапии с использованием химиотерапии. Несмотря на то, что сочетание фотодинамической терапии и химиотерапии дает лучший результат при лечении злокачественных новообразований, у этой стратегии лечения есть ограничения. Одна из главных проблем заключается в том, что исследований по комбинированной фотодинамической терапии с использованием химиотерапии проведено недостаточно, для понимания механизмов повышения эффективности комбинированной фотодинамической терапии требуется их продолжение. Еще одной проблемой является то, что вопрос недостаточно глубокого применения фотодинамической терапии остается нерешенным, что сужает возможности и комбинированной фотодинамической терапии. Необходимы дополнительные исследования для определения наиболее эффективных фотосенсибилизаторов и технологий использования неионизирующего излучения. В обзоре мы показали и новые стратегии, использующие нанофармацевтику, для усиления эффекта комбинированной фотодинамической терапии с химиотерапией, показывающие обнадеживающие экспериментальные и клинические результаты. Заключение. Повышенный терапевтический эффект и уменьшение побочных эффектов при комбинированной фотодинамической терапии с использованием химиотерапии заслуживают дальнейшего изучения.

The aim of the study was to analyze the effectiveness of experimental and clinical photodynamic therapy combined with chemotherapy in the treatment of malignant and premalignant lesions. Material and methods. The WoS, Scopus, MedLine, and RSCI databases have been searched and analyzed on this issue, mainly over the past 7 years. We found 288 sources on pharmaceutical and experimental-clinical studies of combined photodynamic therapy in combination with chemotherapy to compare the therapeutic effects of combination therapy and monotherapy, of which 50 were included in the review. Results. Photodynamic therapy is a new cancer treatment technology that has become increasingly common in recent years. In some cases, it is often an alternative method of treating cancer when there is a high risk of side effects and complications during traditional treatments such as surgery, radiation therapy and chemotherapy. The review summarized current pharmaceutical and experimental-clinical aspects of performing photodynamic therapy combined with chemotherapy. Despite the fact that the combination of photodynamic therapy and chemotherapy gives the best results in the treatment of malignant neoplasms, this treatment strategy has limitations. One of the major challenges is that very little research has been conducted in this field. Additional research is also needed to understand the mechanisms of increasing the effectiveness of combined photodynamic therapy. The challenge of reaching and effectively treating deeper tissues remains a significant obstacle to wider application of photodynamic therapy. Therefore, further research is needed to determine the most effective photosensitizers and technologies for using non-ionizing radiation. In the review, we have also shown new strategies of using nanopharmaceuticals, which demonstrated encouraging results. Conclusion. The improved therapeutic efficacy with reduced side effects of combination of photodynamic therapy and chemotherapy deserve further comprehensive study.

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The authors declare that there are no conflicts of interest present.