oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2025-24-1-39-48oncotomsk-3466Research ArticleКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯCLINICAL STUDIESПрофили экспрессии ферментов CYP1A1 и CYP1B1 при немелкоклеточном раке легкого у турецких пациентовExpression profiles of CYP1A1 and CYP1B1 enzymes in Non-small Cell Lung Cancer of Turkish Patientshttps://orcid.org/0009-0000-8100-596XBayramH.BayramH.

Hakan Bayram - биолог, кафедра биологии, факультет искусств и наук, Центральная научно-исследовательская лаборатория, Университет Кырыккале.

Кырыккале

Hakan Bayram - Biologist, Department of Biology, Faculty of Arts and Sciences, Central Research Laboratory, Kırıkkale University.

Kirikkale

https://orcid.org/0000-0003-0511-6611DiricanO.DiricanO.

Onur Dirican - доцент, старший научный сотрудник, кафедра лабораторных методов патологии, профессиональная школа здравоохранения, Стамбульский университет Гелисим.

Стамбул

Onur Dirican - Assistant Professor, Senior scientist, Department of Pathology Laboratory Techniques, Vocational School of Health Services, Istanbul Gelisim University.

Istanbul

odirican@gelisim.edu.trhttps://orcid.org/0000-0003-0127-1753KaygınP.KaygınP.

Pınar Kaygin - MSc, биолог, кафедра биологии, факультет искусств и наук, Университет Кырыккале.

Кырыккале

Pınar Kaygin - MSc, Biologist, Department of Biology, Faculty of Arts and Sciences, Kırıkkale University.

Kirikkale

https://orcid.org/0000-0003-1960-8924BaşakK.BaşakK.

Kayhan Başak - доцент кафедры патологии, Городская больница им. д-ра Лютфи Кырдара в Картале, Министерство здравоохранения Турции, Университет медицинских наук.

Стамбул

Kayhan Başak - MD, Associate Professor, Department of Pathology, Kartal Dr. Lütfi Kırdar City Hospital, Turkish Ministry of Health, University of Health Sciences.

İstanbul

https://orcid.org/0000-0002-8861-7106HusseiniА. А.HusseiniA. A.

Abbas Ali Husseını - доцент, старший научный сотрудник, Центр прикладных исследований и разработок в области естественных наук и биомедицинской инженерии, Стамбульский университет Гелисим.

Стамбул

Abbas Ali Husseını - Assistent Professor, Senior scientist, Life Sciences and Biomedical Engineering Application and Research Centre, Istanbul Gelisim University.

Istanbul

https://orcid.org/0000-0002-2453-1370AtlıМ.AtlıM.

Muharrem Atlı - MSc, PhD, научный сотрудник, кафедра биологии, факультет искусств и наук, Университет Кырыккале.

Кырыккале

Muharrem Atlı - MSc, PhD, Researcher, Department of Biology, Faculty of Arts and Sciences, Kırıkkale University.

Kirikkale

https://orcid.org/0000-0001-5064-0952KazancıF. Ç.KazancıF. Ç.

Fatma Çakmak Kazancı - врач, Клиника медицинской патологии, Государственная больница Черкезкёй.

Стамбул

Fatma Çakmak Kazancı - MD, Clinician, Medical Pathology Clinic, Çerkezköy State Hospital.

İstanbul

https://orcid.org/0000-0002-5892-3735OğuztüzünS.OğuztüzünS.

Serpil Oğuztüzün - профессор, кафедра биологии, факультет искусств и наук, Университет Кырыккале.

Кырыккале

Serpil Oğuztüzün - Professor Dr., Department of Biology, Faculty of Arts and Sciences, Kırıkkale University.

Kirikkale

Кафедра биологии, факультет искусств и наук, Университет КырыккалеТурцияDepartment of Biology, Faculty of Arts and Sciences, Kirikkale UniversityTurkeyКафедра лабораторных методов патологии, профессиональная школа здравоохранения, Стамбульский университет ГелисимТурцияDepartment of Pathology Laboratory Techniques, Vocational School of Health Services, Istanbul Gelişim UniversityTurkeyКафедра патологии, Городская больница им. д-ра Лютфи Кырдара в Картале, Министерство здравоохранения Турции, Университет медицинских наукТурцияDepartment of Pathology, Kartal Dr. Lütfi Kırdar City Hospital, Turkish Ministry of Health, University of Health SciencesTurkeyЦентр прикладных исследований и разработок в области естественных наук и биомедицинской инженерии, Стамбульский университет ГелисимТурцияLife Sciences and Biomedical Engineering Application and Research Centre, Istanbul Gelisim UniversityTurkeyКлиника медицинской патологии, Государственная больница ЧеркезкёйТурцияMedical Pathology Clinic, Çerkezkoy State HospitalTurkey2025190320252413948Copyright © Bayram H., Dirican O., Kaygın P., Başak K., Husseini А.А., Atlı М., Kazancı F.Ç., Oğuztüzün S., 20252025Bayram H., Dirican O., Kaygın P., Başak K., Husseini А.А., Atlı М., Kazancı F.Ç., Oğuztüzün S.Bayram H., Dirican O., Kaygın P., Başak K., Husseini A.A., Atlı M., Kazancı F.Ç., Oğuztüzün S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/3466

Актуальность. Ферменты цитохрома P450 CYP1A1 и CYP1B1 участвуют в метаболизме канцерогенов и связаны с различными видами рака, включая рак легкого, в основном за счет повышенной экспрессии в опухолевых тканях. Цель исследования – оценка уровней экспрессии CYP1A1 и CYP1B1 при аденокарциноме и плоскоклеточном раке легкого, а также их связи с демографическими и клиническими показателями у турецких пациентов. Материал и методы. В ретроспективном исследовании проведен сравнительный анализ клинических данных 40 пациентов с аденокарциномой и плоскоклеточным раком легкого. Уровни экспрессии CYP1A1 и CYP1B1 оценивались при иммуногистохимическом исследовании образцов опухоли и прилегающих здоровых тканей. Изучены ассоциации между уровнями экспрессии белка и клинико-морфологическими характеристиками пациентов. Результаты. Обнаружены значительные иммуногистохимические различия в уровнях экспрессии генов CYP1A1 и CYP1B1 между опухолевыми и здоровыми тканями. Заключение. Профили экспрессии CYP1A1 и CYP1B1 в образцах аденокарциномы и плоскоклеточной карциномы легкого могут быть потенциальными биомаркерами для стратификации риска и раннего выявления рака.

Background. The cytochrome P450 enzymes CYP1A1 and CYP1B1 are involved in the metabolism of carcinogens and have been linked to various cancers, including lung cancer, primarily through their overexpression in tumor tissues. Aim of study. This study describes the CYP1A1 and CYP1B1 expression profiles in lung adenocarcinoma (AC) and lung squamous cell carcinoma (SCC), and explores the possible associations with demographic and clinical features among Turkish patients. Material and methods. This retrospective study analyzed clinical data from 40 patients with lung adenocarcinoma and lung squamous cell carcinoma. tumor and adjacent healthy tissue samples were immunohistochemically stained to profile CYP1A1 and CYP1B1 expression. Associations between protein expression levels and patient characteristics were examined. Results. Significant immunohistochemical differences were found between tumorous and healthy tissues for CYP1A1 and CYP1B1. Conclusion. The study suggests that the CYP1A1 and CYP1B1 expression profiles in lung adenocarcinoma and lung squamous cell carcinoma among Turkish patients may have biomarker value for risk stratification and early detection.

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The authors declare that there are no conflicts of interest present.