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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21294/1814-4861-2025-24-2-79-92</article-id><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-3538</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОПЫТ РАБОТЫ ОНКОЛОГИЧЕСКИХ УЧРЕЖДЕНИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ONCOLOGY PRACTICE</subject></subj-group></article-categories><title-group><article-title>Лапароскопическая резекция почки с внутриартериальной холодовой перфузией. Что может пойти не так?</article-title><trans-title-group xml:lang="en"><trans-title>Laparoscopic partial nephrectomy with intra-arterial cold perfusion. What can go wrong?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7231-6093</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иноземцев</surname><given-names>Р. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Inozemtsev</surname><given-names>R. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иноземцев Роман Олегович, аспирант кафедры урологии и оперативной нефрологии с курсом онкоурологии </p><p>Researcher ID (WOS): KYR-4883-2024 </p><p>117198, г Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>Roman O. Inozemtsev, MD, Postgraduate, Department Urology and Operative Nephrology with the Course of Urologic Oncology </p><p>Researcher ID (WOS): KYR-4883-2024 </p><p>6, Miklukho-Maklaya St., Moscow, 117198 </p></bio><email xlink:type="simple">roman.inozemcev.97@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0792-6012</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Костин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kostin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Костин Андрей Александрович, доктор медицинских наук, профессор, член-корреспондент РАН, первый проректор по научной работе, заведующий кафедрой урологии и оперативной нефрологии с курсом онкоурологии</p><p>117198, г Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>Andrey A. Kostin, MD, DSc, Professor, Corresponding Member of Russian Academy of Sciences, first Vice-Rector for research, Head of Department of Urology and Operative Nephrology with the Course of Urologic Oncology</p><p>6, Miklukho-Maklaya St., Moscow, 117198 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8784-8415</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каприн</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaprin</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каприн Андрей Дмитриевич, доктор медицинских наук, профессор, академик РАН, генеральный директор; директор; профессор кафедры урологии и оперативной нефрологии с курсом онкоурологии</p><p>Researcher ID (WOS): K-1445-2014. Author ID (Scopus): 6602709853</p><p>117198, г Москва, ул. Миклухо-Маклая, 6</p><p>125284, г Москва, 2-й Боткинский пр-д, 3</p><p>249036, г Обнинск, ул. Королева, 42</p></bio><bio xml:lang="en"><p>Andrey D. Kaprin, MD, DSc, Professor, Academician of Russian Academy of Sciences, General Director; Director; Professor, Department of Urology and Operative Nephrology with the Course of Urologic Oncology</p><p>Researcher ID (WOS): K-1445-2014. Author ID (Scopus): 6602709853</p><p>6, Miklukho-Maklaya St., Moscow, 117198 </p><p>3, 2nd Botkinsky Dr., Moscow, 125284 </p><p>4, Koroleva St., Obninsk, 249036 </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5597-9533</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воробьев</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorobyev</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воробьев Николай Владимирович, кандидат медицинских наук, заместитель директора по хирургии; уролог, доцент кафедры онкологии, лучевой терапии и пластической хирургии</p><p>125284, г Москва, 2-й Боткинский пр-д, 3</p><p>119991, г Москва, ул. Трубецкая, 8/2</p></bio><bio xml:lang="en"><p>Nikolay V. Vorobyev, MD, PhD, Deputy Director General for Surgery; Urologist, Associate Professor, Department of Oncology, Radiotherapy and Plastic Surgery</p><p>3, 2nd Botkinsky Dr., Moscow, 125284 </p><p>8/2, Trubetskaya St., Moscow, 119991 </p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9854-7375</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крашенинников</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasheninnikov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крашенинников Алексей Артурович, кандидат медицинских наук, заведующий отделением урологии </p><p>125284, г Москва, 2-й Боткинский пр-д, 3</p></bio><bio xml:lang="en"><p>Aleksey A. Krasheninnikov, MD, PhD, Head of the Urology Department </p><p>3, 2nd Botkinsky Dr., Moscow, 125284 </p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1037-2364</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рябов</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryabov</surname><given-names>A. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рябов Андрей Борисович, доктор медицинских наук, заместитель генерального директора по хирургии; заведующий отделением торакоабдоминальной онкологической хирургии</p><p>125284, г Москва, 2-й Боткинский пр-д, 3</p><p>249036, г Обнинск, ул. Королева, 42</p></bio><bio xml:lang="en"><p>Andrey B. Ryabov, MD, DSc, Deputy Director General for Surgery; Head of the Department of Thoracoabdominal Oncology Surgery</p><p>3, 2nd Botkinsky Dr., Moscow, 125284 </p><p>4, Koroleva St., Obninsk, 249036 </p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-8580-2817</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чалышева</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chalysheva</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чалышева Виктория Александровна, студентка </p><p>117198, г Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>Vyctoria A. Chalysheva, student </p><p>6, Miklukho-Maklaya St., Moscow, 117198 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9533-8220</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванова Елизавета Сергееевна, студентка</p><p>Researcher ID (WOS): MTD-5945-2025</p><p>117198, г Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>Elizaveta S. Ivanova, student </p><p>Researcher ID (WOS): MTD-5945-2025 </p><p>6, Miklukho-Maklaya St., Moscow, 117198 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-2976-165X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ростаханова</surname><given-names>З. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rostakhanova</surname><given-names>Z. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростаханова Зара Асланбековна, студентка </p><p>Researcher ID (WOS): MTD-8471-2025 </p><p>117198, г Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>Zara A. Rostakhanova, student </p><p>Researcher ID (WOS): MTD-8471-2025 </p><p>6, Miklukho-Maklaya St., Moscow, 117198 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-3768-8391</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лысенкова</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Lysenkova</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лысенкова Ангелина Романовна, студентка </p><p>Researcher ID (WOS): MTD-8412-2025 </p><p>117198, г Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>Angelina R. Lysenkova, student </p><p>Researcher ID (WOS): MTD-8412-2025 </p><p>6, Miklukho-Maklaya St., Moscow, 117198 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-6324-6300</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абрамочкина</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Abramochkina</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абрамочкина Полина Антоновна, студентка </p><p>117198, г Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>Polina A. Abramochkina, student </p><p>6, Miklukho-Maklaya St., Moscow, 117198 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГАОУ ВО «Российский университет дружбы народов»<country>Россия</country></aff><aff xml:lang="en">RUDN University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГАОУ ВО «Российский университет дружбы народов» ; Московский научно-исследовательский онкологический институт им. П.А. Герцена - филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России ; ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России<country>Россия</country></aff><aff xml:lang="en">RUDN University ; P.A. Hertzen Moscow Cancer Research Institute – branch of National Medical Research Center of Radiology of the Ministry of Health of the Russia ; National Medical Research Center of Radiology of the Ministry of Health of the Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Московский научно-исследовательский онкологический институт им. П.А. Герцена - филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России ; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России<country>Россия</country></aff><aff xml:lang="en">P.A. Hertzen Moscow Cancer Research Institute – branch of National Medical Research Center of Radiology of the Ministry of Health of the Russia ; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">Московский научно-исследовательский онкологический институт им. П.А. Герцена - филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России<country>Россия</country></aff><aff xml:lang="en">P.A. Hertzen Moscow Cancer Research Institute – branch of National Medical Research Center of Radiology of the Ministry of Health of the Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru">Московский научно-исследовательский онкологический институт им. П.А. Герцена - филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России ; ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России<country>Россия</country></aff><aff xml:lang="en">P.A. Hertzen Moscow Cancer Research Institute – branch of National Medical Research Center of Radiology of the Ministry of Health of the Russia ; National Medical Research Center of Radiology of the Ministry of Health of the Russia<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>17</day><month>05</month><year>2025</year></pub-date><volume>24</volume><issue>2</issue><fpage>79</fpage><lpage>92</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Иноземцев Р.О., Костин А.А., Каприн А.Д., Воробьев Н.В., Крашенинников А.А., Рябов А.Б., Чалышева В.А., Иванова Е.С., Ростаханова З.А., Лысенкова А.Р., Абрамочкина П.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Иноземцев Р.О., Костин А.А., Каприн А.Д., Воробьев Н.В., Крашенинников А.А., Рябов А.Б., Чалышева В.А., Иванова Е.С., Ростаханова З.А., Лысенкова А.Р., Абрамочкина П.А.</copyright-holder><copyright-holder xml:lang="en">Inozemtsev R.O., Kostin A.A., Kaprin A.D., Vorobyev N.V., Krasheninnikov A.A., Ryabov A.B., Chalysheva V.A., Ivanova E.S., Rostakhanova Z.A., Lysenkova A.R., Abramochkina P.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/3538">https://www.siboncoj.ru/jour/article/view/3538</self-uri><abstract><p>Введение. При выявлении у пациентов образований почки высокого нефрометрического индекса в большинстве случаев необходимо прибегнуть к одному из вариантов ишемии почки, а для увеличения доступного времени пережатия почечной артерии может быть применим метод холодовой ишемии почки. Преимуществами внутриартериальной холодовой перфузии (ВАХП) являются хорошая визуализация и равномерное охлаждение всей толщи почечной паренхимы. Данный метод не лишен недостатков и сложностей, которые могут приводить к интра- и послеоперационным осложнениям. Цель исследова­ния - описание возможных осложнений при выполнении резекции почки в условиях ВАХП и вариантов их разрешения с предоставлением практических рекомендаций на основании данных литературы и 14 клинических случаев лечения пациентов в нашем центре. Материал и методы. В исследование включены 14 пациентов с образованиями почек высокого нефрометрического индекса (RENAL 10 и более), которым в МНИОИ им. П.А. Герцена за период с 2021 по 2024 г в качестве экспериментальной методики выполнены резекции почки в условиях ВАХП. Результаты. Интра- и послеоперационные осложнения при резекциях почки в условиях ВАХП возникли в 6 случаях: перфорация почечной ар­терии (n=1), тромбоз плечевой артерии (n=1), тромбоз почечной артерии (n=1), воздушная эмболия сегментарных ветвей почечной артерии (n=2), мочевой затек (n=1). Заключение. Частота интраоперационных осложнений, связанных с ВАХП, уменьшилась по мере освоения методики вмешательства. Данная медицинская технология является реализуемой, эффективной и может быть рекомендована к использованию в крупных, технически оснащенных центрах. С набором опыта данная методика может быть вариантом лечения у пациентов с единственной или единственной функционирующей почкой, у которых выявлены образования высокого нефрометрического индекса, требующие длительного времени ишемии при выполнении резекции.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. In kidney masses of a high nephrometric index, a variant of renal ischemia is mostly needed, and to increase the time of compression of the renal artery, the cold renal ischemia may be relevant. Advantages of intra-arterial cold perfusion (IACP) are: good visualization and uniform cooling of the entire thickness of the renal parenchyma. This approach is not without its own set of challenges and potential complications during and after surgery. Purpose: to describe complications during kidney resection under IACP and options for their resolution with the practical recommendations based on literature data and clinical cases from our center. Material and Methods. The study included 14 patients with kidney masses of a high nephrometric index (RENAL 10 or more), who underwent kidney resections as an experimental technique under IACP from 2021 to 2024 at P.A. Hertzen Moscow Cancer Research Institute. Results. We identified both intra- and postoperative complications in 6 cases: perforation of the renal artery (n=1), brachial artery thrombosis (n=1), thrombosis of the renal artery (n=1), air embolism of segmental branches of the renal artery (n=2), urine leakage (n=1). Conclusion. The IACP-associated intraoperative complications in our cohort diminished over time as familiarity with the technique improved. The IACP is workable, efficient, and holds promise, indicating its appropriateness for large, well-equipped centers. In patients with just one functioning kidney and high nephrometric index masses needing prolonged ischemia during removal, this technique could become a lifesaving option as expertise grows.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>внутриартериальная холодовая перфузия</kwd><kwd>холодовая ишемия почки</kwd><kwd>резекция почки</kwd><kwd>высокий нефрометрический индекс</kwd><kwd>почечно-клеточная карцинома</kwd><kwd>интраоперационные осложнения</kwd><kwd>послеоперационные осложнения.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>intra-arterial cold perfusion</kwd><kwd>cold renal ischemia</kwd><kwd>kidney resection</kwd><kwd>partial nephrectomy</kwd><kwd>high nephrometric index</kwd><kwd>renal cell carcinoma</kwd><kwd>intraoperative complications</kwd><kwd>postoperative complications</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ferlay J., Colombet M., Soerjomataram I., Dyba T., Randi G., Bettio M., Gavin A., Visser O., Bray F. 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