oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2016-15-3-85-92oncotomsk-355Research ArticleОБЗОРЫREVIEWSРОЛЬ МИКРООКРУЖЕНИЯ В РАЗВИТИИ И ПРОГРЕСИИ РАКА ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫROLE OF MICROENVIRONMENT IN THE DEVELOPMENT AND PROGRESSION OF PANCREATIC CANCERОкладниковаЕ. Е.OkladnikovaE. V.

кандидат медицинских наук, доцент кафедры фармакологии

MD, PhD, Associate Professor, Department of Pharmacology

farmasis@yandex.ruРукшаТ. Г.RukshaT. G>

доктор медицинских наук, заведующая кафедрой патологической физиологии

MD, DSc, Head of the Department of Pathological Physiology

tatyana_ruksha@mail.ruГБОУ ВПО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России, г. КрасноярскРоссияKrasnoyarsk State Medical University named after prof. V.F. Voino-YasenetskyRussian Federation2016210720161538290Copyright © Окладникова Е.Е., Рукша Т.Г., 20162016Окладникова Е.Е., Рукша Т.Г.Okladnikova E.V., Ruksha T.G.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/355

Рак поджелудочной железы обладает быстрым инвазивным ростом, ранней склонностью к метастазированию и плохо поддается химиотерапии. Ипользование таргетных препаратов пока не позволило добиться значительных успехов в борьбе с раком поджелудочной железы. Одним из перспективных направлений молекулярной онкологии последних лет является изучение микроокружения опухоли для осуществления целенаправленного воздействия. В представленном обзоре обсуждаются морфофункциональные особенности микроокружения опухоли поджелудочной железы, а также механизмы межклеточных коммуникаций. Изучение данной темы актуально для разработки новых методов терапии рака поджелудочной железы.

Pancreatic cancer is a highly aggressive malignancy with metastatic potential and poor response to chemotherapy. Unfortunately, molecular-based targeted therapies failed to make significant progress against pancreatic cancer. One of the promising subjects of molecular oncology is the study of tumor microenvironment modulation for therapeutic purposes. In the present review, the description of pancreatic cancer microenvironment is provided, including intercellular interaction regulation which is important for tumor growth and progression. The study of this topic is important for the development of new therapies for pancreatic cancer.

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The authors declare that there are no conflicts of interest present.