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oncotomsk

Сибирский онкологический журнал

Siberian journal of oncology

1814-48612312-3168

Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences

10.21294/1814-4861-2025-24-4-112-121

oncotomsk-3773

Research Article

ОБЗОРЫ

REVIEWS

Современные представления о биопсии сторожевых лимфоузлов при раке молочной железы: обзор

Current concepts of sentinel lymph node biopsy in breast cancer: a literature review

https://orcid.org/0000-0003-1840-8111

Кострыгин

А. К.

Kostrygin

A. K.

Кострыгин Александр Константинович, кандидат медицинских наук, заведующий кафедрой онкологии и лучевой терапии; главный врач

Author ID (Scopus): 56152200900

153000, г. Иваново, пр. Шереметевский, 8

153051, г. Иваново, ул. Любимова, 5

Aleksandr K. Kostrygin, MD, PhD, Head of the Department of Oncology and Radiation Therapy; Chief Physician

Author ID (Scopus): 56152200900

8, Sheremetevsky ave., Ivanovo, 153000

5, Lyubimova st., Ivanovo, 153051

https://orcid.org/0000-0002-2896-8764

Блинова

К. А.

Blinova

K. A.

Блинова Ксения Александровна, кандидат медицинских наук, доцент кафедры онкологии и лучевой терапии; врач

Author ID (Scopus): 59415662400

153000, г. Иваново, пр. Шереметевский, 8

153051, г. Иваново, ул. Любимова, 5

Ksenia A. Blinova, MD, PhD, Associate Professor, Department of Oncology and Radiation Therapy; Physician

8, Sheremetevsky ave., Ivanovo, 153000

5, Lyubimova st., Ivanovo, 153051

Author ID (Scopus): 59415662400

k.a.blinova@mail.ru

https://orcid.org/0000-0002-2022-4779

Алексеев

В. В.

Alekseev

V. V.

Алексеев Валентин Валерьевич, кандидат медицинских наук, доцент кафедры онкологии и лучевой терапии; заместитель главного врача по медицинской части

153000, г. Иваново, пр. Шереметевский, 8

153051, г. Иваново, ул. Любимова, 5

Valentin V. Alekseev, MD, PhD, Associate Professor, Department of Oncology and Radiation Therapy; Deputy Chief Physician for Medical Affairs

8, Sheremetevsky ave., Ivanovo, 153000

5, Lyubimova st., Ivanovo, 153051

https://orcid.org/0000-0002-1912-4607

Фролова

Д. Е.

Frolova

D. E.

Фролова Дарья Евгеньевна, кандидат медицинских наук, доцент кафедры онкологии и лучевой терапии; врач

153000, г. Иваново, пр. Шереметевский, 8

153051, г. Иваново, ул. Любимова, 5

Darya E. Frolova, MD, PhD, Associate Professor, Department of Oncology and Radiation Therapy; Physician

8, Sheremetevsky ave., Ivanovo, 153000

5, Lyubimova st., Ivanovo, 153051

https://orcid.org/0000-0002-9114-6683

Суворов

В. А.

Suvorov

V. A.

Суворов Владимир Александрович, кандидат медицинских наук, ассистент кафедры онкологии и лучевой терапии; врач

Researcher ID (WOS): HJY-4463-2023. Author ID (Scopus): 57220123738

153000, г. Иваново, пр. Шереметевский, 8

153051, г. Иваново, ул. Любимова, 5

Vladimir A. Suvorov, MD, PhD, Assistant, Department of Oncology and Radiation Therapy; Physician

Researcher ID (WOS): HJY-4463-2023. Author ID (Scopus): 57220123738

8, Sheremetevsky ave., Ivanovo, 153000

5, Lyubimova st., Ivanovo, 153051

https://orcid.org/0009-0006-8271-0488

Золкина

М. А.

Zolkina

M. A.

Золкина Мария Андреевна, ассистент кафедры онкологии и лучевой терапии; врач

153000, г. Иваново, пр. Шереметевский, 8

153051, г. Иваново, ул. Любимова, 5

Maria A. Zolkina, Assistant, Department of Oncology and Radiation Therapy; Physician

8, Sheremetevsky ave., Ivanovo, 153000

5, Lyubimova st., Ivanovo, 153051

https://orcid.org/0009-0007-9165-9829

Гутова

Д. В.

Gutova

D. V.

Гутова Дарья Владимировна, студентка

153000, г. Иваново, пр. Шереметевский, 8

Daria V. Gutova, Student

8, Sheremetevsky ave., Ivanovo, 153000

https://orcid.org/0009-0008-7225-1884

Ионов

К. А.

Ionov

K. A.

Ионов Кирилл Анатольевич, студент

153000, г. Иваново, пр. Шереметевский, 8

Kirill A. Ionov, Student

8, Sheremetevsky ave., Ivanovo, 153000

https://orcid.org/0009-0009-6935-1793

Антропова

В. В.

Antropova

V. V.

Антропова Владислава Владиславовна, ординатор

153000, г. Иваново, пр. Шереметевский, 8

Vladislava V. Antropova, Resident

8, Sheremetevsky ave., Ivanovo, 153000

https://orcid.org/0000-0002-7659-8008

Мишина

И. Е.

Mishina

I. E.

Мишина Ирина Евгеньевна, доктор медицинских наук, профессор, профессор кафедры последипломного медицинского образования, первый заместитель директора, Медицинский институт

Researcher ID (WOS): F-3262-2019. Author ID (Scopus): 36958772100

199034, г. Санкт-Петербург, Университетская наб., 7–9

Irina E. Mishina, MD, DSc, Professor, Department of Postgraduate Medical Education, First Deputy Director, Medical Institute

Researcher ID (WOS): F-3262-2019. Author ID (Scopus): 36958772100

7–9, Universitetskaya nab., Saint Petersburg, 199034

ФГОУ ВО «Ивановский государственный медицинский университет» Минздрава России ; ОБУЗ «Ивановский областной онкологический диспансер»РоссияIvanovo State Medical University, Ministry of Health of Russia ; Ivanovo Regional Oncology DispensaryRussian Federation

ФГОУ ВО «Ивановский государственный медицинский университет» Минздрава РоссииРоссияIvanovo State Medical University, Ministry of Health of RussiaRussian Federation

ФГБОУ ВО «Санкт-Петербургский государственный университет»РоссияSaint Petersburg State UniversityRussian Federation

2025

01102025

244112121

2025

Кострыгин А.К., Блинова К.А., Алексеев В.В., Фролова Д.Е., Суворов В.А., Золкина М.А., Гутова Д.В., Ионов К.А., Антропова В.В., Мишина И.Е.

Kostrygin A.K., Blinova K.A., Alekseev V.V., Frolova D.E., Suvorov V.A., Zolkina M.A., Gutova D.V., Ionov K.A., Antropova V.V., Mishina I.E.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.siboncoj.ru/jour/article/view/3773

Цель исследования – провести систематический анализ имеющихся в современной литературе данных о проведении биопсии сторожевых лимфоузлов при раке молочной железы в различных клинических ситуациях. Материал и методы. Поиск проводился в базах данных Web of science, PubMed, scopus, Google scholar. Было проанализировано 213 источников, посвященных особенностям применения биопсии сторожевых лимфоузлов при раке молочной железы, из которых 48 были включены в обзор. Результаты. Биопсия сторожевых лимфоузлов утверждена как стандартная процедура при ранних стадиях рака молочной железы, демонстрируя эффективность и безопасность при небольших опухолях, интактных лимфоузлах и микрометастазах. В настоящее время активно изучается возможность расширения показаний к биопсии сигнальных лимфоузлов на более сложные случаи, включая изменение статуса лимфоузлов после неоадъювантной химиотерапии, мультицентричный рак и рецидивы рака молочной железы, что ранее считалось противопоказанием. Проводятся исследования, оценивающие безопасность применения биопсии сторожевых лимфоузлов во время беременности, открывая новые перспективы для лечения этой уязвимой группы пациенток. Расширение показаний к биопсии сигнальных лимфоузлов позволит избежать радикальной лимфаденэктомии и связанных с ней осложнений, таких как постмастэктомический синдром. Это, в свою очередь, значительно улучшит качество жизни онкологических пациенток за счет снижения послеоперационной заболеваемости и ускорения реабилитации. Заключение. Дальнейшее изучение и внедрение расширенных показаний к биопсии сторожевых лимфоузлов представляют собой перспективное направление в современной онкологии, направленное на оптимизацию лечения и сохранение качества жизни пациенток.

Objective: to systematically analyze the data available in the modern literature on sentinel lymph node biopsy in breast cancer in various clinical situations. Material and Methods. The search was conducted in the Web of science, PubMed, scopus, Google scholar databases. A total of 213 sources devoted to sentinel lymph node biopsy in breast cancer were analyzed, of which 48 were included in the review. Results. Sentinel lymph node biopsy has been established as a standard procedure in early stages of breast cancer, demonstrating efficacy and safety in small tumors, intact lymph nodes and micrometastases. Currently, there is a clear trend toward expanding sentinel lymph node biopsy indications into more complex cases, including changes in lymph node status after neoadjuvant chemotherapy, multicentric cancer, and recurrent breast cancer. Studies are underway to evaluate the safety of sentinel lymph node biopsy during pregnancy, opening up new perspectives for the treatment of this vulnerable group of patients. Expanding the indications for sentinel lymph node biopsy will help avoid radical lymphadenectomy and its associated complications, such as postmastectomy syndrome. this, in turn, will significantly improve the quality of life of cancer patients by reducing postoperative morbidity and accelerating rehabilitation. Conclusion. Further study and implementation of expanded indications for sentinel lymph node biopsy is a promising direction in modern oncology aimed at optimizing treatment and maintaining the quality of life of patients.

биопсия сторожевых лимфоузловрак молочной железыдиссекция подмышечных лимфоузловлимфаденэктомияметастазыкачество жизниминимально инвазивная хирургиярак при беременности

sentinel lymph node biopsybreast canceraxillary lymph node dissectionlymphadenectomymetastasesquality of lifeminimally invasive surgerycancer in pregnancy

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The authors declare that there are no conflicts of interest present.