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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">oncotomsk</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский онкологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Siberian journal of oncology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-4861</issn><issn pub-type="epub">2312-3168</issn><publisher><publisher-name>Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21294/1814-4861-2025-24-6-173-182</article-id><article-id custom-type="elpub" pub-id-type="custom">oncotomsk-3961</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАЙ ИЗ КЛИНИЧЕСКОЙ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Редкое новообразование молочной железы: клинический случай аденомиоэпителиомы</article-title><trans-title-group xml:lang="en"><trans-title>Adenomyoepithelioma of the breast: a case report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7261-8956</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бересток</surname><given-names>Т. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Berestok</surname><given-names>T. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бересток Татьяна Сергеевна - кандидат медицинских наук, онколог, Онкологический центр № 1.</p><p>115446, Москва, Коломенский пр-д, 4</p></bio><bio xml:lang="en"><p>Tatiana S. Berestok - MD, PhD, Oncologist, Oncology Center No. 1.</p><p>18A, Zagorodnoe shosse, Moscow, 117152</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4178-9592</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ермощенкова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ermoshchenkova</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ермощенкова Мария Владимировна - доктор медицинских наук, заведующая онкологическим отделением № 1, Онкологический центр № 1, ГБУЗ «ГКБ им. С.С. Юдина ДЗМ»; профессор кафедры онкологии, радиотерапии и реконструктивной хирургии ИКМ им. Н.В. Склифосовского, ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова».</p><p>115446, Москва, Коломенский пр-д, 4; 119435, Москва, Большая Пироговская ул., 2/4</p></bio><bio xml:lang="en"><p>Maria V. Ermoshchenkova - MD, DSc, Head of the First Oncology Surgery Department, Oncology Center No. 1, S. S. Yudin CCH, Moscow Department of Health; Professor, Department of Oncology, Radiotherapy and Reconstructive Surgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow SMU.</p><p>18A, Zagorodnoe shosse, Moscow, 117152; 8-2, Trubetskaya St., Moscow, 119992</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6619-6179</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галкин</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Galkin</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Галкин Всеволод Николаевич - доктор медицинских наук, главный врач, ГБУЗ «ГКБ им. С.С. Юдина ДЗМ»; профессор кафедры онкологии, радиотерапии и реконструктивной хирургии ИКМ им. Н.В. Склифосовского, ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова».</p><p>115446, Москва, Коломенский пр-д, 4; 119435, Москва, Большая Пироговская ул., 2/4</p></bio><bio xml:lang="en"><p>Vsevolod N. Galkin - MD, DSc, Chief Physician, S. S. Yudin CCH, Moscow Department of Health; Professor, Department of Oncology, Radiotherapy and Reconstructive Surgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow SMU.</p><p>18A, Zagorodnoe shosse, Moscow, 117152; 8-2, Trubetskaya St., Moscow, 119992</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8433-0837</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семенова</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Semenova</surname><given-names>A. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Семенова Анна Борисовна - доктор медицинских наук, заведующая центром патологоанатомической диагностики и молекулярной генетики, Онкологический центр № 1.</p><p>115446, Москва, Коломенский пр-д, 4</p></bio><bio xml:lang="en"><p>Anna B. Semenova - MD, DSc, Head of the Center for Pathoanatomic Diagnostics and Molecular Genetics, Oncology Center No. 1.</p><p>18A, Zagorodnoe shosse, Moscow, 117152</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9068-1273</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Диденко</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Didenko</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Диденко Вера Владимировна - заведующая отделением диагностики и лечения заболеваний молочной железы и репродуктивной системы ЦАОП, Онкологический центр № 1.</p><p>115446, Москва, Коломенский пр-д, 4</p></bio><bio xml:lang="en"><p>Vera V. Didenko - MD, Head of the Department of Diagnosis and Treatment of Diseases of the Breast and Reproductive System, Oncology Center No. 1.</p><p>18A, Zagorodnoe shosse, Moscow, 117152</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-9004-0476</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаталов</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Shatalov</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шаталов Виталий Геннадьевич - заведующий патологоанатомическим отделением, Онкологический центр № 1.</p><p>115446, Москва, Коломенский пр-д, 4</p></bio><bio xml:lang="en"><p>Vitaly G. Shatalov - MD, Head of the Pathology Department, Oncology Center No. 1.</p><p>18A, Zagorodnoe shosse, Moscow, 117152</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-3072-6739</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исаева</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Isaeva</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Исаева Оксана Игоревна - патологоанатом, Онкологический центр № 1.</p><p>115446, Москва, Коломенский пр-д, 4</p></bio><bio xml:lang="en"><p>Oxana I. Isaeva - MD, Pathologist, Oncology Center No. 1.</p><p>18A, Zagorodnoe shosse, Moscow, 117152</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-4991-350X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Богатырёва</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogatyreva</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Богатырёва Марина Андреевна - патологоанатом, Онкологический центр № 1.</p><p>115446, Москва, Коломенский пр-д, 4</p></bio><bio xml:lang="en"><p>Marina A. Bogatyreva - MD, Pathologist, Oncology Center No. 1.</p><p>18A, Zagorodnoe shosse, Moscow, 117152</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9778-2624</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Старцева</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Startsevа</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Старцева Олеся Игоревна - доктор медицинских наук, профессор кафедры онкологии, радиотерапии и реконструктивной хирургии ИКМ им. Н.В. Склифосовского, ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; онколог онкологического отделения № 1, Онкологический центр № 1, ГБУЗ «ГКБ им. С.С. Юдина ДЗМ».</p><p>115446, Москва, Коломенский пр-д, 4; 119435, Москва, Большая Пироговская ул., 2/4</p></bio><bio xml:lang="en"><p>Olesya I. Startseva - MD, DSc, Professor, Department of Oncology, Radiotherapy and Reconstructive Surgery, I.M. Sechenov First Moscow SMU; Oncologist, Oncology Department No. 1, Oncology Center No. 1, S. S. Yudin CCH, Moscow Department of Health.</p><p>18A, Zagorodnoe shosse, Moscow, 117152; 8-2, Trubetskaya St., Moscow, 119992</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-3244-5768</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эминова</surname><given-names>К. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Eminova</surname><given-names>K. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эминова Камила Ролановна - студентка 6-го курса.</p><p>119435, Москва, Большая Пироговская ул., 2/4</p></bio><bio xml:lang="en"><p>Kamila R. Eminova - 6th year student.</p><p>8-2, Trubetskaya St., Moscow, 119992</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «ГКБ им. С.С. Юдина ДЗМ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>S.S. Yudin City Clinical Hospital, Moscow Department of Health</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «ГКБ им. С.С. Юдина ДЗМ»; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>S.S. Yudin City Clinical Hospital, Moscow Department of Health; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>13</day><month>01</month><year>2026</year></pub-date><volume>24</volume><issue>6</issue><fpage>173</fpage><lpage>182</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бересток Т.С., Ермощенкова М.В., Галкин В.Н., Семенова А.Б., Диденко В.В., Шаталов В.Г., Исаева О.И., Богатырёва М.А., Старцева О.И., Эминова К.Р., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Бересток Т.С., Ермощенкова М.В., Галкин В.Н., Семенова А.Б., Диденко В.В., Шаталов В.Г., Исаева О.И., Богатырёва М.А., Старцева О.И., Эминова К.Р.</copyright-holder><copyright-holder xml:lang="en">Berestok T.S., Ermoshchenkova M.S., Galkin V.N., Semenova A.B., Didenko V.V., Shatalov V.G., Isaeva O.I., Bogatyreva M.A., Startsevа O.I., Eminova K.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.siboncoj.ru/jour/article/view/3961">https://www.siboncoj.ru/jour/article/view/3961</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Аденомиоэпителиома молочной железы – редкая доброкачественная опухоль, характеризующаяся двухфазной пролиферацией эпителиальных и миоэпителиальных клеток долькового и протокового компонентов молочной железы. Несмотря на доброкачественную природу, аденомиоэпителиома может подвергаться злокачественной трансформации, что делает раннюю диагностику и вовремя начатое лечение особенно актуальными. В настоящее время нет установленных клинических, рентгенологических и морфологических критериев для раннего выявления этого типа опухоли, что затрудняет диагностику и требует гистологического исследования опухоли. Описание клинического случая. Пациентка С., 39 лет, обратилась в Онкологический центр № 1 ГБУЗ «ГКБ им. С.С. Юдина ДЗМ» по поводу новообразования молочной железы, выявленного при плановом обследовании. По данным ультразвукового исследования было предположено наличие фиброаденомы. При гистологическом исследовании трепан-биоптата опухоли была диагностирована аденомиоэпителиома. Пациентке выполнена секторальная резекция правой молочной железы, гистологические и иммуногистохимические исследования операционного материала подтвердили диагноз аденомиоэпителиомы.</p></sec><sec><title>Заключение</title><p>Заключение. Аденомиоэпителиома молочной железы – редкая опухоль с уникальными гистологическими характеристиками. Диагноз устанавливают на основании гистологического и иммуногистохимического исследования. Основным методом лечения является хирургический. Необходимы дальнейшие исследования для изучения патогенеза.</p></sec></abstract><trans-abstract xml:lang="en"><p>Background. Adenomyoepithelioma of the breast is a rare benign tumor characterized by biphasic proliferation of epithelial and myoepithelial cells of the lobular and ductal components of the breast. Although benign, adenomyoepithelioma has a potential for malignant transformation; therefore its early detection is crucial. Currently, there are no established clinical, radiological and morphological criteria for early detection of this type of tumor, which can complicate diagnosis and requires histological examination of the tumor. Description of the clinical case. A 39-year-old female patient presented to the Oncology Center No. 1 of the S.S. Yudin Clinical Hospital with the breast neoplasm detected during a routine examination. Ultrasound examination showed fibroadenoma. Histological examination of the trepan biopsy specimen revealed adenomyoepithelioma. The patient underwent a sectoral resection of the right breast. Histology and immunohistochemistry confirmed the diagnosis of adenomyoepithelioma. Conclusion. Breast adenomyoepithelioma is a rare tumor diagnosed by histology/immunohistochemistry, with surgery as a main treatment. Further research is needed to study the pathogenesis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>аденомиоэпителиома молочной железы</kwd><kwd>секторальная резекция</kwd><kwd>рак молочной железы</kwd><kwd>иммуногистохимическое исследование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>adenomyoepithelioma of mammary gland</kwd><kwd>sectoral resection</kwd><kwd>breast cancer</kwd><kwd>immunohistochemical examination</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Это исследование не потребовало дополнительного финансирования</funding-statement><funding-statement xml:lang="en">This study required no funding</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO Classification of Tumours. Breast Tumors. 5th Edition. 2019. [Internet]. [cited 01.11.2024]. 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