oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2026-25-1-123-134oncotomsk-4119Research ArticleОБЗОРЫREVIEWSНЕ4 – потенциальный опухолеассоциированный маркер при раке легкогоHE4 as a potential tumor-associated marker in lung cancerhttps://orcid.org/0000-0002-5920-5823АлентовИ. И.AlentovI. I.

Алентов Игорь Игоревич, кандидат биологических наук, старший научный сотрудник отделения прогноза эффективности консервативного лечения Researcher ID (WOS): HPF-2560-2023. Author ID (Scopus): 54683346300.

125284, г. Москва, 2-й Боткинский пр-д, 3

Igor I. Alentov, PhD, Senior Researcher, Department of Prediction of the Effectiveness of Conservative Treatment Researcher ID (WOS): HPF-2560-2023. Author ID (Scopus): 54683346300.

3, 2nd Botkinsky Passage, Moscow, 125284

igoralentov@yandex.ruhttps://orcid.org/0000-0001-7406-9973СергееваН. С.SergeevaN. S.

Сергеева Наталья Сергеевна, доктор биологических наук, профессор, заведующая отделением прогноза эффективности консервативного лечения Researcher ID (WOS): I-2033-2014. Author ID (Scopus): 7102748586.

125284, г. Москва, 2-й Боткинский пр-д, 3

Natalia S. Sergeeva, DSc, Professor, Head of the Department of Prediction of the Effectiveness of Conservative Treatment Researcher ID (WOS): I-2033-2014. Author ID (Scopus): 7102748586 

3, 2nd Botkinsky Passage, Moscow, 125284

https://orcid.org/0000-0002-0488-5577ШуманскаяД. В.ShumanskayaD. V.

Шуманская Дарья Вячеславовна, онколог торакального хирургического отделения, младший научный сотрудник группы миастении, отдела торакоабдоминальной хирургии Researcher ID (WOS): GOG-8510-2022.

125284, г. Москва, 2-й Боткинский пр-д, 3

Daria V. Shumanskaya, MD, Oncologist, Thoracic Surgical Department, Junior Researcher, Myasthenia Group, Department of Thoracoabdominal Surgery Researcher ID (WOS): GOG-8510-2022.

3, 2nd Botkinsky Passage, Moscow, 125284

https://orcid.org/0000-0002-8017-5657КармаковаТ. А.KarmakovaT. A.

Кармакова Татьяна Анатольевна, доктор биологических наук, ведущий научный сотрудник отделения прогноза эффективности консервативного лечения Researcher ID (WOS): L-3592-2018. Author ID (Scopus): 6603382243.

125284, г. Москва, 2-й Боткинский пр-д, 3

Tatiana A. Karmakova, DSc, Leading Researcher, Department of Prediction of the Effectiveness of Conservative Treatment Researcher ID (WOS): L-3592-2018. Author ID (Scopus): 6603382243.

3, 2nd Botkinsky Passage, Moscow, 125284

https://orcid.org/0000-0001-6871-6804ПикинО. В.PikinO. V.

Пикин Олег Валентинович, доктор медицинских наук, профессор кафедры торакальной хирургии, ФГБОУ ДПО РМАНПО Минздрава России; руководитель отделения торакальной хирургии 

125284, г. Москва, 2-й Боткинский пр-д, 3

Oleg V. Pikin, MD, DSc, Professor, Department of Thoracic Surgery, Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia; Head of the Department of Thoracic Surgery 

3, 2nd Botkinsky Passage, Moscow, 125284

https://orcid.org/0000-0003-2997-4936МаршутинаН. В.MarshutinaN. V.

Маршутина Нина Викторовна, кандидат биологических наук, научный сотрудник отделения прогноза эффективности консервативного лечения Researcher ID (WOS): I-2027-2014. Author ID (Scopus): 6602904590.

125284, г. Москва, 2-й Боткинский пр-д, 3

Nina V. Marshutina, PhD, Researcher, Department of Prediction of the Effectiveness of Conservative Treatment Researcher ID (WOS): I-2027-2014. Author ID (Scopus): 6602904590.

3, 2nd Botkinsky Passage, Moscow, 125284

https://orcid.org/0000-0001-8784-8415КапринА. Д.KaprinA. D.

Каприн Андрей Дмитриевич, доктор медицинских наук, профессор, академик РАН и РАО, заведующий кафедрой онкологии и рентгенорадиологии им. В.П. Харченко; директор; генеральный директор Researcher ID (WOS): K-1445-2014.

125284, г. Москва, 2-й Боткинский пр-д, 3;249036, г. Обнинск, ул. Королева, 4;117198, г. Москва, ул. Миклухо-Маклая, 6

Andrey D. Kaprin, MD, DSc, Professor, Academician of the Russian Academy of Sciences, Head of Chair of Oncology and Radiology named after Kharchenko; Director; Director General Researcher ID (WOS): K-1445-2014.

3, 2nd Botkinsky Passage, Moscow, 125284;4, Koroleva St., Obninsk, 249036;6, Miklouho-Maklaya St., Moscow, 117198

Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииРоссияP.A. Herzen Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Centre, Ministry of Health of RussiaRussian FederationМосковский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России; ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России; АОУ ВО «Российский университет дружбы народов» Минобрнауки РоссииРоссияP.A. Herzen Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Centre, Ministry of Health of Russia; National Medical Research Radiological Centre, Ministry of Health of Russia; Peoples’ Friendship University of RussiaRussian Federation202607042026251123134Copyright © Алентов И.И., Сергеева Н.С., Шуманская Д.В., Кармакова Т.А., Пикин О.В., Маршутина Н.В., Каприн А.Д., 20262026Алентов И.И., Сергеева Н.С., Шуманская Д.В., Кармакова Т.А., Пикин О.В., Маршутина Н.В., Каприн А.Д.Alentov I.I., Sergeeva N.S., Shumanskaya D.V., Karmakova T.A., Pikin O.V., Marshutina N.V., Kaprin A.D.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/4119

Цель исследования – систематизировать и представить современные данные, касающиеся использования в сравнении с другими серологическими маркерами белка эпидидимиса человека 4 (НЕ4) в качестве опухолеассоциированного маркера для уточняющей диагностики рака легкого (РЛ), прогноза эффективности лечения и мониторинга данной категории пациентов. Материал и методы. Выполнен поиск и анализ доступных отечественных и англоязычных источников по базам данных РИНЦ и PubMed по ключевым словам «lung cancer (рак легкого)» и «HE4». В обзор включено 70 работ, опубликованных в период с 2006 по 2024 г. Результаты. НЕ4 принимает участие в канцерогенезе и прогрессировании ряда гинекологических опухолей, однако его роль в развитии РЛ остается малоизученной, несмотря на его выраженную экспрессию в опухолевой ткани. Современные исследования демонстрируют, что НЕ4 по своим диагностическим характеристикам сравним или несколько превосходит другие маркеры, применяемые в диагностике РЛ (CYFRA21-1, РЭА, NSE, ProGRP и др.). В ряде работ отмечено, что сывороточный уровень НЕ4 может служить предиктором ответа на химиотерапию, продолжительности безрецидивного интервала при РЛ. Отдельные исследования свидетельствуют о целесообразности применения НЕ4 как маркера мониторинга больных РЛ для раннего выявления рецидива. Вместе с тем, показатели диагностической и прогностической значимости НЕ4 значительно варьируют в разных работах, что обусловлено разнородностью включенных групп обследуемых, различиями в используемых референсных значениях и методах оценки уровней этого маркера. Это не позволяет принять единый диагностический алгоритм использования НЕ4. Заключение. Накопленные к настоящему времени данные свидетельствуют о возможности и целесообразности применения НЕ4 в качестве опухолеассоциированного маркера при РЛ. Однако целый ряд аспектов, важных для практического применения НЕ4 как опухолевого маркера, остаются неясными. Таким образом, внедрение этого маркера в клиническую практику требует проведения дальнейших систематизированных и углубленных исследований.

The aim of the study was to systematize current data on the use of human epididymis protein 4 (HE4) as a tumor-associated marker for lung cancer (LC) diagnosis, prognosis of treatment response, and monitoring of this category of patients. Material and Methods. A search and analysis of available Russian and Englishlanguage sources was performed in the RSCI and PubMed databases using keywords “lung cancer” and “HE4”. The review includes 44 papers published between 2006 and 2024. Results. HE4 is involved in gynecological cancer progression, but its role in the development of LC remains poorly studied despite its high expression in tumor tissue. Modern studies demonstrate that diagnostic characteristics of serum HE4 are comparable to or slightly superior to other markers used in the diagnosis of LC (CYFRA21-1, CEA, NSE, ProGRP, etc.). Several studies report that the HE4 serum level can serve as a predictor of response to chemotherapy and the duration of the relapse-free interval in LC. Some studies indicate the feasibility of HE4 as a marker for monitoring patients for early detection of lung cancer relapse. The indicators of the diagnostic and prognostic signifcance of serum HE4 vary signifcantly in different studies due to the heterogeneity of the included groups, differences in the reference values and methods for assessing the HE4 levels. This does not allow us to adopt a unifed diagnostic algorithm for using HE4. Conclusion. The accumulated data indicate the feasibility of using HE4 as a tumor-associated marker in LC. However, some aspects that are important for the practical application of HE4 remain unclear. Thus, the introduction of this marker into clinical practice requires further systematic and in-depth studies.

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The authors declare that there are no conflicts of interest present.