oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciencesoncotomsk-49Research ArticleЛАБОРАТОРНЫЕ И ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯLABORATORY AND EXPERIMENTAL STUDIESКЛИНИКО-ПАТОМОРФОЛОГИЧЕСКОЕ ИССЛЕДОВАНИЕ МИЕЛОФИБРОЗА ПРИ МНОЖЕСТВЕННОЙ МИЕЛОМЕCLINICO-PATHOMORPHOLOGICAL STUDY OF MYELOFIBROSIS IN MULTIPLE MYELOMAДьячковаЮ. А.DyachkovaYu. A.

г. Новосибирск, ул. Тимакова, 2

Timakova Street, 630117-Novosibirsk, 2

pathol@soramn.ruДолгихТ. Ю.DolgikhT. Yu.

г. Новосибирск, ул. Тимакова, 2

pathol@soramn.ruДомниковаН. П.DomnikovaN. P.

г. Новосибирск, ул. Тимакова, 2

pathol@soramn.ruНИИ региональной патологии и патоморфологии СО РАМН, г. Новосибирск, 630117РоссияResearch Institute of Regional Pathology and Pathomorphology of Siberian Division of the Russian Academy of Medical Scienсеs, Novosibirsk 2Russian Federation201410022016033438Copyright © Дьячкова Ю.А., Долгих Т.Ю., Домникова Н.П., 20162016Дьячкова Ю.А., Долгих Т.Ю., Домникова Н.П.Dyachkova Y.A., Dolgikh T.Y., Domnikova N.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/49

Проведено патоморфологическое исследование миелофиброза (МФ) у пациентов с множественной миеломой путём использования программы морфометрического анализа изображений. Выявлено, что МФ встречается в 1,5 раза чаще при рецидиве заболевания, чем в дебюте и при ответе на химиотерапию. Наиболее высокая относительная площадь фиброзной ткани при МФ II и III степеней наблюдается при рецидиве множественной миеломы. Обнаружена прямая корреляция между относительной площадью опухолевой ткани в костном мозге и относительной площадью фиброзной ткани при МФ I и II степеней. У больных с рецидивом заболевания чаще выявляется миелофиброз II и III степеней. Частота и степень выраженности миелофиброза не связаны с полом и возрастом пациентов.

Pathomorphology study of bone marrow fibrosis in patients with multiple myeloma by using morphometric image analysis software was performed. It was revealed that bone marrow fibrosis occurs 1.5 times more frequently in relapse of disease than in the initial presentation of the disease and in response to chemotherapy. The highest relative area of fibrous tissue in marrow fibrosis of 2nd and 3rd grade is observed in relapsed multiple myeloma. There is a direct correlation between the relative area of the tumor tissue in the bone marrow and the relative area of fibrous tissue in bone marrow fibrosis of the 1st and the 2nd grade. Chemotherapy is a factor associated with bone marrow fibrosis of the 2nd and the 3rd grade. Gender and age of the patients are not associated with marrow fibrosis.

множественная миеломамиелофиброзотносительная площадь фиброзной тканиотносительная площадь опухолевой тканиmultiple myelomamyelofibrosisthe relative area of fibrous tissuethe relative area of the tumor tissueReferencesРоссийские клинические рекомендации по диагностике и лечению лимфопролиферативных заболеваний / Под ред. И.В. Поддубной, В.Г. Савченко. М.: Медиа Медика, 2013. 104 с.Russian Clinical practice guidelines for the diagnosis and treatment of lymphoproliferative diseases / Ed. I.V. Poddubnaya, V.G. Savchenko. М.: Media Medika, 2013. 104 p. [in Russian]Abildgaard N., Bendix-Hansen K., Kristensen J.E., Vejlgaard T., Risteli L., Nielsen J.L., Heickendorff L. Bone marrow fibrosis and disease activity in multiple myeloma monitored by the aminoterminal propeptide of procollagen III in serum // Br. J. Haematol. 1997. Vol. 99 (3). P. 641–648.Abildgaard N., Bendix-Hansen K., Kristensen J.E., Vejlgaard T., Risteli L., Nielsen J.L., Heickendorff L. Bone marrow fibrosis and disease activity in multiple myeloma monitored by the aminoterminal propeptide of procollagen III in serum // Br. J. Haematol. 1997. Vol. 99 (3). P. 641–648.Babarović E., Valković T., Štifter S., Budisavljević I., Seili-Bekafigo I., Duletić-Načinović A., Lučin K., Jonjić N. Assessment of bone marrow fibrosis and angiogenesis in monitoring patients with multiple myeloma // Am. J. Clin. Pathol. 2012. 137 (6): 870–8. doi: 10.1309/AJCPT5Y2JRIUUCUB.Babarović E., Valković T., Štifter S., Budisavljević I., Seili-Bekafigo I., Duletić-Načinović A., Lučin K., Jonjić N. Assessment of bone marrow fibrosis and angiogenesis in monitoring patients with multiple myeloma // Am. J. Clin. Pathol. 2012. 137 (6): 870–8. doi: 10.1309/AJCPT5Y2JRIUUCUB.Bladé J., Samson D., Reece D., Apperley J., Björkstrand B., Gahrton G., Gertz M., Giralt S., Jagannath S., Vesole D. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant // Br. J. Haematol. 1998. Vol. 102 (5). P. 1115–1123.Bladé J., Samson D., Reece D., Apperley J., Björkstrand B., Gahrton G., Gertz M., Giralt S., Jagannath S., Vesole D. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant // Br. J. Haematol. 1998. Vol. 102 (5). P. 1115–1123.Chen H.S., Liu E.B., Wang T.T., Yang R.C., Fang L.H., Yang Q.Y., Gao J.Y., Yu M.H., Qian L.S. Morphologic and clinical study of 131 cases of plasma cell myeloma // Zhonghua Bing Li Xue Za Zhi. 2004. Vol. 33 (1). P. 44–48.Chen H.S., Liu E.B., Wang T.T., Yang R.C., Fang L.H., Yang Q.Y., Gao J.Y., Yu M.H., Qian L.S. Morphologic and clinical study of 131 cases of plasma cell myeloma // Zhonghua Bing Li Xue Za Zhi. 2004. Vol. 33 (1). P. 44–48.Durie B.G., Salmon S.E. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival // Cancer. 1975. Vol. 36 (3). P. 842–854.Durie B.G., Salmon S.E. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival // Cancer. 1975. Vol. 36 (3). P. 842–854.Huang Y.W., Hamilton A., Arnuk O.J., Chaftari P., Chemaly R. Current drug therapy for multiple myeloma // Drugs. 1999. Vol. 57 (4). P. 485–506.Huang Y.W., Hamilton A., Arnuk O.J., Chaftari P., Chemaly R. Current drug therapy for multiple myeloma // Drugs. 1999. Vol. 57 (4). P. 485–506.Kyle R.A., Rajkumar S.V. Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma // Leukemia. 2009. № 23. P. 3–9. doi: 10.1038/leu.2008.291.Kyle R.A., Rajkumar S.V. Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma // Leukemia. 2009. № 23. P. 3–9. doi: 10.1038/leu.2008.291.Singhal N., Singh T., Singh Z.N., Shome D.K., Gaiha M. Histomorphology of multiple myeloma on bone marrow biopsy // Indian J. Pathol. Microbiol. 2004. Vol. 47 (3). P. 359–363.Singhal N., Singh T., Singh Z.N., Shome D.K., Gaiha M. Histomorphology of multiple myeloma on bone marrow biopsy // Indian J. Pathol. Microbiol. 2004. Vol. 47 (3). P. 359–363.Subramanian R., Basu D., Dutta TK. Significance of bone marrow fibrosis in multiple myeloma // Pathology. 2007. Vol. 39 (5). P. 512–515.Subramanian R., Basu D., Dutta TK. Significance of bone marrow fibrosis in multiple myeloma // Pathology. 2007. Vol. 39 (5). P. 512–515.Tadmor T., Shvidel L., Aviv A., Ruchlemer R., Bairey O., Yuklea M., Herishanu Y., Braester A., Rahimi-Levene N., Vernea F., Ben-Ezra J., Bejar J., Polliack A. Significance of bone marrow reticulin fibrosis in chronic lymphocytic leukemia at diagnosis // Cancer. 2013. Vol. 119 (10). P. 1853–1859. doi: 10.1002/cncr.27930.Tadmor T., Shvidel L., Aviv A., Ruchlemer R., Bairey O., Yuklea M., Herishanu Y., Braester A., Rahimi-Levene N., Vernea F., Ben-Ezra J., Bejar J., Polliack A. Significance of bone marrow reticulin fibrosis in chronic lymphocytic leukemia at diagnosis // Cancer. 2013. Vol. 119 (10). P. 1853–1859. doi: 10.1002/cncr.27930.Thiele J., Kvasnicka H.M., Facchetti F., Franco V., van der Walt J., Orazi A. European consensus on grading bone marrow fibrosis and assessment of cellularity // Haematologica. 2005. Vol. 90. P. 1128–1132.Thiele J., Kvasnicka H.M., Facchetti F., Franco V., van der Walt J., Orazi A. European consensus on grading bone marrow fibrosis and assessment of cellularity // Haematologica. 2005. Vol. 90. P. 1128–1132.

The authors declare that there are no conflicts of interest present.