References

oncotomsk

Сибирский онкологический журнал

Siberian journal of oncology

1814-48612312-3168

Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences

10.21294/1814-4861-2017-16-1-82-90

oncotomsk-496

Research Article

ОБЗОРЫ

REVIEWS

МОЛЕКУЛЯРНО-БИОЛОГИЧЕСКИЕ ФАКТОРЫ ПРОГНОЗА ПРИ РАКЕ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ

MOLECULAR BIOLOGICAL FACTORS IN THE PREDICTION OF PROSTATE CANCER

Вторушин

С. В.

Vtorushin

S. V.

доктор медицинских наук, доцент, старший научный сотрудник отделения патологической анатомии и цитологии, Научно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук; профессор кафедры патологической анатомии, Сибирский государственный медицинский университет Минздрава России

SPIN-код: 2442-4720.

MD, DSc, Senior Researcher, Department of Anatomical Pathology and Cytology, Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences

SPINcode; 2441-4720

wtorushin@rambler.ru

Безгодова

Н. В.

Bezgodova

N. V.

очный аспирант кафедры патологической анатомии, Сибирский государственный медицинский университет Минздрава России

postgraduate, Anatomical Pathology Department

natalia.bezgodova@mail.ru

Плешкунов

А. А.

Pleshkunov

A. A.

студент 6-го курса лечебного факультета, Сибирский государственный медицинский университет Минздрава России

student

alexandrpleshkunoff@mail.ru

Научно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. Томск ФГБОУ ВО «Сибирский государственный медицинский университет», г. ТомскРоссияCancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk Siberian State Medical University, TomskRussian Federation

ФГБОУ ВО «Сибирский государственный медицинский университет», г. ТомскРоссияSiberian State Medical University, TomskRussian Federation

2017

22032017

1618290

2017

Вторушин С.В., Безгодова Н.В., Плешкунов А.А.

Vtorushin S.V., Bezgodova N.V., Pleshkunov A.A.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.siboncoj.ru/jour/article/view/496

Цель исследования – обобщить имеющиеся данные о различных молекулярно-генетических диагностических и прогностических маркерах рака предстательной железы. Материал и методы. Поиск соответствующих источников производился в системах Medline, Cochrane Library, Elibrary. Из 540 найденных исследований 61 были использованы для написания систематического обзора. результаты. В настоящее время существует многообразие как прогностических, так и диагностических маркеров, используемых при изучении, диагностике и лечении рака предстательной железы. В обзоре приведена их классификация в зависимости от метода и среды, в которой они были выделены. Рассмотрены молекулярные механизмы участия различных генов и белков в патогенезе и прогрессировании карциномы предстательной железы, представлено потенциальное значение использования их в клинической практике. Заключение. Многие из существующих маркеров могут быть использованы для скрининга и раннего выявления опухоли, а также имеют доказанную прогностическую ценность. Однако противоречивые результаты исследований в отношении некоторых белков и генов требуют дальнейшего изучения, их валидации с последующим внедрением в клиническую практику.

Purpose: to review the available data on molecular-genetic diagnostic and prognostic markers in prostate cancer. Material and methods. The following electronic databases were used for our systematic review: Medline, Cochrane Library and Elibrary. Of 540 studies, 61 were used for our systematic review. Results. There are currently a variety of both prognostic and diagnostic markers used for diagnosis and treatment of prostate cancer. The review presents the classification of markers depending on the method and medium in which they were identified. The molecular mechanisms of participation of the different genes and proteins in the pathogenesis and progression of prostate carcinoma were analyzed and the potential importance of their use in clinical practice was provided. Conclusion. Many of the existing markers can be used for screening and early detection of tumors, and they have been proved to have a prognostic value. However, contradictory findings with regard to certain proteins and genes require further study, their validation with the subsequent implementation into clinical practice.

рак предстательной железымолекулярно-биологические маркеры прогноза

prostate cancermolecular biological prognostic markers

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The authors declare that there are no conflicts of interest present.