oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2017-16-2-71-81oncotomsk-523Research ArticleОБЗОРЫREVIEWSРАКОВЫЕ ТЕСТИКУЛЯРНЫЕ АНТИГЕНЫ В ИММУНОТЕРАПИИ ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЕЙCANCER TESTIS ANTIGENS IN CANCER IMMUNOTHERAPYВодолажскийД. И.VodolazhskyD. I.

Водолажский Дмитрий Игоревич - кандидат биологических наук, руководитель лаборатории молекулярной онкологии.

344037, г. Ростов-на-Дону, 14-я линия, 63. E-mail: dvodolazhsky@gmail.com. SPIN-код: 6660-5361

Vodolazhskij Dmitrij I. - PhD, Head of Laboratory of Molecular Oncology.

14th line, 63, Rostov-on-Don-344037. E-mail: dvodolazhsky@gmail.com. SPIN-code: 6660-5361

dvodolazhsky@gmail.coКитО. И.KitO. I.

Кит Олег Иванович - доктор медицинских наук, профессор, директор.

344037, г. Ростов-на-Дону, 14-я линия, 63. SPIN-код: 1728-0329

Kit Oleg I. - MD, DSc, Professor, Director.

14th line, 63, Rostov-on-Don-344037. SPIN-code: 1728-0329

МогушковаХ. А.MogushkovaKh. A.

Могушкова Хава Ахметовна, ординатор.

344037, г. Ростов-на-Дону, 14-я линия, 63. E-mail: hava_zanzibar@mail.ru

Mogushkova Hava A. - Researcher.

14th line, 63, Rostov-on-Don-344037. E-mail: hava_zanzibar@mail.ru

hava_zanzibar@mail.ruПушкинА. А.PushkinA. A.

Пушкин Антон Андреевич - младший научный сотрудник лаборатории молекулярной онкологии, ФГБУ «Ростовский научноисследовательский онкологический институт»

344037, г. Ростов-на-Дону, 14-я линия, 63. E-mail: cellculture.rnioi@gmail.com 

Pushkin Anton A. - Researcher Laboratory of Molecular Oncology.

14th line, 63, Rostov-on-Don-344037. E-mail: cellculture.rnioi@gmail.com

cellculture.rnioi@gmail.comТимошкинаН. Н.TimoshkinaN. N.

Тимошкина Наталья Николаевна, кандидат биологических наук, старший научный сотрудник лаборатории молекулярной онкологии.

344037, г. Ростов-на-Дону, 14-я линия, 63. E-mail: n_timoshkina@mail.ru. SPIN-код: 9483-4330

Timoshkina Natal’ja N. - PhD, Senior Researcher, Laboratory of Molecular Oncology.

14th line, 63, Rostov-on-Don-344037.  E-mail: n_timoshkina@mail.ru. SPIN-code: 9483-4330

n_timoshkina@mail.ruФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава РоссииРоссияRostov Research Institute of OncologyRussian Federation2017280520171627181Copyright © Водолажский Д.И., Кит О.И., Могушкова Х.А., Пушкин А.А., Тимошкина Н.Н., 20172017Водолажский Д.И., Кит О.И., Могушкова Х.А., Пушкин А.А., Тимошкина Н.Н.Vodolazhsky D.I., Kit O.I., Mogushkova K.A., Pushkin A.A., Timoshkina N.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/523

Низкая токсичность, онкоспецифичность, иммуногенность и относительно частая экспрессия во многих типах рака СТ-антигенов послужили основанием для их использования в иммунотерапии онкологических заболеваний. В настоящем обзоре представлены данные использования СТ-антигенов в новых клинических подходах контроля злокачественного процесса, развитых из представлений о механизмах противоопухолевого иммунитета. В частности, освещены результаты применения ингибиторов иммунных контрольных точек, коррекции иммунного ответа извне путем вакцинации культивированными ex vivo дендритными клетками, натуральными киллерами, Т-лимфоцитами; индукции и синхронизации экспрессии СТА с помощью ДНК гипометилирующих агентов для повышения иммуногенности раковых клеток и др. В итоге демонстрируется необходимость переосмысления современных клинических стратегий в отношении как выбора химиотерапевтических агентов, так и дизайна иммунотерапии, что в перспективе существенно повысит эффективность лечения рака.

Low toxicity, oncospecificity, immunogenicity and relatively frequent expression of CT antigens in many types of cancer justify their use in cancer immunotherapy. This review presents the data on CTA use in new clinical approaches to the malignant process control, developed from the ideas of the anti-tumor immunity mechanisms. In particular, we highlight the results of application of immune checkpoint inhibitors, external correction of the immune response by vaccination with ex vivo generated dendritic cells, natural killer cells and T-lymphocytes; induction and synchronization of CTA expression with DNA hypomethylating agents to enhance the immunogenicity of cancer cells, etc. As a result, we demonstrate the need for rethinking current clinical strategies in terms of the choice of chemotherapeutic agents and immunotherapy design, which will significantly increase the effectiveness of cancer treatment.

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The authors declare that there are no conflicts of interest present.