oncotomskСибирский онкологический журналSiberian journal of oncology1814-48612312-3168Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences10.21294/1814-4861-2017-16-3-65-78oncotomsk-543Research ArticleОБЗОРЫREVIEWSВОСПАЛЕНИЕ КАК ТЕРАПЕВТИЧЕСКАЯ МИШЕНЬ ПРИ КОМПЛЕКСНОМ ЛЕЧЕНИИ ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЕЙINFLAMMATION AS A THERAPEUTIC TARGET IN THE COMPLEX TREATMENT OF MALIGNANT TUMORSСавельеваО. Е.SavelievaO. E.

доктор медицинских наук, старший научный сотрудник отделения патологической анатомии и цитологии

634009, г. Томск, пер. Кооперативный, 5

SPIN-код: 9633-9449

MD, DSc, Senior Researcher, Department of Pathological Anatomy and Cytology

SPIN-code: 9633-9449

5, Kooperativny str., 634009-Tomsk

olga.sav.1980@gmail.comПерельмутерВ. М.PerelmuterV. M.

доктор медицинских наук, профессор, заведующий отделением патологической анатомии и цитологии

634009, г. Томск, пер. Кооперативный, 5

SPIN-код: 6252-5319

MD, DSc, Professor, Head of Department of Pathological Anatomy and Cytology

SPIN-code: 6252- 5319

5, Kooperativny str., 634009-Tomsk

pvm@ngs.ruТаширеваЛ. А.TashirevaL. A.

кандидат медицинских наук, научный сотрудник отделения патологической анатомии и цитологии

634009, г. Томск, пер. Кооперативный, 5

SPIN-код: 4371-5340

 

PhD, Researcher, Department of Pathological Anatomy and Cytology

SPIN-code: 4371-5340

5, Kooperativny str., 634009-Tomsk

lkleptsova@mail.ruДенисовЕ. В.DenisovE. V.

кандидат биологических наук, старший научный сотрудник лаборатории молекулярной онкологии и иммунологии

634009, г. Томск, пер. Кооперативный, 5

SPIN-код: 9498-5797

PhD, Senior Researcher, Laboratory of Molecular Oncology and Immunology

SPIN-code: 9498-5797

5, Kooperativny str., 634009-Tomsk

d_evgeniy@oncology.tomsk.ruИсаеваА. В.IsaevaA. V.

врач отделения патологической анатомии и цитологии

634009, г. Томск, пер. Кооперативный, 5

SPIN-код: 2058-7166

MD, Physician, Department of Pathological Anatomy and Cytology

SPIN-code: 2058-7166

5, Kooperativny str., 634009-Tomsk

seneann@mail.ruНаучно-исследовательский институт онкологии, Томский национальный исследовательский медицинский центр Российской академии наук, г. ТомскРоссияCancer Research Institute, Tomsk National Research Medical Center, TomskRussian Federation2017230720171636578Copyright © Савельева О.Е., Перельмутер В.М., Таширева Л.А., Денисов Е.В., Исаева А.В., 20172017Савельева О.Е., Перельмутер В.М., Таширева Л.А., Денисов Е.В., Исаева А.В.Savelieva O.E., Perelmuter V.M., Tashireva L.A., Denisov E.V., Isaeva A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.siboncoj.ru/jour/article/view/543

В обзоре анализируется роль воспаления в канцерогенезе, развитии опухоли и метастазировании. Обобщены многочисленные данные об эффективности противовоспалительных препаратов с целью профилактики и вспомогательной терапии опухолевой болезни. Обсуждены механизмы действия и причины противоречивости результатов использования нестероидных противовоспалительных препаратов (НПВП). Разнонаправленность эффектов может быть обусловлена особенностями иммуновоспалительных реакций, реализующихся в процессе канцерогенеза и развития опухолей, которые еще предстоит изучить. Обращается внимание на избирательность эффектов НПВП в отношении разных нозологических форм опухолей и противоположный характер противоопухолевых эффектов препаратов, относящихся по механизму действия к одной группе. Сделано заключение, что неудачи применения НПВП с профилактической и лечебной целью чаще возникают при карциномах, происходящих из плоского эпителия. Анализ литературы позволяет прийти к заключению, что имеются неоспоримые данные, позволяющие включать противовоспалительные препараты в существующие схемы противоопухолевого лечения при некоторых нозологических формах с определением молекулярных предикторов эффекта. Противовоспалительная терапия позволит устранить факторы, способствующие приобретению опухолевыми клетками инвазивных и метастатических свойств и формированию опухолевых и преметастатических ниш, а значит, развитию метастазов и рецидивов опухоли. Особенно перспективны при солидных опухолях определенные неселективные (аспирин) и селективные (целекоксиб) НПВП. 

In this review, we analyzed the role of inflammation in carcinogenesis, tumor development, and metastasis. In addition, the mechanisms of non-steroidal anti-inflammatory drugs (NSAIDs) and the reasons of their contradictory influence on cancers were discussed. We summarized the numerous data about effectiveness of anti-inflammatory drugs for the prevention and additional therapy of tumor diseases. In particular, divergent effects of NSAIDs may be due to the peculiarities of immune-inflammatory responses that are realized in carcinogenesis and tumor development that have yet to be studied. We also discussed the selectivity of NSAID effects on different cancers and opposite effects of anticancer drugs with similar mechanisms of action. Apparently, the unsuccessful use of NSAIDs in cancer prevention and therapy are more specific for squamous cell carcinomas. Based on the literature, we provided significant clinical findings regarding the need of NSAID use in the current therapy of certain cancers and the determination of molecular predictors of the drug effect. In fact, anti-inflammatory therapy could eliminate the factors that contribute to the appearance of invasive and metastatic tumor cells, cancer and premetastatic niches and thus prevent metastasis and recurrence. At present, some non-selective (aspirin) and selective (celecoxib) NSAIDs are highly promising in the therapy of solid tumors. 

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The authors declare that there are no conflicts of interest present.