References

oncotomsk

Сибирский онкологический журнал

Siberian journal of oncology

1814-48612312-3168

Tomsk National Research Medical Сепtеr of the Russian Academy of Sciences

10.21294/1814-4861-2017-16-4-65-75

oncotomsk-571

Research Article

ОБЗОРЫ

REVIEWS

ИММУНОТЕРАПИЯ МЕЛАНОМЫ

IMMUNOTHERAPY FOR MELANOMA

Боробова

Е. А.

Borobova

E. A.

Боробова Елена Александровна - врач клинической лабораторной диагностики, Сибирский федеральный биомедицинский исследовательский центр им. акад. Е.Н. Мешалкина; младший научный сотрудник, ФБУН ГНЦ ВБ «Вектор».

630055, г. Новосибирск, ул. Речкуновская, 15.

Borobova Elena A., MD, Junior Research Fellow, E.N. Meshalkin Siberian Biomedical Research Center; State Research Center ofVirology and Biotechnology «VECTOR».

15, Rechkunovskay str., 630055-Novosibirsk, Russia.

borobova-elena@rambler.ru

Жеравин

А. А.

Zheravin

A. A.

Жеравин Александр Александрович, кандидат медицинских наук, руководитель центра онкологии и радиотерапии, Сибирский федеральный биомедицинский исследовательский центр им. акад. Е.Н. Мешалкина.

630055, г. Новосибирск, ул. Речкуновская, 15.

Zheravin Alexander A., MD, PhD, Head of Oncology and Radiotherapy Department, E.N. Meshalkin Siberian Biomedical Research Center.

15, Rechkunovskay str., 630055-Novosibirsk, Russia.

a_zheravin@meshalkin.ru

Сибирский федеральный биомедицинский исследовательский центр им. акад. Е.Н. Мешалкина; ФБУН «Государственный научный центр вирусологии и биотехнологии «Вектор».РоссияE.N. Meshalkin Siberian Biomedical Research Center; State Research Center of Virology and Biotechnology «VECTOR».Russian Federation

Сибирский федеральный биомедицинский исследовательский центр им. акад. Е.Н. Мешалкина.РоссияE.N. Meshalkin Siberian Biomedical Research Center.Russian Federation

2017

12092017

1646575

2017

Боробова Е.А., Жеравин А.А.

Borobova E.A., Zheravin A.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.siboncoj.ru/jour/article/view/571

Меланома – это одна из наиболее опасных злокачественных опухолей человека. Агрессивный характер роста с риском формирования отдаленных метастазов является причиной высокого уровня смертности от меланомы кожи во всем мире. Ограниченные возможности таких методов, как хирургия, химиотерапия и лучевая терапия, делают актуальной разработку более эффективных способов лечения. В настоящее время одним из привлекательных подходов для борьбы с опухолевыми клетками является иммунотерапия. В обзоре проанализированы основные направления иммунотерапии меланомы, в том числе подходы в области создания терапевтических вакцин на основе опухолевых клеток, синтетических пептидов и полиэпитопных иммуногенов.

Melanoma is one of the most dangerous forms of skin cancer. Aggressive growth with a high risk of distant metastasis is the cause of the high death rate from skin melanoma worldwide. Melanoma that has metastasized beyond the lymph nodes requires more aggressive treatment. The standard treatment modalities including surgery, radiation therapy and chemotherapy are not very effective for most patients. The aggressive nature of this disease sustains an urgent need for more effective treatment methods. Immunotherapy is currently one of the most promising approaches for fighting cancer cells. The review analyses the main immunotherapeutic approaches to melanoma treatment, including therapeutic vaccines based on tumor cells, synthetic peptides and polyepitopic immunogens. Many of these vaccines are currently being studied in various clinical trials.

меланомаиммунотерапияантигеныклеточные вакциныпептидные вакциныДНК-вакциныдендритные клетки

melanomaimmunotherapyantigenscell vaccinespeptide vaccinesDNA-vaccinesdendritic cells

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The authors declare that there are no conflicts of interest present.